Noncanonical Hippo Signalling in the Regulation of Leukocyte Function
The mammalian sterile 20-like (MST) kinases are central constituents of the evolutionary ancient canonical Hippo pathway regulating cell proliferation and survival. However, perhaps surprisingly, MST1 deficiency in human patients leads to a severe combined immunodeficiency syndrome with features of...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Kurz, Angela R.M. [verfasserIn] |
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E-Artikel |
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Englisch |
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2018transfer abstract |
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14 |
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Enthalten in: The journey of a mental health professional with co-morbid mental health and alcohol use disorder from despair, to acceptance, to advocacy - Thomas, Brandon ELSEVIER, 2023, Amsterdam [u.a.] |
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volume:39 ; year:2018 ; number:8 ; pages:656-669 ; extent:14 |
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10.1016/j.it.2018.05.003 |
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| 520 | |a The mammalian sterile 20-like (MST) kinases are central constituents of the evolutionary ancient canonical Hippo pathway regulating cell proliferation and survival. However, perhaps surprisingly, MST1 deficiency in human patients leads to a severe combined immunodeficiency syndrome with features of autoimmune disease. In line with this, Mst1-deficient mice exhibit severe defects in lymphocyte and neutrophil functions as well as disturbed intracellular vesicle transport. These findings spurred research on the noncanonical functions of MST1 in leukocytes. Here, we summarise the latest findings on this topic and discuss MST1 as a critical regulator of various leukocyte functions. | ||
| 520 | |a The mammalian sterile 20-like (MST) kinases are central constituents of the evolutionary ancient canonical Hippo pathway regulating cell proliferation and survival. However, perhaps surprisingly, MST1 deficiency in human patients leads to a severe combined immunodeficiency syndrome with features of autoimmune disease. In line with this, Mst1-deficient mice exhibit severe defects in lymphocyte and neutrophil functions as well as disturbed intracellular vesicle transport. These findings spurred research on the noncanonical functions of MST1 in leukocytes. Here, we summarise the latest findings on this topic and discuss MST1 as a critical regulator of various leukocyte functions. | ||
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10.1016/j.it.2018.05.003 doi GBV00000000000310_01.pica (DE-627)ELV044734433 (ELSEVIER)S1471-4906(18)30106-6 DE-627 ger DE-627 rakwb eng Kurz, Angela R.M. verfasserin aut Noncanonical Hippo Signalling in the Regulation of Leukocyte Function 2018transfer abstract 14 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The mammalian sterile 20-like (MST) kinases are central constituents of the evolutionary ancient canonical Hippo pathway regulating cell proliferation and survival. However, perhaps surprisingly, MST1 deficiency in human patients leads to a severe combined immunodeficiency syndrome with features of autoimmune disease. In line with this, Mst1-deficient mice exhibit severe defects in lymphocyte and neutrophil functions as well as disturbed intracellular vesicle transport. These findings spurred research on the noncanonical functions of MST1 in leukocytes. Here, we summarise the latest findings on this topic and discuss MST1 as a critical regulator of various leukocyte functions. The mammalian sterile 20-like (MST) kinases are central constituents of the evolutionary ancient canonical Hippo pathway regulating cell proliferation and survival. However, perhaps surprisingly, MST1 deficiency in human patients leads to a severe combined immunodeficiency syndrome with features of autoimmune disease. In line with this, Mst1-deficient mice exhibit severe defects in lymphocyte and neutrophil functions as well as disturbed intracellular vesicle transport. These findings spurred research on the noncanonical functions of MST1 in leukocytes. Here, we summarise the latest findings on this topic and discuss MST1 as a critical regulator of various leukocyte functions. MST2 Elsevier Hippo pathway Elsevier MST1 Elsevier leukocyte Elsevier vesicle transport Elsevier Catz, Sergio D. oth Sperandio, Markus oth Enthalten in Elsevier Science Thomas, Brandon ELSEVIER The journey of a mental health professional with co-morbid mental health and alcohol use disorder from despair, to acceptance, to advocacy 2023 Amsterdam [u.a.] (DE-627)ELV009586830 volume:39 year:2018 number:8 pages:656-669 extent:14 https://doi.org/10.1016/j.it.2018.05.003 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 39 2018 8 656-669 14 |
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10.1016/j.it.2018.05.003 doi GBV00000000000310_01.pica (DE-627)ELV044734433 (ELSEVIER)S1471-4906(18)30106-6 DE-627 ger DE-627 rakwb eng Kurz, Angela R.M. verfasserin aut Noncanonical Hippo Signalling in the Regulation of Leukocyte Function 2018transfer abstract 14 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The mammalian sterile 20-like (MST) kinases are central constituents of the evolutionary ancient canonical Hippo pathway regulating cell proliferation and survival. However, perhaps surprisingly, MST1 deficiency in human patients leads to a severe combined immunodeficiency syndrome with features of autoimmune disease. In line with this, Mst1-deficient mice exhibit severe defects in lymphocyte and neutrophil functions as well as disturbed intracellular vesicle transport. These findings spurred research on the noncanonical functions of MST1 in leukocytes. Here, we summarise the latest findings on this topic and discuss MST1 as a critical regulator of various leukocyte functions. The mammalian sterile 20-like (MST) kinases are central constituents of the evolutionary ancient canonical Hippo pathway regulating cell proliferation and survival. However, perhaps surprisingly, MST1 deficiency in human patients leads to a severe combined immunodeficiency syndrome with features of autoimmune disease. In line with this, Mst1-deficient mice exhibit severe defects in lymphocyte and neutrophil functions as well as disturbed intracellular vesicle transport. These findings spurred research on the noncanonical functions of MST1 in leukocytes. Here, we summarise the latest findings on this topic and discuss MST1 as a critical regulator of various leukocyte functions. MST2 Elsevier Hippo pathway Elsevier MST1 Elsevier leukocyte Elsevier vesicle transport Elsevier Catz, Sergio D. oth Sperandio, Markus oth Enthalten in Elsevier Science Thomas, Brandon ELSEVIER The journey of a mental health professional with co-morbid mental health and alcohol use disorder from despair, to acceptance, to advocacy 2023 Amsterdam [u.a.] (DE-627)ELV009586830 volume:39 year:2018 number:8 pages:656-669 extent:14 https://doi.org/10.1016/j.it.2018.05.003 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 39 2018 8 656-669 14 |
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10.1016/j.it.2018.05.003 doi GBV00000000000310_01.pica (DE-627)ELV044734433 (ELSEVIER)S1471-4906(18)30106-6 DE-627 ger DE-627 rakwb eng Kurz, Angela R.M. verfasserin aut Noncanonical Hippo Signalling in the Regulation of Leukocyte Function 2018transfer abstract 14 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The mammalian sterile 20-like (MST) kinases are central constituents of the evolutionary ancient canonical Hippo pathway regulating cell proliferation and survival. However, perhaps surprisingly, MST1 deficiency in human patients leads to a severe combined immunodeficiency syndrome with features of autoimmune disease. In line with this, Mst1-deficient mice exhibit severe defects in lymphocyte and neutrophil functions as well as disturbed intracellular vesicle transport. These findings spurred research on the noncanonical functions of MST1 in leukocytes. Here, we summarise the latest findings on this topic and discuss MST1 as a critical regulator of various leukocyte functions. The mammalian sterile 20-like (MST) kinases are central constituents of the evolutionary ancient canonical Hippo pathway regulating cell proliferation and survival. However, perhaps surprisingly, MST1 deficiency in human patients leads to a severe combined immunodeficiency syndrome with features of autoimmune disease. In line with this, Mst1-deficient mice exhibit severe defects in lymphocyte and neutrophil functions as well as disturbed intracellular vesicle transport. These findings spurred research on the noncanonical functions of MST1 in leukocytes. Here, we summarise the latest findings on this topic and discuss MST1 as a critical regulator of various leukocyte functions. MST2 Elsevier Hippo pathway Elsevier MST1 Elsevier leukocyte Elsevier vesicle transport Elsevier Catz, Sergio D. oth Sperandio, Markus oth Enthalten in Elsevier Science Thomas, Brandon ELSEVIER The journey of a mental health professional with co-morbid mental health and alcohol use disorder from despair, to acceptance, to advocacy 2023 Amsterdam [u.a.] (DE-627)ELV009586830 volume:39 year:2018 number:8 pages:656-669 extent:14 https://doi.org/10.1016/j.it.2018.05.003 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 39 2018 8 656-669 14 |
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10.1016/j.it.2018.05.003 doi GBV00000000000310_01.pica (DE-627)ELV044734433 (ELSEVIER)S1471-4906(18)30106-6 DE-627 ger DE-627 rakwb eng Kurz, Angela R.M. verfasserin aut Noncanonical Hippo Signalling in the Regulation of Leukocyte Function 2018transfer abstract 14 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The mammalian sterile 20-like (MST) kinases are central constituents of the evolutionary ancient canonical Hippo pathway regulating cell proliferation and survival. However, perhaps surprisingly, MST1 deficiency in human patients leads to a severe combined immunodeficiency syndrome with features of autoimmune disease. In line with this, Mst1-deficient mice exhibit severe defects in lymphocyte and neutrophil functions as well as disturbed intracellular vesicle transport. These findings spurred research on the noncanonical functions of MST1 in leukocytes. Here, we summarise the latest findings on this topic and discuss MST1 as a critical regulator of various leukocyte functions. The mammalian sterile 20-like (MST) kinases are central constituents of the evolutionary ancient canonical Hippo pathway regulating cell proliferation and survival. However, perhaps surprisingly, MST1 deficiency in human patients leads to a severe combined immunodeficiency syndrome with features of autoimmune disease. In line with this, Mst1-deficient mice exhibit severe defects in lymphocyte and neutrophil functions as well as disturbed intracellular vesicle transport. These findings spurred research on the noncanonical functions of MST1 in leukocytes. Here, we summarise the latest findings on this topic and discuss MST1 as a critical regulator of various leukocyte functions. MST2 Elsevier Hippo pathway Elsevier MST1 Elsevier leukocyte Elsevier vesicle transport Elsevier Catz, Sergio D. oth Sperandio, Markus oth Enthalten in Elsevier Science Thomas, Brandon ELSEVIER The journey of a mental health professional with co-morbid mental health and alcohol use disorder from despair, to acceptance, to advocacy 2023 Amsterdam [u.a.] (DE-627)ELV009586830 volume:39 year:2018 number:8 pages:656-669 extent:14 https://doi.org/10.1016/j.it.2018.05.003 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 39 2018 8 656-669 14 |
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10.1016/j.it.2018.05.003 doi GBV00000000000310_01.pica (DE-627)ELV044734433 (ELSEVIER)S1471-4906(18)30106-6 DE-627 ger DE-627 rakwb eng Kurz, Angela R.M. verfasserin aut Noncanonical Hippo Signalling in the Regulation of Leukocyte Function 2018transfer abstract 14 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The mammalian sterile 20-like (MST) kinases are central constituents of the evolutionary ancient canonical Hippo pathway regulating cell proliferation and survival. However, perhaps surprisingly, MST1 deficiency in human patients leads to a severe combined immunodeficiency syndrome with features of autoimmune disease. In line with this, Mst1-deficient mice exhibit severe defects in lymphocyte and neutrophil functions as well as disturbed intracellular vesicle transport. These findings spurred research on the noncanonical functions of MST1 in leukocytes. Here, we summarise the latest findings on this topic and discuss MST1 as a critical regulator of various leukocyte functions. The mammalian sterile 20-like (MST) kinases are central constituents of the evolutionary ancient canonical Hippo pathway regulating cell proliferation and survival. However, perhaps surprisingly, MST1 deficiency in human patients leads to a severe combined immunodeficiency syndrome with features of autoimmune disease. In line with this, Mst1-deficient mice exhibit severe defects in lymphocyte and neutrophil functions as well as disturbed intracellular vesicle transport. These findings spurred research on the noncanonical functions of MST1 in leukocytes. Here, we summarise the latest findings on this topic and discuss MST1 as a critical regulator of various leukocyte functions. MST2 Elsevier Hippo pathway Elsevier MST1 Elsevier leukocyte Elsevier vesicle transport Elsevier Catz, Sergio D. oth Sperandio, Markus oth Enthalten in Elsevier Science Thomas, Brandon ELSEVIER The journey of a mental health professional with co-morbid mental health and alcohol use disorder from despair, to acceptance, to advocacy 2023 Amsterdam [u.a.] (DE-627)ELV009586830 volume:39 year:2018 number:8 pages:656-669 extent:14 https://doi.org/10.1016/j.it.2018.05.003 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 39 2018 8 656-669 14 |
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The mammalian sterile 20-like (MST) kinases are central constituents of the evolutionary ancient canonical Hippo pathway regulating cell proliferation and survival. However, perhaps surprisingly, MST1 deficiency in human patients leads to a severe combined immunodeficiency syndrome with features of autoimmune disease. In line with this, Mst1-deficient mice exhibit severe defects in lymphocyte and neutrophil functions as well as disturbed intracellular vesicle transport. These findings spurred research on the noncanonical functions of MST1 in leukocytes. Here, we summarise the latest findings on this topic and discuss MST1 as a critical regulator of various leukocyte functions. |
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The mammalian sterile 20-like (MST) kinases are central constituents of the evolutionary ancient canonical Hippo pathway regulating cell proliferation and survival. However, perhaps surprisingly, MST1 deficiency in human patients leads to a severe combined immunodeficiency syndrome with features of autoimmune disease. In line with this, Mst1-deficient mice exhibit severe defects in lymphocyte and neutrophil functions as well as disturbed intracellular vesicle transport. These findings spurred research on the noncanonical functions of MST1 in leukocytes. Here, we summarise the latest findings on this topic and discuss MST1 as a critical regulator of various leukocyte functions. |
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The mammalian sterile 20-like (MST) kinases are central constituents of the evolutionary ancient canonical Hippo pathway regulating cell proliferation and survival. However, perhaps surprisingly, MST1 deficiency in human patients leads to a severe combined immunodeficiency syndrome with features of autoimmune disease. In line with this, Mst1-deficient mice exhibit severe defects in lymphocyte and neutrophil functions as well as disturbed intracellular vesicle transport. These findings spurred research on the noncanonical functions of MST1 in leukocytes. Here, we summarise the latest findings on this topic and discuss MST1 as a critical regulator of various leukocyte functions. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV044734433</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230626005653.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">181123s2018 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.it.2018.05.003</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">GBV00000000000310_01.pica</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV044734433</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S1471-4906(18)30106-6</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Kurz, Angela R.M.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Noncanonical Hippo Signalling in the Regulation of Leukocyte Function</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2018transfer abstract</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">14</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The mammalian sterile 20-like (MST) kinases are central constituents of the evolutionary ancient canonical Hippo pathway regulating cell proliferation and survival. However, perhaps surprisingly, MST1 deficiency in human patients leads to a severe combined immunodeficiency syndrome with features of autoimmune disease. In line with this, Mst1-deficient mice exhibit severe defects in lymphocyte and neutrophil functions as well as disturbed intracellular vesicle transport. These findings spurred research on the noncanonical functions of MST1 in leukocytes. Here, we summarise the latest findings on this topic and discuss MST1 as a critical regulator of various leukocyte functions.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The mammalian sterile 20-like (MST) kinases are central constituents of the evolutionary ancient canonical Hippo pathway regulating cell proliferation and survival. However, perhaps surprisingly, MST1 deficiency in human patients leads to a severe combined immunodeficiency syndrome with features of autoimmune disease. 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