Monitoring of prenatal exposure to organic and inorganic contaminants using meconium from an Eastern Canada cohort
Evaluating in utero exposure to inorganic and multiclass organic contaminants is critical to better evaluate potential harmful effects on prenatal and postnatal development. The analysis of meconium, the first bowel discharge of the newborn, has been proposed as a non-invasive way to assess cumulati...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Cassoulet, Raphael [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2019transfer abstract |
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| Schlagwörter: |
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| Umfang: |
8 |
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| Übergeordnetes Werk: |
Enthalten in: Simultaneous monitoring of each component on degradation of blended bioplastic using gas chromatography-mass spectrometry - Cho, Jang Yeon ELSEVIER, 2022, ER : a journal of environmental sciences, San Diego, Calif |
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| Übergeordnetes Werk: |
volume:171 ; year:2019 ; pages:44-51 ; extent:8 |
| Links: |
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| DOI / URN: |
10.1016/j.envres.2018.12.044 |
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ELV045840644 |
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| 520 | |a Evaluating in utero exposure to inorganic and multiclass organic contaminants is critical to better evaluate potential harmful effects on prenatal and postnatal development. The analysis of meconium, the first bowel discharge of the newborn, has been proposed as a non-invasive way to assess cumulative prenatal exposure. The aim of this study was to implement an analytical method for quantifying 72 targeted organic compounds, including pesticides, pharmaceutical compounds and daily life xenobiotics, in meconium in addition to selected elements (17 elements). We report initial monitoring results based on the analysis of 396 meconium samples from an Eastern Canada cohort (Quebec, Canada). Element contents in meconium were analysed by mass spectrometry after digestion in nitric acid and peroxide. Targeted organic compounds were extracted and purified from meconium samples by a solid-liquid extraction followed by a dispersive-SPE purification before tandem mass spectrometry analysis. Concentrations of targeted elements were within the range of concentration reported in European and US studies but were lower than concentrations found in a developing country cohort (i.e., Pb, Cd). Out of the 72 targeted organic compounds, 31 were detected at least once and 30 were quantified. Compounds with the highest frequency of detection were caffeine, detected in all samples (from 2.80 to 6186 ng g−1), followed by acetaminophen detected in 53% of the samples (up to ~402 µg g−1) and methyl paraben detected in 20% of the samples (up to ~10 µg g−1). Pesticides were detected in low frequencies (< 2%) and low concentration (< 35 ng g−1). Results show that meconium can be used to monitor prenatal exposure of foetus to a wide array of inorganic and organic contaminants. | ||
| 520 | |a Evaluating in utero exposure to inorganic and multiclass organic contaminants is critical to better evaluate potential harmful effects on prenatal and postnatal development. The analysis of meconium, the first bowel discharge of the newborn, has been proposed as a non-invasive way to assess cumulative prenatal exposure. The aim of this study was to implement an analytical method for quantifying 72 targeted organic compounds, including pesticides, pharmaceutical compounds and daily life xenobiotics, in meconium in addition to selected elements (17 elements). We report initial monitoring results based on the analysis of 396 meconium samples from an Eastern Canada cohort (Quebec, Canada). Element contents in meconium were analysed by mass spectrometry after digestion in nitric acid and peroxide. Targeted organic compounds were extracted and purified from meconium samples by a solid-liquid extraction followed by a dispersive-SPE purification before tandem mass spectrometry analysis. Concentrations of targeted elements were within the range of concentration reported in European and US studies but were lower than concentrations found in a developing country cohort (i.e., Pb, Cd). Out of the 72 targeted organic compounds, 31 were detected at least once and 30 were quantified. Compounds with the highest frequency of detection were caffeine, detected in all samples (from 2.80 to 6186 ng g−1), followed by acetaminophen detected in 53% of the samples (up to ~402 µg g−1) and methyl paraben detected in 20% of the samples (up to ~10 µg g−1). Pesticides were detected in low frequencies (< 2%) and low concentration (< 35 ng g−1). Results show that meconium can be used to monitor prenatal exposure of foetus to a wide array of inorganic and organic contaminants. | ||
| 650 | 7 | |a Organic contaminants |2 Elsevier | |
| 650 | 7 | |a Meconium |2 Elsevier | |
| 650 | 7 | |a Prenatal exposure |2 Elsevier | |
| 650 | 7 | |a Inorganic contaminants |2 Elsevier | |
| 700 | 1 | |a Haroune, Lounes |4 oth | |
| 700 | 1 | |a Abdelouahab, Nadia |4 oth | |
| 700 | 1 | |a Gillet, Virginie |4 oth | |
| 700 | 1 | |a Baccarelli, Andrea A. |4 oth | |
| 700 | 1 | |a Cabana, Hubert |4 oth | |
| 700 | 1 | |a Takser, Larissa |4 oth | |
| 700 | 1 | |a Bellenger, Jean-Philippe |4 oth | |
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10.1016/j.envres.2018.12.044 doi GBV00000000000526.pica (DE-627)ELV045840644 (ELSEVIER)S0013-9351(18)30680-7 DE-627 ger DE-627 rakwb eng 570 540 VZ 12 ssgn 35.71 bkl Cassoulet, Raphael verfasserin aut Monitoring of prenatal exposure to organic and inorganic contaminants using meconium from an Eastern Canada cohort 2019transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Evaluating in utero exposure to inorganic and multiclass organic contaminants is critical to better evaluate potential harmful effects on prenatal and postnatal development. The analysis of meconium, the first bowel discharge of the newborn, has been proposed as a non-invasive way to assess cumulative prenatal exposure. The aim of this study was to implement an analytical method for quantifying 72 targeted organic compounds, including pesticides, pharmaceutical compounds and daily life xenobiotics, in meconium in addition to selected elements (17 elements). We report initial monitoring results based on the analysis of 396 meconium samples from an Eastern Canada cohort (Quebec, Canada). Element contents in meconium were analysed by mass spectrometry after digestion in nitric acid and peroxide. Targeted organic compounds were extracted and purified from meconium samples by a solid-liquid extraction followed by a dispersive-SPE purification before tandem mass spectrometry analysis. Concentrations of targeted elements were within the range of concentration reported in European and US studies but were lower than concentrations found in a developing country cohort (i.e., Pb, Cd). Out of the 72 targeted organic compounds, 31 were detected at least once and 30 were quantified. Compounds with the highest frequency of detection were caffeine, detected in all samples (from 2.80 to 6186 ng g−1), followed by acetaminophen detected in 53% of the samples (up to ~402 µg g−1) and methyl paraben detected in 20% of the samples (up to ~10 µg g−1). Pesticides were detected in low frequencies (< 2%) and low concentration (< 35 ng g−1). Results show that meconium can be used to monitor prenatal exposure of foetus to a wide array of inorganic and organic contaminants. Evaluating in utero exposure to inorganic and multiclass organic contaminants is critical to better evaluate potential harmful effects on prenatal and postnatal development. The analysis of meconium, the first bowel discharge of the newborn, has been proposed as a non-invasive way to assess cumulative prenatal exposure. The aim of this study was to implement an analytical method for quantifying 72 targeted organic compounds, including pesticides, pharmaceutical compounds and daily life xenobiotics, in meconium in addition to selected elements (17 elements). We report initial monitoring results based on the analysis of 396 meconium samples from an Eastern Canada cohort (Quebec, Canada). Element contents in meconium were analysed by mass spectrometry after digestion in nitric acid and peroxide. Targeted organic compounds were extracted and purified from meconium samples by a solid-liquid extraction followed by a dispersive-SPE purification before tandem mass spectrometry analysis. Concentrations of targeted elements were within the range of concentration reported in European and US studies but were lower than concentrations found in a developing country cohort (i.e., Pb, Cd). Out of the 72 targeted organic compounds, 31 were detected at least once and 30 were quantified. Compounds with the highest frequency of detection were caffeine, detected in all samples (from 2.80 to 6186 ng g−1), followed by acetaminophen detected in 53% of the samples (up to ~402 µg g−1) and methyl paraben detected in 20% of the samples (up to ~10 µg g−1). Pesticides were detected in low frequencies (< 2%) and low concentration (< 35 ng g−1). Results show that meconium can be used to monitor prenatal exposure of foetus to a wide array of inorganic and organic contaminants. Organic contaminants Elsevier Meconium Elsevier Prenatal exposure Elsevier Inorganic contaminants Elsevier Haroune, Lounes oth Abdelouahab, Nadia oth Gillet, Virginie oth Baccarelli, Andrea A. oth Cabana, Hubert oth Takser, Larissa oth Bellenger, Jean-Philippe oth Enthalten in Elsevier Cho, Jang Yeon ELSEVIER Simultaneous monitoring of each component on degradation of blended bioplastic using gas chromatography-mass spectrometry 2022 ER : a journal of environmental sciences San Diego, Calif (DE-627)ELV00840027X volume:171 year:2019 pages:44-51 extent:8 https://doi.org/10.1016/j.envres.2018.12.044 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 35.71 Biochemische Methoden VZ AR 171 2019 44-51 8 |
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10.1016/j.envres.2018.12.044 doi GBV00000000000526.pica (DE-627)ELV045840644 (ELSEVIER)S0013-9351(18)30680-7 DE-627 ger DE-627 rakwb eng 570 540 VZ 12 ssgn 35.71 bkl Cassoulet, Raphael verfasserin aut Monitoring of prenatal exposure to organic and inorganic contaminants using meconium from an Eastern Canada cohort 2019transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Evaluating in utero exposure to inorganic and multiclass organic contaminants is critical to better evaluate potential harmful effects on prenatal and postnatal development. The analysis of meconium, the first bowel discharge of the newborn, has been proposed as a non-invasive way to assess cumulative prenatal exposure. The aim of this study was to implement an analytical method for quantifying 72 targeted organic compounds, including pesticides, pharmaceutical compounds and daily life xenobiotics, in meconium in addition to selected elements (17 elements). We report initial monitoring results based on the analysis of 396 meconium samples from an Eastern Canada cohort (Quebec, Canada). Element contents in meconium were analysed by mass spectrometry after digestion in nitric acid and peroxide. Targeted organic compounds were extracted and purified from meconium samples by a solid-liquid extraction followed by a dispersive-SPE purification before tandem mass spectrometry analysis. Concentrations of targeted elements were within the range of concentration reported in European and US studies but were lower than concentrations found in a developing country cohort (i.e., Pb, Cd). Out of the 72 targeted organic compounds, 31 were detected at least once and 30 were quantified. Compounds with the highest frequency of detection were caffeine, detected in all samples (from 2.80 to 6186 ng g−1), followed by acetaminophen detected in 53% of the samples (up to ~402 µg g−1) and methyl paraben detected in 20% of the samples (up to ~10 µg g−1). Pesticides were detected in low frequencies (< 2%) and low concentration (< 35 ng g−1). Results show that meconium can be used to monitor prenatal exposure of foetus to a wide array of inorganic and organic contaminants. Evaluating in utero exposure to inorganic and multiclass organic contaminants is critical to better evaluate potential harmful effects on prenatal and postnatal development. The analysis of meconium, the first bowel discharge of the newborn, has been proposed as a non-invasive way to assess cumulative prenatal exposure. The aim of this study was to implement an analytical method for quantifying 72 targeted organic compounds, including pesticides, pharmaceutical compounds and daily life xenobiotics, in meconium in addition to selected elements (17 elements). We report initial monitoring results based on the analysis of 396 meconium samples from an Eastern Canada cohort (Quebec, Canada). Element contents in meconium were analysed by mass spectrometry after digestion in nitric acid and peroxide. Targeted organic compounds were extracted and purified from meconium samples by a solid-liquid extraction followed by a dispersive-SPE purification before tandem mass spectrometry analysis. Concentrations of targeted elements were within the range of concentration reported in European and US studies but were lower than concentrations found in a developing country cohort (i.e., Pb, Cd). Out of the 72 targeted organic compounds, 31 were detected at least once and 30 were quantified. Compounds with the highest frequency of detection were caffeine, detected in all samples (from 2.80 to 6186 ng g−1), followed by acetaminophen detected in 53% of the samples (up to ~402 µg g−1) and methyl paraben detected in 20% of the samples (up to ~10 µg g−1). Pesticides were detected in low frequencies (< 2%) and low concentration (< 35 ng g−1). Results show that meconium can be used to monitor prenatal exposure of foetus to a wide array of inorganic and organic contaminants. Organic contaminants Elsevier Meconium Elsevier Prenatal exposure Elsevier Inorganic contaminants Elsevier Haroune, Lounes oth Abdelouahab, Nadia oth Gillet, Virginie oth Baccarelli, Andrea A. oth Cabana, Hubert oth Takser, Larissa oth Bellenger, Jean-Philippe oth Enthalten in Elsevier Cho, Jang Yeon ELSEVIER Simultaneous monitoring of each component on degradation of blended bioplastic using gas chromatography-mass spectrometry 2022 ER : a journal of environmental sciences San Diego, Calif (DE-627)ELV00840027X volume:171 year:2019 pages:44-51 extent:8 https://doi.org/10.1016/j.envres.2018.12.044 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 35.71 Biochemische Methoden VZ AR 171 2019 44-51 8 |
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10.1016/j.envres.2018.12.044 doi GBV00000000000526.pica (DE-627)ELV045840644 (ELSEVIER)S0013-9351(18)30680-7 DE-627 ger DE-627 rakwb eng 570 540 VZ 12 ssgn 35.71 bkl Cassoulet, Raphael verfasserin aut Monitoring of prenatal exposure to organic and inorganic contaminants using meconium from an Eastern Canada cohort 2019transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Evaluating in utero exposure to inorganic and multiclass organic contaminants is critical to better evaluate potential harmful effects on prenatal and postnatal development. The analysis of meconium, the first bowel discharge of the newborn, has been proposed as a non-invasive way to assess cumulative prenatal exposure. The aim of this study was to implement an analytical method for quantifying 72 targeted organic compounds, including pesticides, pharmaceutical compounds and daily life xenobiotics, in meconium in addition to selected elements (17 elements). We report initial monitoring results based on the analysis of 396 meconium samples from an Eastern Canada cohort (Quebec, Canada). Element contents in meconium were analysed by mass spectrometry after digestion in nitric acid and peroxide. Targeted organic compounds were extracted and purified from meconium samples by a solid-liquid extraction followed by a dispersive-SPE purification before tandem mass spectrometry analysis. Concentrations of targeted elements were within the range of concentration reported in European and US studies but were lower than concentrations found in a developing country cohort (i.e., Pb, Cd). Out of the 72 targeted organic compounds, 31 were detected at least once and 30 were quantified. Compounds with the highest frequency of detection were caffeine, detected in all samples (from 2.80 to 6186 ng g−1), followed by acetaminophen detected in 53% of the samples (up to ~402 µg g−1) and methyl paraben detected in 20% of the samples (up to ~10 µg g−1). Pesticides were detected in low frequencies (< 2%) and low concentration (< 35 ng g−1). Results show that meconium can be used to monitor prenatal exposure of foetus to a wide array of inorganic and organic contaminants. Evaluating in utero exposure to inorganic and multiclass organic contaminants is critical to better evaluate potential harmful effects on prenatal and postnatal development. The analysis of meconium, the first bowel discharge of the newborn, has been proposed as a non-invasive way to assess cumulative prenatal exposure. The aim of this study was to implement an analytical method for quantifying 72 targeted organic compounds, including pesticides, pharmaceutical compounds and daily life xenobiotics, in meconium in addition to selected elements (17 elements). We report initial monitoring results based on the analysis of 396 meconium samples from an Eastern Canada cohort (Quebec, Canada). Element contents in meconium were analysed by mass spectrometry after digestion in nitric acid and peroxide. Targeted organic compounds were extracted and purified from meconium samples by a solid-liquid extraction followed by a dispersive-SPE purification before tandem mass spectrometry analysis. Concentrations of targeted elements were within the range of concentration reported in European and US studies but were lower than concentrations found in a developing country cohort (i.e., Pb, Cd). Out of the 72 targeted organic compounds, 31 were detected at least once and 30 were quantified. Compounds with the highest frequency of detection were caffeine, detected in all samples (from 2.80 to 6186 ng g−1), followed by acetaminophen detected in 53% of the samples (up to ~402 µg g−1) and methyl paraben detected in 20% of the samples (up to ~10 µg g−1). Pesticides were detected in low frequencies (< 2%) and low concentration (< 35 ng g−1). Results show that meconium can be used to monitor prenatal exposure of foetus to a wide array of inorganic and organic contaminants. Organic contaminants Elsevier Meconium Elsevier Prenatal exposure Elsevier Inorganic contaminants Elsevier Haroune, Lounes oth Abdelouahab, Nadia oth Gillet, Virginie oth Baccarelli, Andrea A. oth Cabana, Hubert oth Takser, Larissa oth Bellenger, Jean-Philippe oth Enthalten in Elsevier Cho, Jang Yeon ELSEVIER Simultaneous monitoring of each component on degradation of blended bioplastic using gas chromatography-mass spectrometry 2022 ER : a journal of environmental sciences San Diego, Calif (DE-627)ELV00840027X volume:171 year:2019 pages:44-51 extent:8 https://doi.org/10.1016/j.envres.2018.12.044 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 35.71 Biochemische Methoden VZ AR 171 2019 44-51 8 |
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10.1016/j.envres.2018.12.044 doi GBV00000000000526.pica (DE-627)ELV045840644 (ELSEVIER)S0013-9351(18)30680-7 DE-627 ger DE-627 rakwb eng 570 540 VZ 12 ssgn 35.71 bkl Cassoulet, Raphael verfasserin aut Monitoring of prenatal exposure to organic and inorganic contaminants using meconium from an Eastern Canada cohort 2019transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Evaluating in utero exposure to inorganic and multiclass organic contaminants is critical to better evaluate potential harmful effects on prenatal and postnatal development. The analysis of meconium, the first bowel discharge of the newborn, has been proposed as a non-invasive way to assess cumulative prenatal exposure. The aim of this study was to implement an analytical method for quantifying 72 targeted organic compounds, including pesticides, pharmaceutical compounds and daily life xenobiotics, in meconium in addition to selected elements (17 elements). We report initial monitoring results based on the analysis of 396 meconium samples from an Eastern Canada cohort (Quebec, Canada). Element contents in meconium were analysed by mass spectrometry after digestion in nitric acid and peroxide. Targeted organic compounds were extracted and purified from meconium samples by a solid-liquid extraction followed by a dispersive-SPE purification before tandem mass spectrometry analysis. Concentrations of targeted elements were within the range of concentration reported in European and US studies but were lower than concentrations found in a developing country cohort (i.e., Pb, Cd). Out of the 72 targeted organic compounds, 31 were detected at least once and 30 were quantified. Compounds with the highest frequency of detection were caffeine, detected in all samples (from 2.80 to 6186 ng g−1), followed by acetaminophen detected in 53% of the samples (up to ~402 µg g−1) and methyl paraben detected in 20% of the samples (up to ~10 µg g−1). Pesticides were detected in low frequencies (< 2%) and low concentration (< 35 ng g−1). Results show that meconium can be used to monitor prenatal exposure of foetus to a wide array of inorganic and organic contaminants. Evaluating in utero exposure to inorganic and multiclass organic contaminants is critical to better evaluate potential harmful effects on prenatal and postnatal development. The analysis of meconium, the first bowel discharge of the newborn, has been proposed as a non-invasive way to assess cumulative prenatal exposure. The aim of this study was to implement an analytical method for quantifying 72 targeted organic compounds, including pesticides, pharmaceutical compounds and daily life xenobiotics, in meconium in addition to selected elements (17 elements). We report initial monitoring results based on the analysis of 396 meconium samples from an Eastern Canada cohort (Quebec, Canada). Element contents in meconium were analysed by mass spectrometry after digestion in nitric acid and peroxide. Targeted organic compounds were extracted and purified from meconium samples by a solid-liquid extraction followed by a dispersive-SPE purification before tandem mass spectrometry analysis. Concentrations of targeted elements were within the range of concentration reported in European and US studies but were lower than concentrations found in a developing country cohort (i.e., Pb, Cd). Out of the 72 targeted organic compounds, 31 were detected at least once and 30 were quantified. Compounds with the highest frequency of detection were caffeine, detected in all samples (from 2.80 to 6186 ng g−1), followed by acetaminophen detected in 53% of the samples (up to ~402 µg g−1) and methyl paraben detected in 20% of the samples (up to ~10 µg g−1). Pesticides were detected in low frequencies (< 2%) and low concentration (< 35 ng g−1). Results show that meconium can be used to monitor prenatal exposure of foetus to a wide array of inorganic and organic contaminants. Organic contaminants Elsevier Meconium Elsevier Prenatal exposure Elsevier Inorganic contaminants Elsevier Haroune, Lounes oth Abdelouahab, Nadia oth Gillet, Virginie oth Baccarelli, Andrea A. oth Cabana, Hubert oth Takser, Larissa oth Bellenger, Jean-Philippe oth Enthalten in Elsevier Cho, Jang Yeon ELSEVIER Simultaneous monitoring of each component on degradation of blended bioplastic using gas chromatography-mass spectrometry 2022 ER : a journal of environmental sciences San Diego, Calif (DE-627)ELV00840027X volume:171 year:2019 pages:44-51 extent:8 https://doi.org/10.1016/j.envres.2018.12.044 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 35.71 Biochemische Methoden VZ AR 171 2019 44-51 8 |
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10.1016/j.envres.2018.12.044 doi GBV00000000000526.pica (DE-627)ELV045840644 (ELSEVIER)S0013-9351(18)30680-7 DE-627 ger DE-627 rakwb eng 570 540 VZ 12 ssgn 35.71 bkl Cassoulet, Raphael verfasserin aut Monitoring of prenatal exposure to organic and inorganic contaminants using meconium from an Eastern Canada cohort 2019transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Evaluating in utero exposure to inorganic and multiclass organic contaminants is critical to better evaluate potential harmful effects on prenatal and postnatal development. The analysis of meconium, the first bowel discharge of the newborn, has been proposed as a non-invasive way to assess cumulative prenatal exposure. The aim of this study was to implement an analytical method for quantifying 72 targeted organic compounds, including pesticides, pharmaceutical compounds and daily life xenobiotics, in meconium in addition to selected elements (17 elements). We report initial monitoring results based on the analysis of 396 meconium samples from an Eastern Canada cohort (Quebec, Canada). Element contents in meconium were analysed by mass spectrometry after digestion in nitric acid and peroxide. Targeted organic compounds were extracted and purified from meconium samples by a solid-liquid extraction followed by a dispersive-SPE purification before tandem mass spectrometry analysis. Concentrations of targeted elements were within the range of concentration reported in European and US studies but were lower than concentrations found in a developing country cohort (i.e., Pb, Cd). Out of the 72 targeted organic compounds, 31 were detected at least once and 30 were quantified. Compounds with the highest frequency of detection were caffeine, detected in all samples (from 2.80 to 6186 ng g−1), followed by acetaminophen detected in 53% of the samples (up to ~402 µg g−1) and methyl paraben detected in 20% of the samples (up to ~10 µg g−1). Pesticides were detected in low frequencies (< 2%) and low concentration (< 35 ng g−1). Results show that meconium can be used to monitor prenatal exposure of foetus to a wide array of inorganic and organic contaminants. Evaluating in utero exposure to inorganic and multiclass organic contaminants is critical to better evaluate potential harmful effects on prenatal and postnatal development. The analysis of meconium, the first bowel discharge of the newborn, has been proposed as a non-invasive way to assess cumulative prenatal exposure. The aim of this study was to implement an analytical method for quantifying 72 targeted organic compounds, including pesticides, pharmaceutical compounds and daily life xenobiotics, in meconium in addition to selected elements (17 elements). We report initial monitoring results based on the analysis of 396 meconium samples from an Eastern Canada cohort (Quebec, Canada). Element contents in meconium were analysed by mass spectrometry after digestion in nitric acid and peroxide. Targeted organic compounds were extracted and purified from meconium samples by a solid-liquid extraction followed by a dispersive-SPE purification before tandem mass spectrometry analysis. Concentrations of targeted elements were within the range of concentration reported in European and US studies but were lower than concentrations found in a developing country cohort (i.e., Pb, Cd). Out of the 72 targeted organic compounds, 31 were detected at least once and 30 were quantified. Compounds with the highest frequency of detection were caffeine, detected in all samples (from 2.80 to 6186 ng g−1), followed by acetaminophen detected in 53% of the samples (up to ~402 µg g−1) and methyl paraben detected in 20% of the samples (up to ~10 µg g−1). Pesticides were detected in low frequencies (< 2%) and low concentration (< 35 ng g−1). Results show that meconium can be used to monitor prenatal exposure of foetus to a wide array of inorganic and organic contaminants. Organic contaminants Elsevier Meconium Elsevier Prenatal exposure Elsevier Inorganic contaminants Elsevier Haroune, Lounes oth Abdelouahab, Nadia oth Gillet, Virginie oth Baccarelli, Andrea A. oth Cabana, Hubert oth Takser, Larissa oth Bellenger, Jean-Philippe oth Enthalten in Elsevier Cho, Jang Yeon ELSEVIER Simultaneous monitoring of each component on degradation of blended bioplastic using gas chromatography-mass spectrometry 2022 ER : a journal of environmental sciences San Diego, Calif (DE-627)ELV00840027X volume:171 year:2019 pages:44-51 extent:8 https://doi.org/10.1016/j.envres.2018.12.044 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 35.71 Biochemische Methoden VZ AR 171 2019 44-51 8 |
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Cassoulet, Raphael @@aut@@ Haroune, Lounes @@oth@@ Abdelouahab, Nadia @@oth@@ Gillet, Virginie @@oth@@ Baccarelli, Andrea A. @@oth@@ Cabana, Hubert @@oth@@ Takser, Larissa @@oth@@ Bellenger, Jean-Philippe @@oth@@ |
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Monitoring of prenatal exposure to organic and inorganic contaminants using meconium from an Eastern Canada cohort |
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Evaluating in utero exposure to inorganic and multiclass organic contaminants is critical to better evaluate potential harmful effects on prenatal and postnatal development. The analysis of meconium, the first bowel discharge of the newborn, has been proposed as a non-invasive way to assess cumulative prenatal exposure. The aim of this study was to implement an analytical method for quantifying 72 targeted organic compounds, including pesticides, pharmaceutical compounds and daily life xenobiotics, in meconium in addition to selected elements (17 elements). We report initial monitoring results based on the analysis of 396 meconium samples from an Eastern Canada cohort (Quebec, Canada). Element contents in meconium were analysed by mass spectrometry after digestion in nitric acid and peroxide. Targeted organic compounds were extracted and purified from meconium samples by a solid-liquid extraction followed by a dispersive-SPE purification before tandem mass spectrometry analysis. Concentrations of targeted elements were within the range of concentration reported in European and US studies but were lower than concentrations found in a developing country cohort (i.e., Pb, Cd). Out of the 72 targeted organic compounds, 31 were detected at least once and 30 were quantified. Compounds with the highest frequency of detection were caffeine, detected in all samples (from 2.80 to 6186 ng g−1), followed by acetaminophen detected in 53% of the samples (up to ~402 µg g−1) and methyl paraben detected in 20% of the samples (up to ~10 µg g−1). Pesticides were detected in low frequencies (< 2%) and low concentration (< 35 ng g−1). Results show that meconium can be used to monitor prenatal exposure of foetus to a wide array of inorganic and organic contaminants. |
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Evaluating in utero exposure to inorganic and multiclass organic contaminants is critical to better evaluate potential harmful effects on prenatal and postnatal development. The analysis of meconium, the first bowel discharge of the newborn, has been proposed as a non-invasive way to assess cumulative prenatal exposure. The aim of this study was to implement an analytical method for quantifying 72 targeted organic compounds, including pesticides, pharmaceutical compounds and daily life xenobiotics, in meconium in addition to selected elements (17 elements). We report initial monitoring results based on the analysis of 396 meconium samples from an Eastern Canada cohort (Quebec, Canada). Element contents in meconium were analysed by mass spectrometry after digestion in nitric acid and peroxide. Targeted organic compounds were extracted and purified from meconium samples by a solid-liquid extraction followed by a dispersive-SPE purification before tandem mass spectrometry analysis. Concentrations of targeted elements were within the range of concentration reported in European and US studies but were lower than concentrations found in a developing country cohort (i.e., Pb, Cd). Out of the 72 targeted organic compounds, 31 were detected at least once and 30 were quantified. Compounds with the highest frequency of detection were caffeine, detected in all samples (from 2.80 to 6186 ng g−1), followed by acetaminophen detected in 53% of the samples (up to ~402 µg g−1) and methyl paraben detected in 20% of the samples (up to ~10 µg g−1). Pesticides were detected in low frequencies (< 2%) and low concentration (< 35 ng g−1). Results show that meconium can be used to monitor prenatal exposure of foetus to a wide array of inorganic and organic contaminants. |
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Evaluating in utero exposure to inorganic and multiclass organic contaminants is critical to better evaluate potential harmful effects on prenatal and postnatal development. The analysis of meconium, the first bowel discharge of the newborn, has been proposed as a non-invasive way to assess cumulative prenatal exposure. The aim of this study was to implement an analytical method for quantifying 72 targeted organic compounds, including pesticides, pharmaceutical compounds and daily life xenobiotics, in meconium in addition to selected elements (17 elements). We report initial monitoring results based on the analysis of 396 meconium samples from an Eastern Canada cohort (Quebec, Canada). Element contents in meconium were analysed by mass spectrometry after digestion in nitric acid and peroxide. Targeted organic compounds were extracted and purified from meconium samples by a solid-liquid extraction followed by a dispersive-SPE purification before tandem mass spectrometry analysis. Concentrations of targeted elements were within the range of concentration reported in European and US studies but were lower than concentrations found in a developing country cohort (i.e., Pb, Cd). Out of the 72 targeted organic compounds, 31 were detected at least once and 30 were quantified. Compounds with the highest frequency of detection were caffeine, detected in all samples (from 2.80 to 6186 ng g−1), followed by acetaminophen detected in 53% of the samples (up to ~402 µg g−1) and methyl paraben detected in 20% of the samples (up to ~10 µg g−1). Pesticides were detected in low frequencies (< 2%) and low concentration (< 35 ng g−1). Results show that meconium can be used to monitor prenatal exposure of foetus to a wide array of inorganic and organic contaminants. |
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