Function and Evolution of Upstream ORFs in Eukaryotes
There is growing interest in the role of translational regulation in cellular homeostasis during organismal development. Translation initiation is the rate-limiting step in mRNA translation and is central to translational regulation. Upstream open reading frames (uORFs) are regulatory elements that...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Zhang, Hong [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2019transfer abstract |
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| Umfang: |
13 |
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| Übergeordnetes Werk: |
Enthalten in: Prognostic value of preoperative FDG-PET in stage IA lung adenocarcinoma - 2012, TIBS, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:44 ; year:2019 ; number:9 ; pages:782-794 ; extent:13 |
| Links: |
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| DOI / URN: |
10.1016/j.tibs.2019.03.002 |
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| 520 | |a There is growing interest in the role of translational regulation in cellular homeostasis during organismal development. Translation initiation is the rate-limiting step in mRNA translation and is central to translational regulation. Upstream open reading frames (uORFs) are regulatory elements that are prevalent in eukaryotic mRNAs. uORFs modulate the translation initiation rate of downstream coding sequences (CDSs) by sequestering ribosomes. Over the past several years, genome-wide studies have revealed the widespread regulatory functions of uORFs in different species in different biological contexts. Here, we review the current understanding of uORF-mediated translational regulation from the perspective of functional and evolutionary genomics and address remaining gaps that deserve further study. | ||
| 520 | |a There is growing interest in the role of translational regulation in cellular homeostasis during organismal development. Translation initiation is the rate-limiting step in mRNA translation and is central to translational regulation. Upstream open reading frames (uORFs) are regulatory elements that are prevalent in eukaryotic mRNAs. uORFs modulate the translation initiation rate of downstream coding sequences (CDSs) by sequestering ribosomes. Over the past several years, genome-wide studies have revealed the widespread regulatory functions of uORFs in different species in different biological contexts. Here, we review the current understanding of uORF-mediated translational regulation from the perspective of functional and evolutionary genomics and address remaining gaps that deserve further study. | ||
| 700 | 1 | |a Wang, Yirong |4 oth | |
| 700 | 1 | |a Lu, Jian |4 oth | |
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10.1016/j.tibs.2019.03.002 doi GBV00000000000719.pica (DE-627)ELV04760476X (ELSEVIER)S0968-0004(19)30055-6 DE-627 ger DE-627 rakwb eng 610 VZ 570 630 VZ BIODIV DE-30 fid 58.34 bkl 48.59 bkl Zhang, Hong verfasserin aut Function and Evolution of Upstream ORFs in Eukaryotes 2019transfer abstract 13 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier There is growing interest in the role of translational regulation in cellular homeostasis during organismal development. Translation initiation is the rate-limiting step in mRNA translation and is central to translational regulation. Upstream open reading frames (uORFs) are regulatory elements that are prevalent in eukaryotic mRNAs. uORFs modulate the translation initiation rate of downstream coding sequences (CDSs) by sequestering ribosomes. Over the past several years, genome-wide studies have revealed the widespread regulatory functions of uORFs in different species in different biological contexts. Here, we review the current understanding of uORF-mediated translational regulation from the perspective of functional and evolutionary genomics and address remaining gaps that deserve further study. There is growing interest in the role of translational regulation in cellular homeostasis during organismal development. Translation initiation is the rate-limiting step in mRNA translation and is central to translational regulation. Upstream open reading frames (uORFs) are regulatory elements that are prevalent in eukaryotic mRNAs. uORFs modulate the translation initiation rate of downstream coding sequences (CDSs) by sequestering ribosomes. Over the past several years, genome-wide studies have revealed the widespread regulatory functions of uORFs in different species in different biological contexts. Here, we review the current understanding of uORF-mediated translational regulation from the perspective of functional and evolutionary genomics and address remaining gaps that deserve further study. Wang, Yirong oth Lu, Jian oth Enthalten in Elsevier Science Prognostic value of preoperative FDG-PET in stage IA lung adenocarcinoma 2012 TIBS Amsterdam [u.a.] (DE-627)ELV016243919 volume:44 year:2019 number:9 pages:782-794 extent:13 https://doi.org/10.1016/j.tibs.2019.03.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_40 GBV_ILN_61 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_92 GBV_ILN_120 GBV_ILN_188 GBV_ILN_285 58.34 Lebensmitteltechnologie VZ 48.59 Pflanzenproduktion: Sonstiges VZ AR 44 2019 9 782-794 13 |
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10.1016/j.tibs.2019.03.002 doi GBV00000000000719.pica (DE-627)ELV04760476X (ELSEVIER)S0968-0004(19)30055-6 DE-627 ger DE-627 rakwb eng 610 VZ 570 630 VZ BIODIV DE-30 fid 58.34 bkl 48.59 bkl Zhang, Hong verfasserin aut Function and Evolution of Upstream ORFs in Eukaryotes 2019transfer abstract 13 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier There is growing interest in the role of translational regulation in cellular homeostasis during organismal development. Translation initiation is the rate-limiting step in mRNA translation and is central to translational regulation. Upstream open reading frames (uORFs) are regulatory elements that are prevalent in eukaryotic mRNAs. uORFs modulate the translation initiation rate of downstream coding sequences (CDSs) by sequestering ribosomes. Over the past several years, genome-wide studies have revealed the widespread regulatory functions of uORFs in different species in different biological contexts. Here, we review the current understanding of uORF-mediated translational regulation from the perspective of functional and evolutionary genomics and address remaining gaps that deserve further study. There is growing interest in the role of translational regulation in cellular homeostasis during organismal development. Translation initiation is the rate-limiting step in mRNA translation and is central to translational regulation. Upstream open reading frames (uORFs) are regulatory elements that are prevalent in eukaryotic mRNAs. uORFs modulate the translation initiation rate of downstream coding sequences (CDSs) by sequestering ribosomes. Over the past several years, genome-wide studies have revealed the widespread regulatory functions of uORFs in different species in different biological contexts. Here, we review the current understanding of uORF-mediated translational regulation from the perspective of functional and evolutionary genomics and address remaining gaps that deserve further study. Wang, Yirong oth Lu, Jian oth Enthalten in Elsevier Science Prognostic value of preoperative FDG-PET in stage IA lung adenocarcinoma 2012 TIBS Amsterdam [u.a.] (DE-627)ELV016243919 volume:44 year:2019 number:9 pages:782-794 extent:13 https://doi.org/10.1016/j.tibs.2019.03.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_40 GBV_ILN_61 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_92 GBV_ILN_120 GBV_ILN_188 GBV_ILN_285 58.34 Lebensmitteltechnologie VZ 48.59 Pflanzenproduktion: Sonstiges VZ AR 44 2019 9 782-794 13 |
| allfields_unstemmed |
10.1016/j.tibs.2019.03.002 doi GBV00000000000719.pica (DE-627)ELV04760476X (ELSEVIER)S0968-0004(19)30055-6 DE-627 ger DE-627 rakwb eng 610 VZ 570 630 VZ BIODIV DE-30 fid 58.34 bkl 48.59 bkl Zhang, Hong verfasserin aut Function and Evolution of Upstream ORFs in Eukaryotes 2019transfer abstract 13 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier There is growing interest in the role of translational regulation in cellular homeostasis during organismal development. Translation initiation is the rate-limiting step in mRNA translation and is central to translational regulation. Upstream open reading frames (uORFs) are regulatory elements that are prevalent in eukaryotic mRNAs. uORFs modulate the translation initiation rate of downstream coding sequences (CDSs) by sequestering ribosomes. Over the past several years, genome-wide studies have revealed the widespread regulatory functions of uORFs in different species in different biological contexts. Here, we review the current understanding of uORF-mediated translational regulation from the perspective of functional and evolutionary genomics and address remaining gaps that deserve further study. There is growing interest in the role of translational regulation in cellular homeostasis during organismal development. Translation initiation is the rate-limiting step in mRNA translation and is central to translational regulation. Upstream open reading frames (uORFs) are regulatory elements that are prevalent in eukaryotic mRNAs. uORFs modulate the translation initiation rate of downstream coding sequences (CDSs) by sequestering ribosomes. Over the past several years, genome-wide studies have revealed the widespread regulatory functions of uORFs in different species in different biological contexts. Here, we review the current understanding of uORF-mediated translational regulation from the perspective of functional and evolutionary genomics and address remaining gaps that deserve further study. Wang, Yirong oth Lu, Jian oth Enthalten in Elsevier Science Prognostic value of preoperative FDG-PET in stage IA lung adenocarcinoma 2012 TIBS Amsterdam [u.a.] (DE-627)ELV016243919 volume:44 year:2019 number:9 pages:782-794 extent:13 https://doi.org/10.1016/j.tibs.2019.03.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_40 GBV_ILN_61 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_92 GBV_ILN_120 GBV_ILN_188 GBV_ILN_285 58.34 Lebensmitteltechnologie VZ 48.59 Pflanzenproduktion: Sonstiges VZ AR 44 2019 9 782-794 13 |
| allfieldsGer |
10.1016/j.tibs.2019.03.002 doi GBV00000000000719.pica (DE-627)ELV04760476X (ELSEVIER)S0968-0004(19)30055-6 DE-627 ger DE-627 rakwb eng 610 VZ 570 630 VZ BIODIV DE-30 fid 58.34 bkl 48.59 bkl Zhang, Hong verfasserin aut Function and Evolution of Upstream ORFs in Eukaryotes 2019transfer abstract 13 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier There is growing interest in the role of translational regulation in cellular homeostasis during organismal development. Translation initiation is the rate-limiting step in mRNA translation and is central to translational regulation. Upstream open reading frames (uORFs) are regulatory elements that are prevalent in eukaryotic mRNAs. uORFs modulate the translation initiation rate of downstream coding sequences (CDSs) by sequestering ribosomes. Over the past several years, genome-wide studies have revealed the widespread regulatory functions of uORFs in different species in different biological contexts. Here, we review the current understanding of uORF-mediated translational regulation from the perspective of functional and evolutionary genomics and address remaining gaps that deserve further study. There is growing interest in the role of translational regulation in cellular homeostasis during organismal development. Translation initiation is the rate-limiting step in mRNA translation and is central to translational regulation. Upstream open reading frames (uORFs) are regulatory elements that are prevalent in eukaryotic mRNAs. uORFs modulate the translation initiation rate of downstream coding sequences (CDSs) by sequestering ribosomes. Over the past several years, genome-wide studies have revealed the widespread regulatory functions of uORFs in different species in different biological contexts. Here, we review the current understanding of uORF-mediated translational regulation from the perspective of functional and evolutionary genomics and address remaining gaps that deserve further study. Wang, Yirong oth Lu, Jian oth Enthalten in Elsevier Science Prognostic value of preoperative FDG-PET in stage IA lung adenocarcinoma 2012 TIBS Amsterdam [u.a.] (DE-627)ELV016243919 volume:44 year:2019 number:9 pages:782-794 extent:13 https://doi.org/10.1016/j.tibs.2019.03.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_40 GBV_ILN_61 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_92 GBV_ILN_120 GBV_ILN_188 GBV_ILN_285 58.34 Lebensmitteltechnologie VZ 48.59 Pflanzenproduktion: Sonstiges VZ AR 44 2019 9 782-794 13 |
| allfieldsSound |
10.1016/j.tibs.2019.03.002 doi GBV00000000000719.pica (DE-627)ELV04760476X (ELSEVIER)S0968-0004(19)30055-6 DE-627 ger DE-627 rakwb eng 610 VZ 570 630 VZ BIODIV DE-30 fid 58.34 bkl 48.59 bkl Zhang, Hong verfasserin aut Function and Evolution of Upstream ORFs in Eukaryotes 2019transfer abstract 13 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier There is growing interest in the role of translational regulation in cellular homeostasis during organismal development. Translation initiation is the rate-limiting step in mRNA translation and is central to translational regulation. Upstream open reading frames (uORFs) are regulatory elements that are prevalent in eukaryotic mRNAs. uORFs modulate the translation initiation rate of downstream coding sequences (CDSs) by sequestering ribosomes. Over the past several years, genome-wide studies have revealed the widespread regulatory functions of uORFs in different species in different biological contexts. Here, we review the current understanding of uORF-mediated translational regulation from the perspective of functional and evolutionary genomics and address remaining gaps that deserve further study. There is growing interest in the role of translational regulation in cellular homeostasis during organismal development. Translation initiation is the rate-limiting step in mRNA translation and is central to translational regulation. Upstream open reading frames (uORFs) are regulatory elements that are prevalent in eukaryotic mRNAs. uORFs modulate the translation initiation rate of downstream coding sequences (CDSs) by sequestering ribosomes. Over the past several years, genome-wide studies have revealed the widespread regulatory functions of uORFs in different species in different biological contexts. Here, we review the current understanding of uORF-mediated translational regulation from the perspective of functional and evolutionary genomics and address remaining gaps that deserve further study. Wang, Yirong oth Lu, Jian oth Enthalten in Elsevier Science Prognostic value of preoperative FDG-PET in stage IA lung adenocarcinoma 2012 TIBS Amsterdam [u.a.] (DE-627)ELV016243919 volume:44 year:2019 number:9 pages:782-794 extent:13 https://doi.org/10.1016/j.tibs.2019.03.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_40 GBV_ILN_61 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_92 GBV_ILN_120 GBV_ILN_188 GBV_ILN_285 58.34 Lebensmitteltechnologie VZ 48.59 Pflanzenproduktion: Sonstiges VZ AR 44 2019 9 782-794 13 |
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Enthalten in Prognostic value of preoperative FDG-PET in stage IA lung adenocarcinoma Amsterdam [u.a.] volume:44 year:2019 number:9 pages:782-794 extent:13 |
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Prognostic value of preoperative FDG-PET in stage IA lung adenocarcinoma |
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Function and Evolution of Upstream ORFs in Eukaryotes |
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There is growing interest in the role of translational regulation in cellular homeostasis during organismal development. Translation initiation is the rate-limiting step in mRNA translation and is central to translational regulation. Upstream open reading frames (uORFs) are regulatory elements that are prevalent in eukaryotic mRNAs. uORFs modulate the translation initiation rate of downstream coding sequences (CDSs) by sequestering ribosomes. Over the past several years, genome-wide studies have revealed the widespread regulatory functions of uORFs in different species in different biological contexts. Here, we review the current understanding of uORF-mediated translational regulation from the perspective of functional and evolutionary genomics and address remaining gaps that deserve further study. |
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There is growing interest in the role of translational regulation in cellular homeostasis during organismal development. Translation initiation is the rate-limiting step in mRNA translation and is central to translational regulation. Upstream open reading frames (uORFs) are regulatory elements that are prevalent in eukaryotic mRNAs. uORFs modulate the translation initiation rate of downstream coding sequences (CDSs) by sequestering ribosomes. Over the past several years, genome-wide studies have revealed the widespread regulatory functions of uORFs in different species in different biological contexts. Here, we review the current understanding of uORF-mediated translational regulation from the perspective of functional and evolutionary genomics and address remaining gaps that deserve further study. |
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There is growing interest in the role of translational regulation in cellular homeostasis during organismal development. Translation initiation is the rate-limiting step in mRNA translation and is central to translational regulation. Upstream open reading frames (uORFs) are regulatory elements that are prevalent in eukaryotic mRNAs. uORFs modulate the translation initiation rate of downstream coding sequences (CDSs) by sequestering ribosomes. Over the past several years, genome-wide studies have revealed the widespread regulatory functions of uORFs in different species in different biological contexts. Here, we review the current understanding of uORF-mediated translational regulation from the perspective of functional and evolutionary genomics and address remaining gaps that deserve further study. |
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