Genetic overlap between vascular pathologies and Alzheimer's dementia and potential causal mechanisms

We sought to examine the genetic overlap between vascular pathologies and Alzheimer's disease (AD) dementia, and the potential mediating role of vascular pathologies between AD-related genetic variants and late-life cognition.

Gespeichert in:
Autor*in:

Lin, Yen-Feng [verfasserIn]

Smith, Albert Vernon

Aspelund, Thor

Betensky, Rebecca A.

Smoller, Jordan W.

Gudnason, Vilmundur

Launer, Lenore J.

Blacker, Deborah

Format:

E-Artikel

Sprache:

Englisch

Erschienen:

2019

Schlagwörter:

Polygenic risk score

White matter lesions

Cerebral microbleeds

Alzheimer's dementia

Coronary calcification

Causal mediation

Cognitive impairment

Umfang:

11

Übergeordnetes Werk:

Enthalten in: Multi-objective optimization of the solar absorptivity distribution inside a cavity solar receiver for solar power towers - Wang, Kun ELSEVIER, 2017, the journal of the Alzheimer's Association, Amsterdam [u.a.]

Übergeordnetes Werk:

volume:15 ; year:2019 ; number:1 ; pages:65-75 ; extent:11

Links:

Volltext

DOI / URN:

10.1016/j.jalz.2018.08.002

Katalog-ID:

ELV045441197

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