Challenging the dose-response-time data approach: Analysis of a complex system
This study presents an extensive dose-response-time (DRT) meta-analysis of the nicotinic acid-induced inhibition of free fatty acids and insulin release. The purpose was to quantify the implications of lacking exposure data when analysing complex pharmacodynamic systems. The DRT model successfully c...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Andersson, Robert [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2019transfer abstract |
|---|
| Umfang: |
20 |
|---|
| Übergeordnetes Werk: |
Enthalten in: The face of wrongdoing? An expectancy violations perspective on CEO facial characteristics and media coverage of misconducting firms - Heyden, Mariano L.M. ELSEVIER, 2022, official journal of the European Federation for Pharmaceutical Sciences, New York, NY [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:128 ; year:2019 ; day:1 ; month:02 ; pages:250-269 ; extent:20 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.ejps.2018.11.015 |
|---|
| Katalog-ID: |
ELV045392579 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | ELV045392579 | ||
| 003 | DE-627 | ||
| 005 | 20230626011324.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190205s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.ejps.2018.11.015 |2 doi | |
| 028 | 5 | 2 | |a GBV00000000000484.pica |
| 035 | |a (DE-627)ELV045392579 | ||
| 035 | |a (ELSEVIER)S0928-0987(18)30506-2 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | 4 | |a 300 |a 330 |a 360 |q VZ |
| 084 | |a 85.05 |2 bkl | ||
| 084 | |a 85.06 |2 bkl | ||
| 084 | |a 89.52 |2 bkl | ||
| 100 | 1 | |a Andersson, Robert |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Challenging the dose-response-time data approach: Analysis of a complex system |
| 264 | 1 | |c 2019transfer abstract | |
| 300 | |a 20 | ||
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a nicht spezifiziert |b z |2 rdamedia | ||
| 338 | |a nicht spezifiziert |b zu |2 rdacarrier | ||
| 520 | |a This study presents an extensive dose-response-time (DRT) meta-analysis of the nicotinic acid-induced inhibition of free fatty acids and insulin release. The purpose was to quantify the implications of lacking exposure data when analysing complex pharmacodynamic systems. The DRT model successfully characterised various response behaviours—including time-delays, rebound, feedback mechanisms, and adaptation—on both the individual and the population level. Comparing the fitted DRT model to an exposure-driven reference analysis showed that bias and uncertainty were introduced in the parameter estimates. However, most estimates were within one standard error from the reference. In both approaches, a few parameters suffered from practical identifiability issues, likely due to large differences in half-lives of the different rate processes. Moreover, the optimal dosing strategies predicted by the DRT model differed slightly from those of the exposure-driven analysis, having a lower optimal steady-state reduction of free fatty acids exposure. | ||
| 520 | |a This study presents an extensive dose-response-time (DRT) meta-analysis of the nicotinic acid-induced inhibition of free fatty acids and insulin release. The purpose was to quantify the implications of lacking exposure data when analysing complex pharmacodynamic systems. The DRT model successfully characterised various response behaviours—including time-delays, rebound, feedback mechanisms, and adaptation—on both the individual and the population level. Comparing the fitted DRT model to an exposure-driven reference analysis showed that bias and uncertainty were introduced in the parameter estimates. However, most estimates were within one standard error from the reference. In both approaches, a few parameters suffered from practical identifiability issues, likely due to large differences in half-lives of the different rate processes. Moreover, the optimal dosing strategies predicted by the DRT model differed slightly from those of the exposure-driven analysis, having a lower optimal steady-state reduction of free fatty acids exposure. | ||
| 700 | 1 | |a Jirstrand, Mats |4 oth | |
| 700 | 1 | |a Almquist, Joachim |4 oth | |
| 700 | 1 | |a Gabrielsson, Johan |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |n Elsevier |a Heyden, Mariano L.M. ELSEVIER |t The face of wrongdoing? An expectancy violations perspective on CEO facial characteristics and media coverage of misconducting firms |d 2022 |d official journal of the European Federation for Pharmaceutical Sciences |g New York, NY [u.a.] |w (DE-627)ELV009954198 |
| 773 | 1 | 8 | |g volume:128 |g year:2019 |g day:1 |g month:02 |g pages:250-269 |g extent:20 |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.ejps.2018.11.015 |3 Volltext |
| 912 | |a GBV_USEFLAG_U | ||
| 912 | |a GBV_ELV | ||
| 912 | |a SYSFLAG_U | ||
| 936 | b | k | |a 85.05 |j Betriebssoziologie |j Betriebspsychologie |q VZ |
| 936 | b | k | |a 85.06 |j Unternehmensführung |q VZ |
| 936 | b | k | |a 89.52 |j Politische Psychologie |j Politische Soziologie |q VZ |
| 951 | |a AR | ||
| 952 | |d 128 |j 2019 |b 1 |c 0201 |h 250-269 |g 20 | ||
| author_variant |
r a ra |
|---|---|
| matchkey_str |
anderssonrobertjirstrandmatsalmquistjoac:2019----:hlegnteoeepneieaaprahnls |
| hierarchy_sort_str |
2019transfer abstract |
| bklnumber |
85.05 85.06 89.52 |
| publishDate |
2019 |
| allfields |
10.1016/j.ejps.2018.11.015 doi GBV00000000000484.pica (DE-627)ELV045392579 (ELSEVIER)S0928-0987(18)30506-2 DE-627 ger DE-627 rakwb eng 300 330 360 VZ 85.05 bkl 85.06 bkl 89.52 bkl Andersson, Robert verfasserin aut Challenging the dose-response-time data approach: Analysis of a complex system 2019transfer abstract 20 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier This study presents an extensive dose-response-time (DRT) meta-analysis of the nicotinic acid-induced inhibition of free fatty acids and insulin release. The purpose was to quantify the implications of lacking exposure data when analysing complex pharmacodynamic systems. The DRT model successfully characterised various response behaviours—including time-delays, rebound, feedback mechanisms, and adaptation—on both the individual and the population level. Comparing the fitted DRT model to an exposure-driven reference analysis showed that bias and uncertainty were introduced in the parameter estimates. However, most estimates were within one standard error from the reference. In both approaches, a few parameters suffered from practical identifiability issues, likely due to large differences in half-lives of the different rate processes. Moreover, the optimal dosing strategies predicted by the DRT model differed slightly from those of the exposure-driven analysis, having a lower optimal steady-state reduction of free fatty acids exposure. This study presents an extensive dose-response-time (DRT) meta-analysis of the nicotinic acid-induced inhibition of free fatty acids and insulin release. The purpose was to quantify the implications of lacking exposure data when analysing complex pharmacodynamic systems. The DRT model successfully characterised various response behaviours—including time-delays, rebound, feedback mechanisms, and adaptation—on both the individual and the population level. Comparing the fitted DRT model to an exposure-driven reference analysis showed that bias and uncertainty were introduced in the parameter estimates. However, most estimates were within one standard error from the reference. In both approaches, a few parameters suffered from practical identifiability issues, likely due to large differences in half-lives of the different rate processes. Moreover, the optimal dosing strategies predicted by the DRT model differed slightly from those of the exposure-driven analysis, having a lower optimal steady-state reduction of free fatty acids exposure. Jirstrand, Mats oth Almquist, Joachim oth Gabrielsson, Johan oth Enthalten in Elsevier Heyden, Mariano L.M. ELSEVIER The face of wrongdoing? An expectancy violations perspective on CEO facial characteristics and media coverage of misconducting firms 2022 official journal of the European Federation for Pharmaceutical Sciences New York, NY [u.a.] (DE-627)ELV009954198 volume:128 year:2019 day:1 month:02 pages:250-269 extent:20 https://doi.org/10.1016/j.ejps.2018.11.015 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 85.05 Betriebssoziologie Betriebspsychologie VZ 85.06 Unternehmensführung VZ 89.52 Politische Psychologie Politische Soziologie VZ AR 128 2019 1 0201 250-269 20 |
| spelling |
10.1016/j.ejps.2018.11.015 doi GBV00000000000484.pica (DE-627)ELV045392579 (ELSEVIER)S0928-0987(18)30506-2 DE-627 ger DE-627 rakwb eng 300 330 360 VZ 85.05 bkl 85.06 bkl 89.52 bkl Andersson, Robert verfasserin aut Challenging the dose-response-time data approach: Analysis of a complex system 2019transfer abstract 20 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier This study presents an extensive dose-response-time (DRT) meta-analysis of the nicotinic acid-induced inhibition of free fatty acids and insulin release. The purpose was to quantify the implications of lacking exposure data when analysing complex pharmacodynamic systems. The DRT model successfully characterised various response behaviours—including time-delays, rebound, feedback mechanisms, and adaptation—on both the individual and the population level. Comparing the fitted DRT model to an exposure-driven reference analysis showed that bias and uncertainty were introduced in the parameter estimates. However, most estimates were within one standard error from the reference. In both approaches, a few parameters suffered from practical identifiability issues, likely due to large differences in half-lives of the different rate processes. Moreover, the optimal dosing strategies predicted by the DRT model differed slightly from those of the exposure-driven analysis, having a lower optimal steady-state reduction of free fatty acids exposure. This study presents an extensive dose-response-time (DRT) meta-analysis of the nicotinic acid-induced inhibition of free fatty acids and insulin release. The purpose was to quantify the implications of lacking exposure data when analysing complex pharmacodynamic systems. The DRT model successfully characterised various response behaviours—including time-delays, rebound, feedback mechanisms, and adaptation—on both the individual and the population level. Comparing the fitted DRT model to an exposure-driven reference analysis showed that bias and uncertainty were introduced in the parameter estimates. However, most estimates were within one standard error from the reference. In both approaches, a few parameters suffered from practical identifiability issues, likely due to large differences in half-lives of the different rate processes. Moreover, the optimal dosing strategies predicted by the DRT model differed slightly from those of the exposure-driven analysis, having a lower optimal steady-state reduction of free fatty acids exposure. Jirstrand, Mats oth Almquist, Joachim oth Gabrielsson, Johan oth Enthalten in Elsevier Heyden, Mariano L.M. ELSEVIER The face of wrongdoing? An expectancy violations perspective on CEO facial characteristics and media coverage of misconducting firms 2022 official journal of the European Federation for Pharmaceutical Sciences New York, NY [u.a.] (DE-627)ELV009954198 volume:128 year:2019 day:1 month:02 pages:250-269 extent:20 https://doi.org/10.1016/j.ejps.2018.11.015 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 85.05 Betriebssoziologie Betriebspsychologie VZ 85.06 Unternehmensführung VZ 89.52 Politische Psychologie Politische Soziologie VZ AR 128 2019 1 0201 250-269 20 |
| allfields_unstemmed |
10.1016/j.ejps.2018.11.015 doi GBV00000000000484.pica (DE-627)ELV045392579 (ELSEVIER)S0928-0987(18)30506-2 DE-627 ger DE-627 rakwb eng 300 330 360 VZ 85.05 bkl 85.06 bkl 89.52 bkl Andersson, Robert verfasserin aut Challenging the dose-response-time data approach: Analysis of a complex system 2019transfer abstract 20 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier This study presents an extensive dose-response-time (DRT) meta-analysis of the nicotinic acid-induced inhibition of free fatty acids and insulin release. The purpose was to quantify the implications of lacking exposure data when analysing complex pharmacodynamic systems. The DRT model successfully characterised various response behaviours—including time-delays, rebound, feedback mechanisms, and adaptation—on both the individual and the population level. Comparing the fitted DRT model to an exposure-driven reference analysis showed that bias and uncertainty were introduced in the parameter estimates. However, most estimates were within one standard error from the reference. In both approaches, a few parameters suffered from practical identifiability issues, likely due to large differences in half-lives of the different rate processes. Moreover, the optimal dosing strategies predicted by the DRT model differed slightly from those of the exposure-driven analysis, having a lower optimal steady-state reduction of free fatty acids exposure. This study presents an extensive dose-response-time (DRT) meta-analysis of the nicotinic acid-induced inhibition of free fatty acids and insulin release. The purpose was to quantify the implications of lacking exposure data when analysing complex pharmacodynamic systems. The DRT model successfully characterised various response behaviours—including time-delays, rebound, feedback mechanisms, and adaptation—on both the individual and the population level. Comparing the fitted DRT model to an exposure-driven reference analysis showed that bias and uncertainty were introduced in the parameter estimates. However, most estimates were within one standard error from the reference. In both approaches, a few parameters suffered from practical identifiability issues, likely due to large differences in half-lives of the different rate processes. Moreover, the optimal dosing strategies predicted by the DRT model differed slightly from those of the exposure-driven analysis, having a lower optimal steady-state reduction of free fatty acids exposure. Jirstrand, Mats oth Almquist, Joachim oth Gabrielsson, Johan oth Enthalten in Elsevier Heyden, Mariano L.M. ELSEVIER The face of wrongdoing? An expectancy violations perspective on CEO facial characteristics and media coverage of misconducting firms 2022 official journal of the European Federation for Pharmaceutical Sciences New York, NY [u.a.] (DE-627)ELV009954198 volume:128 year:2019 day:1 month:02 pages:250-269 extent:20 https://doi.org/10.1016/j.ejps.2018.11.015 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 85.05 Betriebssoziologie Betriebspsychologie VZ 85.06 Unternehmensführung VZ 89.52 Politische Psychologie Politische Soziologie VZ AR 128 2019 1 0201 250-269 20 |
| allfieldsGer |
10.1016/j.ejps.2018.11.015 doi GBV00000000000484.pica (DE-627)ELV045392579 (ELSEVIER)S0928-0987(18)30506-2 DE-627 ger DE-627 rakwb eng 300 330 360 VZ 85.05 bkl 85.06 bkl 89.52 bkl Andersson, Robert verfasserin aut Challenging the dose-response-time data approach: Analysis of a complex system 2019transfer abstract 20 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier This study presents an extensive dose-response-time (DRT) meta-analysis of the nicotinic acid-induced inhibition of free fatty acids and insulin release. The purpose was to quantify the implications of lacking exposure data when analysing complex pharmacodynamic systems. The DRT model successfully characterised various response behaviours—including time-delays, rebound, feedback mechanisms, and adaptation—on both the individual and the population level. Comparing the fitted DRT model to an exposure-driven reference analysis showed that bias and uncertainty were introduced in the parameter estimates. However, most estimates were within one standard error from the reference. In both approaches, a few parameters suffered from practical identifiability issues, likely due to large differences in half-lives of the different rate processes. Moreover, the optimal dosing strategies predicted by the DRT model differed slightly from those of the exposure-driven analysis, having a lower optimal steady-state reduction of free fatty acids exposure. This study presents an extensive dose-response-time (DRT) meta-analysis of the nicotinic acid-induced inhibition of free fatty acids and insulin release. The purpose was to quantify the implications of lacking exposure data when analysing complex pharmacodynamic systems. The DRT model successfully characterised various response behaviours—including time-delays, rebound, feedback mechanisms, and adaptation—on both the individual and the population level. Comparing the fitted DRT model to an exposure-driven reference analysis showed that bias and uncertainty were introduced in the parameter estimates. However, most estimates were within one standard error from the reference. In both approaches, a few parameters suffered from practical identifiability issues, likely due to large differences in half-lives of the different rate processes. Moreover, the optimal dosing strategies predicted by the DRT model differed slightly from those of the exposure-driven analysis, having a lower optimal steady-state reduction of free fatty acids exposure. Jirstrand, Mats oth Almquist, Joachim oth Gabrielsson, Johan oth Enthalten in Elsevier Heyden, Mariano L.M. ELSEVIER The face of wrongdoing? An expectancy violations perspective on CEO facial characteristics and media coverage of misconducting firms 2022 official journal of the European Federation for Pharmaceutical Sciences New York, NY [u.a.] (DE-627)ELV009954198 volume:128 year:2019 day:1 month:02 pages:250-269 extent:20 https://doi.org/10.1016/j.ejps.2018.11.015 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 85.05 Betriebssoziologie Betriebspsychologie VZ 85.06 Unternehmensführung VZ 89.52 Politische Psychologie Politische Soziologie VZ AR 128 2019 1 0201 250-269 20 |
| allfieldsSound |
10.1016/j.ejps.2018.11.015 doi GBV00000000000484.pica (DE-627)ELV045392579 (ELSEVIER)S0928-0987(18)30506-2 DE-627 ger DE-627 rakwb eng 300 330 360 VZ 85.05 bkl 85.06 bkl 89.52 bkl Andersson, Robert verfasserin aut Challenging the dose-response-time data approach: Analysis of a complex system 2019transfer abstract 20 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier This study presents an extensive dose-response-time (DRT) meta-analysis of the nicotinic acid-induced inhibition of free fatty acids and insulin release. The purpose was to quantify the implications of lacking exposure data when analysing complex pharmacodynamic systems. The DRT model successfully characterised various response behaviours—including time-delays, rebound, feedback mechanisms, and adaptation—on both the individual and the population level. Comparing the fitted DRT model to an exposure-driven reference analysis showed that bias and uncertainty were introduced in the parameter estimates. However, most estimates were within one standard error from the reference. In both approaches, a few parameters suffered from practical identifiability issues, likely due to large differences in half-lives of the different rate processes. Moreover, the optimal dosing strategies predicted by the DRT model differed slightly from those of the exposure-driven analysis, having a lower optimal steady-state reduction of free fatty acids exposure. This study presents an extensive dose-response-time (DRT) meta-analysis of the nicotinic acid-induced inhibition of free fatty acids and insulin release. The purpose was to quantify the implications of lacking exposure data when analysing complex pharmacodynamic systems. The DRT model successfully characterised various response behaviours—including time-delays, rebound, feedback mechanisms, and adaptation—on both the individual and the population level. Comparing the fitted DRT model to an exposure-driven reference analysis showed that bias and uncertainty were introduced in the parameter estimates. However, most estimates were within one standard error from the reference. In both approaches, a few parameters suffered from practical identifiability issues, likely due to large differences in half-lives of the different rate processes. Moreover, the optimal dosing strategies predicted by the DRT model differed slightly from those of the exposure-driven analysis, having a lower optimal steady-state reduction of free fatty acids exposure. Jirstrand, Mats oth Almquist, Joachim oth Gabrielsson, Johan oth Enthalten in Elsevier Heyden, Mariano L.M. ELSEVIER The face of wrongdoing? An expectancy violations perspective on CEO facial characteristics and media coverage of misconducting firms 2022 official journal of the European Federation for Pharmaceutical Sciences New York, NY [u.a.] (DE-627)ELV009954198 volume:128 year:2019 day:1 month:02 pages:250-269 extent:20 https://doi.org/10.1016/j.ejps.2018.11.015 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 85.05 Betriebssoziologie Betriebspsychologie VZ 85.06 Unternehmensführung VZ 89.52 Politische Psychologie Politische Soziologie VZ AR 128 2019 1 0201 250-269 20 |
| language |
English |
| source |
Enthalten in The face of wrongdoing? An expectancy violations perspective on CEO facial characteristics and media coverage of misconducting firms New York, NY [u.a.] volume:128 year:2019 day:1 month:02 pages:250-269 extent:20 |
| sourceStr |
Enthalten in The face of wrongdoing? An expectancy violations perspective on CEO facial characteristics and media coverage of misconducting firms New York, NY [u.a.] volume:128 year:2019 day:1 month:02 pages:250-269 extent:20 |
| format_phy_str_mv |
Article |
| bklname |
Betriebssoziologie Betriebspsychologie Unternehmensführung Politische Psychologie Politische Soziologie |
| institution |
findex.gbv.de |
| dewey-raw |
300 |
| isfreeaccess_bool |
false |
| container_title |
The face of wrongdoing? An expectancy violations perspective on CEO facial characteristics and media coverage of misconducting firms |
| authorswithroles_txt_mv |
Andersson, Robert @@aut@@ Jirstrand, Mats @@oth@@ Almquist, Joachim @@oth@@ Gabrielsson, Johan @@oth@@ |
| publishDateDaySort_date |
2019-01-01T00:00:00Z |
| hierarchy_top_id |
ELV009954198 |
| dewey-sort |
3300 |
| id |
ELV045392579 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV045392579</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230626011324.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">190205s2019 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.ejps.2018.11.015</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">GBV00000000000484.pica</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV045392579</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0928-0987(18)30506-2</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">300</subfield><subfield code="a">330</subfield><subfield code="a">360</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">85.05</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">85.06</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">89.52</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Andersson, Robert</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Challenging the dose-response-time data approach: Analysis of a complex system</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2019transfer abstract</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">20</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">This study presents an extensive dose-response-time (DRT) meta-analysis of the nicotinic acid-induced inhibition of free fatty acids and insulin release. The purpose was to quantify the implications of lacking exposure data when analysing complex pharmacodynamic systems. The DRT model successfully characterised various response behaviours—including time-delays, rebound, feedback mechanisms, and adaptation—on both the individual and the population level. Comparing the fitted DRT model to an exposure-driven reference analysis showed that bias and uncertainty were introduced in the parameter estimates. However, most estimates were within one standard error from the reference. In both approaches, a few parameters suffered from practical identifiability issues, likely due to large differences in half-lives of the different rate processes. Moreover, the optimal dosing strategies predicted by the DRT model differed slightly from those of the exposure-driven analysis, having a lower optimal steady-state reduction of free fatty acids exposure.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">This study presents an extensive dose-response-time (DRT) meta-analysis of the nicotinic acid-induced inhibition of free fatty acids and insulin release. The purpose was to quantify the implications of lacking exposure data when analysing complex pharmacodynamic systems. The DRT model successfully characterised various response behaviours—including time-delays, rebound, feedback mechanisms, and adaptation—on both the individual and the population level. Comparing the fitted DRT model to an exposure-driven reference analysis showed that bias and uncertainty were introduced in the parameter estimates. However, most estimates were within one standard error from the reference. In both approaches, a few parameters suffered from practical identifiability issues, likely due to large differences in half-lives of the different rate processes. Moreover, the optimal dosing strategies predicted by the DRT model differed slightly from those of the exposure-driven analysis, having a lower optimal steady-state reduction of free fatty acids exposure.</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Jirstrand, Mats</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Almquist, Joachim</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Gabrielsson, Johan</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="n">Elsevier</subfield><subfield code="a">Heyden, Mariano L.M. ELSEVIER</subfield><subfield code="t">The face of wrongdoing? An expectancy violations perspective on CEO facial characteristics and media coverage of misconducting firms</subfield><subfield code="d">2022</subfield><subfield code="d">official journal of the European Federation for Pharmaceutical Sciences</subfield><subfield code="g">New York, NY [u.a.]</subfield><subfield code="w">(DE-627)ELV009954198</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:128</subfield><subfield code="g">year:2019</subfield><subfield code="g">day:1</subfield><subfield code="g">month:02</subfield><subfield code="g">pages:250-269</subfield><subfield code="g">extent:20</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.ejps.2018.11.015</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ELV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_U</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">85.05</subfield><subfield code="j">Betriebssoziologie</subfield><subfield code="j">Betriebspsychologie</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">85.06</subfield><subfield code="j">Unternehmensführung</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">89.52</subfield><subfield code="j">Politische Psychologie</subfield><subfield code="j">Politische Soziologie</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">128</subfield><subfield code="j">2019</subfield><subfield code="b">1</subfield><subfield code="c">0201</subfield><subfield code="h">250-269</subfield><subfield code="g">20</subfield></datafield></record></collection>
|
| author |
Andersson, Robert |
| spellingShingle |
Andersson, Robert ddc 300 bkl 85.05 bkl 85.06 bkl 89.52 Challenging the dose-response-time data approach: Analysis of a complex system |
| authorStr |
Andersson, Robert |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)ELV009954198 |
| format |
electronic Article |
| dewey-ones |
300 - Social sciences 330 - Economics 360 - Social problems & services; associations |
| delete_txt_mv |
keep |
| author_role |
aut |
| collection |
elsevier |
| remote_str |
true |
| illustrated |
Not Illustrated |
| topic_title |
300 330 360 VZ 85.05 bkl 85.06 bkl 89.52 bkl Challenging the dose-response-time data approach: Analysis of a complex system |
| topic |
ddc 300 bkl 85.05 bkl 85.06 bkl 89.52 |
| topic_unstemmed |
ddc 300 bkl 85.05 bkl 85.06 bkl 89.52 |
| topic_browse |
ddc 300 bkl 85.05 bkl 85.06 bkl 89.52 |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
zu |
| author2_variant |
m j mj j a ja j g jg |
| hierarchy_parent_title |
The face of wrongdoing? An expectancy violations perspective on CEO facial characteristics and media coverage of misconducting firms |
| hierarchy_parent_id |
ELV009954198 |
| dewey-tens |
300 - Social sciences, sociology & anthropology 330 - Economics 360 - Social problems & social services |
| hierarchy_top_title |
The face of wrongdoing? An expectancy violations perspective on CEO facial characteristics and media coverage of misconducting firms |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)ELV009954198 |
| title |
Challenging the dose-response-time data approach: Analysis of a complex system |
| ctrlnum |
(DE-627)ELV045392579 (ELSEVIER)S0928-0987(18)30506-2 |
| title_full |
Challenging the dose-response-time data approach: Analysis of a complex system |
| author_sort |
Andersson, Robert |
| journal |
The face of wrongdoing? An expectancy violations perspective on CEO facial characteristics and media coverage of misconducting firms |
| journalStr |
The face of wrongdoing? An expectancy violations perspective on CEO facial characteristics and media coverage of misconducting firms |
| lang_code |
eng |
| isOA_bool |
false |
| dewey-hundreds |
300 - Social sciences |
| recordtype |
marc |
| publishDateSort |
2019 |
| contenttype_str_mv |
zzz |
| container_start_page |
250 |
| author_browse |
Andersson, Robert |
| container_volume |
128 |
| physical |
20 |
| class |
300 330 360 VZ 85.05 bkl 85.06 bkl 89.52 bkl |
| format_se |
Elektronische Aufsätze |
| author-letter |
Andersson, Robert |
| doi_str_mv |
10.1016/j.ejps.2018.11.015 |
| dewey-full |
300 330 360 |
| title_sort |
challenging the dose-response-time data approach: analysis of a complex system |
| title_auth |
Challenging the dose-response-time data approach: Analysis of a complex system |
| abstract |
This study presents an extensive dose-response-time (DRT) meta-analysis of the nicotinic acid-induced inhibition of free fatty acids and insulin release. The purpose was to quantify the implications of lacking exposure data when analysing complex pharmacodynamic systems. The DRT model successfully characterised various response behaviours—including time-delays, rebound, feedback mechanisms, and adaptation—on both the individual and the population level. Comparing the fitted DRT model to an exposure-driven reference analysis showed that bias and uncertainty were introduced in the parameter estimates. However, most estimates were within one standard error from the reference. In both approaches, a few parameters suffered from practical identifiability issues, likely due to large differences in half-lives of the different rate processes. Moreover, the optimal dosing strategies predicted by the DRT model differed slightly from those of the exposure-driven analysis, having a lower optimal steady-state reduction of free fatty acids exposure. |
| abstractGer |
This study presents an extensive dose-response-time (DRT) meta-analysis of the nicotinic acid-induced inhibition of free fatty acids and insulin release. The purpose was to quantify the implications of lacking exposure data when analysing complex pharmacodynamic systems. The DRT model successfully characterised various response behaviours—including time-delays, rebound, feedback mechanisms, and adaptation—on both the individual and the population level. Comparing the fitted DRT model to an exposure-driven reference analysis showed that bias and uncertainty were introduced in the parameter estimates. However, most estimates were within one standard error from the reference. In both approaches, a few parameters suffered from practical identifiability issues, likely due to large differences in half-lives of the different rate processes. Moreover, the optimal dosing strategies predicted by the DRT model differed slightly from those of the exposure-driven analysis, having a lower optimal steady-state reduction of free fatty acids exposure. |
| abstract_unstemmed |
This study presents an extensive dose-response-time (DRT) meta-analysis of the nicotinic acid-induced inhibition of free fatty acids and insulin release. The purpose was to quantify the implications of lacking exposure data when analysing complex pharmacodynamic systems. The DRT model successfully characterised various response behaviours—including time-delays, rebound, feedback mechanisms, and adaptation—on both the individual and the population level. Comparing the fitted DRT model to an exposure-driven reference analysis showed that bias and uncertainty were introduced in the parameter estimates. However, most estimates were within one standard error from the reference. In both approaches, a few parameters suffered from practical identifiability issues, likely due to large differences in half-lives of the different rate processes. Moreover, the optimal dosing strategies predicted by the DRT model differed slightly from those of the exposure-driven analysis, having a lower optimal steady-state reduction of free fatty acids exposure. |
| collection_details |
GBV_USEFLAG_U GBV_ELV SYSFLAG_U |
| title_short |
Challenging the dose-response-time data approach: Analysis of a complex system |
| url |
https://doi.org/10.1016/j.ejps.2018.11.015 |
| remote_bool |
true |
| author2 |
Jirstrand, Mats Almquist, Joachim Gabrielsson, Johan |
| author2Str |
Jirstrand, Mats Almquist, Joachim Gabrielsson, Johan |
| ppnlink |
ELV009954198 |
| mediatype_str_mv |
z |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| author2_role |
oth oth oth |
| doi_str |
10.1016/j.ejps.2018.11.015 |
| up_date |
2024-07-06T17:24:29.088Z |
| _version_ |
1803851314326667264 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV045392579</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230626011324.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">190205s2019 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.ejps.2018.11.015</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">GBV00000000000484.pica</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV045392579</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0928-0987(18)30506-2</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">300</subfield><subfield code="a">330</subfield><subfield code="a">360</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">85.05</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">85.06</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">89.52</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Andersson, Robert</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Challenging the dose-response-time data approach: Analysis of a complex system</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2019transfer abstract</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">20</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">This study presents an extensive dose-response-time (DRT) meta-analysis of the nicotinic acid-induced inhibition of free fatty acids and insulin release. The purpose was to quantify the implications of lacking exposure data when analysing complex pharmacodynamic systems. The DRT model successfully characterised various response behaviours—including time-delays, rebound, feedback mechanisms, and adaptation—on both the individual and the population level. Comparing the fitted DRT model to an exposure-driven reference analysis showed that bias and uncertainty were introduced in the parameter estimates. However, most estimates were within one standard error from the reference. In both approaches, a few parameters suffered from practical identifiability issues, likely due to large differences in half-lives of the different rate processes. Moreover, the optimal dosing strategies predicted by the DRT model differed slightly from those of the exposure-driven analysis, having a lower optimal steady-state reduction of free fatty acids exposure.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">This study presents an extensive dose-response-time (DRT) meta-analysis of the nicotinic acid-induced inhibition of free fatty acids and insulin release. The purpose was to quantify the implications of lacking exposure data when analysing complex pharmacodynamic systems. The DRT model successfully characterised various response behaviours—including time-delays, rebound, feedback mechanisms, and adaptation—on both the individual and the population level. Comparing the fitted DRT model to an exposure-driven reference analysis showed that bias and uncertainty were introduced in the parameter estimates. However, most estimates were within one standard error from the reference. In both approaches, a few parameters suffered from practical identifiability issues, likely due to large differences in half-lives of the different rate processes. Moreover, the optimal dosing strategies predicted by the DRT model differed slightly from those of the exposure-driven analysis, having a lower optimal steady-state reduction of free fatty acids exposure.</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Jirstrand, Mats</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Almquist, Joachim</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Gabrielsson, Johan</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="n">Elsevier</subfield><subfield code="a">Heyden, Mariano L.M. ELSEVIER</subfield><subfield code="t">The face of wrongdoing? An expectancy violations perspective on CEO facial characteristics and media coverage of misconducting firms</subfield><subfield code="d">2022</subfield><subfield code="d">official journal of the European Federation for Pharmaceutical Sciences</subfield><subfield code="g">New York, NY [u.a.]</subfield><subfield code="w">(DE-627)ELV009954198</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:128</subfield><subfield code="g">year:2019</subfield><subfield code="g">day:1</subfield><subfield code="g">month:02</subfield><subfield code="g">pages:250-269</subfield><subfield code="g">extent:20</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.ejps.2018.11.015</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ELV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_U</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">85.05</subfield><subfield code="j">Betriebssoziologie</subfield><subfield code="j">Betriebspsychologie</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">85.06</subfield><subfield code="j">Unternehmensführung</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">89.52</subfield><subfield code="j">Politische Psychologie</subfield><subfield code="j">Politische Soziologie</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">128</subfield><subfield code="j">2019</subfield><subfield code="b">1</subfield><subfield code="c">0201</subfield><subfield code="h">250-269</subfield><subfield code="g">20</subfield></datafield></record></collection>
|
| score |
7.401374 |