The Salt-Inducible Kinases: Emerging Metabolic Regulators
The discovery of liver kinase B1 (LKB1) as an upstream kinase for AMP-activated protein kinase (AMPK) led to the identification of several related kinases that also rely on LKB1 for their catalytic activity. Among these, the salt-inducible kinases (SIKs) have emerged as key regulators of metabolism....
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Sakamoto, Kei [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2018transfer abstract |
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| Schlagwörter: |
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| Umfang: |
14 |
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| Übergeordnetes Werk: |
Enthalten in: The gaze of sleep loss: acute effects of sleep loss on facial perception - van Egmond, L.T. ELSEVIER, 2022, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:29 ; year:2018 ; number:12 ; pages:827-840 ; extent:14 |
| Links: |
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| DOI / URN: |
10.1016/j.tem.2018.09.007 |
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ELV044915098 |
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| 520 | |a The discovery of liver kinase B1 (LKB1) as an upstream kinase for AMP-activated protein kinase (AMPK) led to the identification of several related kinases that also rely on LKB1 for their catalytic activity. Among these, the salt-inducible kinases (SIKs) have emerged as key regulators of metabolism. Unlike AMPK, SIKs do not respond to nucleotides, but their function is regulated by extracellular signals, such as hormones, through complex LKB1-independent mechanisms. While AMPK acts on multiple targets, including metabolic enzymes, to maintain cellular ATP levels, SIKs primarily regulate gene expression, by acting on transcriptional regulators, such as the cAMP response element-binding protein-regulated transcription coactivators and class IIa histone deacetylases. This review describes the development of research on SIKs, from their discovery to the most recent findings on metabolic regulation. | ||
| 520 | |a The discovery of liver kinase B1 (LKB1) as an upstream kinase for AMP-activated protein kinase (AMPK) led to the identification of several related kinases that also rely on LKB1 for their catalytic activity. Among these, the salt-inducible kinases (SIKs) have emerged as key regulators of metabolism. Unlike AMPK, SIKs do not respond to nucleotides, but their function is regulated by extracellular signals, such as hormones, through complex LKB1-independent mechanisms. While AMPK acts on multiple targets, including metabolic enzymes, to maintain cellular ATP levels, SIKs primarily regulate gene expression, by acting on transcriptional regulators, such as the cAMP response element-binding protein-regulated transcription coactivators and class IIa histone deacetylases. This review describes the development of research on SIKs, from their discovery to the most recent findings on metabolic regulation. | ||
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10.1016/j.tem.2018.09.007 doi GBV00000000000425.pica (DE-627)ELV044915098 (ELSEVIER)S1043-2760(18)30168-1 DE-627 ger DE-627 rakwb eng 610 VZ 44.90 bkl Sakamoto, Kei verfasserin aut The Salt-Inducible Kinases: Emerging Metabolic Regulators 2018transfer abstract 14 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The discovery of liver kinase B1 (LKB1) as an upstream kinase for AMP-activated protein kinase (AMPK) led to the identification of several related kinases that also rely on LKB1 for their catalytic activity. Among these, the salt-inducible kinases (SIKs) have emerged as key regulators of metabolism. Unlike AMPK, SIKs do not respond to nucleotides, but their function is regulated by extracellular signals, such as hormones, through complex LKB1-independent mechanisms. While AMPK acts on multiple targets, including metabolic enzymes, to maintain cellular ATP levels, SIKs primarily regulate gene expression, by acting on transcriptional regulators, such as the cAMP response element-binding protein-regulated transcription coactivators and class IIa histone deacetylases. This review describes the development of research on SIKs, from their discovery to the most recent findings on metabolic regulation. The discovery of liver kinase B1 (LKB1) as an upstream kinase for AMP-activated protein kinase (AMPK) led to the identification of several related kinases that also rely on LKB1 for their catalytic activity. Among these, the salt-inducible kinases (SIKs) have emerged as key regulators of metabolism. Unlike AMPK, SIKs do not respond to nucleotides, but their function is regulated by extracellular signals, such as hormones, through complex LKB1-independent mechanisms. While AMPK acts on multiple targets, including metabolic enzymes, to maintain cellular ATP levels, SIKs primarily regulate gene expression, by acting on transcriptional regulators, such as the cAMP response element-binding protein-regulated transcription coactivators and class IIa histone deacetylases. This review describes the development of research on SIKs, from their discovery to the most recent findings on metabolic regulation. AMPK-related kinase Elsevier AMPK Elsevier AMP-activated protein kinase Elsevier LKB1 Elsevier gluconeogenesis Elsevier energy metabolism Elsevier Bultot, Laurent oth Göransson, Olga oth Enthalten in Elsevier Science van Egmond, L.T. ELSEVIER The gaze of sleep loss: acute effects of sleep loss on facial perception 2022 Amsterdam [u.a.] (DE-627)ELV008220654 volume:29 year:2018 number:12 pages:827-840 extent:14 https://doi.org/10.1016/j.tem.2018.09.007 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.90 Neurologie VZ AR 29 2018 12 827-840 14 |
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10.1016/j.tem.2018.09.007 doi GBV00000000000425.pica (DE-627)ELV044915098 (ELSEVIER)S1043-2760(18)30168-1 DE-627 ger DE-627 rakwb eng 610 VZ 44.90 bkl Sakamoto, Kei verfasserin aut The Salt-Inducible Kinases: Emerging Metabolic Regulators 2018transfer abstract 14 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The discovery of liver kinase B1 (LKB1) as an upstream kinase for AMP-activated protein kinase (AMPK) led to the identification of several related kinases that also rely on LKB1 for their catalytic activity. Among these, the salt-inducible kinases (SIKs) have emerged as key regulators of metabolism. Unlike AMPK, SIKs do not respond to nucleotides, but their function is regulated by extracellular signals, such as hormones, through complex LKB1-independent mechanisms. While AMPK acts on multiple targets, including metabolic enzymes, to maintain cellular ATP levels, SIKs primarily regulate gene expression, by acting on transcriptional regulators, such as the cAMP response element-binding protein-regulated transcription coactivators and class IIa histone deacetylases. This review describes the development of research on SIKs, from their discovery to the most recent findings on metabolic regulation. The discovery of liver kinase B1 (LKB1) as an upstream kinase for AMP-activated protein kinase (AMPK) led to the identification of several related kinases that also rely on LKB1 for their catalytic activity. Among these, the salt-inducible kinases (SIKs) have emerged as key regulators of metabolism. Unlike AMPK, SIKs do not respond to nucleotides, but their function is regulated by extracellular signals, such as hormones, through complex LKB1-independent mechanisms. While AMPK acts on multiple targets, including metabolic enzymes, to maintain cellular ATP levels, SIKs primarily regulate gene expression, by acting on transcriptional regulators, such as the cAMP response element-binding protein-regulated transcription coactivators and class IIa histone deacetylases. This review describes the development of research on SIKs, from their discovery to the most recent findings on metabolic regulation. AMPK-related kinase Elsevier AMPK Elsevier AMP-activated protein kinase Elsevier LKB1 Elsevier gluconeogenesis Elsevier energy metabolism Elsevier Bultot, Laurent oth Göransson, Olga oth Enthalten in Elsevier Science van Egmond, L.T. ELSEVIER The gaze of sleep loss: acute effects of sleep loss on facial perception 2022 Amsterdam [u.a.] (DE-627)ELV008220654 volume:29 year:2018 number:12 pages:827-840 extent:14 https://doi.org/10.1016/j.tem.2018.09.007 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.90 Neurologie VZ AR 29 2018 12 827-840 14 |
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10.1016/j.tem.2018.09.007 doi GBV00000000000425.pica (DE-627)ELV044915098 (ELSEVIER)S1043-2760(18)30168-1 DE-627 ger DE-627 rakwb eng 610 VZ 44.90 bkl Sakamoto, Kei verfasserin aut The Salt-Inducible Kinases: Emerging Metabolic Regulators 2018transfer abstract 14 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The discovery of liver kinase B1 (LKB1) as an upstream kinase for AMP-activated protein kinase (AMPK) led to the identification of several related kinases that also rely on LKB1 for their catalytic activity. Among these, the salt-inducible kinases (SIKs) have emerged as key regulators of metabolism. Unlike AMPK, SIKs do not respond to nucleotides, but their function is regulated by extracellular signals, such as hormones, through complex LKB1-independent mechanisms. While AMPK acts on multiple targets, including metabolic enzymes, to maintain cellular ATP levels, SIKs primarily regulate gene expression, by acting on transcriptional regulators, such as the cAMP response element-binding protein-regulated transcription coactivators and class IIa histone deacetylases. This review describes the development of research on SIKs, from their discovery to the most recent findings on metabolic regulation. The discovery of liver kinase B1 (LKB1) as an upstream kinase for AMP-activated protein kinase (AMPK) led to the identification of several related kinases that also rely on LKB1 for their catalytic activity. Among these, the salt-inducible kinases (SIKs) have emerged as key regulators of metabolism. Unlike AMPK, SIKs do not respond to nucleotides, but their function is regulated by extracellular signals, such as hormones, through complex LKB1-independent mechanisms. While AMPK acts on multiple targets, including metabolic enzymes, to maintain cellular ATP levels, SIKs primarily regulate gene expression, by acting on transcriptional regulators, such as the cAMP response element-binding protein-regulated transcription coactivators and class IIa histone deacetylases. This review describes the development of research on SIKs, from their discovery to the most recent findings on metabolic regulation. AMPK-related kinase Elsevier AMPK Elsevier AMP-activated protein kinase Elsevier LKB1 Elsevier gluconeogenesis Elsevier energy metabolism Elsevier Bultot, Laurent oth Göransson, Olga oth Enthalten in Elsevier Science van Egmond, L.T. ELSEVIER The gaze of sleep loss: acute effects of sleep loss on facial perception 2022 Amsterdam [u.a.] (DE-627)ELV008220654 volume:29 year:2018 number:12 pages:827-840 extent:14 https://doi.org/10.1016/j.tem.2018.09.007 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.90 Neurologie VZ AR 29 2018 12 827-840 14 |
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10.1016/j.tem.2018.09.007 doi GBV00000000000425.pica (DE-627)ELV044915098 (ELSEVIER)S1043-2760(18)30168-1 DE-627 ger DE-627 rakwb eng 610 VZ 44.90 bkl Sakamoto, Kei verfasserin aut The Salt-Inducible Kinases: Emerging Metabolic Regulators 2018transfer abstract 14 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The discovery of liver kinase B1 (LKB1) as an upstream kinase for AMP-activated protein kinase (AMPK) led to the identification of several related kinases that also rely on LKB1 for their catalytic activity. Among these, the salt-inducible kinases (SIKs) have emerged as key regulators of metabolism. Unlike AMPK, SIKs do not respond to nucleotides, but their function is regulated by extracellular signals, such as hormones, through complex LKB1-independent mechanisms. While AMPK acts on multiple targets, including metabolic enzymes, to maintain cellular ATP levels, SIKs primarily regulate gene expression, by acting on transcriptional regulators, such as the cAMP response element-binding protein-regulated transcription coactivators and class IIa histone deacetylases. This review describes the development of research on SIKs, from their discovery to the most recent findings on metabolic regulation. The discovery of liver kinase B1 (LKB1) as an upstream kinase for AMP-activated protein kinase (AMPK) led to the identification of several related kinases that also rely on LKB1 for their catalytic activity. Among these, the salt-inducible kinases (SIKs) have emerged as key regulators of metabolism. Unlike AMPK, SIKs do not respond to nucleotides, but their function is regulated by extracellular signals, such as hormones, through complex LKB1-independent mechanisms. While AMPK acts on multiple targets, including metabolic enzymes, to maintain cellular ATP levels, SIKs primarily regulate gene expression, by acting on transcriptional regulators, such as the cAMP response element-binding protein-regulated transcription coactivators and class IIa histone deacetylases. This review describes the development of research on SIKs, from their discovery to the most recent findings on metabolic regulation. AMPK-related kinase Elsevier AMPK Elsevier AMP-activated protein kinase Elsevier LKB1 Elsevier gluconeogenesis Elsevier energy metabolism Elsevier Bultot, Laurent oth Göransson, Olga oth Enthalten in Elsevier Science van Egmond, L.T. ELSEVIER The gaze of sleep loss: acute effects of sleep loss on facial perception 2022 Amsterdam [u.a.] (DE-627)ELV008220654 volume:29 year:2018 number:12 pages:827-840 extent:14 https://doi.org/10.1016/j.tem.2018.09.007 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.90 Neurologie VZ AR 29 2018 12 827-840 14 |
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10.1016/j.tem.2018.09.007 doi GBV00000000000425.pica (DE-627)ELV044915098 (ELSEVIER)S1043-2760(18)30168-1 DE-627 ger DE-627 rakwb eng 610 VZ 44.90 bkl Sakamoto, Kei verfasserin aut The Salt-Inducible Kinases: Emerging Metabolic Regulators 2018transfer abstract 14 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The discovery of liver kinase B1 (LKB1) as an upstream kinase for AMP-activated protein kinase (AMPK) led to the identification of several related kinases that also rely on LKB1 for their catalytic activity. Among these, the salt-inducible kinases (SIKs) have emerged as key regulators of metabolism. Unlike AMPK, SIKs do not respond to nucleotides, but their function is regulated by extracellular signals, such as hormones, through complex LKB1-independent mechanisms. While AMPK acts on multiple targets, including metabolic enzymes, to maintain cellular ATP levels, SIKs primarily regulate gene expression, by acting on transcriptional regulators, such as the cAMP response element-binding protein-regulated transcription coactivators and class IIa histone deacetylases. This review describes the development of research on SIKs, from their discovery to the most recent findings on metabolic regulation. The discovery of liver kinase B1 (LKB1) as an upstream kinase for AMP-activated protein kinase (AMPK) led to the identification of several related kinases that also rely on LKB1 for their catalytic activity. Among these, the salt-inducible kinases (SIKs) have emerged as key regulators of metabolism. Unlike AMPK, SIKs do not respond to nucleotides, but their function is regulated by extracellular signals, such as hormones, through complex LKB1-independent mechanisms. While AMPK acts on multiple targets, including metabolic enzymes, to maintain cellular ATP levels, SIKs primarily regulate gene expression, by acting on transcriptional regulators, such as the cAMP response element-binding protein-regulated transcription coactivators and class IIa histone deacetylases. This review describes the development of research on SIKs, from their discovery to the most recent findings on metabolic regulation. AMPK-related kinase Elsevier AMPK Elsevier AMP-activated protein kinase Elsevier LKB1 Elsevier gluconeogenesis Elsevier energy metabolism Elsevier Bultot, Laurent oth Göransson, Olga oth Enthalten in Elsevier Science van Egmond, L.T. ELSEVIER The gaze of sleep loss: acute effects of sleep loss on facial perception 2022 Amsterdam [u.a.] (DE-627)ELV008220654 volume:29 year:2018 number:12 pages:827-840 extent:14 https://doi.org/10.1016/j.tem.2018.09.007 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.90 Neurologie VZ AR 29 2018 12 827-840 14 |
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The gaze of sleep loss: acute effects of sleep loss on facial perception |
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The gaze of sleep loss: acute effects of sleep loss on facial perception |
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The Salt-Inducible Kinases: Emerging Metabolic Regulators |
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The Salt-Inducible Kinases: Emerging Metabolic Regulators |
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Sakamoto, Kei |
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The gaze of sleep loss: acute effects of sleep loss on facial perception |
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The gaze of sleep loss: acute effects of sleep loss on facial perception |
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eng |
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2018 |
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Sakamoto, Kei |
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Elektronische Aufsätze |
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Sakamoto, Kei |
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10.1016/j.tem.2018.09.007 |
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610 |
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salt-inducible kinases: emerging metabolic regulators |
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The Salt-Inducible Kinases: Emerging Metabolic Regulators |
| abstract |
The discovery of liver kinase B1 (LKB1) as an upstream kinase for AMP-activated protein kinase (AMPK) led to the identification of several related kinases that also rely on LKB1 for their catalytic activity. Among these, the salt-inducible kinases (SIKs) have emerged as key regulators of metabolism. Unlike AMPK, SIKs do not respond to nucleotides, but their function is regulated by extracellular signals, such as hormones, through complex LKB1-independent mechanisms. While AMPK acts on multiple targets, including metabolic enzymes, to maintain cellular ATP levels, SIKs primarily regulate gene expression, by acting on transcriptional regulators, such as the cAMP response element-binding protein-regulated transcription coactivators and class IIa histone deacetylases. This review describes the development of research on SIKs, from their discovery to the most recent findings on metabolic regulation. |
| abstractGer |
The discovery of liver kinase B1 (LKB1) as an upstream kinase for AMP-activated protein kinase (AMPK) led to the identification of several related kinases that also rely on LKB1 for their catalytic activity. Among these, the salt-inducible kinases (SIKs) have emerged as key regulators of metabolism. Unlike AMPK, SIKs do not respond to nucleotides, but their function is regulated by extracellular signals, such as hormones, through complex LKB1-independent mechanisms. While AMPK acts on multiple targets, including metabolic enzymes, to maintain cellular ATP levels, SIKs primarily regulate gene expression, by acting on transcriptional regulators, such as the cAMP response element-binding protein-regulated transcription coactivators and class IIa histone deacetylases. This review describes the development of research on SIKs, from their discovery to the most recent findings on metabolic regulation. |
| abstract_unstemmed |
The discovery of liver kinase B1 (LKB1) as an upstream kinase for AMP-activated protein kinase (AMPK) led to the identification of several related kinases that also rely on LKB1 for their catalytic activity. Among these, the salt-inducible kinases (SIKs) have emerged as key regulators of metabolism. Unlike AMPK, SIKs do not respond to nucleotides, but their function is regulated by extracellular signals, such as hormones, through complex LKB1-independent mechanisms. While AMPK acts on multiple targets, including metabolic enzymes, to maintain cellular ATP levels, SIKs primarily regulate gene expression, by acting on transcriptional regulators, such as the cAMP response element-binding protein-regulated transcription coactivators and class IIa histone deacetylases. This review describes the development of research on SIKs, from their discovery to the most recent findings on metabolic regulation. |
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The Salt-Inducible Kinases: Emerging Metabolic Regulators |
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https://doi.org/10.1016/j.tem.2018.09.007 |
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Bultot, Laurent Göransson, Olga |
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2024-07-06T22:44:24.617Z |
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