Did AFP-L3 save ultrasonography in community screening?
In the community screening, those subjects with elevated serum alpha-fetoprotein (AFP) required further abdomen ultrasonography (US) to detect hepatocellular carcinoma (HCC). However, some chronic hepatitis patients might have elevated AFP. AFP-L3, has been proposed to differentiate HCC and hepatiti...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Yen, Chih-Wei [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2018transfer abstract |
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| Schlagwörter: |
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| Umfang: |
5 |
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| Übergeordnetes Werk: |
Enthalten in: Under-developed bronchial arteries as a risk factor for complications in balloon pulmonary angioplasty - Takei, Makoto ELSEVIER, 2016, KJMS, Hong Kong [u.a.] |
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| Übergeordnetes Werk: |
volume:34 ; year:2018 ; number:10 ; pages:583-587 ; extent:5 |
| Links: |
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| DOI / URN: |
10.1016/j.kjms.2018.05.005 |
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ELV044356285 |
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| 520 | |a In the community screening, those subjects with elevated serum alpha-fetoprotein (AFP) required further abdomen ultrasonography (US) to detect hepatocellular carcinoma (HCC). However, some chronic hepatitis patients might have elevated AFP. AFP-L3, has been proposed to differentiate HCC and hepatitis in elevated AFP cases in Japan for decades, but the utility is limited outside Japan. We conducted this study to elucidate the role of AFP-L3 in the community and the possibility of saving unnecessary US. A total of 56,702 subjects underwent a large-scale healthcare screening in Tainan county in 2004. Among them, 286 residents with AFP more than 20 ng/ml further received US and 169 (59%) had stored baseline sera were enrolled into this study in 2013. Their AFP and AFP-L3 levels were further detected. HCC patients were initially identified through US and personal history. Among 169 studied sera, only 148 (87.6%) samples still had AFP level more than 20 ng/ml after a 10-years frozen period. The decrease of AFP level was significant (481.3 ± 2093.8 ng/ml and 456.1 ± 2095.3 ng/ml in paired-T test, p < 0.001). Focusing on these 148 cases, 23 (15.5%) HCC cases were diagnosed at the baseline screening. There was no difference of AFP-L3 level between HCC and non-HCC cases. Using AFP-L3 to predict HCC, the area under Receiver Operating Characteristic curve was as low as 52%, p = 0.757. Too long frozen period might lower the quality of stored sera. Additionally, AFP-L3 might not provide more information for HCC identification to save advanced US examinations in the community screening. | ||
| 520 | |a In the community screening, those subjects with elevated serum alpha-fetoprotein (AFP) required further abdomen ultrasonography (US) to detect hepatocellular carcinoma (HCC). However, some chronic hepatitis patients might have elevated AFP. AFP-L3, has been proposed to differentiate HCC and hepatitis in elevated AFP cases in Japan for decades, but the utility is limited outside Japan. We conducted this study to elucidate the role of AFP-L3 in the community and the possibility of saving unnecessary US. A total of 56,702 subjects underwent a large-scale healthcare screening in Tainan county in 2004. Among them, 286 residents with AFP more than 20 ng/ml further received US and 169 (59%) had stored baseline sera were enrolled into this study in 2013. Their AFP and AFP-L3 levels were further detected. HCC patients were initially identified through US and personal history. Among 169 studied sera, only 148 (87.6%) samples still had AFP level more than 20 ng/ml after a 10-years frozen period. The decrease of AFP level was significant (481.3 ± 2093.8 ng/ml and 456.1 ± 2095.3 ng/ml in paired-T test, p < 0.001). Focusing on these 148 cases, 23 (15.5%) HCC cases were diagnosed at the baseline screening. There was no difference of AFP-L3 level between HCC and non-HCC cases. Using AFP-L3 to predict HCC, the area under Receiver Operating Characteristic curve was as low as 52%, p = 0.757. Too long frozen period might lower the quality of stored sera. Additionally, AFP-L3 might not provide more information for HCC identification to save advanced US examinations in the community screening. | ||
| 650 | 7 | |a Community hepatocellular carcinoma screening |2 Elsevier | |
| 650 | 7 | |a Ultrasonography |2 Elsevier | |
| 650 | 7 | |a Alpha-fetoprotein-L3 |2 Elsevier | |
| 650 | 7 | |a Alpha-fetoprotein |2 Elsevier | |
| 700 | 1 | |a Kuo, Yuan-Hung |4 oth | |
| 700 | 1 | |a Wang, Jing-Houng |4 oth | |
| 700 | 1 | |a Chang, Kuo-Chin |4 oth | |
| 700 | 1 | |a Kee, Kwong-Ming |4 oth | |
| 700 | 1 | |a Hung, Shu-Feng |4 oth | |
| 700 | 1 | |a Chen, Yi |4 oth | |
| 700 | 1 | |a Tsai, Lin-San |4 oth | |
| 700 | 1 | |a Chen, Shu-Chuan |4 oth | |
| 700 | 1 | |a Hung, Chao-Hung |4 oth | |
| 700 | 1 | |a Lu, Sheng-Nan |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |n Elsevier |a Takei, Makoto ELSEVIER |t Under-developed bronchial arteries as a risk factor for complications in balloon pulmonary angioplasty |d 2016 |d KJMS |g Hong Kong [u.a.] |w (DE-627)ELV013890123 |
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10.1016/j.kjms.2018.05.005 doi GBV00000000000388.pica (DE-627)ELV044356285 (ELSEVIER)S1607-551X(18)30123-2 DE-627 ger DE-627 rakwb eng 610 VZ 630 640 610 VZ Yen, Chih-Wei verfasserin aut Did AFP-L3 save ultrasonography in community screening? 2018transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In the community screening, those subjects with elevated serum alpha-fetoprotein (AFP) required further abdomen ultrasonography (US) to detect hepatocellular carcinoma (HCC). However, some chronic hepatitis patients might have elevated AFP. AFP-L3, has been proposed to differentiate HCC and hepatitis in elevated AFP cases in Japan for decades, but the utility is limited outside Japan. We conducted this study to elucidate the role of AFP-L3 in the community and the possibility of saving unnecessary US. A total of 56,702 subjects underwent a large-scale healthcare screening in Tainan county in 2004. Among them, 286 residents with AFP more than 20 ng/ml further received US and 169 (59%) had stored baseline sera were enrolled into this study in 2013. Their AFP and AFP-L3 levels were further detected. HCC patients were initially identified through US and personal history. Among 169 studied sera, only 148 (87.6%) samples still had AFP level more than 20 ng/ml after a 10-years frozen period. The decrease of AFP level was significant (481.3 ± 2093.8 ng/ml and 456.1 ± 2095.3 ng/ml in paired-T test, p < 0.001). Focusing on these 148 cases, 23 (15.5%) HCC cases were diagnosed at the baseline screening. There was no difference of AFP-L3 level between HCC and non-HCC cases. Using AFP-L3 to predict HCC, the area under Receiver Operating Characteristic curve was as low as 52%, p = 0.757. Too long frozen period might lower the quality of stored sera. Additionally, AFP-L3 might not provide more information for HCC identification to save advanced US examinations in the community screening. In the community screening, those subjects with elevated serum alpha-fetoprotein (AFP) required further abdomen ultrasonography (US) to detect hepatocellular carcinoma (HCC). However, some chronic hepatitis patients might have elevated AFP. AFP-L3, has been proposed to differentiate HCC and hepatitis in elevated AFP cases in Japan for decades, but the utility is limited outside Japan. We conducted this study to elucidate the role of AFP-L3 in the community and the possibility of saving unnecessary US. A total of 56,702 subjects underwent a large-scale healthcare screening in Tainan county in 2004. Among them, 286 residents with AFP more than 20 ng/ml further received US and 169 (59%) had stored baseline sera were enrolled into this study in 2013. Their AFP and AFP-L3 levels were further detected. HCC patients were initially identified through US and personal history. Among 169 studied sera, only 148 (87.6%) samples still had AFP level more than 20 ng/ml after a 10-years frozen period. The decrease of AFP level was significant (481.3 ± 2093.8 ng/ml and 456.1 ± 2095.3 ng/ml in paired-T test, p < 0.001). Focusing on these 148 cases, 23 (15.5%) HCC cases were diagnosed at the baseline screening. There was no difference of AFP-L3 level between HCC and non-HCC cases. Using AFP-L3 to predict HCC, the area under Receiver Operating Characteristic curve was as low as 52%, p = 0.757. Too long frozen period might lower the quality of stored sera. Additionally, AFP-L3 might not provide more information for HCC identification to save advanced US examinations in the community screening. Community hepatocellular carcinoma screening Elsevier Ultrasonography Elsevier Alpha-fetoprotein-L3 Elsevier Alpha-fetoprotein Elsevier Kuo, Yuan-Hung oth Wang, Jing-Houng oth Chang, Kuo-Chin oth Kee, Kwong-Ming oth Hung, Shu-Feng oth Chen, Yi oth Tsai, Lin-San oth Chen, Shu-Chuan oth Hung, Chao-Hung oth Lu, Sheng-Nan oth Enthalten in Elsevier Takei, Makoto ELSEVIER Under-developed bronchial arteries as a risk factor for complications in balloon pulmonary angioplasty 2016 KJMS Hong Kong [u.a.] (DE-627)ELV013890123 volume:34 year:2018 number:10 pages:583-587 extent:5 https://doi.org/10.1016/j.kjms.2018.05.005 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_11 GBV_ILN_40 AR 34 2018 10 583-587 5 |
| spelling |
10.1016/j.kjms.2018.05.005 doi GBV00000000000388.pica (DE-627)ELV044356285 (ELSEVIER)S1607-551X(18)30123-2 DE-627 ger DE-627 rakwb eng 610 VZ 630 640 610 VZ Yen, Chih-Wei verfasserin aut Did AFP-L3 save ultrasonography in community screening? 2018transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In the community screening, those subjects with elevated serum alpha-fetoprotein (AFP) required further abdomen ultrasonography (US) to detect hepatocellular carcinoma (HCC). However, some chronic hepatitis patients might have elevated AFP. AFP-L3, has been proposed to differentiate HCC and hepatitis in elevated AFP cases in Japan for decades, but the utility is limited outside Japan. We conducted this study to elucidate the role of AFP-L3 in the community and the possibility of saving unnecessary US. A total of 56,702 subjects underwent a large-scale healthcare screening in Tainan county in 2004. Among them, 286 residents with AFP more than 20 ng/ml further received US and 169 (59%) had stored baseline sera were enrolled into this study in 2013. Their AFP and AFP-L3 levels were further detected. HCC patients were initially identified through US and personal history. Among 169 studied sera, only 148 (87.6%) samples still had AFP level more than 20 ng/ml after a 10-years frozen period. The decrease of AFP level was significant (481.3 ± 2093.8 ng/ml and 456.1 ± 2095.3 ng/ml in paired-T test, p < 0.001). Focusing on these 148 cases, 23 (15.5%) HCC cases were diagnosed at the baseline screening. There was no difference of AFP-L3 level between HCC and non-HCC cases. Using AFP-L3 to predict HCC, the area under Receiver Operating Characteristic curve was as low as 52%, p = 0.757. Too long frozen period might lower the quality of stored sera. Additionally, AFP-L3 might not provide more information for HCC identification to save advanced US examinations in the community screening. In the community screening, those subjects with elevated serum alpha-fetoprotein (AFP) required further abdomen ultrasonography (US) to detect hepatocellular carcinoma (HCC). However, some chronic hepatitis patients might have elevated AFP. AFP-L3, has been proposed to differentiate HCC and hepatitis in elevated AFP cases in Japan for decades, but the utility is limited outside Japan. We conducted this study to elucidate the role of AFP-L3 in the community and the possibility of saving unnecessary US. A total of 56,702 subjects underwent a large-scale healthcare screening in Tainan county in 2004. Among them, 286 residents with AFP more than 20 ng/ml further received US and 169 (59%) had stored baseline sera were enrolled into this study in 2013. Their AFP and AFP-L3 levels were further detected. HCC patients were initially identified through US and personal history. Among 169 studied sera, only 148 (87.6%) samples still had AFP level more than 20 ng/ml after a 10-years frozen period. The decrease of AFP level was significant (481.3 ± 2093.8 ng/ml and 456.1 ± 2095.3 ng/ml in paired-T test, p < 0.001). Focusing on these 148 cases, 23 (15.5%) HCC cases were diagnosed at the baseline screening. There was no difference of AFP-L3 level between HCC and non-HCC cases. Using AFP-L3 to predict HCC, the area under Receiver Operating Characteristic curve was as low as 52%, p = 0.757. Too long frozen period might lower the quality of stored sera. Additionally, AFP-L3 might not provide more information for HCC identification to save advanced US examinations in the community screening. Community hepatocellular carcinoma screening Elsevier Ultrasonography Elsevier Alpha-fetoprotein-L3 Elsevier Alpha-fetoprotein Elsevier Kuo, Yuan-Hung oth Wang, Jing-Houng oth Chang, Kuo-Chin oth Kee, Kwong-Ming oth Hung, Shu-Feng oth Chen, Yi oth Tsai, Lin-San oth Chen, Shu-Chuan oth Hung, Chao-Hung oth Lu, Sheng-Nan oth Enthalten in Elsevier Takei, Makoto ELSEVIER Under-developed bronchial arteries as a risk factor for complications in balloon pulmonary angioplasty 2016 KJMS Hong Kong [u.a.] (DE-627)ELV013890123 volume:34 year:2018 number:10 pages:583-587 extent:5 https://doi.org/10.1016/j.kjms.2018.05.005 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_11 GBV_ILN_40 AR 34 2018 10 583-587 5 |
| allfields_unstemmed |
10.1016/j.kjms.2018.05.005 doi GBV00000000000388.pica (DE-627)ELV044356285 (ELSEVIER)S1607-551X(18)30123-2 DE-627 ger DE-627 rakwb eng 610 VZ 630 640 610 VZ Yen, Chih-Wei verfasserin aut Did AFP-L3 save ultrasonography in community screening? 2018transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In the community screening, those subjects with elevated serum alpha-fetoprotein (AFP) required further abdomen ultrasonography (US) to detect hepatocellular carcinoma (HCC). However, some chronic hepatitis patients might have elevated AFP. AFP-L3, has been proposed to differentiate HCC and hepatitis in elevated AFP cases in Japan for decades, but the utility is limited outside Japan. We conducted this study to elucidate the role of AFP-L3 in the community and the possibility of saving unnecessary US. A total of 56,702 subjects underwent a large-scale healthcare screening in Tainan county in 2004. Among them, 286 residents with AFP more than 20 ng/ml further received US and 169 (59%) had stored baseline sera were enrolled into this study in 2013. Their AFP and AFP-L3 levels were further detected. HCC patients were initially identified through US and personal history. Among 169 studied sera, only 148 (87.6%) samples still had AFP level more than 20 ng/ml after a 10-years frozen period. The decrease of AFP level was significant (481.3 ± 2093.8 ng/ml and 456.1 ± 2095.3 ng/ml in paired-T test, p < 0.001). Focusing on these 148 cases, 23 (15.5%) HCC cases were diagnosed at the baseline screening. There was no difference of AFP-L3 level between HCC and non-HCC cases. Using AFP-L3 to predict HCC, the area under Receiver Operating Characteristic curve was as low as 52%, p = 0.757. Too long frozen period might lower the quality of stored sera. Additionally, AFP-L3 might not provide more information for HCC identification to save advanced US examinations in the community screening. In the community screening, those subjects with elevated serum alpha-fetoprotein (AFP) required further abdomen ultrasonography (US) to detect hepatocellular carcinoma (HCC). However, some chronic hepatitis patients might have elevated AFP. AFP-L3, has been proposed to differentiate HCC and hepatitis in elevated AFP cases in Japan for decades, but the utility is limited outside Japan. We conducted this study to elucidate the role of AFP-L3 in the community and the possibility of saving unnecessary US. A total of 56,702 subjects underwent a large-scale healthcare screening in Tainan county in 2004. Among them, 286 residents with AFP more than 20 ng/ml further received US and 169 (59%) had stored baseline sera were enrolled into this study in 2013. Their AFP and AFP-L3 levels were further detected. HCC patients were initially identified through US and personal history. Among 169 studied sera, only 148 (87.6%) samples still had AFP level more than 20 ng/ml after a 10-years frozen period. The decrease of AFP level was significant (481.3 ± 2093.8 ng/ml and 456.1 ± 2095.3 ng/ml in paired-T test, p < 0.001). Focusing on these 148 cases, 23 (15.5%) HCC cases were diagnosed at the baseline screening. There was no difference of AFP-L3 level between HCC and non-HCC cases. Using AFP-L3 to predict HCC, the area under Receiver Operating Characteristic curve was as low as 52%, p = 0.757. Too long frozen period might lower the quality of stored sera. Additionally, AFP-L3 might not provide more information for HCC identification to save advanced US examinations in the community screening. Community hepatocellular carcinoma screening Elsevier Ultrasonography Elsevier Alpha-fetoprotein-L3 Elsevier Alpha-fetoprotein Elsevier Kuo, Yuan-Hung oth Wang, Jing-Houng oth Chang, Kuo-Chin oth Kee, Kwong-Ming oth Hung, Shu-Feng oth Chen, Yi oth Tsai, Lin-San oth Chen, Shu-Chuan oth Hung, Chao-Hung oth Lu, Sheng-Nan oth Enthalten in Elsevier Takei, Makoto ELSEVIER Under-developed bronchial arteries as a risk factor for complications in balloon pulmonary angioplasty 2016 KJMS Hong Kong [u.a.] (DE-627)ELV013890123 volume:34 year:2018 number:10 pages:583-587 extent:5 https://doi.org/10.1016/j.kjms.2018.05.005 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_11 GBV_ILN_40 AR 34 2018 10 583-587 5 |
| allfieldsGer |
10.1016/j.kjms.2018.05.005 doi GBV00000000000388.pica (DE-627)ELV044356285 (ELSEVIER)S1607-551X(18)30123-2 DE-627 ger DE-627 rakwb eng 610 VZ 630 640 610 VZ Yen, Chih-Wei verfasserin aut Did AFP-L3 save ultrasonography in community screening? 2018transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In the community screening, those subjects with elevated serum alpha-fetoprotein (AFP) required further abdomen ultrasonography (US) to detect hepatocellular carcinoma (HCC). However, some chronic hepatitis patients might have elevated AFP. AFP-L3, has been proposed to differentiate HCC and hepatitis in elevated AFP cases in Japan for decades, but the utility is limited outside Japan. We conducted this study to elucidate the role of AFP-L3 in the community and the possibility of saving unnecessary US. A total of 56,702 subjects underwent a large-scale healthcare screening in Tainan county in 2004. Among them, 286 residents with AFP more than 20 ng/ml further received US and 169 (59%) had stored baseline sera were enrolled into this study in 2013. Their AFP and AFP-L3 levels were further detected. HCC patients were initially identified through US and personal history. Among 169 studied sera, only 148 (87.6%) samples still had AFP level more than 20 ng/ml after a 10-years frozen period. The decrease of AFP level was significant (481.3 ± 2093.8 ng/ml and 456.1 ± 2095.3 ng/ml in paired-T test, p < 0.001). Focusing on these 148 cases, 23 (15.5%) HCC cases were diagnosed at the baseline screening. There was no difference of AFP-L3 level between HCC and non-HCC cases. Using AFP-L3 to predict HCC, the area under Receiver Operating Characteristic curve was as low as 52%, p = 0.757. Too long frozen period might lower the quality of stored sera. Additionally, AFP-L3 might not provide more information for HCC identification to save advanced US examinations in the community screening. In the community screening, those subjects with elevated serum alpha-fetoprotein (AFP) required further abdomen ultrasonography (US) to detect hepatocellular carcinoma (HCC). However, some chronic hepatitis patients might have elevated AFP. AFP-L3, has been proposed to differentiate HCC and hepatitis in elevated AFP cases in Japan for decades, but the utility is limited outside Japan. We conducted this study to elucidate the role of AFP-L3 in the community and the possibility of saving unnecessary US. A total of 56,702 subjects underwent a large-scale healthcare screening in Tainan county in 2004. Among them, 286 residents with AFP more than 20 ng/ml further received US and 169 (59%) had stored baseline sera were enrolled into this study in 2013. Their AFP and AFP-L3 levels were further detected. HCC patients were initially identified through US and personal history. Among 169 studied sera, only 148 (87.6%) samples still had AFP level more than 20 ng/ml after a 10-years frozen period. The decrease of AFP level was significant (481.3 ± 2093.8 ng/ml and 456.1 ± 2095.3 ng/ml in paired-T test, p < 0.001). Focusing on these 148 cases, 23 (15.5%) HCC cases were diagnosed at the baseline screening. There was no difference of AFP-L3 level between HCC and non-HCC cases. Using AFP-L3 to predict HCC, the area under Receiver Operating Characteristic curve was as low as 52%, p = 0.757. Too long frozen period might lower the quality of stored sera. Additionally, AFP-L3 might not provide more information for HCC identification to save advanced US examinations in the community screening. Community hepatocellular carcinoma screening Elsevier Ultrasonography Elsevier Alpha-fetoprotein-L3 Elsevier Alpha-fetoprotein Elsevier Kuo, Yuan-Hung oth Wang, Jing-Houng oth Chang, Kuo-Chin oth Kee, Kwong-Ming oth Hung, Shu-Feng oth Chen, Yi oth Tsai, Lin-San oth Chen, Shu-Chuan oth Hung, Chao-Hung oth Lu, Sheng-Nan oth Enthalten in Elsevier Takei, Makoto ELSEVIER Under-developed bronchial arteries as a risk factor for complications in balloon pulmonary angioplasty 2016 KJMS Hong Kong [u.a.] (DE-627)ELV013890123 volume:34 year:2018 number:10 pages:583-587 extent:5 https://doi.org/10.1016/j.kjms.2018.05.005 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_11 GBV_ILN_40 AR 34 2018 10 583-587 5 |
| allfieldsSound |
10.1016/j.kjms.2018.05.005 doi GBV00000000000388.pica (DE-627)ELV044356285 (ELSEVIER)S1607-551X(18)30123-2 DE-627 ger DE-627 rakwb eng 610 VZ 630 640 610 VZ Yen, Chih-Wei verfasserin aut Did AFP-L3 save ultrasonography in community screening? 2018transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In the community screening, those subjects with elevated serum alpha-fetoprotein (AFP) required further abdomen ultrasonography (US) to detect hepatocellular carcinoma (HCC). However, some chronic hepatitis patients might have elevated AFP. AFP-L3, has been proposed to differentiate HCC and hepatitis in elevated AFP cases in Japan for decades, but the utility is limited outside Japan. We conducted this study to elucidate the role of AFP-L3 in the community and the possibility of saving unnecessary US. A total of 56,702 subjects underwent a large-scale healthcare screening in Tainan county in 2004. Among them, 286 residents with AFP more than 20 ng/ml further received US and 169 (59%) had stored baseline sera were enrolled into this study in 2013. Their AFP and AFP-L3 levels were further detected. HCC patients were initially identified through US and personal history. Among 169 studied sera, only 148 (87.6%) samples still had AFP level more than 20 ng/ml after a 10-years frozen period. The decrease of AFP level was significant (481.3 ± 2093.8 ng/ml and 456.1 ± 2095.3 ng/ml in paired-T test, p < 0.001). Focusing on these 148 cases, 23 (15.5%) HCC cases were diagnosed at the baseline screening. There was no difference of AFP-L3 level between HCC and non-HCC cases. Using AFP-L3 to predict HCC, the area under Receiver Operating Characteristic curve was as low as 52%, p = 0.757. Too long frozen period might lower the quality of stored sera. Additionally, AFP-L3 might not provide more information for HCC identification to save advanced US examinations in the community screening. In the community screening, those subjects with elevated serum alpha-fetoprotein (AFP) required further abdomen ultrasonography (US) to detect hepatocellular carcinoma (HCC). However, some chronic hepatitis patients might have elevated AFP. AFP-L3, has been proposed to differentiate HCC and hepatitis in elevated AFP cases in Japan for decades, but the utility is limited outside Japan. We conducted this study to elucidate the role of AFP-L3 in the community and the possibility of saving unnecessary US. A total of 56,702 subjects underwent a large-scale healthcare screening in Tainan county in 2004. Among them, 286 residents with AFP more than 20 ng/ml further received US and 169 (59%) had stored baseline sera were enrolled into this study in 2013. Their AFP and AFP-L3 levels were further detected. HCC patients were initially identified through US and personal history. Among 169 studied sera, only 148 (87.6%) samples still had AFP level more than 20 ng/ml after a 10-years frozen period. The decrease of AFP level was significant (481.3 ± 2093.8 ng/ml and 456.1 ± 2095.3 ng/ml in paired-T test, p < 0.001). Focusing on these 148 cases, 23 (15.5%) HCC cases were diagnosed at the baseline screening. There was no difference of AFP-L3 level between HCC and non-HCC cases. Using AFP-L3 to predict HCC, the area under Receiver Operating Characteristic curve was as low as 52%, p = 0.757. Too long frozen period might lower the quality of stored sera. Additionally, AFP-L3 might not provide more information for HCC identification to save advanced US examinations in the community screening. Community hepatocellular carcinoma screening Elsevier Ultrasonography Elsevier Alpha-fetoprotein-L3 Elsevier Alpha-fetoprotein Elsevier Kuo, Yuan-Hung oth Wang, Jing-Houng oth Chang, Kuo-Chin oth Kee, Kwong-Ming oth Hung, Shu-Feng oth Chen, Yi oth Tsai, Lin-San oth Chen, Shu-Chuan oth Hung, Chao-Hung oth Lu, Sheng-Nan oth Enthalten in Elsevier Takei, Makoto ELSEVIER Under-developed bronchial arteries as a risk factor for complications in balloon pulmonary angioplasty 2016 KJMS Hong Kong [u.a.] (DE-627)ELV013890123 volume:34 year:2018 number:10 pages:583-587 extent:5 https://doi.org/10.1016/j.kjms.2018.05.005 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_11 GBV_ILN_40 AR 34 2018 10 583-587 5 |
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Focusing on these 148 cases, 23 (15.5%) HCC cases were diagnosed at the baseline screening. There was no difference of AFP-L3 level between HCC and non-HCC cases. Using AFP-L3 to predict HCC, the area under Receiver Operating Characteristic curve was as low as 52%, p = 0.757. Too long frozen period might lower the quality of stored sera. Additionally, AFP-L3 might not provide more information for HCC identification to save advanced US examinations in the community screening.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">In the community screening, those subjects with elevated serum alpha-fetoprotein (AFP) required further abdomen ultrasonography (US) to detect hepatocellular carcinoma (HCC). However, some chronic hepatitis patients might have elevated AFP. AFP-L3, has been proposed to differentiate HCC and hepatitis in elevated AFP cases in Japan for decades, but the utility is limited outside Japan. 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Using AFP-L3 to predict HCC, the area under Receiver Operating Characteristic curve was as low as 52%, p = 0.757. Too long frozen period might lower the quality of stored sera. 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Did AFP-L3 save ultrasonography in community screening? |
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In the community screening, those subjects with elevated serum alpha-fetoprotein (AFP) required further abdomen ultrasonography (US) to detect hepatocellular carcinoma (HCC). However, some chronic hepatitis patients might have elevated AFP. AFP-L3, has been proposed to differentiate HCC and hepatitis in elevated AFP cases in Japan for decades, but the utility is limited outside Japan. We conducted this study to elucidate the role of AFP-L3 in the community and the possibility of saving unnecessary US. A total of 56,702 subjects underwent a large-scale healthcare screening in Tainan county in 2004. Among them, 286 residents with AFP more than 20 ng/ml further received US and 169 (59%) had stored baseline sera were enrolled into this study in 2013. Their AFP and AFP-L3 levels were further detected. HCC patients were initially identified through US and personal history. Among 169 studied sera, only 148 (87.6%) samples still had AFP level more than 20 ng/ml after a 10-years frozen period. The decrease of AFP level was significant (481.3 ± 2093.8 ng/ml and 456.1 ± 2095.3 ng/ml in paired-T test, p < 0.001). Focusing on these 148 cases, 23 (15.5%) HCC cases were diagnosed at the baseline screening. There was no difference of AFP-L3 level between HCC and non-HCC cases. Using AFP-L3 to predict HCC, the area under Receiver Operating Characteristic curve was as low as 52%, p = 0.757. Too long frozen period might lower the quality of stored sera. Additionally, AFP-L3 might not provide more information for HCC identification to save advanced US examinations in the community screening. |
| abstractGer |
In the community screening, those subjects with elevated serum alpha-fetoprotein (AFP) required further abdomen ultrasonography (US) to detect hepatocellular carcinoma (HCC). However, some chronic hepatitis patients might have elevated AFP. AFP-L3, has been proposed to differentiate HCC and hepatitis in elevated AFP cases in Japan for decades, but the utility is limited outside Japan. We conducted this study to elucidate the role of AFP-L3 in the community and the possibility of saving unnecessary US. A total of 56,702 subjects underwent a large-scale healthcare screening in Tainan county in 2004. Among them, 286 residents with AFP more than 20 ng/ml further received US and 169 (59%) had stored baseline sera were enrolled into this study in 2013. Their AFP and AFP-L3 levels were further detected. HCC patients were initially identified through US and personal history. Among 169 studied sera, only 148 (87.6%) samples still had AFP level more than 20 ng/ml after a 10-years frozen period. The decrease of AFP level was significant (481.3 ± 2093.8 ng/ml and 456.1 ± 2095.3 ng/ml in paired-T test, p < 0.001). Focusing on these 148 cases, 23 (15.5%) HCC cases were diagnosed at the baseline screening. There was no difference of AFP-L3 level between HCC and non-HCC cases. Using AFP-L3 to predict HCC, the area under Receiver Operating Characteristic curve was as low as 52%, p = 0.757. Too long frozen period might lower the quality of stored sera. Additionally, AFP-L3 might not provide more information for HCC identification to save advanced US examinations in the community screening. |
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In the community screening, those subjects with elevated serum alpha-fetoprotein (AFP) required further abdomen ultrasonography (US) to detect hepatocellular carcinoma (HCC). However, some chronic hepatitis patients might have elevated AFP. AFP-L3, has been proposed to differentiate HCC and hepatitis in elevated AFP cases in Japan for decades, but the utility is limited outside Japan. We conducted this study to elucidate the role of AFP-L3 in the community and the possibility of saving unnecessary US. A total of 56,702 subjects underwent a large-scale healthcare screening in Tainan county in 2004. Among them, 286 residents with AFP more than 20 ng/ml further received US and 169 (59%) had stored baseline sera were enrolled into this study in 2013. Their AFP and AFP-L3 levels were further detected. HCC patients were initially identified through US and personal history. Among 169 studied sera, only 148 (87.6%) samples still had AFP level more than 20 ng/ml after a 10-years frozen period. The decrease of AFP level was significant (481.3 ± 2093.8 ng/ml and 456.1 ± 2095.3 ng/ml in paired-T test, p < 0.001). Focusing on these 148 cases, 23 (15.5%) HCC cases were diagnosed at the baseline screening. There was no difference of AFP-L3 level between HCC and non-HCC cases. Using AFP-L3 to predict HCC, the area under Receiver Operating Characteristic curve was as low as 52%, p = 0.757. Too long frozen period might lower the quality of stored sera. Additionally, AFP-L3 might not provide more information for HCC identification to save advanced US examinations in the community screening. |
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We conducted this study to elucidate the role of AFP-L3 in the community and the possibility of saving unnecessary US. A total of 56,702 subjects underwent a large-scale healthcare screening in Tainan county in 2004. Among them, 286 residents with AFP more than 20 ng/ml further received US and 169 (59%) had stored baseline sera were enrolled into this study in 2013. Their AFP and AFP-L3 levels were further detected. HCC patients were initially identified through US and personal history. Among 169 studied sera, only 148 (87.6%) samples still had AFP level more than 20 ng/ml after a 10-years frozen period. The decrease of AFP level was significant (481.3 ± 2093.8 ng/ml and 456.1 ± 2095.3 ng/ml in paired-T test, p < 0.001). Focusing on these 148 cases, 23 (15.5%) HCC cases were diagnosed at the baseline screening. There was no difference of AFP-L3 level between HCC and non-HCC cases. Using AFP-L3 to predict HCC, the area under Receiver Operating Characteristic curve was as low as 52%, p = 0.757. Too long frozen period might lower the quality of stored sera. 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