Patients with common variable immunodeficiency with autoimmune cytopenias exhibit hyperplastic yet inefficient germinal center responses

The lack of pathogen-protective, isotype-switched antibodies in patients with common variable immunodeficiency (CVID) suggests germinal center (GC) hypoplasia, yet a subset of patients with CVID is paradoxically affected by autoantibody-mediated autoimmune cytopenias (AICs) and lymphadenopathy.

Gespeichert in:
Autor*in:

Romberg, Neil [verfasserIn]

Le Coz, Carole

Glauzy, Salomé

Schickel, Jean-Nicolas

Trofa, Melissa

Nolan, Brian E.

Paessler, Michele

Xu, Mina L.

Lambert, Michele P.

Lakhani, Saquib A.

Khokha, Mustafa K.

Jyonouchi, Soma

Heimall, Jennifer

Takach, Patricia

Maglione, Paul J.

Catanzaro, Jason

Hsu, F. Ida

Sullivan, Kathleen E.

Cunningham-Rundles, Charlotte

Meffre, Eric

Format:

E-Artikel

Sprache:

Englisch

Erschienen:

2019

Schlagwörter:

germinal center responses

Common variable immunodeficiency

somatic hypermutation

B-cell tolerance

autoimmune cytopenias

commensal bacteria

regulatory T cell

follicular helper T cell

Umfang:

8

Übergeordnetes Werk:

Enthalten in: Antidiabetic treatment in elderly patients with low performance status admitted to internal medicine ward - Papakitsou, I. ELSEVIER, 2022, official publication of the American Academy of Allergy, Asthma and Immunology, Amsterdam [u.a.]

Übergeordnetes Werk:

volume:143 ; year:2019 ; number:1 ; pages:258-265 ; extent:8

Links:

Volltext

DOI / URN:

10.1016/j.jaci.2018.06.012

Katalog-ID:

ELV045368740

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