Placental mitochondrial DNA copy number is associated with reduced birth weight in women with placental malaria
Placental malaria (PM) causes placental insufficiency, leading to reduced birth weight (BW). Placental mtDNA copy number (mtDNA-CN) and relative telomere length (RTL) have been described as potential biomarkers for placental insufficiency and intrauterine growth restriction (IUGR). We investigated t...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Oktavianthi, Sukma [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2019transfer abstract |
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| Schlagwörter: |
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| Umfang: |
3 |
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| Übergeordnetes Werk: |
Enthalten in: O045 : Bioactive lipids in the human liver in ‘Common NAFLD’ and ‘PNPLA3 NAFLD’ - Luukkonen, P. ELSEVIER, 2015, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:80 ; year:2019 ; pages:1-3 ; extent:3 |
| Links: |
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| DOI / URN: |
10.1016/j.placenta.2019.03.005 |
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ELV046779574 |
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| 520 | |a Placental malaria (PM) causes placental insufficiency, leading to reduced birth weight (BW). Placental mtDNA copy number (mtDNA-CN) and relative telomere length (RTL) have been described as potential biomarkers for placental insufficiency and intrauterine growth restriction (IUGR). We investigated their associations with BW in women with PM from malaria-endemic region of Papua, Indonesia. MtDNA-CN and RTL were determined in 50 placentas by quantitative real-time PCR. Increased placental mtDNA-CN was associated with reduced BW (coef = −193.71, p = 0.016), particularly in preterm group (coef = −374.21, p < 0.001). RTL did not associate with BW. Increased placental mtDNA-CN indicates a compensatory mechanism to reduced BW in women with PM. | ||
| 520 | |a Placental malaria (PM) causes placental insufficiency, leading to reduced birth weight (BW). Placental mtDNA copy number (mtDNA-CN) and relative telomere length (RTL) have been described as potential biomarkers for placental insufficiency and intrauterine growth restriction (IUGR). We investigated their associations with BW in women with PM from malaria-endemic region of Papua, Indonesia. MtDNA-CN and RTL were determined in 50 placentas by quantitative real-time PCR. Increased placental mtDNA-CN was associated with reduced BW (coef = −193.71, p = 0.016), particularly in preterm group (coef = −374.21, p < 0.001). RTL did not associate with BW. Increased placental mtDNA-CN indicates a compensatory mechanism to reduced BW in women with PM. | ||
| 650 | 7 | |a Relative telomere length |2 Elsevier | |
| 650 | 7 | |a Birth weight |2 Elsevier | |
| 650 | 7 | |a Placental malaria |2 Elsevier | |
| 650 | 7 | |a mtDNA copy number |2 Elsevier | |
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| 700 | 1 | |a Bowolaksono, Anom |4 oth | |
| 700 | 1 | |a Noviyanti, Rintis |4 oth | |
| 700 | 1 | |a Malik, Safarina G. |4 oth | |
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10.1016/j.placenta.2019.03.005 doi GBV00000000000622.pica (DE-627)ELV046779574 (ELSEVIER)S0143-4004(19)30051-7 DE-627 ger DE-627 rakwb eng 610 VZ 610 VZ 44.44 bkl Oktavianthi, Sukma verfasserin aut Placental mitochondrial DNA copy number is associated with reduced birth weight in women with placental malaria 2019transfer abstract 3 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Placental malaria (PM) causes placental insufficiency, leading to reduced birth weight (BW). Placental mtDNA copy number (mtDNA-CN) and relative telomere length (RTL) have been described as potential biomarkers for placental insufficiency and intrauterine growth restriction (IUGR). We investigated their associations with BW in women with PM from malaria-endemic region of Papua, Indonesia. MtDNA-CN and RTL were determined in 50 placentas by quantitative real-time PCR. Increased placental mtDNA-CN was associated with reduced BW (coef = −193.71, p = 0.016), particularly in preterm group (coef = −374.21, p < 0.001). RTL did not associate with BW. Increased placental mtDNA-CN indicates a compensatory mechanism to reduced BW in women with PM. Placental malaria (PM) causes placental insufficiency, leading to reduced birth weight (BW). Placental mtDNA copy number (mtDNA-CN) and relative telomere length (RTL) have been described as potential biomarkers for placental insufficiency and intrauterine growth restriction (IUGR). We investigated their associations with BW in women with PM from malaria-endemic region of Papua, Indonesia. MtDNA-CN and RTL were determined in 50 placentas by quantitative real-time PCR. Increased placental mtDNA-CN was associated with reduced BW (coef = −193.71, p = 0.016), particularly in preterm group (coef = −374.21, p < 0.001). RTL did not associate with BW. Increased placental mtDNA-CN indicates a compensatory mechanism to reduced BW in women with PM. Relative telomere length Elsevier Birth weight Elsevier Placental malaria Elsevier mtDNA copy number Elsevier Fauzi, Muhammad oth Trianty, Leily oth Trimarsanto, Hidayat oth Bowolaksono, Anom oth Noviyanti, Rintis oth Malik, Safarina G. oth Enthalten in Elsevier Luukkonen, P. ELSEVIER O045 : Bioactive lipids in the human liver in ‘Common NAFLD’ and ‘PNPLA3 NAFLD’ 2015 Amsterdam [u.a.] (DE-627)ELV012874620 volume:80 year:2019 pages:1-3 extent:3 https://doi.org/10.1016/j.placenta.2019.03.005 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.44 Parasitologie Medizin VZ AR 80 2019 1-3 3 |
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10.1016/j.placenta.2019.03.005 doi GBV00000000000622.pica (DE-627)ELV046779574 (ELSEVIER)S0143-4004(19)30051-7 DE-627 ger DE-627 rakwb eng 610 VZ 610 VZ 44.44 bkl Oktavianthi, Sukma verfasserin aut Placental mitochondrial DNA copy number is associated with reduced birth weight in women with placental malaria 2019transfer abstract 3 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Placental malaria (PM) causes placental insufficiency, leading to reduced birth weight (BW). Placental mtDNA copy number (mtDNA-CN) and relative telomere length (RTL) have been described as potential biomarkers for placental insufficiency and intrauterine growth restriction (IUGR). We investigated their associations with BW in women with PM from malaria-endemic region of Papua, Indonesia. MtDNA-CN and RTL were determined in 50 placentas by quantitative real-time PCR. Increased placental mtDNA-CN was associated with reduced BW (coef = −193.71, p = 0.016), particularly in preterm group (coef = −374.21, p < 0.001). RTL did not associate with BW. Increased placental mtDNA-CN indicates a compensatory mechanism to reduced BW in women with PM. Placental malaria (PM) causes placental insufficiency, leading to reduced birth weight (BW). Placental mtDNA copy number (mtDNA-CN) and relative telomere length (RTL) have been described as potential biomarkers for placental insufficiency and intrauterine growth restriction (IUGR). We investigated their associations with BW in women with PM from malaria-endemic region of Papua, Indonesia. MtDNA-CN and RTL were determined in 50 placentas by quantitative real-time PCR. Increased placental mtDNA-CN was associated with reduced BW (coef = −193.71, p = 0.016), particularly in preterm group (coef = −374.21, p < 0.001). RTL did not associate with BW. Increased placental mtDNA-CN indicates a compensatory mechanism to reduced BW in women with PM. Relative telomere length Elsevier Birth weight Elsevier Placental malaria Elsevier mtDNA copy number Elsevier Fauzi, Muhammad oth Trianty, Leily oth Trimarsanto, Hidayat oth Bowolaksono, Anom oth Noviyanti, Rintis oth Malik, Safarina G. oth Enthalten in Elsevier Luukkonen, P. ELSEVIER O045 : Bioactive lipids in the human liver in ‘Common NAFLD’ and ‘PNPLA3 NAFLD’ 2015 Amsterdam [u.a.] (DE-627)ELV012874620 volume:80 year:2019 pages:1-3 extent:3 https://doi.org/10.1016/j.placenta.2019.03.005 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.44 Parasitologie Medizin VZ AR 80 2019 1-3 3 |
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10.1016/j.placenta.2019.03.005 doi GBV00000000000622.pica (DE-627)ELV046779574 (ELSEVIER)S0143-4004(19)30051-7 DE-627 ger DE-627 rakwb eng 610 VZ 610 VZ 44.44 bkl Oktavianthi, Sukma verfasserin aut Placental mitochondrial DNA copy number is associated with reduced birth weight in women with placental malaria 2019transfer abstract 3 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Placental malaria (PM) causes placental insufficiency, leading to reduced birth weight (BW). Placental mtDNA copy number (mtDNA-CN) and relative telomere length (RTL) have been described as potential biomarkers for placental insufficiency and intrauterine growth restriction (IUGR). We investigated their associations with BW in women with PM from malaria-endemic region of Papua, Indonesia. MtDNA-CN and RTL were determined in 50 placentas by quantitative real-time PCR. Increased placental mtDNA-CN was associated with reduced BW (coef = −193.71, p = 0.016), particularly in preterm group (coef = −374.21, p < 0.001). RTL did not associate with BW. Increased placental mtDNA-CN indicates a compensatory mechanism to reduced BW in women with PM. Placental malaria (PM) causes placental insufficiency, leading to reduced birth weight (BW). Placental mtDNA copy number (mtDNA-CN) and relative telomere length (RTL) have been described as potential biomarkers for placental insufficiency and intrauterine growth restriction (IUGR). We investigated their associations with BW in women with PM from malaria-endemic region of Papua, Indonesia. MtDNA-CN and RTL were determined in 50 placentas by quantitative real-time PCR. Increased placental mtDNA-CN was associated with reduced BW (coef = −193.71, p = 0.016), particularly in preterm group (coef = −374.21, p < 0.001). RTL did not associate with BW. Increased placental mtDNA-CN indicates a compensatory mechanism to reduced BW in women with PM. Relative telomere length Elsevier Birth weight Elsevier Placental malaria Elsevier mtDNA copy number Elsevier Fauzi, Muhammad oth Trianty, Leily oth Trimarsanto, Hidayat oth Bowolaksono, Anom oth Noviyanti, Rintis oth Malik, Safarina G. oth Enthalten in Elsevier Luukkonen, P. ELSEVIER O045 : Bioactive lipids in the human liver in ‘Common NAFLD’ and ‘PNPLA3 NAFLD’ 2015 Amsterdam [u.a.] (DE-627)ELV012874620 volume:80 year:2019 pages:1-3 extent:3 https://doi.org/10.1016/j.placenta.2019.03.005 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.44 Parasitologie Medizin VZ AR 80 2019 1-3 3 |
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10.1016/j.placenta.2019.03.005 doi GBV00000000000622.pica (DE-627)ELV046779574 (ELSEVIER)S0143-4004(19)30051-7 DE-627 ger DE-627 rakwb eng 610 VZ 610 VZ 44.44 bkl Oktavianthi, Sukma verfasserin aut Placental mitochondrial DNA copy number is associated with reduced birth weight in women with placental malaria 2019transfer abstract 3 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Placental malaria (PM) causes placental insufficiency, leading to reduced birth weight (BW). Placental mtDNA copy number (mtDNA-CN) and relative telomere length (RTL) have been described as potential biomarkers for placental insufficiency and intrauterine growth restriction (IUGR). We investigated their associations with BW in women with PM from malaria-endemic region of Papua, Indonesia. MtDNA-CN and RTL were determined in 50 placentas by quantitative real-time PCR. Increased placental mtDNA-CN was associated with reduced BW (coef = −193.71, p = 0.016), particularly in preterm group (coef = −374.21, p < 0.001). RTL did not associate with BW. Increased placental mtDNA-CN indicates a compensatory mechanism to reduced BW in women with PM. Placental malaria (PM) causes placental insufficiency, leading to reduced birth weight (BW). Placental mtDNA copy number (mtDNA-CN) and relative telomere length (RTL) have been described as potential biomarkers for placental insufficiency and intrauterine growth restriction (IUGR). We investigated their associations with BW in women with PM from malaria-endemic region of Papua, Indonesia. MtDNA-CN and RTL were determined in 50 placentas by quantitative real-time PCR. Increased placental mtDNA-CN was associated with reduced BW (coef = −193.71, p = 0.016), particularly in preterm group (coef = −374.21, p < 0.001). RTL did not associate with BW. Increased placental mtDNA-CN indicates a compensatory mechanism to reduced BW in women with PM. Relative telomere length Elsevier Birth weight Elsevier Placental malaria Elsevier mtDNA copy number Elsevier Fauzi, Muhammad oth Trianty, Leily oth Trimarsanto, Hidayat oth Bowolaksono, Anom oth Noviyanti, Rintis oth Malik, Safarina G. oth Enthalten in Elsevier Luukkonen, P. ELSEVIER O045 : Bioactive lipids in the human liver in ‘Common NAFLD’ and ‘PNPLA3 NAFLD’ 2015 Amsterdam [u.a.] (DE-627)ELV012874620 volume:80 year:2019 pages:1-3 extent:3 https://doi.org/10.1016/j.placenta.2019.03.005 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.44 Parasitologie Medizin VZ AR 80 2019 1-3 3 |
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10.1016/j.placenta.2019.03.005 doi GBV00000000000622.pica (DE-627)ELV046779574 (ELSEVIER)S0143-4004(19)30051-7 DE-627 ger DE-627 rakwb eng 610 VZ 610 VZ 44.44 bkl Oktavianthi, Sukma verfasserin aut Placental mitochondrial DNA copy number is associated with reduced birth weight in women with placental malaria 2019transfer abstract 3 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Placental malaria (PM) causes placental insufficiency, leading to reduced birth weight (BW). Placental mtDNA copy number (mtDNA-CN) and relative telomere length (RTL) have been described as potential biomarkers for placental insufficiency and intrauterine growth restriction (IUGR). We investigated their associations with BW in women with PM from malaria-endemic region of Papua, Indonesia. MtDNA-CN and RTL were determined in 50 placentas by quantitative real-time PCR. Increased placental mtDNA-CN was associated with reduced BW (coef = −193.71, p = 0.016), particularly in preterm group (coef = −374.21, p < 0.001). RTL did not associate with BW. Increased placental mtDNA-CN indicates a compensatory mechanism to reduced BW in women with PM. Placental malaria (PM) causes placental insufficiency, leading to reduced birth weight (BW). Placental mtDNA copy number (mtDNA-CN) and relative telomere length (RTL) have been described as potential biomarkers for placental insufficiency and intrauterine growth restriction (IUGR). We investigated their associations with BW in women with PM from malaria-endemic region of Papua, Indonesia. MtDNA-CN and RTL were determined in 50 placentas by quantitative real-time PCR. Increased placental mtDNA-CN was associated with reduced BW (coef = −193.71, p = 0.016), particularly in preterm group (coef = −374.21, p < 0.001). RTL did not associate with BW. Increased placental mtDNA-CN indicates a compensatory mechanism to reduced BW in women with PM. Relative telomere length Elsevier Birth weight Elsevier Placental malaria Elsevier mtDNA copy number Elsevier Fauzi, Muhammad oth Trianty, Leily oth Trimarsanto, Hidayat oth Bowolaksono, Anom oth Noviyanti, Rintis oth Malik, Safarina G. oth Enthalten in Elsevier Luukkonen, P. ELSEVIER O045 : Bioactive lipids in the human liver in ‘Common NAFLD’ and ‘PNPLA3 NAFLD’ 2015 Amsterdam [u.a.] (DE-627)ELV012874620 volume:80 year:2019 pages:1-3 extent:3 https://doi.org/10.1016/j.placenta.2019.03.005 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.44 Parasitologie Medizin VZ AR 80 2019 1-3 3 |
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| author |
Oktavianthi, Sukma |
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Oktavianthi, Sukma ddc 610 bkl 44.44 Elsevier Relative telomere length Elsevier Birth weight Elsevier Placental malaria Elsevier mtDNA copy number Placental mitochondrial DNA copy number is associated with reduced birth weight in women with placental malaria |
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610 VZ 44.44 bkl Placental mitochondrial DNA copy number is associated with reduced birth weight in women with placental malaria Relative telomere length Elsevier Birth weight Elsevier Placental malaria Elsevier mtDNA copy number Elsevier |
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Placental mitochondrial DNA copy number is associated with reduced birth weight in women with placental malaria |
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Placental mitochondrial DNA copy number is associated with reduced birth weight in women with placental malaria |
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O045 : Bioactive lipids in the human liver in ‘Common NAFLD’ and ‘PNPLA3 NAFLD’ |
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placental mitochondrial dna copy number is associated with reduced birth weight in women with placental malaria |
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Placental mitochondrial DNA copy number is associated with reduced birth weight in women with placental malaria |
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Placental malaria (PM) causes placental insufficiency, leading to reduced birth weight (BW). Placental mtDNA copy number (mtDNA-CN) and relative telomere length (RTL) have been described as potential biomarkers for placental insufficiency and intrauterine growth restriction (IUGR). We investigated their associations with BW in women with PM from malaria-endemic region of Papua, Indonesia. MtDNA-CN and RTL were determined in 50 placentas by quantitative real-time PCR. Increased placental mtDNA-CN was associated with reduced BW (coef = −193.71, p = 0.016), particularly in preterm group (coef = −374.21, p < 0.001). RTL did not associate with BW. Increased placental mtDNA-CN indicates a compensatory mechanism to reduced BW in women with PM. |
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Placental malaria (PM) causes placental insufficiency, leading to reduced birth weight (BW). Placental mtDNA copy number (mtDNA-CN) and relative telomere length (RTL) have been described as potential biomarkers for placental insufficiency and intrauterine growth restriction (IUGR). We investigated their associations with BW in women with PM from malaria-endemic region of Papua, Indonesia. MtDNA-CN and RTL were determined in 50 placentas by quantitative real-time PCR. Increased placental mtDNA-CN was associated with reduced BW (coef = −193.71, p = 0.016), particularly in preterm group (coef = −374.21, p < 0.001). RTL did not associate with BW. Increased placental mtDNA-CN indicates a compensatory mechanism to reduced BW in women with PM. |
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Placental malaria (PM) causes placental insufficiency, leading to reduced birth weight (BW). Placental mtDNA copy number (mtDNA-CN) and relative telomere length (RTL) have been described as potential biomarkers for placental insufficiency and intrauterine growth restriction (IUGR). We investigated their associations with BW in women with PM from malaria-endemic region of Papua, Indonesia. MtDNA-CN and RTL were determined in 50 placentas by quantitative real-time PCR. Increased placental mtDNA-CN was associated with reduced BW (coef = −193.71, p = 0.016), particularly in preterm group (coef = −374.21, p < 0.001). RTL did not associate with BW. Increased placental mtDNA-CN indicates a compensatory mechanism to reduced BW in women with PM. |
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Placental mitochondrial DNA copy number is associated with reduced birth weight in women with placental malaria |
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Fauzi, Muhammad Trianty, Leily Trimarsanto, Hidayat Bowolaksono, Anom Noviyanti, Rintis Malik, Safarina G. |
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