Association between typical electrocardiographic abnormalities and NT-proBNP elevation in a large cohort of patients with Chagas disease from endemic area
Chagas cardiomyopathy is the most harmful complication of Chagas disease. The electrocardiogram is a well-studied exam and has been considered an important tool for detection and evaluation of Chagas cardiomyopathy since the first years of its description. Many of its abnormalities have been describ...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Brito, Bruno Oliveira de Figueiredo [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2018transfer abstract |
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| Umfang: |
5 |
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| Übergeordnetes Werk: |
Enthalten in: Consensus of generalized integrators: Convergence rate and disturbance attenuation property - Oh, Kwang-Kyo ELSEVIER, 2016, official journal of the International Society for Computerized Electrocardiology and the International Society of Electrocardiology, New York, NY |
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| Übergeordnetes Werk: |
volume:51 ; year:2018 ; number:6 ; pages:1039-1043 ; extent:5 |
| Links: |
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| DOI / URN: |
10.1016/j.jelectrocard.2018.08.031 |
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| 245 | 1 | 0 | |a Association between typical electrocardiographic abnormalities and NT-proBNP elevation in a large cohort of patients with Chagas disease from endemic area |
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| 520 | |a Chagas cardiomyopathy is the most harmful complication of Chagas disease. The electrocardiogram is a well-studied exam and has been considered an important tool for detection and evaluation of Chagas cardiomyopathy since the first years of its description. Many of its abnormalities have been described as associated with a worse prognosis. Serum BNP levels were described as inversely related to the left ventricular ejection fraction and as an independent predictor of death. It was not reported how electrocardiographic alterations correlate to NT-proBNP and its analog. The present study aims to describe the baseline electrocardiograms of a large cohort of patients with Chagas disease from endemic area and to establish an association between the number of electrocardiogram alterations and high levels of NT-ProBNP in Chagas disease patients. This study selected 1959 Chagas disease patients in 21 municipalities within a limited region in the northern part of the State of Minas Gerais (Brazil), 1084 of them had Chagas cardiomyopathy. NT-proBNP levels were suggestive of heart failure in 11.7% of this population. One or more electrocardiographic alterations have an Odds Ratio of 9.12 (CI 95% 5.62–14.80) to have NT-proBNP elevation. Considering the association between the number of 1, 2, and 3 or more alterations in electrocardiogram and NT-proBNP elevation, the ORs were 7.11 (CI 95% 4.33–11.67); 16.04 (CI 95% 9.27–27.77) and 47.82 (CI 95% 17.98–127.20), respectively. The presence and the number of typical electrocardiographic alterations of Chagas disease are independently associated with the severity of the cardiomyopathy. | ||
| 520 | |a Chagas cardiomyopathy is the most harmful complication of Chagas disease. The electrocardiogram is a well-studied exam and has been considered an important tool for detection and evaluation of Chagas cardiomyopathy since the first years of its description. Many of its abnormalities have been described as associated with a worse prognosis. Serum BNP levels were described as inversely related to the left ventricular ejection fraction and as an independent predictor of death. It was not reported how electrocardiographic alterations correlate to NT-proBNP and its analog. The present study aims to describe the baseline electrocardiograms of a large cohort of patients with Chagas disease from endemic area and to establish an association between the number of electrocardiogram alterations and high levels of NT-ProBNP in Chagas disease patients. This study selected 1959 Chagas disease patients in 21 municipalities within a limited region in the northern part of the State of Minas Gerais (Brazil), 1084 of them had Chagas cardiomyopathy. NT-proBNP levels were suggestive of heart failure in 11.7% of this population. One or more electrocardiographic alterations have an Odds Ratio of 9.12 (CI 95% 5.62–14.80) to have NT-proBNP elevation. Considering the association between the number of 1, 2, and 3 or more alterations in electrocardiogram and NT-proBNP elevation, the ORs were 7.11 (CI 95% 4.33–11.67); 16.04 (CI 95% 9.27–27.77) and 47.82 (CI 95% 17.98–127.20), respectively. The presence and the number of typical electrocardiographic alterations of Chagas disease are independently associated with the severity of the cardiomyopathy. | ||
| 700 | 1 | |a Pinto-Filho, Marcelo Martins |4 oth | |
| 700 | 1 | |a Cardoso, Clareci Silva |4 oth | |
| 700 | 1 | |a Di Lorenzo Oliveira, Claudia |4 oth | |
| 700 | 1 | |a Ferreira, Ariela Mota |4 oth | |
| 700 | 1 | |a de Oliveira, Lea Campos |4 oth | |
| 700 | 1 | |a Gomes, Paulo |4 oth | |
| 700 | 1 | |a Nunes, Maria do Carmo Pereira |4 oth | |
| 700 | 1 | |a Sabino, Ester Cerdeira |4 oth | |
| 700 | 1 | |a Ribeiro, Antonio Luiz Pinho |4 oth | |
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10.1016/j.jelectrocard.2018.08.031 doi GBV00000000000487.pica (DE-627)ELV045060398 (ELSEVIER)S0022-0736(18)30415-1 DE-627 ger DE-627 rakwb eng 000 VZ 620 VZ 610 VZ 44.48 bkl Brito, Bruno Oliveira de Figueiredo verfasserin aut Association between typical electrocardiographic abnormalities and NT-proBNP elevation in a large cohort of patients with Chagas disease from endemic area 2018transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Chagas cardiomyopathy is the most harmful complication of Chagas disease. The electrocardiogram is a well-studied exam and has been considered an important tool for detection and evaluation of Chagas cardiomyopathy since the first years of its description. Many of its abnormalities have been described as associated with a worse prognosis. Serum BNP levels were described as inversely related to the left ventricular ejection fraction and as an independent predictor of death. It was not reported how electrocardiographic alterations correlate to NT-proBNP and its analog. The present study aims to describe the baseline electrocardiograms of a large cohort of patients with Chagas disease from endemic area and to establish an association between the number of electrocardiogram alterations and high levels of NT-ProBNP in Chagas disease patients. This study selected 1959 Chagas disease patients in 21 municipalities within a limited region in the northern part of the State of Minas Gerais (Brazil), 1084 of them had Chagas cardiomyopathy. NT-proBNP levels were suggestive of heart failure in 11.7% of this population. One or more electrocardiographic alterations have an Odds Ratio of 9.12 (CI 95% 5.62–14.80) to have NT-proBNP elevation. Considering the association between the number of 1, 2, and 3 or more alterations in electrocardiogram and NT-proBNP elevation, the ORs were 7.11 (CI 95% 4.33–11.67); 16.04 (CI 95% 9.27–27.77) and 47.82 (CI 95% 17.98–127.20), respectively. The presence and the number of typical electrocardiographic alterations of Chagas disease are independently associated with the severity of the cardiomyopathy. Chagas cardiomyopathy is the most harmful complication of Chagas disease. The electrocardiogram is a well-studied exam and has been considered an important tool for detection and evaluation of Chagas cardiomyopathy since the first years of its description. Many of its abnormalities have been described as associated with a worse prognosis. Serum BNP levels were described as inversely related to the left ventricular ejection fraction and as an independent predictor of death. It was not reported how electrocardiographic alterations correlate to NT-proBNP and its analog. The present study aims to describe the baseline electrocardiograms of a large cohort of patients with Chagas disease from endemic area and to establish an association between the number of electrocardiogram alterations and high levels of NT-ProBNP in Chagas disease patients. This study selected 1959 Chagas disease patients in 21 municipalities within a limited region in the northern part of the State of Minas Gerais (Brazil), 1084 of them had Chagas cardiomyopathy. NT-proBNP levels were suggestive of heart failure in 11.7% of this population. One or more electrocardiographic alterations have an Odds Ratio of 9.12 (CI 95% 5.62–14.80) to have NT-proBNP elevation. Considering the association between the number of 1, 2, and 3 or more alterations in electrocardiogram and NT-proBNP elevation, the ORs were 7.11 (CI 95% 4.33–11.67); 16.04 (CI 95% 9.27–27.77) and 47.82 (CI 95% 17.98–127.20), respectively. The presence and the number of typical electrocardiographic alterations of Chagas disease are independently associated with the severity of the cardiomyopathy. Pinto-Filho, Marcelo Martins oth Cardoso, Clareci Silva oth Di Lorenzo Oliveira, Claudia oth Ferreira, Ariela Mota oth de Oliveira, Lea Campos oth Gomes, Paulo oth Nunes, Maria do Carmo Pereira oth Sabino, Ester Cerdeira oth Ribeiro, Antonio Luiz Pinho oth Enthalten in Elsevier Oh, Kwang-Kyo ELSEVIER Consensus of generalized integrators: Convergence rate and disturbance attenuation property 2016 official journal of the International Society for Computerized Electrocardiology and the International Society of Electrocardiology New York, NY (DE-627)ELV019760574 volume:51 year:2018 number:6 pages:1039-1043 extent:5 https://doi.org/10.1016/j.jelectrocard.2018.08.031 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_22 GBV_ILN_24 GBV_ILN_39 GBV_ILN_72 GBV_ILN_92 GBV_ILN_636 GBV_ILN_2001 GBV_ILN_2002 GBV_ILN_2003 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2018 GBV_ILN_2033 GBV_ILN_2035 GBV_ILN_2036 GBV_ILN_2041 GBV_ILN_2470 GBV_ILN_2498 44.48 Medizinische Genetik VZ AR 51 2018 6 1039-1043 5 |
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10.1016/j.jelectrocard.2018.08.031 doi GBV00000000000487.pica (DE-627)ELV045060398 (ELSEVIER)S0022-0736(18)30415-1 DE-627 ger DE-627 rakwb eng 000 VZ 620 VZ 610 VZ 44.48 bkl Brito, Bruno Oliveira de Figueiredo verfasserin aut Association between typical electrocardiographic abnormalities and NT-proBNP elevation in a large cohort of patients with Chagas disease from endemic area 2018transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Chagas cardiomyopathy is the most harmful complication of Chagas disease. The electrocardiogram is a well-studied exam and has been considered an important tool for detection and evaluation of Chagas cardiomyopathy since the first years of its description. Many of its abnormalities have been described as associated with a worse prognosis. Serum BNP levels were described as inversely related to the left ventricular ejection fraction and as an independent predictor of death. It was not reported how electrocardiographic alterations correlate to NT-proBNP and its analog. The present study aims to describe the baseline electrocardiograms of a large cohort of patients with Chagas disease from endemic area and to establish an association between the number of electrocardiogram alterations and high levels of NT-ProBNP in Chagas disease patients. This study selected 1959 Chagas disease patients in 21 municipalities within a limited region in the northern part of the State of Minas Gerais (Brazil), 1084 of them had Chagas cardiomyopathy. NT-proBNP levels were suggestive of heart failure in 11.7% of this population. One or more electrocardiographic alterations have an Odds Ratio of 9.12 (CI 95% 5.62–14.80) to have NT-proBNP elevation. Considering the association between the number of 1, 2, and 3 or more alterations in electrocardiogram and NT-proBNP elevation, the ORs were 7.11 (CI 95% 4.33–11.67); 16.04 (CI 95% 9.27–27.77) and 47.82 (CI 95% 17.98–127.20), respectively. The presence and the number of typical electrocardiographic alterations of Chagas disease are independently associated with the severity of the cardiomyopathy. Chagas cardiomyopathy is the most harmful complication of Chagas disease. The electrocardiogram is a well-studied exam and has been considered an important tool for detection and evaluation of Chagas cardiomyopathy since the first years of its description. Many of its abnormalities have been described as associated with a worse prognosis. Serum BNP levels were described as inversely related to the left ventricular ejection fraction and as an independent predictor of death. It was not reported how electrocardiographic alterations correlate to NT-proBNP and its analog. The present study aims to describe the baseline electrocardiograms of a large cohort of patients with Chagas disease from endemic area and to establish an association between the number of electrocardiogram alterations and high levels of NT-ProBNP in Chagas disease patients. This study selected 1959 Chagas disease patients in 21 municipalities within a limited region in the northern part of the State of Minas Gerais (Brazil), 1084 of them had Chagas cardiomyopathy. NT-proBNP levels were suggestive of heart failure in 11.7% of this population. One or more electrocardiographic alterations have an Odds Ratio of 9.12 (CI 95% 5.62–14.80) to have NT-proBNP elevation. Considering the association between the number of 1, 2, and 3 or more alterations in electrocardiogram and NT-proBNP elevation, the ORs were 7.11 (CI 95% 4.33–11.67); 16.04 (CI 95% 9.27–27.77) and 47.82 (CI 95% 17.98–127.20), respectively. The presence and the number of typical electrocardiographic alterations of Chagas disease are independently associated with the severity of the cardiomyopathy. Pinto-Filho, Marcelo Martins oth Cardoso, Clareci Silva oth Di Lorenzo Oliveira, Claudia oth Ferreira, Ariela Mota oth de Oliveira, Lea Campos oth Gomes, Paulo oth Nunes, Maria do Carmo Pereira oth Sabino, Ester Cerdeira oth Ribeiro, Antonio Luiz Pinho oth Enthalten in Elsevier Oh, Kwang-Kyo ELSEVIER Consensus of generalized integrators: Convergence rate and disturbance attenuation property 2016 official journal of the International Society for Computerized Electrocardiology and the International Society of Electrocardiology New York, NY (DE-627)ELV019760574 volume:51 year:2018 number:6 pages:1039-1043 extent:5 https://doi.org/10.1016/j.jelectrocard.2018.08.031 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_22 GBV_ILN_24 GBV_ILN_39 GBV_ILN_72 GBV_ILN_92 GBV_ILN_636 GBV_ILN_2001 GBV_ILN_2002 GBV_ILN_2003 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2018 GBV_ILN_2033 GBV_ILN_2035 GBV_ILN_2036 GBV_ILN_2041 GBV_ILN_2470 GBV_ILN_2498 44.48 Medizinische Genetik VZ AR 51 2018 6 1039-1043 5 |
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10.1016/j.jelectrocard.2018.08.031 doi GBV00000000000487.pica (DE-627)ELV045060398 (ELSEVIER)S0022-0736(18)30415-1 DE-627 ger DE-627 rakwb eng 000 VZ 620 VZ 610 VZ 44.48 bkl Brito, Bruno Oliveira de Figueiredo verfasserin aut Association between typical electrocardiographic abnormalities and NT-proBNP elevation in a large cohort of patients with Chagas disease from endemic area 2018transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Chagas cardiomyopathy is the most harmful complication of Chagas disease. The electrocardiogram is a well-studied exam and has been considered an important tool for detection and evaluation of Chagas cardiomyopathy since the first years of its description. Many of its abnormalities have been described as associated with a worse prognosis. Serum BNP levels were described as inversely related to the left ventricular ejection fraction and as an independent predictor of death. It was not reported how electrocardiographic alterations correlate to NT-proBNP and its analog. The present study aims to describe the baseline electrocardiograms of a large cohort of patients with Chagas disease from endemic area and to establish an association between the number of electrocardiogram alterations and high levels of NT-ProBNP in Chagas disease patients. This study selected 1959 Chagas disease patients in 21 municipalities within a limited region in the northern part of the State of Minas Gerais (Brazil), 1084 of them had Chagas cardiomyopathy. NT-proBNP levels were suggestive of heart failure in 11.7% of this population. One or more electrocardiographic alterations have an Odds Ratio of 9.12 (CI 95% 5.62–14.80) to have NT-proBNP elevation. Considering the association between the number of 1, 2, and 3 or more alterations in electrocardiogram and NT-proBNP elevation, the ORs were 7.11 (CI 95% 4.33–11.67); 16.04 (CI 95% 9.27–27.77) and 47.82 (CI 95% 17.98–127.20), respectively. The presence and the number of typical electrocardiographic alterations of Chagas disease are independently associated with the severity of the cardiomyopathy. Chagas cardiomyopathy is the most harmful complication of Chagas disease. The electrocardiogram is a well-studied exam and has been considered an important tool for detection and evaluation of Chagas cardiomyopathy since the first years of its description. Many of its abnormalities have been described as associated with a worse prognosis. Serum BNP levels were described as inversely related to the left ventricular ejection fraction and as an independent predictor of death. It was not reported how electrocardiographic alterations correlate to NT-proBNP and its analog. The present study aims to describe the baseline electrocardiograms of a large cohort of patients with Chagas disease from endemic area and to establish an association between the number of electrocardiogram alterations and high levels of NT-ProBNP in Chagas disease patients. This study selected 1959 Chagas disease patients in 21 municipalities within a limited region in the northern part of the State of Minas Gerais (Brazil), 1084 of them had Chagas cardiomyopathy. NT-proBNP levels were suggestive of heart failure in 11.7% of this population. One or more electrocardiographic alterations have an Odds Ratio of 9.12 (CI 95% 5.62–14.80) to have NT-proBNP elevation. Considering the association between the number of 1, 2, and 3 or more alterations in electrocardiogram and NT-proBNP elevation, the ORs were 7.11 (CI 95% 4.33–11.67); 16.04 (CI 95% 9.27–27.77) and 47.82 (CI 95% 17.98–127.20), respectively. The presence and the number of typical electrocardiographic alterations of Chagas disease are independently associated with the severity of the cardiomyopathy. Pinto-Filho, Marcelo Martins oth Cardoso, Clareci Silva oth Di Lorenzo Oliveira, Claudia oth Ferreira, Ariela Mota oth de Oliveira, Lea Campos oth Gomes, Paulo oth Nunes, Maria do Carmo Pereira oth Sabino, Ester Cerdeira oth Ribeiro, Antonio Luiz Pinho oth Enthalten in Elsevier Oh, Kwang-Kyo ELSEVIER Consensus of generalized integrators: Convergence rate and disturbance attenuation property 2016 official journal of the International Society for Computerized Electrocardiology and the International Society of Electrocardiology New York, NY (DE-627)ELV019760574 volume:51 year:2018 number:6 pages:1039-1043 extent:5 https://doi.org/10.1016/j.jelectrocard.2018.08.031 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_22 GBV_ILN_24 GBV_ILN_39 GBV_ILN_72 GBV_ILN_92 GBV_ILN_636 GBV_ILN_2001 GBV_ILN_2002 GBV_ILN_2003 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2018 GBV_ILN_2033 GBV_ILN_2035 GBV_ILN_2036 GBV_ILN_2041 GBV_ILN_2470 GBV_ILN_2498 44.48 Medizinische Genetik VZ AR 51 2018 6 1039-1043 5 |
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10.1016/j.jelectrocard.2018.08.031 doi GBV00000000000487.pica (DE-627)ELV045060398 (ELSEVIER)S0022-0736(18)30415-1 DE-627 ger DE-627 rakwb eng 000 VZ 620 VZ 610 VZ 44.48 bkl Brito, Bruno Oliveira de Figueiredo verfasserin aut Association between typical electrocardiographic abnormalities and NT-proBNP elevation in a large cohort of patients with Chagas disease from endemic area 2018transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Chagas cardiomyopathy is the most harmful complication of Chagas disease. The electrocardiogram is a well-studied exam and has been considered an important tool for detection and evaluation of Chagas cardiomyopathy since the first years of its description. Many of its abnormalities have been described as associated with a worse prognosis. Serum BNP levels were described as inversely related to the left ventricular ejection fraction and as an independent predictor of death. It was not reported how electrocardiographic alterations correlate to NT-proBNP and its analog. The present study aims to describe the baseline electrocardiograms of a large cohort of patients with Chagas disease from endemic area and to establish an association between the number of electrocardiogram alterations and high levels of NT-ProBNP in Chagas disease patients. This study selected 1959 Chagas disease patients in 21 municipalities within a limited region in the northern part of the State of Minas Gerais (Brazil), 1084 of them had Chagas cardiomyopathy. NT-proBNP levels were suggestive of heart failure in 11.7% of this population. One or more electrocardiographic alterations have an Odds Ratio of 9.12 (CI 95% 5.62–14.80) to have NT-proBNP elevation. Considering the association between the number of 1, 2, and 3 or more alterations in electrocardiogram and NT-proBNP elevation, the ORs were 7.11 (CI 95% 4.33–11.67); 16.04 (CI 95% 9.27–27.77) and 47.82 (CI 95% 17.98–127.20), respectively. The presence and the number of typical electrocardiographic alterations of Chagas disease are independently associated with the severity of the cardiomyopathy. Chagas cardiomyopathy is the most harmful complication of Chagas disease. The electrocardiogram is a well-studied exam and has been considered an important tool for detection and evaluation of Chagas cardiomyopathy since the first years of its description. Many of its abnormalities have been described as associated with a worse prognosis. Serum BNP levels were described as inversely related to the left ventricular ejection fraction and as an independent predictor of death. It was not reported how electrocardiographic alterations correlate to NT-proBNP and its analog. The present study aims to describe the baseline electrocardiograms of a large cohort of patients with Chagas disease from endemic area and to establish an association between the number of electrocardiogram alterations and high levels of NT-ProBNP in Chagas disease patients. This study selected 1959 Chagas disease patients in 21 municipalities within a limited region in the northern part of the State of Minas Gerais (Brazil), 1084 of them had Chagas cardiomyopathy. NT-proBNP levels were suggestive of heart failure in 11.7% of this population. One or more electrocardiographic alterations have an Odds Ratio of 9.12 (CI 95% 5.62–14.80) to have NT-proBNP elevation. Considering the association between the number of 1, 2, and 3 or more alterations in electrocardiogram and NT-proBNP elevation, the ORs were 7.11 (CI 95% 4.33–11.67); 16.04 (CI 95% 9.27–27.77) and 47.82 (CI 95% 17.98–127.20), respectively. The presence and the number of typical electrocardiographic alterations of Chagas disease are independently associated with the severity of the cardiomyopathy. Pinto-Filho, Marcelo Martins oth Cardoso, Clareci Silva oth Di Lorenzo Oliveira, Claudia oth Ferreira, Ariela Mota oth de Oliveira, Lea Campos oth Gomes, Paulo oth Nunes, Maria do Carmo Pereira oth Sabino, Ester Cerdeira oth Ribeiro, Antonio Luiz Pinho oth Enthalten in Elsevier Oh, Kwang-Kyo ELSEVIER Consensus of generalized integrators: Convergence rate and disturbance attenuation property 2016 official journal of the International Society for Computerized Electrocardiology and the International Society of Electrocardiology New York, NY (DE-627)ELV019760574 volume:51 year:2018 number:6 pages:1039-1043 extent:5 https://doi.org/10.1016/j.jelectrocard.2018.08.031 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_22 GBV_ILN_24 GBV_ILN_39 GBV_ILN_72 GBV_ILN_92 GBV_ILN_636 GBV_ILN_2001 GBV_ILN_2002 GBV_ILN_2003 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2018 GBV_ILN_2033 GBV_ILN_2035 GBV_ILN_2036 GBV_ILN_2041 GBV_ILN_2470 GBV_ILN_2498 44.48 Medizinische Genetik VZ AR 51 2018 6 1039-1043 5 |
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Association between typical electrocardiographic abnormalities and NT-proBNP elevation in a large cohort of patients with Chagas disease from endemic area |
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Chagas cardiomyopathy is the most harmful complication of Chagas disease. The electrocardiogram is a well-studied exam and has been considered an important tool for detection and evaluation of Chagas cardiomyopathy since the first years of its description. Many of its abnormalities have been described as associated with a worse prognosis. Serum BNP levels were described as inversely related to the left ventricular ejection fraction and as an independent predictor of death. It was not reported how electrocardiographic alterations correlate to NT-proBNP and its analog. The present study aims to describe the baseline electrocardiograms of a large cohort of patients with Chagas disease from endemic area and to establish an association between the number of electrocardiogram alterations and high levels of NT-ProBNP in Chagas disease patients. This study selected 1959 Chagas disease patients in 21 municipalities within a limited region in the northern part of the State of Minas Gerais (Brazil), 1084 of them had Chagas cardiomyopathy. NT-proBNP levels were suggestive of heart failure in 11.7% of this population. One or more electrocardiographic alterations have an Odds Ratio of 9.12 (CI 95% 5.62–14.80) to have NT-proBNP elevation. Considering the association between the number of 1, 2, and 3 or more alterations in electrocardiogram and NT-proBNP elevation, the ORs were 7.11 (CI 95% 4.33–11.67); 16.04 (CI 95% 9.27–27.77) and 47.82 (CI 95% 17.98–127.20), respectively. The presence and the number of typical electrocardiographic alterations of Chagas disease are independently associated with the severity of the cardiomyopathy. |
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Chagas cardiomyopathy is the most harmful complication of Chagas disease. The electrocardiogram is a well-studied exam and has been considered an important tool for detection and evaluation of Chagas cardiomyopathy since the first years of its description. Many of its abnormalities have been described as associated with a worse prognosis. Serum BNP levels were described as inversely related to the left ventricular ejection fraction and as an independent predictor of death. It was not reported how electrocardiographic alterations correlate to NT-proBNP and its analog. The present study aims to describe the baseline electrocardiograms of a large cohort of patients with Chagas disease from endemic area and to establish an association between the number of electrocardiogram alterations and high levels of NT-ProBNP in Chagas disease patients. This study selected 1959 Chagas disease patients in 21 municipalities within a limited region in the northern part of the State of Minas Gerais (Brazil), 1084 of them had Chagas cardiomyopathy. NT-proBNP levels were suggestive of heart failure in 11.7% of this population. One or more electrocardiographic alterations have an Odds Ratio of 9.12 (CI 95% 5.62–14.80) to have NT-proBNP elevation. Considering the association between the number of 1, 2, and 3 or more alterations in electrocardiogram and NT-proBNP elevation, the ORs were 7.11 (CI 95% 4.33–11.67); 16.04 (CI 95% 9.27–27.77) and 47.82 (CI 95% 17.98–127.20), respectively. The presence and the number of typical electrocardiographic alterations of Chagas disease are independently associated with the severity of the cardiomyopathy. |
| abstract_unstemmed |
Chagas cardiomyopathy is the most harmful complication of Chagas disease. The electrocardiogram is a well-studied exam and has been considered an important tool for detection and evaluation of Chagas cardiomyopathy since the first years of its description. Many of its abnormalities have been described as associated with a worse prognosis. Serum BNP levels were described as inversely related to the left ventricular ejection fraction and as an independent predictor of death. It was not reported how electrocardiographic alterations correlate to NT-proBNP and its analog. The present study aims to describe the baseline electrocardiograms of a large cohort of patients with Chagas disease from endemic area and to establish an association between the number of electrocardiogram alterations and high levels of NT-ProBNP in Chagas disease patients. This study selected 1959 Chagas disease patients in 21 municipalities within a limited region in the northern part of the State of Minas Gerais (Brazil), 1084 of them had Chagas cardiomyopathy. NT-proBNP levels were suggestive of heart failure in 11.7% of this population. One or more electrocardiographic alterations have an Odds Ratio of 9.12 (CI 95% 5.62–14.80) to have NT-proBNP elevation. Considering the association between the number of 1, 2, and 3 or more alterations in electrocardiogram and NT-proBNP elevation, the ORs were 7.11 (CI 95% 4.33–11.67); 16.04 (CI 95% 9.27–27.77) and 47.82 (CI 95% 17.98–127.20), respectively. The presence and the number of typical electrocardiographic alterations of Chagas disease are independently associated with the severity of the cardiomyopathy. |
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Association between typical electrocardiographic abnormalities and NT-proBNP elevation in a large cohort of patients with Chagas disease from endemic area |
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Pinto-Filho, Marcelo Martins Cardoso, Clareci Silva Di Lorenzo Oliveira, Claudia Ferreira, Ariela Mota de Oliveira, Lea Campos Gomes, Paulo Nunes, Maria do Carmo Pereira Sabino, Ester Cerdeira Ribeiro, Antonio Luiz Pinho |
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Pinto-Filho, Marcelo Martins Cardoso, Clareci Silva Di Lorenzo Oliveira, Claudia Ferreira, Ariela Mota de Oliveira, Lea Campos Gomes, Paulo Nunes, Maria do Carmo Pereira Sabino, Ester Cerdeira Ribeiro, Antonio Luiz Pinho |
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10.1016/j.jelectrocard.2018.08.031 |
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