CXCL4 is a driver of cytokine mRNA stability in monocyte-derived dendritic cells
• CXCL4-moDCs display a pro-inflammatory phenotype when compared to conventional moDCs. • Increased IL6 and TNF production in CXCL4-moDCs relies on enhanced mRNA stability. • In CXCL4-moDCs, IL12 and IL23 are regulated at the transcriptional level. • The mRNA degrading protein TTP is inactive in CXC...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Silva-Cardoso, Sandra C. [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2019 |
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| Schlagwörter: |
|---|
| Umfang: |
11 |
|---|
| Übergeordnetes Werk: |
Enthalten in: Letter regarding the article: Changes in BNP and cardiac troponin I after high-intensity interval and endurance exercise in heart failure patients and healthy controls - Gayda, Mathieu ELSEVIER, 2015, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:114 ; year:2019 ; pages:524-534 ; extent:11 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.molimm.2019.09.004 |
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| 520 | |a • CXCL4-moDCs display a pro-inflammatory phenotype when compared to conventional moDCs. • Increased IL6 and TNF production in CXCL4-moDCs relies on enhanced mRNA stability. • In CXCL4-moDCs, IL12 and IL23 are regulated at the transcriptional level. • The mRNA degrading protein TTP is inactive in CXCL4-moDCs. • p38 inhibition restores TTP function and decreases cytokine production in CXCL4-moDCs. | ||
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• CXCL4-moDCs display a pro-inflammatory phenotype when compared to conventional moDCs. • Increased IL6 and TNF production in CXCL4-moDCs relies on enhanced mRNA stability. • In CXCL4-moDCs, IL12 and IL23 are regulated at the transcriptional level. • The mRNA degrading protein TTP is inactive in CXCL4-moDCs. • p38 inhibition restores TTP function and decreases cytokine production in CXCL4-moDCs. |
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• CXCL4-moDCs display a pro-inflammatory phenotype when compared to conventional moDCs. • Increased IL6 and TNF production in CXCL4-moDCs relies on enhanced mRNA stability. • In CXCL4-moDCs, IL12 and IL23 are regulated at the transcriptional level. • The mRNA degrading protein TTP is inactive in CXCL4-moDCs. • p38 inhibition restores TTP function and decreases cytokine production in CXCL4-moDCs. |
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• CXCL4-moDCs display a pro-inflammatory phenotype when compared to conventional moDCs. • Increased IL6 and TNF production in CXCL4-moDCs relies on enhanced mRNA stability. • In CXCL4-moDCs, IL12 and IL23 are regulated at the transcriptional level. • The mRNA degrading protein TTP is inactive in CXCL4-moDCs. • p38 inhibition restores TTP function and decreases cytokine production in CXCL4-moDCs. |
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