USP8 ameliorates cognitive and motor impairments via microglial inhibition in a mouse model of sepsis-associated encephalopathy
• Ubiquitin-specific protease 8 (USP8) regulates inflammation. • Cecal ligation and puncture (CLP) is a model of sepsis-associated encephalopathy. • We improved the CLP model and demonstrate a reduced mortality rate. • USP8 is protective against CLP-induced neuroinflammation. • USP8 is protective ag...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Bi, Wei [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2019 |
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| Schlagwörter: |
Sepsis-associated encephalopathy (SAE) Cecal ligation and puncture (CLP) |
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| Umfang: |
9 |
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| Übergeordnetes Werk: |
Enthalten in: DNA methylation mediates gonadal development via regulating the expression levels of - Su, Junxiao ELSEVIER, 2023, an international multidisciplinary journal devoted to fundamental research in the brain sciences, Amsterdam |
|---|---|
| Übergeordnetes Werk: |
volume:1719 ; year:2019 ; day:15 ; month:09 ; pages:40-48 ; extent:9 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.brainres.2019.05.009 |
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| 520 | |a • Ubiquitin-specific protease 8 (USP8) regulates inflammation. • Cecal ligation and puncture (CLP) is a model of sepsis-associated encephalopathy. • We improved the CLP model and demonstrate a reduced mortality rate. • USP8 is protective against CLP-induced neuroinflammation. • USP8 is protective against CLP-induced cognitive and motor impairments. | ||
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10.1016/j.brainres.2019.05.009 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000815.pica (DE-627)ELV047327235 (ELSEVIER)S0006-8993(19)30258-6 DE-627 ger DE-627 rakwb eng 540 570 VZ BIODIV DE-30 fid 35.80 bkl 58.30 bkl Bi, Wei verfasserin aut USP8 ameliorates cognitive and motor impairments via microglial inhibition in a mouse model of sepsis-associated encephalopathy 2019 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • Ubiquitin-specific protease 8 (USP8) regulates inflammation. • Cecal ligation and puncture (CLP) is a model of sepsis-associated encephalopathy. • We improved the CLP model and demonstrate a reduced mortality rate. • USP8 is protective against CLP-induced neuroinflammation. • USP8 is protective against CLP-induced cognitive and motor impairments. Sepsis-associated encephalopathy (SAE) Elsevier Cecal ligation and puncture (CLP) Elsevier Ubiquitin-specific protease 8 (USP8) Elsevier Neuroinflammation Elsevier Motor impairment Elsevier Cognitive impairment Elsevier Lan, Xin oth Zhang, JiaWei oth Xiao, Shu oth Cheng, XiaoFeng oth Wang, HuaDong oth Lu, DaXiang oth Zhu, Lihong oth Enthalten in Elsevier Su, Junxiao ELSEVIER DNA methylation mediates gonadal development via regulating the expression levels of 2023 an international multidisciplinary journal devoted to fundamental research in the brain sciences Amsterdam (DE-627)ELV010071113 volume:1719 year:2019 day:15 month:09 pages:40-48 extent:9 https://doi.org/10.1016/j.brainres.2019.05.009 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA 35.80 Makromolekulare Chemie VZ 58.30 Biotechnologie VZ AR 1719 2019 15 0915 40-48 9 |
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marc |
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2019 |
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zzz |
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| author_browse |
Bi, Wei |
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1719 |
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9 |
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Elektronische Aufsätze |
| author-letter |
Bi, Wei |
| doi_str_mv |
10.1016/j.brainres.2019.05.009 |
| dewey-full |
540 570 |
| title_sort |
usp8 ameliorates cognitive and motor impairments via microglial inhibition in a mouse model of sepsis-associated encephalopathy |
| title_auth |
USP8 ameliorates cognitive and motor impairments via microglial inhibition in a mouse model of sepsis-associated encephalopathy |
| abstract |
• Ubiquitin-specific protease 8 (USP8) regulates inflammation. • Cecal ligation and puncture (CLP) is a model of sepsis-associated encephalopathy. • We improved the CLP model and demonstrate a reduced mortality rate. • USP8 is protective against CLP-induced neuroinflammation. • USP8 is protective against CLP-induced cognitive and motor impairments. |
| abstractGer |
• Ubiquitin-specific protease 8 (USP8) regulates inflammation. • Cecal ligation and puncture (CLP) is a model of sepsis-associated encephalopathy. • We improved the CLP model and demonstrate a reduced mortality rate. • USP8 is protective against CLP-induced neuroinflammation. • USP8 is protective against CLP-induced cognitive and motor impairments. |
| abstract_unstemmed |
• Ubiquitin-specific protease 8 (USP8) regulates inflammation. • Cecal ligation and puncture (CLP) is a model of sepsis-associated encephalopathy. • We improved the CLP model and demonstrate a reduced mortality rate. • USP8 is protective against CLP-induced neuroinflammation. • USP8 is protective against CLP-induced cognitive and motor impairments. |
| collection_details |
GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA |
| title_short |
USP8 ameliorates cognitive and motor impairments via microglial inhibition in a mouse model of sepsis-associated encephalopathy |
| url |
https://doi.org/10.1016/j.brainres.2019.05.009 |
| remote_bool |
true |
| author2 |
Lan, Xin Zhang, JiaWei Xiao, Shu Cheng, XiaoFeng Wang, HuaDong Lu, DaXiang Zhu, Lihong |
| author2Str |
Lan, Xin Zhang, JiaWei Xiao, Shu Cheng, XiaoFeng Wang, HuaDong Lu, DaXiang Zhu, Lihong |
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ELV010071113 |
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| doi_str |
10.1016/j.brainres.2019.05.009 |
| up_date |
2024-07-06T22:35:43.298Z |
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1803870895655092224 |
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