THE GENOMICS OF BIPOLAR AND SCHIZOPHRENIC DISORDERS IN A LARGE PEDIGREE FROM A NORTHERN SWEDISH ISOLATE
Bipolar (BIP) disorders and Schizophrenia (SCZ), are severe and common psychiatric disorders constituting health care problems of major concern worldwide. Both BIP and SCZ are highly heritable and complex disorders. The genetic risk factors are polygenic and involve both common variants of small eff...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Crowley, James [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2019transfer abstract |
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| Umfang: |
2 |
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| Übergeordnetes Werk: |
Enthalten in: Temperature-dependence laws of absorption line shape parameters of the CO - Wilzewski, J.S. ELSEVIER, 2017, ENP : the journal of the European College of Neuropsychopharmacology, Amsterdam |
|---|---|
| Übergeordnetes Werk: |
volume:29 ; year:2019 ; pages:902-903 ; extent:2 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.euroneuro.2017.08.217 |
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| 520 | |a Bipolar (BIP) disorders and Schizophrenia (SCZ), are severe and common psychiatric disorders constituting health care problems of major concern worldwide. Both BIP and SCZ are highly heritable and complex disorders. The genetic risk factors are polygenic and involve both common variants of small effects and rare variants with large effects. Using a variety of genomic technologies, we evaluated the Skea pedigree - a very large multi-generation pedigree densely affected by BIP and to a lesser extent by SCZ, originated from the isolated population in the Northeast part of the county of Västerbotten in Northern Sweden. The enrichment of these disorders in the Skea pedigree is 8.8 times higher than the rest of Sweden. With this approach, we have maximized the chance of finding rare variant risk loci by combining the homogeneity of an isolate population with the extreme likeliness of family-members to share risk variants inherited from a common ancestor. | ||
| 520 | |a Bipolar (BIP) disorders and Schizophrenia (SCZ), are severe and common psychiatric disorders constituting health care problems of major concern worldwide. Both BIP and SCZ are highly heritable and complex disorders. The genetic risk factors are polygenic and involve both common variants of small effects and rare variants with large effects. Using a variety of genomic technologies, we evaluated the Skea pedigree - a very large multi-generation pedigree densely affected by BIP and to a lesser extent by SCZ, originated from the isolated population in the Northeast part of the county of Västerbotten in Northern Sweden. The enrichment of these disorders in the Skea pedigree is 8.8 times higher than the rest of Sweden. With this approach, we have maximized the chance of finding rare variant risk loci by combining the homogeneity of an isolate population with the extreme likeliness of family-members to share risk variants inherited from a common ancestor. | ||
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10.1016/j.euroneuro.2017.08.217 doi GBV00000000000688.pica (DE-627)ELV046224998 (ELSEVIER)S0924-977X(17)30681-8 DE-627 ger DE-627 rakwb eng 530 VZ 33.00 bkl Crowley, James verfasserin aut THE GENOMICS OF BIPOLAR AND SCHIZOPHRENIC DISORDERS IN A LARGE PEDIGREE FROM A NORTHERN SWEDISH ISOLATE 2019transfer abstract 2 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Bipolar (BIP) disorders and Schizophrenia (SCZ), are severe and common psychiatric disorders constituting health care problems of major concern worldwide. Both BIP and SCZ are highly heritable and complex disorders. The genetic risk factors are polygenic and involve both common variants of small effects and rare variants with large effects. Using a variety of genomic technologies, we evaluated the Skea pedigree - a very large multi-generation pedigree densely affected by BIP and to a lesser extent by SCZ, originated from the isolated population in the Northeast part of the county of Västerbotten in Northern Sweden. The enrichment of these disorders in the Skea pedigree is 8.8 times higher than the rest of Sweden. With this approach, we have maximized the chance of finding rare variant risk loci by combining the homogeneity of an isolate population with the extreme likeliness of family-members to share risk variants inherited from a common ancestor. Bipolar (BIP) disorders and Schizophrenia (SCZ), are severe and common psychiatric disorders constituting health care problems of major concern worldwide. Both BIP and SCZ are highly heritable and complex disorders. The genetic risk factors are polygenic and involve both common variants of small effects and rare variants with large effects. Using a variety of genomic technologies, we evaluated the Skea pedigree - a very large multi-generation pedigree densely affected by BIP and to a lesser extent by SCZ, originated from the isolated population in the Northeast part of the county of Västerbotten in Northern Sweden. The enrichment of these disorders in the Skea pedigree is 8.8 times higher than the rest of Sweden. With this approach, we have maximized the chance of finding rare variant risk loci by combining the homogeneity of an isolate population with the extreme likeliness of family-members to share risk variants inherited from a common ancestor. Mudgal, Poorva oth Adolfsson, Annelie oth Åberg, Karolina oth Alaerts, Maaike oth Genovese, Giulio oth McCarroll, Steven oth Del-Favero, Jurgen oth Adolfsson, Rolf oth Sullivan, Patrick oth Enthalten in Elsevier Wilzewski, J.S. ELSEVIER Temperature-dependence laws of absorption line shape parameters of the CO 2017 ENP : the journal of the European College of Neuropsychopharmacology Amsterdam (DE-627)ELV000200816 volume:29 year:2019 pages:902-903 extent:2 https://doi.org/10.1016/j.euroneuro.2017.08.217 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 33.00 Physik: Allgemeines VZ AR 29 2019 902-903 2 29.2019, S902-, (2 S.) |
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10.1016/j.euroneuro.2017.08.217 doi GBV00000000000688.pica (DE-627)ELV046224998 (ELSEVIER)S0924-977X(17)30681-8 DE-627 ger DE-627 rakwb eng 530 VZ 33.00 bkl Crowley, James verfasserin aut THE GENOMICS OF BIPOLAR AND SCHIZOPHRENIC DISORDERS IN A LARGE PEDIGREE FROM A NORTHERN SWEDISH ISOLATE 2019transfer abstract 2 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Bipolar (BIP) disorders and Schizophrenia (SCZ), are severe and common psychiatric disorders constituting health care problems of major concern worldwide. Both BIP and SCZ are highly heritable and complex disorders. The genetic risk factors are polygenic and involve both common variants of small effects and rare variants with large effects. Using a variety of genomic technologies, we evaluated the Skea pedigree - a very large multi-generation pedigree densely affected by BIP and to a lesser extent by SCZ, originated from the isolated population in the Northeast part of the county of Västerbotten in Northern Sweden. The enrichment of these disorders in the Skea pedigree is 8.8 times higher than the rest of Sweden. With this approach, we have maximized the chance of finding rare variant risk loci by combining the homogeneity of an isolate population with the extreme likeliness of family-members to share risk variants inherited from a common ancestor. Bipolar (BIP) disorders and Schizophrenia (SCZ), are severe and common psychiatric disorders constituting health care problems of major concern worldwide. Both BIP and SCZ are highly heritable and complex disorders. The genetic risk factors are polygenic and involve both common variants of small effects and rare variants with large effects. Using a variety of genomic technologies, we evaluated the Skea pedigree - a very large multi-generation pedigree densely affected by BIP and to a lesser extent by SCZ, originated from the isolated population in the Northeast part of the county of Västerbotten in Northern Sweden. The enrichment of these disorders in the Skea pedigree is 8.8 times higher than the rest of Sweden. With this approach, we have maximized the chance of finding rare variant risk loci by combining the homogeneity of an isolate population with the extreme likeliness of family-members to share risk variants inherited from a common ancestor. Mudgal, Poorva oth Adolfsson, Annelie oth Åberg, Karolina oth Alaerts, Maaike oth Genovese, Giulio oth McCarroll, Steven oth Del-Favero, Jurgen oth Adolfsson, Rolf oth Sullivan, Patrick oth Enthalten in Elsevier Wilzewski, J.S. ELSEVIER Temperature-dependence laws of absorption line shape parameters of the CO 2017 ENP : the journal of the European College of Neuropsychopharmacology Amsterdam (DE-627)ELV000200816 volume:29 year:2019 pages:902-903 extent:2 https://doi.org/10.1016/j.euroneuro.2017.08.217 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 33.00 Physik: Allgemeines VZ AR 29 2019 902-903 2 29.2019, S902-, (2 S.) |
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10.1016/j.euroneuro.2017.08.217 doi GBV00000000000688.pica (DE-627)ELV046224998 (ELSEVIER)S0924-977X(17)30681-8 DE-627 ger DE-627 rakwb eng 530 VZ 33.00 bkl Crowley, James verfasserin aut THE GENOMICS OF BIPOLAR AND SCHIZOPHRENIC DISORDERS IN A LARGE PEDIGREE FROM A NORTHERN SWEDISH ISOLATE 2019transfer abstract 2 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Bipolar (BIP) disorders and Schizophrenia (SCZ), are severe and common psychiatric disorders constituting health care problems of major concern worldwide. Both BIP and SCZ are highly heritable and complex disorders. The genetic risk factors are polygenic and involve both common variants of small effects and rare variants with large effects. Using a variety of genomic technologies, we evaluated the Skea pedigree - a very large multi-generation pedigree densely affected by BIP and to a lesser extent by SCZ, originated from the isolated population in the Northeast part of the county of Västerbotten in Northern Sweden. The enrichment of these disorders in the Skea pedigree is 8.8 times higher than the rest of Sweden. With this approach, we have maximized the chance of finding rare variant risk loci by combining the homogeneity of an isolate population with the extreme likeliness of family-members to share risk variants inherited from a common ancestor. Bipolar (BIP) disorders and Schizophrenia (SCZ), are severe and common psychiatric disorders constituting health care problems of major concern worldwide. Both BIP and SCZ are highly heritable and complex disorders. The genetic risk factors are polygenic and involve both common variants of small effects and rare variants with large effects. Using a variety of genomic technologies, we evaluated the Skea pedigree - a very large multi-generation pedigree densely affected by BIP and to a lesser extent by SCZ, originated from the isolated population in the Northeast part of the county of Västerbotten in Northern Sweden. The enrichment of these disorders in the Skea pedigree is 8.8 times higher than the rest of Sweden. With this approach, we have maximized the chance of finding rare variant risk loci by combining the homogeneity of an isolate population with the extreme likeliness of family-members to share risk variants inherited from a common ancestor. Mudgal, Poorva oth Adolfsson, Annelie oth Åberg, Karolina oth Alaerts, Maaike oth Genovese, Giulio oth McCarroll, Steven oth Del-Favero, Jurgen oth Adolfsson, Rolf oth Sullivan, Patrick oth Enthalten in Elsevier Wilzewski, J.S. ELSEVIER Temperature-dependence laws of absorption line shape parameters of the CO 2017 ENP : the journal of the European College of Neuropsychopharmacology Amsterdam (DE-627)ELV000200816 volume:29 year:2019 pages:902-903 extent:2 https://doi.org/10.1016/j.euroneuro.2017.08.217 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 33.00 Physik: Allgemeines VZ AR 29 2019 902-903 2 29.2019, S902-, (2 S.) |
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10.1016/j.euroneuro.2017.08.217 doi GBV00000000000688.pica (DE-627)ELV046224998 (ELSEVIER)S0924-977X(17)30681-8 DE-627 ger DE-627 rakwb eng 530 VZ 33.00 bkl Crowley, James verfasserin aut THE GENOMICS OF BIPOLAR AND SCHIZOPHRENIC DISORDERS IN A LARGE PEDIGREE FROM A NORTHERN SWEDISH ISOLATE 2019transfer abstract 2 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Bipolar (BIP) disorders and Schizophrenia (SCZ), are severe and common psychiatric disorders constituting health care problems of major concern worldwide. Both BIP and SCZ are highly heritable and complex disorders. The genetic risk factors are polygenic and involve both common variants of small effects and rare variants with large effects. Using a variety of genomic technologies, we evaluated the Skea pedigree - a very large multi-generation pedigree densely affected by BIP and to a lesser extent by SCZ, originated from the isolated population in the Northeast part of the county of Västerbotten in Northern Sweden. The enrichment of these disorders in the Skea pedigree is 8.8 times higher than the rest of Sweden. With this approach, we have maximized the chance of finding rare variant risk loci by combining the homogeneity of an isolate population with the extreme likeliness of family-members to share risk variants inherited from a common ancestor. Bipolar (BIP) disorders and Schizophrenia (SCZ), are severe and common psychiatric disorders constituting health care problems of major concern worldwide. Both BIP and SCZ are highly heritable and complex disorders. The genetic risk factors are polygenic and involve both common variants of small effects and rare variants with large effects. Using a variety of genomic technologies, we evaluated the Skea pedigree - a very large multi-generation pedigree densely affected by BIP and to a lesser extent by SCZ, originated from the isolated population in the Northeast part of the county of Västerbotten in Northern Sweden. The enrichment of these disorders in the Skea pedigree is 8.8 times higher than the rest of Sweden. With this approach, we have maximized the chance of finding rare variant risk loci by combining the homogeneity of an isolate population with the extreme likeliness of family-members to share risk variants inherited from a common ancestor. Mudgal, Poorva oth Adolfsson, Annelie oth Åberg, Karolina oth Alaerts, Maaike oth Genovese, Giulio oth McCarroll, Steven oth Del-Favero, Jurgen oth Adolfsson, Rolf oth Sullivan, Patrick oth Enthalten in Elsevier Wilzewski, J.S. ELSEVIER Temperature-dependence laws of absorption line shape parameters of the CO 2017 ENP : the journal of the European College of Neuropsychopharmacology Amsterdam (DE-627)ELV000200816 volume:29 year:2019 pages:902-903 extent:2 https://doi.org/10.1016/j.euroneuro.2017.08.217 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 33.00 Physik: Allgemeines VZ AR 29 2019 902-903 2 29.2019, S902-, (2 S.) |
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10.1016/j.euroneuro.2017.08.217 doi GBV00000000000688.pica (DE-627)ELV046224998 (ELSEVIER)S0924-977X(17)30681-8 DE-627 ger DE-627 rakwb eng 530 VZ 33.00 bkl Crowley, James verfasserin aut THE GENOMICS OF BIPOLAR AND SCHIZOPHRENIC DISORDERS IN A LARGE PEDIGREE FROM A NORTHERN SWEDISH ISOLATE 2019transfer abstract 2 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Bipolar (BIP) disorders and Schizophrenia (SCZ), are severe and common psychiatric disorders constituting health care problems of major concern worldwide. Both BIP and SCZ are highly heritable and complex disorders. The genetic risk factors are polygenic and involve both common variants of small effects and rare variants with large effects. Using a variety of genomic technologies, we evaluated the Skea pedigree - a very large multi-generation pedigree densely affected by BIP and to a lesser extent by SCZ, originated from the isolated population in the Northeast part of the county of Västerbotten in Northern Sweden. The enrichment of these disorders in the Skea pedigree is 8.8 times higher than the rest of Sweden. With this approach, we have maximized the chance of finding rare variant risk loci by combining the homogeneity of an isolate population with the extreme likeliness of family-members to share risk variants inherited from a common ancestor. Bipolar (BIP) disorders and Schizophrenia (SCZ), are severe and common psychiatric disorders constituting health care problems of major concern worldwide. Both BIP and SCZ are highly heritable and complex disorders. The genetic risk factors are polygenic and involve both common variants of small effects and rare variants with large effects. Using a variety of genomic technologies, we evaluated the Skea pedigree - a very large multi-generation pedigree densely affected by BIP and to a lesser extent by SCZ, originated from the isolated population in the Northeast part of the county of Västerbotten in Northern Sweden. The enrichment of these disorders in the Skea pedigree is 8.8 times higher than the rest of Sweden. With this approach, we have maximized the chance of finding rare variant risk loci by combining the homogeneity of an isolate population with the extreme likeliness of family-members to share risk variants inherited from a common ancestor. Mudgal, Poorva oth Adolfsson, Annelie oth Åberg, Karolina oth Alaerts, Maaike oth Genovese, Giulio oth McCarroll, Steven oth Del-Favero, Jurgen oth Adolfsson, Rolf oth Sullivan, Patrick oth Enthalten in Elsevier Wilzewski, J.S. ELSEVIER Temperature-dependence laws of absorption line shape parameters of the CO 2017 ENP : the journal of the European College of Neuropsychopharmacology Amsterdam (DE-627)ELV000200816 volume:29 year:2019 pages:902-903 extent:2 https://doi.org/10.1016/j.euroneuro.2017.08.217 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 33.00 Physik: Allgemeines VZ AR 29 2019 902-903 2 29.2019, S902-, (2 S.) |
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genomics of bipolar and schizophrenic disorders in a large pedigree from a northern swedish isolate |
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THE GENOMICS OF BIPOLAR AND SCHIZOPHRENIC DISORDERS IN A LARGE PEDIGREE FROM A NORTHERN SWEDISH ISOLATE |
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Bipolar (BIP) disorders and Schizophrenia (SCZ), are severe and common psychiatric disorders constituting health care problems of major concern worldwide. Both BIP and SCZ are highly heritable and complex disorders. The genetic risk factors are polygenic and involve both common variants of small effects and rare variants with large effects. Using a variety of genomic technologies, we evaluated the Skea pedigree - a very large multi-generation pedigree densely affected by BIP and to a lesser extent by SCZ, originated from the isolated population in the Northeast part of the county of Västerbotten in Northern Sweden. The enrichment of these disorders in the Skea pedigree is 8.8 times higher than the rest of Sweden. With this approach, we have maximized the chance of finding rare variant risk loci by combining the homogeneity of an isolate population with the extreme likeliness of family-members to share risk variants inherited from a common ancestor. |
| abstractGer |
Bipolar (BIP) disorders and Schizophrenia (SCZ), are severe and common psychiatric disorders constituting health care problems of major concern worldwide. Both BIP and SCZ are highly heritable and complex disorders. The genetic risk factors are polygenic and involve both common variants of small effects and rare variants with large effects. Using a variety of genomic technologies, we evaluated the Skea pedigree - a very large multi-generation pedigree densely affected by BIP and to a lesser extent by SCZ, originated from the isolated population in the Northeast part of the county of Västerbotten in Northern Sweden. The enrichment of these disorders in the Skea pedigree is 8.8 times higher than the rest of Sweden. With this approach, we have maximized the chance of finding rare variant risk loci by combining the homogeneity of an isolate population with the extreme likeliness of family-members to share risk variants inherited from a common ancestor. |
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Bipolar (BIP) disorders and Schizophrenia (SCZ), are severe and common psychiatric disorders constituting health care problems of major concern worldwide. Both BIP and SCZ are highly heritable and complex disorders. The genetic risk factors are polygenic and involve both common variants of small effects and rare variants with large effects. Using a variety of genomic technologies, we evaluated the Skea pedigree - a very large multi-generation pedigree densely affected by BIP and to a lesser extent by SCZ, originated from the isolated population in the Northeast part of the county of Västerbotten in Northern Sweden. The enrichment of these disorders in the Skea pedigree is 8.8 times higher than the rest of Sweden. With this approach, we have maximized the chance of finding rare variant risk loci by combining the homogeneity of an isolate population with the extreme likeliness of family-members to share risk variants inherited from a common ancestor. |
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THE GENOMICS OF BIPOLAR AND SCHIZOPHRENIC DISORDERS IN A LARGE PEDIGREE FROM A NORTHERN SWEDISH ISOLATE |
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