Preparation and cell activities of lactosylated curdlan-triornithine nanoparticles for enhanced DNA/siRNA delivery in hepatoma cells
• Triornithine grafted novel curdlan gene vector was fabricated by click chemistry. • Lactobionic acid ligands target deliver to liver cancer cells. • Curdlan-based carriers show lower cytotoxicity and higher binding capacity than PEI. • Final complex CTOL20% efficiently delivered siRNA into HepG2 c...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Wang, Xia [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2019 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Residue co-evolution helps predict interaction sites in α-helical membrane proteins - Zeng, Bo ELSEVIER, 2019, an international journal devoted to scientific and technological aspects of industrially important polysaccharides, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:225 ; year:2019 ; day:1 ; month:12 ; pages:0 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.carbpol.2019.115252 |
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Preparation and cell activities of lactosylated curdlan-triornithine nanoparticles for enhanced DNA/siRNA delivery in hepatoma cells |
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• Triornithine grafted novel curdlan gene vector was fabricated by click chemistry. • Lactobionic acid ligands target deliver to liver cancer cells. • Curdlan-based carriers show lower cytotoxicity and higher binding capacity than PEI. • Final complex CTOL20% efficiently delivered siRNA into HepG2 cells. |
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• Triornithine grafted novel curdlan gene vector was fabricated by click chemistry. • Lactobionic acid ligands target deliver to liver cancer cells. • Curdlan-based carriers show lower cytotoxicity and higher binding capacity than PEI. • Final complex CTOL20% efficiently delivered siRNA into HepG2 cells. |
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• Triornithine grafted novel curdlan gene vector was fabricated by click chemistry. • Lactobionic acid ligands target deliver to liver cancer cells. • Curdlan-based carriers show lower cytotoxicity and higher binding capacity than PEI. • Final complex CTOL20% efficiently delivered siRNA into HepG2 cells. |
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