Nanosoldiers: A promising strategy to combat triple negative breast cancer

The phenomenal rise in cancer over the past few years has made it the second leading cause of death worldwide. Breast cancer constitutes the predominant cancer encountered in women. Triple negative breast cancer (TNBC) is the most notorious form of breast cancer which involves absence of the estroge...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Pawar, Akshayya [verfasserIn] Prabhu, Priyanka [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	Nanoparticles Theranostic Targeted Photothermal therapy Metastasis Triple negative breast cancer Bioavailability Photodynamic therapy Combination therapy Immunotherapy Clinical trials Multimodal therapy Gene delivery Hyaluronic acid

Übergeordnetes Werk:	Enthalten in: Biomedicine & pharmacotherapy - Amsterdam [u.a.] : Elsevier Science, 1989, 110, Seite 319-341
Übergeordnetes Werk:	volume:110 ; pages:319-341

DOI / URN:	10.1016/j.biopha.2018.11.122

Katalog-ID:	ELV04537466X

Internformat


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520			\|a The phenomenal rise in cancer over the past few years has made it the second leading cause of death worldwide. Breast cancer constitutes the predominant cancer encountered in women. Triple negative breast cancer (TNBC) is the most notorious form of breast cancer which involves absence of the estrogen, progesterone and human epidermal growth factor receptor (EGFR) on breast cancer cells. It is a real challenge for oncologists owing to the recurrence and metastasis which result in poor prognosis. Conventional therapies employed in treatment of TNBC suffer from issues of poor bioavailability, poor cellular uptake, resistance, and undesirable off-site toxicities. Nanosized delivery systems, herein designated as nanosoldiers can be smartly designed to be equipped with multiple weapons (drugs, genetic materials, photosensitizers, etc.) to fight the battle against recalcitrant TNBC in a myriad of ways such as bioavailability enhancement, targeted uptake by the TNBC cells, on-demand drug delivery at tumour site, combination therapy, multimodal therapy, photodynamic therapy, photothermal therapy, anti-metastatic approaches, theranostics, etc. The versatility of nanosoldiers with respect to their material of composition, their mechanism of drug loading and release, ability to modify in vivo drug disposition, multifunctional characteristics enabling detection, treatment, and monitoring, etc. endows them with incredible potential to destroy the intractable TNBC cells. The focus of the review is to highlight the extraordinary potential of nanocarriers in treatment of TNBC and few challenges which need to be overcome for these nanosoldiers to form a part of the clinical armamentarium of anticancer agents.
650		4	\|a Nanoparticles
650		4	\|a Theranostic
650		4	\|a Targeted
650		4	\|a Photothermal therapy
650		4	\|a Metastasis
650		4	\|a Triple negative breast cancer
650		4	\|a Bioavailability
650		4	\|a Photodynamic therapy
650		4	\|a Combination therapy
650		4	\|a Immunotherapy
650		4	\|a Clinical trials
650		4	\|a Multimodal therapy
650		4	\|a Gene delivery
650		4	\|a Hyaluronic acid
700	1		\|a Prabhu, Priyanka \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t Biomedicine & pharmacotherapy \|d Amsterdam [u.a.] : Elsevier Science, 1989 \|g 110, Seite 319-341 \|h Online-Ressource \|w (DE-627)306717565 \|w (DE-600)1501510-5 \|w (DE-576)261593021 \|x 1950-6007 \|7 nnns
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912			\|a GBV_ILN_24
912			\|a GBV_ILN_31
912			\|a GBV_ILN_32
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_70
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_90
912			\|a GBV_ILN_95
912			\|a GBV_ILN_100
912			\|a GBV_ILN_101
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
912			\|a GBV_ILN_161
912			\|a GBV_ILN_165
912			\|a GBV_ILN_170
912			\|a GBV_ILN_187
912			\|a GBV_ILN_206
912			\|a GBV_ILN_213
912			\|a GBV_ILN_224
912			\|a GBV_ILN_230
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
912			\|a GBV_ILN_702
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2007
912			\|a GBV_ILN_2008
912			\|a GBV_ILN_2009
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2038
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2056
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2065
912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2113
912			\|a GBV_ILN_2118
912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2129
912			\|a GBV_ILN_2143
912			\|a GBV_ILN_2147
912			\|a GBV_ILN_2148
912			\|a GBV_ILN_2152
912			\|a GBV_ILN_2153
912			\|a GBV_ILN_2190
912			\|a GBV_ILN_2232
912			\|a GBV_ILN_2336
912			\|a GBV_ILN_2470
912			\|a GBV_ILN_2507
912			\|a GBV_ILN_2522
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4035
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4242
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4335
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4367
912			\|a GBV_ILN_4393
912			\|a GBV_ILN_4700
936	b	k	\|a 44.40 \|j Pharmazie \|j Pharmazeutika \|q VZ
951			\|a AR
952			\|d 110 \|h 319-341

Indexfelder

author_variant	a p ap p p pp
matchkey_str	article:19506007:2018----::aoodespoiigtaeyoobtrpeea
hierarchy_sort_str	2018
bklnumber	44.40
publishDate	2018
allfields	10.1016/j.biopha.2018.11.122 doi (DE-627)ELV04537466X (ELSEVIER)S0753-3322(18)36917-8 DE-627 ger DE-627 rda eng 610 VZ 44.40 bkl Pawar, Akshayya verfasserin aut Nanosoldiers: A promising strategy to combat triple negative breast cancer 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The phenomenal rise in cancer over the past few years has made it the second leading cause of death worldwide. Breast cancer constitutes the predominant cancer encountered in women. Triple negative breast cancer (TNBC) is the most notorious form of breast cancer which involves absence of the estrogen, progesterone and human epidermal growth factor receptor (EGFR) on breast cancer cells. It is a real challenge for oncologists owing to the recurrence and metastasis which result in poor prognosis. Conventional therapies employed in treatment of TNBC suffer from issues of poor bioavailability, poor cellular uptake, resistance, and undesirable off-site toxicities. Nanosized delivery systems, herein designated as nanosoldiers can be smartly designed to be equipped with multiple weapons (drugs, genetic materials, photosensitizers, etc.) to fight the battle against recalcitrant TNBC in a myriad of ways such as bioavailability enhancement, targeted uptake by the TNBC cells, on-demand drug delivery at tumour site, combination therapy, multimodal therapy, photodynamic therapy, photothermal therapy, anti-metastatic approaches, theranostics, etc. The versatility of nanosoldiers with respect to their material of composition, their mechanism of drug loading and release, ability to modify in vivo drug disposition, multifunctional characteristics enabling detection, treatment, and monitoring, etc. endows them with incredible potential to destroy the intractable TNBC cells. The focus of the review is to highlight the extraordinary potential of nanocarriers in treatment of TNBC and few challenges which need to be overcome for these nanosoldiers to form a part of the clinical armamentarium of anticancer agents. Nanoparticles Theranostic Targeted Photothermal therapy Metastasis Triple negative breast cancer Bioavailability Photodynamic therapy Combination therapy Immunotherapy Clinical trials Multimodal therapy Gene delivery Hyaluronic acid Prabhu, Priyanka verfasserin aut Enthalten in Biomedicine & pharmacotherapy Amsterdam [u.a.] : Elsevier Science, 1989 110, Seite 319-341 Online-Ressource (DE-627)306717565 (DE-600)1501510-5 (DE-576)261593021 1950-6007 nnns volume:110 pages:319-341 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.40 Pharmazie Pharmazeutika VZ AR 110 319-341
spelling	10.1016/j.biopha.2018.11.122 doi (DE-627)ELV04537466X (ELSEVIER)S0753-3322(18)36917-8 DE-627 ger DE-627 rda eng 610 VZ 44.40 bkl Pawar, Akshayya verfasserin aut Nanosoldiers: A promising strategy to combat triple negative breast cancer 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The phenomenal rise in cancer over the past few years has made it the second leading cause of death worldwide. Breast cancer constitutes the predominant cancer encountered in women. Triple negative breast cancer (TNBC) is the most notorious form of breast cancer which involves absence of the estrogen, progesterone and human epidermal growth factor receptor (EGFR) on breast cancer cells. It is a real challenge for oncologists owing to the recurrence and metastasis which result in poor prognosis. Conventional therapies employed in treatment of TNBC suffer from issues of poor bioavailability, poor cellular uptake, resistance, and undesirable off-site toxicities. Nanosized delivery systems, herein designated as nanosoldiers can be smartly designed to be equipped with multiple weapons (drugs, genetic materials, photosensitizers, etc.) to fight the battle against recalcitrant TNBC in a myriad of ways such as bioavailability enhancement, targeted uptake by the TNBC cells, on-demand drug delivery at tumour site, combination therapy, multimodal therapy, photodynamic therapy, photothermal therapy, anti-metastatic approaches, theranostics, etc. The versatility of nanosoldiers with respect to their material of composition, their mechanism of drug loading and release, ability to modify in vivo drug disposition, multifunctional characteristics enabling detection, treatment, and monitoring, etc. endows them with incredible potential to destroy the intractable TNBC cells. The focus of the review is to highlight the extraordinary potential of nanocarriers in treatment of TNBC and few challenges which need to be overcome for these nanosoldiers to form a part of the clinical armamentarium of anticancer agents. Nanoparticles Theranostic Targeted Photothermal therapy Metastasis Triple negative breast cancer Bioavailability Photodynamic therapy Combination therapy Immunotherapy Clinical trials Multimodal therapy Gene delivery Hyaluronic acid Prabhu, Priyanka verfasserin aut Enthalten in Biomedicine & pharmacotherapy Amsterdam [u.a.] : Elsevier Science, 1989 110, Seite 319-341 Online-Ressource (DE-627)306717565 (DE-600)1501510-5 (DE-576)261593021 1950-6007 nnns volume:110 pages:319-341 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.40 Pharmazie Pharmazeutika VZ AR 110 319-341
allfields_unstemmed	10.1016/j.biopha.2018.11.122 doi (DE-627)ELV04537466X (ELSEVIER)S0753-3322(18)36917-8 DE-627 ger DE-627 rda eng 610 VZ 44.40 bkl Pawar, Akshayya verfasserin aut Nanosoldiers: A promising strategy to combat triple negative breast cancer 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The phenomenal rise in cancer over the past few years has made it the second leading cause of death worldwide. Breast cancer constitutes the predominant cancer encountered in women. Triple negative breast cancer (TNBC) is the most notorious form of breast cancer which involves absence of the estrogen, progesterone and human epidermal growth factor receptor (EGFR) on breast cancer cells. It is a real challenge for oncologists owing to the recurrence and metastasis which result in poor prognosis. Conventional therapies employed in treatment of TNBC suffer from issues of poor bioavailability, poor cellular uptake, resistance, and undesirable off-site toxicities. Nanosized delivery systems, herein designated as nanosoldiers can be smartly designed to be equipped with multiple weapons (drugs, genetic materials, photosensitizers, etc.) to fight the battle against recalcitrant TNBC in a myriad of ways such as bioavailability enhancement, targeted uptake by the TNBC cells, on-demand drug delivery at tumour site, combination therapy, multimodal therapy, photodynamic therapy, photothermal therapy, anti-metastatic approaches, theranostics, etc. The versatility of nanosoldiers with respect to their material of composition, their mechanism of drug loading and release, ability to modify in vivo drug disposition, multifunctional characteristics enabling detection, treatment, and monitoring, etc. endows them with incredible potential to destroy the intractable TNBC cells. The focus of the review is to highlight the extraordinary potential of nanocarriers in treatment of TNBC and few challenges which need to be overcome for these nanosoldiers to form a part of the clinical armamentarium of anticancer agents. Nanoparticles Theranostic Targeted Photothermal therapy Metastasis Triple negative breast cancer Bioavailability Photodynamic therapy Combination therapy Immunotherapy Clinical trials Multimodal therapy Gene delivery Hyaluronic acid Prabhu, Priyanka verfasserin aut Enthalten in Biomedicine & pharmacotherapy Amsterdam [u.a.] : Elsevier Science, 1989 110, Seite 319-341 Online-Ressource (DE-627)306717565 (DE-600)1501510-5 (DE-576)261593021 1950-6007 nnns volume:110 pages:319-341 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.40 Pharmazie Pharmazeutika VZ AR 110 319-341
allfieldsGer	10.1016/j.biopha.2018.11.122 doi (DE-627)ELV04537466X (ELSEVIER)S0753-3322(18)36917-8 DE-627 ger DE-627 rda eng 610 VZ 44.40 bkl Pawar, Akshayya verfasserin aut Nanosoldiers: A promising strategy to combat triple negative breast cancer 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The phenomenal rise in cancer over the past few years has made it the second leading cause of death worldwide. Breast cancer constitutes the predominant cancer encountered in women. Triple negative breast cancer (TNBC) is the most notorious form of breast cancer which involves absence of the estrogen, progesterone and human epidermal growth factor receptor (EGFR) on breast cancer cells. It is a real challenge for oncologists owing to the recurrence and metastasis which result in poor prognosis. Conventional therapies employed in treatment of TNBC suffer from issues of poor bioavailability, poor cellular uptake, resistance, and undesirable off-site toxicities. Nanosized delivery systems, herein designated as nanosoldiers can be smartly designed to be equipped with multiple weapons (drugs, genetic materials, photosensitizers, etc.) to fight the battle against recalcitrant TNBC in a myriad of ways such as bioavailability enhancement, targeted uptake by the TNBC cells, on-demand drug delivery at tumour site, combination therapy, multimodal therapy, photodynamic therapy, photothermal therapy, anti-metastatic approaches, theranostics, etc. The versatility of nanosoldiers with respect to their material of composition, their mechanism of drug loading and release, ability to modify in vivo drug disposition, multifunctional characteristics enabling detection, treatment, and monitoring, etc. endows them with incredible potential to destroy the intractable TNBC cells. The focus of the review is to highlight the extraordinary potential of nanocarriers in treatment of TNBC and few challenges which need to be overcome for these nanosoldiers to form a part of the clinical armamentarium of anticancer agents. Nanoparticles Theranostic Targeted Photothermal therapy Metastasis Triple negative breast cancer Bioavailability Photodynamic therapy Combination therapy Immunotherapy Clinical trials Multimodal therapy Gene delivery Hyaluronic acid Prabhu, Priyanka verfasserin aut Enthalten in Biomedicine & pharmacotherapy Amsterdam [u.a.] : Elsevier Science, 1989 110, Seite 319-341 Online-Ressource (DE-627)306717565 (DE-600)1501510-5 (DE-576)261593021 1950-6007 nnns volume:110 pages:319-341 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.40 Pharmazie Pharmazeutika VZ AR 110 319-341
allfieldsSound	10.1016/j.biopha.2018.11.122 doi (DE-627)ELV04537466X (ELSEVIER)S0753-3322(18)36917-8 DE-627 ger DE-627 rda eng 610 VZ 44.40 bkl Pawar, Akshayya verfasserin aut Nanosoldiers: A promising strategy to combat triple negative breast cancer 2018 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The phenomenal rise in cancer over the past few years has made it the second leading cause of death worldwide. Breast cancer constitutes the predominant cancer encountered in women. Triple negative breast cancer (TNBC) is the most notorious form of breast cancer which involves absence of the estrogen, progesterone and human epidermal growth factor receptor (EGFR) on breast cancer cells. It is a real challenge for oncologists owing to the recurrence and metastasis which result in poor prognosis. Conventional therapies employed in treatment of TNBC suffer from issues of poor bioavailability, poor cellular uptake, resistance, and undesirable off-site toxicities. Nanosized delivery systems, herein designated as nanosoldiers can be smartly designed to be equipped with multiple weapons (drugs, genetic materials, photosensitizers, etc.) to fight the battle against recalcitrant TNBC in a myriad of ways such as bioavailability enhancement, targeted uptake by the TNBC cells, on-demand drug delivery at tumour site, combination therapy, multimodal therapy, photodynamic therapy, photothermal therapy, anti-metastatic approaches, theranostics, etc. The versatility of nanosoldiers with respect to their material of composition, their mechanism of drug loading and release, ability to modify in vivo drug disposition, multifunctional characteristics enabling detection, treatment, and monitoring, etc. endows them with incredible potential to destroy the intractable TNBC cells. The focus of the review is to highlight the extraordinary potential of nanocarriers in treatment of TNBC and few challenges which need to be overcome for these nanosoldiers to form a part of the clinical armamentarium of anticancer agents. Nanoparticles Theranostic Targeted Photothermal therapy Metastasis Triple negative breast cancer Bioavailability Photodynamic therapy Combination therapy Immunotherapy Clinical trials Multimodal therapy Gene delivery Hyaluronic acid Prabhu, Priyanka verfasserin aut Enthalten in Biomedicine & pharmacotherapy Amsterdam [u.a.] : Elsevier Science, 1989 110, Seite 319-341 Online-Ressource (DE-627)306717565 (DE-600)1501510-5 (DE-576)261593021 1950-6007 nnns volume:110 pages:319-341 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 44.40 Pharmazie Pharmazeutika VZ AR 110 319-341
language	English
source	Enthalten in Biomedicine & pharmacotherapy 110, Seite 319-341 volume:110 pages:319-341
sourceStr	Enthalten in Biomedicine & pharmacotherapy 110, Seite 319-341 volume:110 pages:319-341
format_phy_str_mv	Article
bklname	Pharmazie Pharmazeutika
institution	findex.gbv.de
topic_facet	Nanoparticles Theranostic Targeted Photothermal therapy Metastasis Triple negative breast cancer Bioavailability Photodynamic therapy Combination therapy Immunotherapy Clinical trials Multimodal therapy Gene delivery Hyaluronic acid
dewey-raw	610
isfreeaccess_bool	false
container_title	Biomedicine & pharmacotherapy
authorswithroles_txt_mv	Pawar, Akshayya @@aut@@ Prabhu, Priyanka @@aut@@
publishDateDaySort_date	2018-01-01T00:00:00Z
hierarchy_top_id	306717565
dewey-sort	3610
id	ELV04537466X
language_de	englisch
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author	Pawar, Akshayya
spellingShingle	Pawar, Akshayya ddc 610 bkl 44.40 misc Nanoparticles misc Theranostic misc Targeted misc Photothermal therapy misc Metastasis misc Triple negative breast cancer misc Bioavailability misc Photodynamic therapy misc Combination therapy misc Immunotherapy misc Clinical trials misc Multimodal therapy misc Gene delivery misc Hyaluronic acid Nanosoldiers: A promising strategy to combat triple negative breast cancer
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topic_title	610 VZ 44.40 bkl Nanosoldiers: A promising strategy to combat triple negative breast cancer Nanoparticles Theranostic Targeted Photothermal therapy Metastasis Triple negative breast cancer Bioavailability Photodynamic therapy Combination therapy Immunotherapy Clinical trials Multimodal therapy Gene delivery Hyaluronic acid
topic	ddc 610 bkl 44.40 misc Nanoparticles misc Theranostic misc Targeted misc Photothermal therapy misc Metastasis misc Triple negative breast cancer misc Bioavailability misc Photodynamic therapy misc Combination therapy misc Immunotherapy misc Clinical trials misc Multimodal therapy misc Gene delivery misc Hyaluronic acid
topic_unstemmed	ddc 610 bkl 44.40 misc Nanoparticles misc Theranostic misc Targeted misc Photothermal therapy misc Metastasis misc Triple negative breast cancer misc Bioavailability misc Photodynamic therapy misc Combination therapy misc Immunotherapy misc Clinical trials misc Multimodal therapy misc Gene delivery misc Hyaluronic acid
topic_browse	ddc 610 bkl 44.40 misc Nanoparticles misc Theranostic misc Targeted misc Photothermal therapy misc Metastasis misc Triple negative breast cancer misc Bioavailability misc Photodynamic therapy misc Combination therapy misc Immunotherapy misc Clinical trials misc Multimodal therapy misc Gene delivery misc Hyaluronic acid
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title	Nanosoldiers: A promising strategy to combat triple negative breast cancer
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title_full	Nanosoldiers: A promising strategy to combat triple negative breast cancer
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title_sort	nanosoldiers: a promising strategy to combat triple negative breast cancer
title_auth	Nanosoldiers: A promising strategy to combat triple negative breast cancer
abstract	The phenomenal rise in cancer over the past few years has made it the second leading cause of death worldwide. Breast cancer constitutes the predominant cancer encountered in women. Triple negative breast cancer (TNBC) is the most notorious form of breast cancer which involves absence of the estrogen, progesterone and human epidermal growth factor receptor (EGFR) on breast cancer cells. It is a real challenge for oncologists owing to the recurrence and metastasis which result in poor prognosis. Conventional therapies employed in treatment of TNBC suffer from issues of poor bioavailability, poor cellular uptake, resistance, and undesirable off-site toxicities. Nanosized delivery systems, herein designated as nanosoldiers can be smartly designed to be equipped with multiple weapons (drugs, genetic materials, photosensitizers, etc.) to fight the battle against recalcitrant TNBC in a myriad of ways such as bioavailability enhancement, targeted uptake by the TNBC cells, on-demand drug delivery at tumour site, combination therapy, multimodal therapy, photodynamic therapy, photothermal therapy, anti-metastatic approaches, theranostics, etc. The versatility of nanosoldiers with respect to their material of composition, their mechanism of drug loading and release, ability to modify in vivo drug disposition, multifunctional characteristics enabling detection, treatment, and monitoring, etc. endows them with incredible potential to destroy the intractable TNBC cells. The focus of the review is to highlight the extraordinary potential of nanocarriers in treatment of TNBC and few challenges which need to be overcome for these nanosoldiers to form a part of the clinical armamentarium of anticancer agents.
abstractGer	The phenomenal rise in cancer over the past few years has made it the second leading cause of death worldwide. Breast cancer constitutes the predominant cancer encountered in women. Triple negative breast cancer (TNBC) is the most notorious form of breast cancer which involves absence of the estrogen, progesterone and human epidermal growth factor receptor (EGFR) on breast cancer cells. It is a real challenge for oncologists owing to the recurrence and metastasis which result in poor prognosis. Conventional therapies employed in treatment of TNBC suffer from issues of poor bioavailability, poor cellular uptake, resistance, and undesirable off-site toxicities. Nanosized delivery systems, herein designated as nanosoldiers can be smartly designed to be equipped with multiple weapons (drugs, genetic materials, photosensitizers, etc.) to fight the battle against recalcitrant TNBC in a myriad of ways such as bioavailability enhancement, targeted uptake by the TNBC cells, on-demand drug delivery at tumour site, combination therapy, multimodal therapy, photodynamic therapy, photothermal therapy, anti-metastatic approaches, theranostics, etc. The versatility of nanosoldiers with respect to their material of composition, their mechanism of drug loading and release, ability to modify in vivo drug disposition, multifunctional characteristics enabling detection, treatment, and monitoring, etc. endows them with incredible potential to destroy the intractable TNBC cells. The focus of the review is to highlight the extraordinary potential of nanocarriers in treatment of TNBC and few challenges which need to be overcome for these nanosoldiers to form a part of the clinical armamentarium of anticancer agents.
abstract_unstemmed	The phenomenal rise in cancer over the past few years has made it the second leading cause of death worldwide. Breast cancer constitutes the predominant cancer encountered in women. Triple negative breast cancer (TNBC) is the most notorious form of breast cancer which involves absence of the estrogen, progesterone and human epidermal growth factor receptor (EGFR) on breast cancer cells. It is a real challenge for oncologists owing to the recurrence and metastasis which result in poor prognosis. Conventional therapies employed in treatment of TNBC suffer from issues of poor bioavailability, poor cellular uptake, resistance, and undesirable off-site toxicities. Nanosized delivery systems, herein designated as nanosoldiers can be smartly designed to be equipped with multiple weapons (drugs, genetic materials, photosensitizers, etc.) to fight the battle against recalcitrant TNBC in a myriad of ways such as bioavailability enhancement, targeted uptake by the TNBC cells, on-demand drug delivery at tumour site, combination therapy, multimodal therapy, photodynamic therapy, photothermal therapy, anti-metastatic approaches, theranostics, etc. The versatility of nanosoldiers with respect to their material of composition, their mechanism of drug loading and release, ability to modify in vivo drug disposition, multifunctional characteristics enabling detection, treatment, and monitoring, etc. endows them with incredible potential to destroy the intractable TNBC cells. The focus of the review is to highlight the extraordinary potential of nanocarriers in treatment of TNBC and few challenges which need to be overcome for these nanosoldiers to form a part of the clinical armamentarium of anticancer agents.
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title_short	Nanosoldiers: A promising strategy to combat triple negative breast cancer
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up_date	2024-07-06T17:21:23.074Z
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Nanosized delivery systems, herein designated as nanosoldiers can be smartly designed to be equipped with multiple weapons (drugs, genetic materials, photosensitizers, etc.) to fight the battle against recalcitrant TNBC in a myriad of ways such as bioavailability enhancement, targeted uptake by the TNBC cells, on-demand drug delivery at tumour site, combination therapy, multimodal therapy, photodynamic therapy, photothermal therapy, anti-metastatic approaches, theranostics, etc. The versatility of nanosoldiers with respect to their material of composition, their mechanism of drug loading and release, ability to modify in vivo drug disposition, multifunctional characteristics enabling detection, treatment, and monitoring, etc. endows them with incredible potential to destroy the intractable TNBC cells. 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Nanosoldiers: A promising strategy to combat triple negative breast cancer

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