Efficient and easy synthesis of new Benzo[h]chromene and Benzo[h]quinoline derivatives as a new class of cytotoxic agents
The present study presents easy and rapid methods to synthesize new benzo[h]chromene and benzo[h] quinoline derivatives. Cytotoxic evaluations of most of the examined compounds indicated that they had significant cytotoxic activities against HepG-2 (human cancer cells) and MCF-7 (breast cancer cells...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Haiba, Mogedda E. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2019transfer abstract |
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| Umfang: |
10 |
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| Übergeordnetes Werk: |
Enthalten in: Artificial neural network modelling of amido black dye sorption on iron composite nano material: Kinetics and thermodynamics studies - Ali, Imran ELSEVIER, 2017, New York, NY [u.a.] |
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| Übergeordnetes Werk: |
volume:1195 ; year:2019 ; day:5 ; month:11 ; pages:702-711 ; extent:10 |
| Links: |
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| DOI / URN: |
10.1016/j.molstruc.2019.05.081 |
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| 520 | |a The present study presents easy and rapid methods to synthesize new benzo[h]chromene and benzo[h] quinoline derivatives. Cytotoxic evaluations of most of the examined compounds indicated that they had significant cytotoxic activities against HepG-2 (human cancer cells) and MCF-7 (breast cancer cells). Compounds 4 and 11 had stronger cytotoxic activity against HepG-2 human cancer cells than the reference drug Doxorubicin. All the examined compounds were significantly active against MCF-7 human cancer cells and were more potent than Doxorubicin. The structures of the new compounds were established from their spectral and elemental data. In addition the structures of benzo[h] chromene 3 and benzo[h]quinoline 7 were recognized by x-ray crystallography. Herein detailed syntheses, spectroscopic information and biological actions of the tested compounds are reported. | ||
| 520 | |a The present study presents easy and rapid methods to synthesize new benzo[h]chromene and benzo[h] quinoline derivatives. Cytotoxic evaluations of most of the examined compounds indicated that they had significant cytotoxic activities against HepG-2 (human cancer cells) and MCF-7 (breast cancer cells). Compounds 4 and 11 had stronger cytotoxic activity against HepG-2 human cancer cells than the reference drug Doxorubicin. All the examined compounds were significantly active against MCF-7 human cancer cells and were more potent than Doxorubicin. The structures of the new compounds were established from their spectral and elemental data. In addition the structures of benzo[h] chromene 3 and benzo[h]quinoline 7 were recognized by x-ray crystallography. Herein detailed syntheses, spectroscopic information and biological actions of the tested compounds are reported. | ||
| 650 | 7 | |a X-ray crystallography |2 Elsevier | |
| 650 | 7 | |a Benzo[h]chromene |2 Elsevier | |
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| 700 | 1 | |a Al-Abdullah, Ebtehal S. |4 oth | |
| 700 | 1 | |a Ahmed, Nesreen S. |4 oth | |
| 700 | 1 | |a Ghabbour, Hazem A. |4 oth | |
| 700 | 1 | |a Awad, Hanem M. |4 oth | |
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10.1016/j.molstruc.2019.05.081 doi GBV00000000000685.pica (DE-627)ELV047335637 (ELSEVIER)S0022-2860(19)30651-9 DE-627 ger DE-627 rakwb eng 540 VZ 35.21 bkl Haiba, Mogedda E. verfasserin aut Efficient and easy synthesis of new Benzo[h]chromene and Benzo[h]quinoline derivatives as a new class of cytotoxic agents 2019transfer abstract 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The present study presents easy and rapid methods to synthesize new benzo[h]chromene and benzo[h] quinoline derivatives. Cytotoxic evaluations of most of the examined compounds indicated that they had significant cytotoxic activities against HepG-2 (human cancer cells) and MCF-7 (breast cancer cells). Compounds 4 and 11 had stronger cytotoxic activity against HepG-2 human cancer cells than the reference drug Doxorubicin. All the examined compounds were significantly active against MCF-7 human cancer cells and were more potent than Doxorubicin. The structures of the new compounds were established from their spectral and elemental data. In addition the structures of benzo[h] chromene 3 and benzo[h]quinoline 7 were recognized by x-ray crystallography. Herein detailed syntheses, spectroscopic information and biological actions of the tested compounds are reported. The present study presents easy and rapid methods to synthesize new benzo[h]chromene and benzo[h] quinoline derivatives. Cytotoxic evaluations of most of the examined compounds indicated that they had significant cytotoxic activities against HepG-2 (human cancer cells) and MCF-7 (breast cancer cells). Compounds 4 and 11 had stronger cytotoxic activity against HepG-2 human cancer cells than the reference drug Doxorubicin. All the examined compounds were significantly active against MCF-7 human cancer cells and were more potent than Doxorubicin. The structures of the new compounds were established from their spectral and elemental data. In addition the structures of benzo[h] chromene 3 and benzo[h]quinoline 7 were recognized by x-ray crystallography. Herein detailed syntheses, spectroscopic information and biological actions of the tested compounds are reported. X-ray crystallography Elsevier Benzo[h]chromene Elsevier Benzo[h]quinoline Elsevier Cytotoxicity Elsevier Al-Abdullah, Ebtehal S. oth Ahmed, Nesreen S. oth Ghabbour, Hazem A. oth Awad, Hanem M. oth Enthalten in Elsevier Ali, Imran ELSEVIER Artificial neural network modelling of amido black dye sorption on iron composite nano material: Kinetics and thermodynamics studies 2017 New York, NY [u.a.] (DE-627)ELV005044758 volume:1195 year:2019 day:5 month:11 pages:702-711 extent:10 https://doi.org/10.1016/j.molstruc.2019.05.081 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 35.21 Lösungen Flüssigkeiten Physikalische Chemie VZ AR 1195 2019 5 1105 702-711 10 |
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10.1016/j.molstruc.2019.05.081 doi GBV00000000000685.pica (DE-627)ELV047335637 (ELSEVIER)S0022-2860(19)30651-9 DE-627 ger DE-627 rakwb eng 540 VZ 35.21 bkl Haiba, Mogedda E. verfasserin aut Efficient and easy synthesis of new Benzo[h]chromene and Benzo[h]quinoline derivatives as a new class of cytotoxic agents 2019transfer abstract 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The present study presents easy and rapid methods to synthesize new benzo[h]chromene and benzo[h] quinoline derivatives. Cytotoxic evaluations of most of the examined compounds indicated that they had significant cytotoxic activities against HepG-2 (human cancer cells) and MCF-7 (breast cancer cells). Compounds 4 and 11 had stronger cytotoxic activity against HepG-2 human cancer cells than the reference drug Doxorubicin. All the examined compounds were significantly active against MCF-7 human cancer cells and were more potent than Doxorubicin. The structures of the new compounds were established from their spectral and elemental data. In addition the structures of benzo[h] chromene 3 and benzo[h]quinoline 7 were recognized by x-ray crystallography. Herein detailed syntheses, spectroscopic information and biological actions of the tested compounds are reported. The present study presents easy and rapid methods to synthesize new benzo[h]chromene and benzo[h] quinoline derivatives. Cytotoxic evaluations of most of the examined compounds indicated that they had significant cytotoxic activities against HepG-2 (human cancer cells) and MCF-7 (breast cancer cells). Compounds 4 and 11 had stronger cytotoxic activity against HepG-2 human cancer cells than the reference drug Doxorubicin. All the examined compounds were significantly active against MCF-7 human cancer cells and were more potent than Doxorubicin. The structures of the new compounds were established from their spectral and elemental data. In addition the structures of benzo[h] chromene 3 and benzo[h]quinoline 7 were recognized by x-ray crystallography. Herein detailed syntheses, spectroscopic information and biological actions of the tested compounds are reported. X-ray crystallography Elsevier Benzo[h]chromene Elsevier Benzo[h]quinoline Elsevier Cytotoxicity Elsevier Al-Abdullah, Ebtehal S. oth Ahmed, Nesreen S. oth Ghabbour, Hazem A. oth Awad, Hanem M. oth Enthalten in Elsevier Ali, Imran ELSEVIER Artificial neural network modelling of amido black dye sorption on iron composite nano material: Kinetics and thermodynamics studies 2017 New York, NY [u.a.] (DE-627)ELV005044758 volume:1195 year:2019 day:5 month:11 pages:702-711 extent:10 https://doi.org/10.1016/j.molstruc.2019.05.081 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 35.21 Lösungen Flüssigkeiten Physikalische Chemie VZ AR 1195 2019 5 1105 702-711 10 |
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10.1016/j.molstruc.2019.05.081 doi GBV00000000000685.pica (DE-627)ELV047335637 (ELSEVIER)S0022-2860(19)30651-9 DE-627 ger DE-627 rakwb eng 540 VZ 35.21 bkl Haiba, Mogedda E. verfasserin aut Efficient and easy synthesis of new Benzo[h]chromene and Benzo[h]quinoline derivatives as a new class of cytotoxic agents 2019transfer abstract 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The present study presents easy and rapid methods to synthesize new benzo[h]chromene and benzo[h] quinoline derivatives. Cytotoxic evaluations of most of the examined compounds indicated that they had significant cytotoxic activities against HepG-2 (human cancer cells) and MCF-7 (breast cancer cells). Compounds 4 and 11 had stronger cytotoxic activity against HepG-2 human cancer cells than the reference drug Doxorubicin. All the examined compounds were significantly active against MCF-7 human cancer cells and were more potent than Doxorubicin. The structures of the new compounds were established from their spectral and elemental data. In addition the structures of benzo[h] chromene 3 and benzo[h]quinoline 7 were recognized by x-ray crystallography. Herein detailed syntheses, spectroscopic information and biological actions of the tested compounds are reported. The present study presents easy and rapid methods to synthesize new benzo[h]chromene and benzo[h] quinoline derivatives. Cytotoxic evaluations of most of the examined compounds indicated that they had significant cytotoxic activities against HepG-2 (human cancer cells) and MCF-7 (breast cancer cells). Compounds 4 and 11 had stronger cytotoxic activity against HepG-2 human cancer cells than the reference drug Doxorubicin. All the examined compounds were significantly active against MCF-7 human cancer cells and were more potent than Doxorubicin. The structures of the new compounds were established from their spectral and elemental data. In addition the structures of benzo[h] chromene 3 and benzo[h]quinoline 7 were recognized by x-ray crystallography. Herein detailed syntheses, spectroscopic information and biological actions of the tested compounds are reported. X-ray crystallography Elsevier Benzo[h]chromene Elsevier Benzo[h]quinoline Elsevier Cytotoxicity Elsevier Al-Abdullah, Ebtehal S. oth Ahmed, Nesreen S. oth Ghabbour, Hazem A. oth Awad, Hanem M. oth Enthalten in Elsevier Ali, Imran ELSEVIER Artificial neural network modelling of amido black dye sorption on iron composite nano material: Kinetics and thermodynamics studies 2017 New York, NY [u.a.] (DE-627)ELV005044758 volume:1195 year:2019 day:5 month:11 pages:702-711 extent:10 https://doi.org/10.1016/j.molstruc.2019.05.081 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 35.21 Lösungen Flüssigkeiten Physikalische Chemie VZ AR 1195 2019 5 1105 702-711 10 |
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10.1016/j.molstruc.2019.05.081 doi GBV00000000000685.pica (DE-627)ELV047335637 (ELSEVIER)S0022-2860(19)30651-9 DE-627 ger DE-627 rakwb eng 540 VZ 35.21 bkl Haiba, Mogedda E. verfasserin aut Efficient and easy synthesis of new Benzo[h]chromene and Benzo[h]quinoline derivatives as a new class of cytotoxic agents 2019transfer abstract 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The present study presents easy and rapid methods to synthesize new benzo[h]chromene and benzo[h] quinoline derivatives. Cytotoxic evaluations of most of the examined compounds indicated that they had significant cytotoxic activities against HepG-2 (human cancer cells) and MCF-7 (breast cancer cells). Compounds 4 and 11 had stronger cytotoxic activity against HepG-2 human cancer cells than the reference drug Doxorubicin. All the examined compounds were significantly active against MCF-7 human cancer cells and were more potent than Doxorubicin. The structures of the new compounds were established from their spectral and elemental data. In addition the structures of benzo[h] chromene 3 and benzo[h]quinoline 7 were recognized by x-ray crystallography. Herein detailed syntheses, spectroscopic information and biological actions of the tested compounds are reported. The present study presents easy and rapid methods to synthesize new benzo[h]chromene and benzo[h] quinoline derivatives. Cytotoxic evaluations of most of the examined compounds indicated that they had significant cytotoxic activities against HepG-2 (human cancer cells) and MCF-7 (breast cancer cells). Compounds 4 and 11 had stronger cytotoxic activity against HepG-2 human cancer cells than the reference drug Doxorubicin. All the examined compounds were significantly active against MCF-7 human cancer cells and were more potent than Doxorubicin. The structures of the new compounds were established from their spectral and elemental data. In addition the structures of benzo[h] chromene 3 and benzo[h]quinoline 7 were recognized by x-ray crystallography. Herein detailed syntheses, spectroscopic information and biological actions of the tested compounds are reported. X-ray crystallography Elsevier Benzo[h]chromene Elsevier Benzo[h]quinoline Elsevier Cytotoxicity Elsevier Al-Abdullah, Ebtehal S. oth Ahmed, Nesreen S. oth Ghabbour, Hazem A. oth Awad, Hanem M. oth Enthalten in Elsevier Ali, Imran ELSEVIER Artificial neural network modelling of amido black dye sorption on iron composite nano material: Kinetics and thermodynamics studies 2017 New York, NY [u.a.] (DE-627)ELV005044758 volume:1195 year:2019 day:5 month:11 pages:702-711 extent:10 https://doi.org/10.1016/j.molstruc.2019.05.081 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 35.21 Lösungen Flüssigkeiten Physikalische Chemie VZ AR 1195 2019 5 1105 702-711 10 |
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10.1016/j.molstruc.2019.05.081 doi GBV00000000000685.pica (DE-627)ELV047335637 (ELSEVIER)S0022-2860(19)30651-9 DE-627 ger DE-627 rakwb eng 540 VZ 35.21 bkl Haiba, Mogedda E. verfasserin aut Efficient and easy synthesis of new Benzo[h]chromene and Benzo[h]quinoline derivatives as a new class of cytotoxic agents 2019transfer abstract 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The present study presents easy and rapid methods to synthesize new benzo[h]chromene and benzo[h] quinoline derivatives. Cytotoxic evaluations of most of the examined compounds indicated that they had significant cytotoxic activities against HepG-2 (human cancer cells) and MCF-7 (breast cancer cells). Compounds 4 and 11 had stronger cytotoxic activity against HepG-2 human cancer cells than the reference drug Doxorubicin. All the examined compounds were significantly active against MCF-7 human cancer cells and were more potent than Doxorubicin. The structures of the new compounds were established from their spectral and elemental data. In addition the structures of benzo[h] chromene 3 and benzo[h]quinoline 7 were recognized by x-ray crystallography. Herein detailed syntheses, spectroscopic information and biological actions of the tested compounds are reported. The present study presents easy and rapid methods to synthesize new benzo[h]chromene and benzo[h] quinoline derivatives. Cytotoxic evaluations of most of the examined compounds indicated that they had significant cytotoxic activities against HepG-2 (human cancer cells) and MCF-7 (breast cancer cells). Compounds 4 and 11 had stronger cytotoxic activity against HepG-2 human cancer cells than the reference drug Doxorubicin. All the examined compounds were significantly active against MCF-7 human cancer cells and were more potent than Doxorubicin. The structures of the new compounds were established from their spectral and elemental data. In addition the structures of benzo[h] chromene 3 and benzo[h]quinoline 7 were recognized by x-ray crystallography. Herein detailed syntheses, spectroscopic information and biological actions of the tested compounds are reported. X-ray crystallography Elsevier Benzo[h]chromene Elsevier Benzo[h]quinoline Elsevier Cytotoxicity Elsevier Al-Abdullah, Ebtehal S. oth Ahmed, Nesreen S. oth Ghabbour, Hazem A. oth Awad, Hanem M. oth Enthalten in Elsevier Ali, Imran ELSEVIER Artificial neural network modelling of amido black dye sorption on iron composite nano material: Kinetics and thermodynamics studies 2017 New York, NY [u.a.] (DE-627)ELV005044758 volume:1195 year:2019 day:5 month:11 pages:702-711 extent:10 https://doi.org/10.1016/j.molstruc.2019.05.081 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 35.21 Lösungen Flüssigkeiten Physikalische Chemie VZ AR 1195 2019 5 1105 702-711 10 |
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English |
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Enthalten in Artificial neural network modelling of amido black dye sorption on iron composite nano material: Kinetics and thermodynamics studies New York, NY [u.a.] volume:1195 year:2019 day:5 month:11 pages:702-711 extent:10 |
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Enthalten in Artificial neural network modelling of amido black dye sorption on iron composite nano material: Kinetics and thermodynamics studies New York, NY [u.a.] volume:1195 year:2019 day:5 month:11 pages:702-711 extent:10 |
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Artificial neural network modelling of amido black dye sorption on iron composite nano material: Kinetics and thermodynamics studies |
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Efficient and easy synthesis of new Benzo[h]chromene and Benzo[h]quinoline derivatives as a new class of cytotoxic agents |
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The present study presents easy and rapid methods to synthesize new benzo[h]chromene and benzo[h] quinoline derivatives. Cytotoxic evaluations of most of the examined compounds indicated that they had significant cytotoxic activities against HepG-2 (human cancer cells) and MCF-7 (breast cancer cells). Compounds 4 and 11 had stronger cytotoxic activity against HepG-2 human cancer cells than the reference drug Doxorubicin. All the examined compounds were significantly active against MCF-7 human cancer cells and were more potent than Doxorubicin. The structures of the new compounds were established from their spectral and elemental data. In addition the structures of benzo[h] chromene 3 and benzo[h]quinoline 7 were recognized by x-ray crystallography. Herein detailed syntheses, spectroscopic information and biological actions of the tested compounds are reported. |
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The present study presents easy and rapid methods to synthesize new benzo[h]chromene and benzo[h] quinoline derivatives. Cytotoxic evaluations of most of the examined compounds indicated that they had significant cytotoxic activities against HepG-2 (human cancer cells) and MCF-7 (breast cancer cells). Compounds 4 and 11 had stronger cytotoxic activity against HepG-2 human cancer cells than the reference drug Doxorubicin. All the examined compounds were significantly active against MCF-7 human cancer cells and were more potent than Doxorubicin. The structures of the new compounds were established from their spectral and elemental data. In addition the structures of benzo[h] chromene 3 and benzo[h]quinoline 7 were recognized by x-ray crystallography. Herein detailed syntheses, spectroscopic information and biological actions of the tested compounds are reported. |
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The present study presents easy and rapid methods to synthesize new benzo[h]chromene and benzo[h] quinoline derivatives. Cytotoxic evaluations of most of the examined compounds indicated that they had significant cytotoxic activities against HepG-2 (human cancer cells) and MCF-7 (breast cancer cells). Compounds 4 and 11 had stronger cytotoxic activity against HepG-2 human cancer cells than the reference drug Doxorubicin. All the examined compounds were significantly active against MCF-7 human cancer cells and were more potent than Doxorubicin. The structures of the new compounds were established from their spectral and elemental data. In addition the structures of benzo[h] chromene 3 and benzo[h]quinoline 7 were recognized by x-ray crystallography. Herein detailed syntheses, spectroscopic information and biological actions of the tested compounds are reported. |
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