Antioxidative response of Phanerochaete chrysosporium against silver nanoparticle-induced toxicity and its potential mechanism
Antioxidative response of Phanerochaete chrysosporium induced by silver nanoparticles (AgNPs) and their toxicity mechanisms were comprehensively investigated in a complex system with 2,4-dichlorophenol (2,4-DCP) and Ag+. Malondialdehyde content was elevated by 2,4-DCP, AgNPs, and/or Ag+ in concentra...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Huang, Zhenzhen [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2018transfer abstract |
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| Schlagwörter: |
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| Umfang: |
11 |
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| Übergeordnetes Werk: |
Enthalten in: MPI vs Fortran coarrays beyond 100k cores: 3D cellular automata - Shterenlikht, Anton ELSEVIER, 2019, chemistry, biology and toxicology as related to environmental problems, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:211 ; year:2018 ; pages:573-583 ; extent:11 |
| Links: |
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| DOI / URN: |
10.1016/j.chemosphere.2018.07.192 |
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ELV044055862 |
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| 520 | |a Antioxidative response of Phanerochaete chrysosporium induced by silver nanoparticles (AgNPs) and their toxicity mechanisms were comprehensively investigated in a complex system with 2,4-dichlorophenol (2,4-DCP) and Ag+. Malondialdehyde content was elevated by 2,4-DCP, AgNPs, and/or Ag+ in concentration- and time-dependent manners within 24 h, indicating an increase in lipid peroxidation. However, beyond 48 h of exposure, lipid peroxidation was alleviated by upregulation of intracellular protein production and enhancement in the activities of superoxide dismutase (SOD), catalase (CAT), and peroxidase (POD). Comparatively, POD played more major roles in cell protection against oxidative damage. Furthermore, the dynamic change in reactive oxygen species (ROS) level was parallel to that of oxidized glutathione (GSSG), and ROS levels correlated well with GSSG contents (R 2 = 0.953) after exposure to AgNPs for 24 h. This finding suggested that elimination of oxidative stress resulted in depletion of reduced glutathione. Coupled with the analyses of anoxidative responses of P. chrysosporium under the single and combined treatments of AgNPs and Ag+, HAADF-STEM, SEM, and EDX demonstrated that AgNP-induced cytotoxicity could originate from the original AgNPs, rather than dissolved Ag+ or the biosynthesized AgNPs. | ||
| 520 | |a Antioxidative response of Phanerochaete chrysosporium induced by silver nanoparticles (AgNPs) and their toxicity mechanisms were comprehensively investigated in a complex system with 2,4-dichlorophenol (2,4-DCP) and Ag+. Malondialdehyde content was elevated by 2,4-DCP, AgNPs, and/or Ag+ in concentration- and time-dependent manners within 24 h, indicating an increase in lipid peroxidation. However, beyond 48 h of exposure, lipid peroxidation was alleviated by upregulation of intracellular protein production and enhancement in the activities of superoxide dismutase (SOD), catalase (CAT), and peroxidase (POD). Comparatively, POD played more major roles in cell protection against oxidative damage. Furthermore, the dynamic change in reactive oxygen species (ROS) level was parallel to that of oxidized glutathione (GSSG), and ROS levels correlated well with GSSG contents (R 2 = 0.953) after exposure to AgNPs for 24 h. This finding suggested that elimination of oxidative stress resulted in depletion of reduced glutathione. Coupled with the analyses of anoxidative responses of P. chrysosporium under the single and combined treatments of AgNPs and Ag+, HAADF-STEM, SEM, and EDX demonstrated that AgNP-induced cytotoxicity could originate from the original AgNPs, rather than dissolved Ag+ or the biosynthesized AgNPs. | ||
| 650 | 7 | |a Phanerochaete chrysosporium |2 Elsevier | |
| 650 | 7 | |a “Particle-specific” effects |2 Elsevier | |
| 650 | 7 | |a Oxidative stress |2 Elsevier | |
| 650 | 7 | |a Antioxidative enzymes |2 Elsevier | |
| 650 | 7 | |a Silver nanoparticles |2 Elsevier | |
| 700 | 1 | |a He, Kai |4 oth | |
| 700 | 1 | |a Song, Zhongxian |4 oth | |
| 700 | 1 | |a Zeng, Guangming |4 oth | |
| 700 | 1 | |a Chen, Anwei |4 oth | |
| 700 | 1 | |a Yuan, Lei |4 oth | |
| 700 | 1 | |a Li, Hui |4 oth | |
| 700 | 1 | |a Hu, Liang |4 oth | |
| 700 | 1 | |a Guo, Zhi |4 oth | |
| 700 | 1 | |a Chen, Guiqiu |4 oth | |
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10.1016/j.chemosphere.2018.07.192 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001064.pica (DE-627)ELV044055862 (ELSEVIER)S0045-6535(18)31454-1 DE-627 ger DE-627 rakwb eng 004 620 VZ 54.25 bkl Huang, Zhenzhen verfasserin aut Antioxidative response of Phanerochaete chrysosporium against silver nanoparticle-induced toxicity and its potential mechanism 2018transfer abstract 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Antioxidative response of Phanerochaete chrysosporium induced by silver nanoparticles (AgNPs) and their toxicity mechanisms were comprehensively investigated in a complex system with 2,4-dichlorophenol (2,4-DCP) and Ag+. Malondialdehyde content was elevated by 2,4-DCP, AgNPs, and/or Ag+ in concentration- and time-dependent manners within 24 h, indicating an increase in lipid peroxidation. However, beyond 48 h of exposure, lipid peroxidation was alleviated by upregulation of intracellular protein production and enhancement in the activities of superoxide dismutase (SOD), catalase (CAT), and peroxidase (POD). Comparatively, POD played more major roles in cell protection against oxidative damage. Furthermore, the dynamic change in reactive oxygen species (ROS) level was parallel to that of oxidized glutathione (GSSG), and ROS levels correlated well with GSSG contents (R 2 = 0.953) after exposure to AgNPs for 24 h. This finding suggested that elimination of oxidative stress resulted in depletion of reduced glutathione. Coupled with the analyses of anoxidative responses of P. chrysosporium under the single and combined treatments of AgNPs and Ag+, HAADF-STEM, SEM, and EDX demonstrated that AgNP-induced cytotoxicity could originate from the original AgNPs, rather than dissolved Ag+ or the biosynthesized AgNPs. Antioxidative response of Phanerochaete chrysosporium induced by silver nanoparticles (AgNPs) and their toxicity mechanisms were comprehensively investigated in a complex system with 2,4-dichlorophenol (2,4-DCP) and Ag+. Malondialdehyde content was elevated by 2,4-DCP, AgNPs, and/or Ag+ in concentration- and time-dependent manners within 24 h, indicating an increase in lipid peroxidation. However, beyond 48 h of exposure, lipid peroxidation was alleviated by upregulation of intracellular protein production and enhancement in the activities of superoxide dismutase (SOD), catalase (CAT), and peroxidase (POD). Comparatively, POD played more major roles in cell protection against oxidative damage. Furthermore, the dynamic change in reactive oxygen species (ROS) level was parallel to that of oxidized glutathione (GSSG), and ROS levels correlated well with GSSG contents (R 2 = 0.953) after exposure to AgNPs for 24 h. This finding suggested that elimination of oxidative stress resulted in depletion of reduced glutathione. Coupled with the analyses of anoxidative responses of P. chrysosporium under the single and combined treatments of AgNPs and Ag+, HAADF-STEM, SEM, and EDX demonstrated that AgNP-induced cytotoxicity could originate from the original AgNPs, rather than dissolved Ag+ or the biosynthesized AgNPs. Phanerochaete chrysosporium Elsevier “Particle-specific” effects Elsevier Oxidative stress Elsevier Antioxidative enzymes Elsevier Silver nanoparticles Elsevier He, Kai oth Song, Zhongxian oth Zeng, Guangming oth Chen, Anwei oth Yuan, Lei oth Li, Hui oth Hu, Liang oth Guo, Zhi oth Chen, Guiqiu oth Enthalten in Elsevier Science Shterenlikht, Anton ELSEVIER MPI vs Fortran coarrays beyond 100k cores: 3D cellular automata 2019 chemistry, biology and toxicology as related to environmental problems Amsterdam [u.a.] (DE-627)ELV002112701 volume:211 year:2018 pages:573-583 extent:11 https://doi.org/10.1016/j.chemosphere.2018.07.192 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 54.25 Parallele Datenverarbeitung VZ AR 211 2018 573-583 11 |
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10.1016/j.chemosphere.2018.07.192 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001064.pica (DE-627)ELV044055862 (ELSEVIER)S0045-6535(18)31454-1 DE-627 ger DE-627 rakwb eng 004 620 VZ 54.25 bkl Huang, Zhenzhen verfasserin aut Antioxidative response of Phanerochaete chrysosporium against silver nanoparticle-induced toxicity and its potential mechanism 2018transfer abstract 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Antioxidative response of Phanerochaete chrysosporium induced by silver nanoparticles (AgNPs) and their toxicity mechanisms were comprehensively investigated in a complex system with 2,4-dichlorophenol (2,4-DCP) and Ag+. Malondialdehyde content was elevated by 2,4-DCP, AgNPs, and/or Ag+ in concentration- and time-dependent manners within 24 h, indicating an increase in lipid peroxidation. However, beyond 48 h of exposure, lipid peroxidation was alleviated by upregulation of intracellular protein production and enhancement in the activities of superoxide dismutase (SOD), catalase (CAT), and peroxidase (POD). Comparatively, POD played more major roles in cell protection against oxidative damage. Furthermore, the dynamic change in reactive oxygen species (ROS) level was parallel to that of oxidized glutathione (GSSG), and ROS levels correlated well with GSSG contents (R 2 = 0.953) after exposure to AgNPs for 24 h. This finding suggested that elimination of oxidative stress resulted in depletion of reduced glutathione. Coupled with the analyses of anoxidative responses of P. chrysosporium under the single and combined treatments of AgNPs and Ag+, HAADF-STEM, SEM, and EDX demonstrated that AgNP-induced cytotoxicity could originate from the original AgNPs, rather than dissolved Ag+ or the biosynthesized AgNPs. Antioxidative response of Phanerochaete chrysosporium induced by silver nanoparticles (AgNPs) and their toxicity mechanisms were comprehensively investigated in a complex system with 2,4-dichlorophenol (2,4-DCP) and Ag+. Malondialdehyde content was elevated by 2,4-DCP, AgNPs, and/or Ag+ in concentration- and time-dependent manners within 24 h, indicating an increase in lipid peroxidation. However, beyond 48 h of exposure, lipid peroxidation was alleviated by upregulation of intracellular protein production and enhancement in the activities of superoxide dismutase (SOD), catalase (CAT), and peroxidase (POD). Comparatively, POD played more major roles in cell protection against oxidative damage. Furthermore, the dynamic change in reactive oxygen species (ROS) level was parallel to that of oxidized glutathione (GSSG), and ROS levels correlated well with GSSG contents (R 2 = 0.953) after exposure to AgNPs for 24 h. This finding suggested that elimination of oxidative stress resulted in depletion of reduced glutathione. Coupled with the analyses of anoxidative responses of P. chrysosporium under the single and combined treatments of AgNPs and Ag+, HAADF-STEM, SEM, and EDX demonstrated that AgNP-induced cytotoxicity could originate from the original AgNPs, rather than dissolved Ag+ or the biosynthesized AgNPs. Phanerochaete chrysosporium Elsevier “Particle-specific” effects Elsevier Oxidative stress Elsevier Antioxidative enzymes Elsevier Silver nanoparticles Elsevier He, Kai oth Song, Zhongxian oth Zeng, Guangming oth Chen, Anwei oth Yuan, Lei oth Li, Hui oth Hu, Liang oth Guo, Zhi oth Chen, Guiqiu oth Enthalten in Elsevier Science Shterenlikht, Anton ELSEVIER MPI vs Fortran coarrays beyond 100k cores: 3D cellular automata 2019 chemistry, biology and toxicology as related to environmental problems Amsterdam [u.a.] (DE-627)ELV002112701 volume:211 year:2018 pages:573-583 extent:11 https://doi.org/10.1016/j.chemosphere.2018.07.192 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 54.25 Parallele Datenverarbeitung VZ AR 211 2018 573-583 11 |
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10.1016/j.chemosphere.2018.07.192 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001064.pica (DE-627)ELV044055862 (ELSEVIER)S0045-6535(18)31454-1 DE-627 ger DE-627 rakwb eng 004 620 VZ 54.25 bkl Huang, Zhenzhen verfasserin aut Antioxidative response of Phanerochaete chrysosporium against silver nanoparticle-induced toxicity and its potential mechanism 2018transfer abstract 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Antioxidative response of Phanerochaete chrysosporium induced by silver nanoparticles (AgNPs) and their toxicity mechanisms were comprehensively investigated in a complex system with 2,4-dichlorophenol (2,4-DCP) and Ag+. Malondialdehyde content was elevated by 2,4-DCP, AgNPs, and/or Ag+ in concentration- and time-dependent manners within 24 h, indicating an increase in lipid peroxidation. However, beyond 48 h of exposure, lipid peroxidation was alleviated by upregulation of intracellular protein production and enhancement in the activities of superoxide dismutase (SOD), catalase (CAT), and peroxidase (POD). Comparatively, POD played more major roles in cell protection against oxidative damage. Furthermore, the dynamic change in reactive oxygen species (ROS) level was parallel to that of oxidized glutathione (GSSG), and ROS levels correlated well with GSSG contents (R 2 = 0.953) after exposure to AgNPs for 24 h. This finding suggested that elimination of oxidative stress resulted in depletion of reduced glutathione. Coupled with the analyses of anoxidative responses of P. chrysosporium under the single and combined treatments of AgNPs and Ag+, HAADF-STEM, SEM, and EDX demonstrated that AgNP-induced cytotoxicity could originate from the original AgNPs, rather than dissolved Ag+ or the biosynthesized AgNPs. Antioxidative response of Phanerochaete chrysosporium induced by silver nanoparticles (AgNPs) and their toxicity mechanisms were comprehensively investigated in a complex system with 2,4-dichlorophenol (2,4-DCP) and Ag+. Malondialdehyde content was elevated by 2,4-DCP, AgNPs, and/or Ag+ in concentration- and time-dependent manners within 24 h, indicating an increase in lipid peroxidation. However, beyond 48 h of exposure, lipid peroxidation was alleviated by upregulation of intracellular protein production and enhancement in the activities of superoxide dismutase (SOD), catalase (CAT), and peroxidase (POD). Comparatively, POD played more major roles in cell protection against oxidative damage. Furthermore, the dynamic change in reactive oxygen species (ROS) level was parallel to that of oxidized glutathione (GSSG), and ROS levels correlated well with GSSG contents (R 2 = 0.953) after exposure to AgNPs for 24 h. This finding suggested that elimination of oxidative stress resulted in depletion of reduced glutathione. Coupled with the analyses of anoxidative responses of P. chrysosporium under the single and combined treatments of AgNPs and Ag+, HAADF-STEM, SEM, and EDX demonstrated that AgNP-induced cytotoxicity could originate from the original AgNPs, rather than dissolved Ag+ or the biosynthesized AgNPs. Phanerochaete chrysosporium Elsevier “Particle-specific” effects Elsevier Oxidative stress Elsevier Antioxidative enzymes Elsevier Silver nanoparticles Elsevier He, Kai oth Song, Zhongxian oth Zeng, Guangming oth Chen, Anwei oth Yuan, Lei oth Li, Hui oth Hu, Liang oth Guo, Zhi oth Chen, Guiqiu oth Enthalten in Elsevier Science Shterenlikht, Anton ELSEVIER MPI vs Fortran coarrays beyond 100k cores: 3D cellular automata 2019 chemistry, biology and toxicology as related to environmental problems Amsterdam [u.a.] (DE-627)ELV002112701 volume:211 year:2018 pages:573-583 extent:11 https://doi.org/10.1016/j.chemosphere.2018.07.192 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 54.25 Parallele Datenverarbeitung VZ AR 211 2018 573-583 11 |
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10.1016/j.chemosphere.2018.07.192 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001064.pica (DE-627)ELV044055862 (ELSEVIER)S0045-6535(18)31454-1 DE-627 ger DE-627 rakwb eng 004 620 VZ 54.25 bkl Huang, Zhenzhen verfasserin aut Antioxidative response of Phanerochaete chrysosporium against silver nanoparticle-induced toxicity and its potential mechanism 2018transfer abstract 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Antioxidative response of Phanerochaete chrysosporium induced by silver nanoparticles (AgNPs) and their toxicity mechanisms were comprehensively investigated in a complex system with 2,4-dichlorophenol (2,4-DCP) and Ag+. Malondialdehyde content was elevated by 2,4-DCP, AgNPs, and/or Ag+ in concentration- and time-dependent manners within 24 h, indicating an increase in lipid peroxidation. However, beyond 48 h of exposure, lipid peroxidation was alleviated by upregulation of intracellular protein production and enhancement in the activities of superoxide dismutase (SOD), catalase (CAT), and peroxidase (POD). Comparatively, POD played more major roles in cell protection against oxidative damage. Furthermore, the dynamic change in reactive oxygen species (ROS) level was parallel to that of oxidized glutathione (GSSG), and ROS levels correlated well with GSSG contents (R 2 = 0.953) after exposure to AgNPs for 24 h. This finding suggested that elimination of oxidative stress resulted in depletion of reduced glutathione. Coupled with the analyses of anoxidative responses of P. chrysosporium under the single and combined treatments of AgNPs and Ag+, HAADF-STEM, SEM, and EDX demonstrated that AgNP-induced cytotoxicity could originate from the original AgNPs, rather than dissolved Ag+ or the biosynthesized AgNPs. Antioxidative response of Phanerochaete chrysosporium induced by silver nanoparticles (AgNPs) and their toxicity mechanisms were comprehensively investigated in a complex system with 2,4-dichlorophenol (2,4-DCP) and Ag+. Malondialdehyde content was elevated by 2,4-DCP, AgNPs, and/or Ag+ in concentration- and time-dependent manners within 24 h, indicating an increase in lipid peroxidation. However, beyond 48 h of exposure, lipid peroxidation was alleviated by upregulation of intracellular protein production and enhancement in the activities of superoxide dismutase (SOD), catalase (CAT), and peroxidase (POD). Comparatively, POD played more major roles in cell protection against oxidative damage. Furthermore, the dynamic change in reactive oxygen species (ROS) level was parallel to that of oxidized glutathione (GSSG), and ROS levels correlated well with GSSG contents (R 2 = 0.953) after exposure to AgNPs for 24 h. This finding suggested that elimination of oxidative stress resulted in depletion of reduced glutathione. Coupled with the analyses of anoxidative responses of P. chrysosporium under the single and combined treatments of AgNPs and Ag+, HAADF-STEM, SEM, and EDX demonstrated that AgNP-induced cytotoxicity could originate from the original AgNPs, rather than dissolved Ag+ or the biosynthesized AgNPs. Phanerochaete chrysosporium Elsevier “Particle-specific” effects Elsevier Oxidative stress Elsevier Antioxidative enzymes Elsevier Silver nanoparticles Elsevier He, Kai oth Song, Zhongxian oth Zeng, Guangming oth Chen, Anwei oth Yuan, Lei oth Li, Hui oth Hu, Liang oth Guo, Zhi oth Chen, Guiqiu oth Enthalten in Elsevier Science Shterenlikht, Anton ELSEVIER MPI vs Fortran coarrays beyond 100k cores: 3D cellular automata 2019 chemistry, biology and toxicology as related to environmental problems Amsterdam [u.a.] (DE-627)ELV002112701 volume:211 year:2018 pages:573-583 extent:11 https://doi.org/10.1016/j.chemosphere.2018.07.192 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 54.25 Parallele Datenverarbeitung VZ AR 211 2018 573-583 11 |
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10.1016/j.chemosphere.2018.07.192 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001064.pica (DE-627)ELV044055862 (ELSEVIER)S0045-6535(18)31454-1 DE-627 ger DE-627 rakwb eng 004 620 VZ 54.25 bkl Huang, Zhenzhen verfasserin aut Antioxidative response of Phanerochaete chrysosporium against silver nanoparticle-induced toxicity and its potential mechanism 2018transfer abstract 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Antioxidative response of Phanerochaete chrysosporium induced by silver nanoparticles (AgNPs) and their toxicity mechanisms were comprehensively investigated in a complex system with 2,4-dichlorophenol (2,4-DCP) and Ag+. Malondialdehyde content was elevated by 2,4-DCP, AgNPs, and/or Ag+ in concentration- and time-dependent manners within 24 h, indicating an increase in lipid peroxidation. However, beyond 48 h of exposure, lipid peroxidation was alleviated by upregulation of intracellular protein production and enhancement in the activities of superoxide dismutase (SOD), catalase (CAT), and peroxidase (POD). Comparatively, POD played more major roles in cell protection against oxidative damage. Furthermore, the dynamic change in reactive oxygen species (ROS) level was parallel to that of oxidized glutathione (GSSG), and ROS levels correlated well with GSSG contents (R 2 = 0.953) after exposure to AgNPs for 24 h. This finding suggested that elimination of oxidative stress resulted in depletion of reduced glutathione. Coupled with the analyses of anoxidative responses of P. chrysosporium under the single and combined treatments of AgNPs and Ag+, HAADF-STEM, SEM, and EDX demonstrated that AgNP-induced cytotoxicity could originate from the original AgNPs, rather than dissolved Ag+ or the biosynthesized AgNPs. Antioxidative response of Phanerochaete chrysosporium induced by silver nanoparticles (AgNPs) and their toxicity mechanisms were comprehensively investigated in a complex system with 2,4-dichlorophenol (2,4-DCP) and Ag+. Malondialdehyde content was elevated by 2,4-DCP, AgNPs, and/or Ag+ in concentration- and time-dependent manners within 24 h, indicating an increase in lipid peroxidation. However, beyond 48 h of exposure, lipid peroxidation was alleviated by upregulation of intracellular protein production and enhancement in the activities of superoxide dismutase (SOD), catalase (CAT), and peroxidase (POD). Comparatively, POD played more major roles in cell protection against oxidative damage. Furthermore, the dynamic change in reactive oxygen species (ROS) level was parallel to that of oxidized glutathione (GSSG), and ROS levels correlated well with GSSG contents (R 2 = 0.953) after exposure to AgNPs for 24 h. This finding suggested that elimination of oxidative stress resulted in depletion of reduced glutathione. Coupled with the analyses of anoxidative responses of P. chrysosporium under the single and combined treatments of AgNPs and Ag+, HAADF-STEM, SEM, and EDX demonstrated that AgNP-induced cytotoxicity could originate from the original AgNPs, rather than dissolved Ag+ or the biosynthesized AgNPs. Phanerochaete chrysosporium Elsevier “Particle-specific” effects Elsevier Oxidative stress Elsevier Antioxidative enzymes Elsevier Silver nanoparticles Elsevier He, Kai oth Song, Zhongxian oth Zeng, Guangming oth Chen, Anwei oth Yuan, Lei oth Li, Hui oth Hu, Liang oth Guo, Zhi oth Chen, Guiqiu oth Enthalten in Elsevier Science Shterenlikht, Anton ELSEVIER MPI vs Fortran coarrays beyond 100k cores: 3D cellular automata 2019 chemistry, biology and toxicology as related to environmental problems Amsterdam [u.a.] (DE-627)ELV002112701 volume:211 year:2018 pages:573-583 extent:11 https://doi.org/10.1016/j.chemosphere.2018.07.192 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 54.25 Parallele Datenverarbeitung VZ AR 211 2018 573-583 11 |
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Antioxidative response of Phanerochaete chrysosporium against silver nanoparticle-induced toxicity and its potential mechanism |
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Antioxidative response of Phanerochaete chrysosporium induced by silver nanoparticles (AgNPs) and their toxicity mechanisms were comprehensively investigated in a complex system with 2,4-dichlorophenol (2,4-DCP) and Ag+. Malondialdehyde content was elevated by 2,4-DCP, AgNPs, and/or Ag+ in concentration- and time-dependent manners within 24 h, indicating an increase in lipid peroxidation. However, beyond 48 h of exposure, lipid peroxidation was alleviated by upregulation of intracellular protein production and enhancement in the activities of superoxide dismutase (SOD), catalase (CAT), and peroxidase (POD). Comparatively, POD played more major roles in cell protection against oxidative damage. Furthermore, the dynamic change in reactive oxygen species (ROS) level was parallel to that of oxidized glutathione (GSSG), and ROS levels correlated well with GSSG contents (R 2 = 0.953) after exposure to AgNPs for 24 h. This finding suggested that elimination of oxidative stress resulted in depletion of reduced glutathione. Coupled with the analyses of anoxidative responses of P. chrysosporium under the single and combined treatments of AgNPs and Ag+, HAADF-STEM, SEM, and EDX demonstrated that AgNP-induced cytotoxicity could originate from the original AgNPs, rather than dissolved Ag+ or the biosynthesized AgNPs. |
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Antioxidative response of Phanerochaete chrysosporium induced by silver nanoparticles (AgNPs) and their toxicity mechanisms were comprehensively investigated in a complex system with 2,4-dichlorophenol (2,4-DCP) and Ag+. Malondialdehyde content was elevated by 2,4-DCP, AgNPs, and/or Ag+ in concentration- and time-dependent manners within 24 h, indicating an increase in lipid peroxidation. However, beyond 48 h of exposure, lipid peroxidation was alleviated by upregulation of intracellular protein production and enhancement in the activities of superoxide dismutase (SOD), catalase (CAT), and peroxidase (POD). Comparatively, POD played more major roles in cell protection against oxidative damage. Furthermore, the dynamic change in reactive oxygen species (ROS) level was parallel to that of oxidized glutathione (GSSG), and ROS levels correlated well with GSSG contents (R 2 = 0.953) after exposure to AgNPs for 24 h. This finding suggested that elimination of oxidative stress resulted in depletion of reduced glutathione. Coupled with the analyses of anoxidative responses of P. chrysosporium under the single and combined treatments of AgNPs and Ag+, HAADF-STEM, SEM, and EDX demonstrated that AgNP-induced cytotoxicity could originate from the original AgNPs, rather than dissolved Ag+ or the biosynthesized AgNPs. |
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Antioxidative response of Phanerochaete chrysosporium induced by silver nanoparticles (AgNPs) and their toxicity mechanisms were comprehensively investigated in a complex system with 2,4-dichlorophenol (2,4-DCP) and Ag+. Malondialdehyde content was elevated by 2,4-DCP, AgNPs, and/or Ag+ in concentration- and time-dependent manners within 24 h, indicating an increase in lipid peroxidation. However, beyond 48 h of exposure, lipid peroxidation was alleviated by upregulation of intracellular protein production and enhancement in the activities of superoxide dismutase (SOD), catalase (CAT), and peroxidase (POD). Comparatively, POD played more major roles in cell protection against oxidative damage. Furthermore, the dynamic change in reactive oxygen species (ROS) level was parallel to that of oxidized glutathione (GSSG), and ROS levels correlated well with GSSG contents (R 2 = 0.953) after exposure to AgNPs for 24 h. This finding suggested that elimination of oxidative stress resulted in depletion of reduced glutathione. Coupled with the analyses of anoxidative responses of P. chrysosporium under the single and combined treatments of AgNPs and Ag+, HAADF-STEM, SEM, and EDX demonstrated that AgNP-induced cytotoxicity could originate from the original AgNPs, rather than dissolved Ag+ or the biosynthesized AgNPs. |
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