The Impact of Intratumoral and Gastrointestinal Microbiota on Systemic Cancer Therapy
The human microbiome is a complex aggregate of microorganisms, and their genomes exert a number of influences crucial to the metabolic, immunologic, hormonal, and homeostatic function of the host. Recent work, both in preclinical mouse models and human studies, has shed light on the impact of gut an...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Cogdill, Alexandria P. [verfasserIn] |
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E-Artikel |
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| Sprache: |
Englisch |
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2018transfer abstract |
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21 |
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Enthalten in: The journey of a mental health professional with co-morbid mental health and alcohol use disorder from despair, to acceptance, to advocacy - Thomas, Brandon ELSEVIER, 2023, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:39 ; year:2018 ; number:11 ; pages:900-920 ; extent:21 |
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10.1016/j.it.2018.09.007 |
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| 520 | |a The human microbiome is a complex aggregate of microorganisms, and their genomes exert a number of influences crucial to the metabolic, immunologic, hormonal, and homeostatic function of the host. Recent work, both in preclinical mouse models and human studies, has shed light on the impact of gut and tumor microbiota on responses to systemic anticancer therapeutics. In light of this, strategies to target the microbiome to improve therapeutic responses are underway, including efforts to target gut and intratumoral microbes. Here, we discuss mechanisms by which microbiota may impact systemic and antitumor immunity, in addition to outstanding questions in the field. A deeper understanding of these is critical as we devise putative strategies to target the microbiome. | ||
| 520 | |a The human microbiome is a complex aggregate of microorganisms, and their genomes exert a number of influences crucial to the metabolic, immunologic, hormonal, and homeostatic function of the host. Recent work, both in preclinical mouse models and human studies, has shed light on the impact of gut and tumor microbiota on responses to systemic anticancer therapeutics. In light of this, strategies to target the microbiome to improve therapeutic responses are underway, including efforts to target gut and intratumoral microbes. Here, we discuss mechanisms by which microbiota may impact systemic and antitumor immunity, in addition to outstanding questions in the field. A deeper understanding of these is critical as we devise putative strategies to target the microbiome. | ||
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10.1016/j.it.2018.09.007 doi GBV00000000000413.pica (DE-627)ELV044629478 (ELSEVIER)S1471-4906(18)30172-8 DE-627 ger DE-627 rakwb eng Cogdill, Alexandria P. verfasserin aut The Impact of Intratumoral and Gastrointestinal Microbiota on Systemic Cancer Therapy 2018transfer abstract 21 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The human microbiome is a complex aggregate of microorganisms, and their genomes exert a number of influences crucial to the metabolic, immunologic, hormonal, and homeostatic function of the host. Recent work, both in preclinical mouse models and human studies, has shed light on the impact of gut and tumor microbiota on responses to systemic anticancer therapeutics. In light of this, strategies to target the microbiome to improve therapeutic responses are underway, including efforts to target gut and intratumoral microbes. Here, we discuss mechanisms by which microbiota may impact systemic and antitumor immunity, in addition to outstanding questions in the field. A deeper understanding of these is critical as we devise putative strategies to target the microbiome. The human microbiome is a complex aggregate of microorganisms, and their genomes exert a number of influences crucial to the metabolic, immunologic, hormonal, and homeostatic function of the host. Recent work, both in preclinical mouse models and human studies, has shed light on the impact of gut and tumor microbiota on responses to systemic anticancer therapeutics. In light of this, strategies to target the microbiome to improve therapeutic responses are underway, including efforts to target gut and intratumoral microbes. Here, we discuss mechanisms by which microbiota may impact systemic and antitumor immunity, in addition to outstanding questions in the field. A deeper understanding of these is critical as we devise putative strategies to target the microbiome. immunotherapy Elsevier cancer Elsevier microbiome Elsevier Gaudreau, Pierre Olivier oth Arora, Reetakshi oth Gopalakrishnan, Vancheswaran oth Wargo, Jennifer A. oth Enthalten in Elsevier Science Thomas, Brandon ELSEVIER The journey of a mental health professional with co-morbid mental health and alcohol use disorder from despair, to acceptance, to advocacy 2023 Amsterdam [u.a.] (DE-627)ELV009586830 volume:39 year:2018 number:11 pages:900-920 extent:21 https://doi.org/10.1016/j.it.2018.09.007 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 39 2018 11 900-920 21 |
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10.1016/j.it.2018.09.007 doi GBV00000000000413.pica (DE-627)ELV044629478 (ELSEVIER)S1471-4906(18)30172-8 DE-627 ger DE-627 rakwb eng Cogdill, Alexandria P. verfasserin aut The Impact of Intratumoral and Gastrointestinal Microbiota on Systemic Cancer Therapy 2018transfer abstract 21 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The human microbiome is a complex aggregate of microorganisms, and their genomes exert a number of influences crucial to the metabolic, immunologic, hormonal, and homeostatic function of the host. Recent work, both in preclinical mouse models and human studies, has shed light on the impact of gut and tumor microbiota on responses to systemic anticancer therapeutics. In light of this, strategies to target the microbiome to improve therapeutic responses are underway, including efforts to target gut and intratumoral microbes. Here, we discuss mechanisms by which microbiota may impact systemic and antitumor immunity, in addition to outstanding questions in the field. A deeper understanding of these is critical as we devise putative strategies to target the microbiome. The human microbiome is a complex aggregate of microorganisms, and their genomes exert a number of influences crucial to the metabolic, immunologic, hormonal, and homeostatic function of the host. Recent work, both in preclinical mouse models and human studies, has shed light on the impact of gut and tumor microbiota on responses to systemic anticancer therapeutics. In light of this, strategies to target the microbiome to improve therapeutic responses are underway, including efforts to target gut and intratumoral microbes. Here, we discuss mechanisms by which microbiota may impact systemic and antitumor immunity, in addition to outstanding questions in the field. A deeper understanding of these is critical as we devise putative strategies to target the microbiome. immunotherapy Elsevier cancer Elsevier microbiome Elsevier Gaudreau, Pierre Olivier oth Arora, Reetakshi oth Gopalakrishnan, Vancheswaran oth Wargo, Jennifer A. oth Enthalten in Elsevier Science Thomas, Brandon ELSEVIER The journey of a mental health professional with co-morbid mental health and alcohol use disorder from despair, to acceptance, to advocacy 2023 Amsterdam [u.a.] (DE-627)ELV009586830 volume:39 year:2018 number:11 pages:900-920 extent:21 https://doi.org/10.1016/j.it.2018.09.007 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 39 2018 11 900-920 21 |
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impact of intratumoral and gastrointestinal microbiota on systemic cancer therapy |
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The Impact of Intratumoral and Gastrointestinal Microbiota on Systemic Cancer Therapy |
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The human microbiome is a complex aggregate of microorganisms, and their genomes exert a number of influences crucial to the metabolic, immunologic, hormonal, and homeostatic function of the host. Recent work, both in preclinical mouse models and human studies, has shed light on the impact of gut and tumor microbiota on responses to systemic anticancer therapeutics. In light of this, strategies to target the microbiome to improve therapeutic responses are underway, including efforts to target gut and intratumoral microbes. Here, we discuss mechanisms by which microbiota may impact systemic and antitumor immunity, in addition to outstanding questions in the field. A deeper understanding of these is critical as we devise putative strategies to target the microbiome. |
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The human microbiome is a complex aggregate of microorganisms, and their genomes exert a number of influences crucial to the metabolic, immunologic, hormonal, and homeostatic function of the host. Recent work, both in preclinical mouse models and human studies, has shed light on the impact of gut and tumor microbiota on responses to systemic anticancer therapeutics. In light of this, strategies to target the microbiome to improve therapeutic responses are underway, including efforts to target gut and intratumoral microbes. Here, we discuss mechanisms by which microbiota may impact systemic and antitumor immunity, in addition to outstanding questions in the field. A deeper understanding of these is critical as we devise putative strategies to target the microbiome. |
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The human microbiome is a complex aggregate of microorganisms, and their genomes exert a number of influences crucial to the metabolic, immunologic, hormonal, and homeostatic function of the host. Recent work, both in preclinical mouse models and human studies, has shed light on the impact of gut and tumor microbiota on responses to systemic anticancer therapeutics. In light of this, strategies to target the microbiome to improve therapeutic responses are underway, including efforts to target gut and intratumoral microbes. Here, we discuss mechanisms by which microbiota may impact systemic and antitumor immunity, in addition to outstanding questions in the field. A deeper understanding of these is critical as we devise putative strategies to target the microbiome. |
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