Revisiting the binding kinetics and inhibitory potency of cardiac glycosides on Na<ce:sup loc="post">+</ce:sup>,K<ce:sup loc="post">+</ce:sup>-ATPase (α1β1): Methodological considerations
Ouabain and digoxin are classical inhibitors of the Na+,K+-ATPase. In addition to their conventional uses as therapeutic agents or experimental tools there is renewed interest due to evidence suggesting they could be endogenous hormones. Somewhat surprisingly, different publications show large discr...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Noël, François [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2018 |
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| Umfang: |
9 |
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| Übergeordnetes Werk: |
Enthalten in: Differential roles of Sirt1 in HIF-1α and HIF-2α mediated hypoxic responses - Yoon, Haejin ELSEVIER, 2014, New York, NY [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:94 ; year:2018 ; pages:64-72 ; extent:9 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.vascn.2018.09.001 |
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10.1016/j.vascn.2018.09.001 doi GBV00000000000407.pica (DE-627)ELV044573472 (ELSEVIER)S1056-8719(18)30662-2 DE-627 ger DE-627 rakwb eng 570 VZ 670 VZ 51.60 bkl 58.45 bkl Noël, François verfasserin aut Revisiting the binding kinetics and inhibitory potency of cardiac glycosides on Na<ce:sup loc="post">+</ce:sup>,K<ce:sup loc="post">+</ce:sup>-ATPase (α1β1): Methodological considerations 2018 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Ouabain and digoxin are classical inhibitors of the Na+,K+-ATPase. In addition to their conventional uses as therapeutic agents or experimental tools there is renewed interest due to evidence suggesting they could be endogenous hormones. Somewhat surprisingly, different publications show large discrepancies in potency for inhibiting Na+,K+-ATPase activity (IC50), particularly for the slow binding inhibitors, ouabain and digoxin. Azalim, Pedro oth do Monte, Fernando M. oth Quintas, Luis Eduardo M. oth Katz, Adriana oth Karlish, Steven J.D. oth Enthalten in Elsevier Yoon, Haejin ELSEVIER Differential roles of Sirt1 in HIF-1α and HIF-2α mediated hypoxic responses 2014 New York, NY [u.a.] (DE-627)ELV017940486 volume:94 year:2018 pages:64-72 extent:9 https://doi.org/10.1016/j.vascn.2018.09.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_23 GBV_ILN_70 GBV_ILN_170 51.60 Keramische Werkstoffe Hartstoffe Werkstoffkunde VZ 58.45 Gesteinshüttenkunde VZ AR 94 2018 64-72 9 |
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revisiting the binding kinetics and inhibitory potency of cardiac glycosides on na<ce:sup loc="post">+</ce:sup>,k<ce:sup loc="post">+</ce:sup>-atpase (α1β1): methodological considerations |
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Revisiting the binding kinetics and inhibitory potency of cardiac glycosides on Na<ce:sup loc="post">+</ce:sup>,K<ce:sup loc="post">+</ce:sup>-ATPase (α1β1): Methodological considerations |
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Ouabain and digoxin are classical inhibitors of the Na+,K+-ATPase. In addition to their conventional uses as therapeutic agents or experimental tools there is renewed interest due to evidence suggesting they could be endogenous hormones. Somewhat surprisingly, different publications show large discrepancies in potency for inhibiting Na+,K+-ATPase activity (IC50), particularly for the slow binding inhibitors, ouabain and digoxin. |
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Ouabain and digoxin are classical inhibitors of the Na+,K+-ATPase. In addition to their conventional uses as therapeutic agents or experimental tools there is renewed interest due to evidence suggesting they could be endogenous hormones. Somewhat surprisingly, different publications show large discrepancies in potency for inhibiting Na+,K+-ATPase activity (IC50), particularly for the slow binding inhibitors, ouabain and digoxin. |
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Ouabain and digoxin are classical inhibitors of the Na+,K+-ATPase. In addition to their conventional uses as therapeutic agents or experimental tools there is renewed interest due to evidence suggesting they could be endogenous hormones. Somewhat surprisingly, different publications show large discrepancies in potency for inhibiting Na+,K+-ATPase activity (IC50), particularly for the slow binding inhibitors, ouabain and digoxin. |
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Revisiting the binding kinetics and inhibitory potency of cardiac glycosides on Na<ce:sup loc="post">+</ce:sup>,K<ce:sup loc="post">+</ce:sup>-ATPase (α1β1): Methodological considerations |
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Azalim, Pedro do Monte, Fernando M. Quintas, Luis Eduardo M. Katz, Adriana Karlish, Steven J.D. |
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10.1016/j.vascn.2018.09.001 |
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2024-07-06T21:50:56.750Z |
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