Multifunctional nanoplatforms for subcellular delivery of drugs in cancer therapy

To achieve highly effective treatment to diseases, successful delivery of drugs with a carrier into the specific organelles (nucleus, mitochondria, lysosomes, etc.) is of great importance. Targeted delivery based on nanoparticle (NP)-based drug delivery systems (NDDSs) is mainly focused on cell-memb...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Guo, Xing [verfasserIn] Wei, Xiao Chen, Zi Zhang, Xiaobin Yang, Guang Zhou, Shaobing

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020transfer abstract

Schlagwörter:	TfR BBB PS EPR MHC HT OLL GLS Nups PI3K UPR IA CME NDDSs R8 DOX OMM PAMAM AR DLCs SV40 LCST Ab ABC Ad MCF-7 Ir CvME CPPs HeLa DQA LSDs TPP NCs B55 Phis HIV ICP NER ATP CPT TAT HNPs LRP VNB ELS MTS IUSs Tf MD mTOR SNPs Gb3 IDS MDR NLSs PSD P-gp VAMP IMM N9 MAPK ER IMS RGD ERHNPs LCVs NE ROS PCL ANG HPMA QDs NP LIMP PLA GILT EGFP FR MSNP STxB EGFR PLL AuNPs HepG2 GA GSH DOPE ApDCs GI EGF Fab M6P FPs RAW 264.7 SNAP GALA LMP PEG PLGA PEI NPCs DOTAP LAMP DMMA

Übergeordnetes Werk:	Enthalten in: Assessing the potential of solid dispersions to improve dissolution rate and bioavailability of valsartan: - Medarević, Djordje ELSEVIER, 2018, Amsterdam [u.a.]
Übergeordnetes Werk:	volume:107 ; year:2020 ; pages:0

Links:	Volltext

DOI / URN:	10.1016/j.pmatsci.2019.100599

Katalog-ID:	ELV048151564

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allfields	10.1016/j.pmatsci.2019.100599 doi GBV00000000000776.pica (DE-627)ELV048151564 (ELSEVIER)S0079-6425(19)30081-7 DE-627 ger DE-627 rakwb eng 610 VZ 15,3 ssgn PHARM DE-84 fid 44.40 bkl Guo, Xing verfasserin aut Multifunctional nanoplatforms for subcellular delivery of drugs in cancer therapy 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier To achieve highly effective treatment to diseases, successful delivery of drugs with a carrier into the specific organelles (nucleus, mitochondria, lysosomes, etc.) is of great importance. Targeted delivery based on nanoparticle (NP)-based drug delivery systems (NDDSs) is mainly focused on cell-membrane targeting. In this review we summarize researches on organelle-specific drug delivery with multifunctional NPs. Many effective strategies are introduced for functionalizing these NPs by altering their chemical composition or by grafting functional groups onto their surface for improving organelle-targeting ability. Only when the concentrationof released drugs becomes high enough will they interact with molecular targets on specific organelles to induce tumor cell apoptosis. Organelle-specific delivery will become one of the primary goals for targeted drug delivery research. To achieve highly effective treatment to diseases, successful delivery of drugs with a carrier into the specific organelles (nucleus, mitochondria, lysosomes, etc.) is of great importance. Targeted delivery based on nanoparticle (NP)-based drug delivery systems (NDDSs) is mainly focused on cell-membrane targeting. In this review we summarize researches on organelle-specific drug delivery with multifunctional NPs. Many effective strategies are introduced for functionalizing these NPs by altering their chemical composition or by grafting functional groups onto their surface for improving organelle-targeting ability. Only when the concentrationof released drugs becomes high enough will they interact with molecular targets on specific organelles to induce tumor cell apoptosis. Organelle-specific delivery will become one of the primary goals for targeted drug delivery research. TfR Elsevier BBB Elsevier PS Elsevier EPR Elsevier MHC Elsevier HT Elsevier OLL Elsevier GLS Elsevier Nups Elsevier PI3K Elsevier UPR Elsevier IA Elsevier CME Elsevier NDDSs Elsevier R8 Elsevier DOX Elsevier OMM Elsevier PAMAM Elsevier AR Elsevier DLCs Elsevier SV40 Elsevier LCST Elsevier Ab Elsevier ABC Elsevier Ad Elsevier MCF-7 Elsevier Ir Elsevier CvME Elsevier CPPs Elsevier HeLa Elsevier DQA Elsevier LSDs Elsevier TPP Elsevier NCs Elsevier B55 Elsevier Phis Elsevier HIV Elsevier ICP Elsevier NER Elsevier ATP Elsevier CPT Elsevier TAT Elsevier HNPs Elsevier LRP Elsevier VNB Elsevier ELS Elsevier MTS Elsevier IUSs Elsevier Tf Elsevier MD Elsevier mTOR Elsevier SNPs Elsevier Gb3 Elsevier IDS Elsevier MDR Elsevier NLSs Elsevier PSD Elsevier P-gp Elsevier VAMP Elsevier IMM Elsevier N9 Elsevier MAPK Elsevier ER Elsevier IMS Elsevier RGD Elsevier ERHNPs Elsevier LCVs Elsevier NE Elsevier ROS Elsevier PCL Elsevier ANG Elsevier HPMA Elsevier QDs Elsevier NP Elsevier LIMP Elsevier PLA Elsevier GILT Elsevier EGFP Elsevier FR Elsevier MSNP Elsevier STxB Elsevier EGFR Elsevier PLL Elsevier AuNPs Elsevier HepG2 Elsevier GA Elsevier GSH Elsevier DOPE Elsevier ApDCs Elsevier GI Elsevier EGF Elsevier Fab Elsevier M6P Elsevier FPs Elsevier RAW 264.7 Elsevier SNAP Elsevier GALA Elsevier LMP Elsevier PEG Elsevier PLGA Elsevier PEI Elsevier NPCs Elsevier DOTAP Elsevier LAMP Elsevier DMMA Elsevier Wei, Xiao oth Chen, Zi oth Zhang, Xiaobin oth Yang, Guang oth Zhou, Shaobing oth Enthalten in Elsevier Science Medarević, Djordje ELSEVIER Assessing the potential of solid dispersions to improve dissolution rate and bioavailability of valsartan: 2018 Amsterdam [u.a.] (DE-627)ELV000698369 volume:107 year:2020 pages:0 https://doi.org/10.1016/j.pmatsci.2019.100599 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-PHARM SSG-OLC-PHA SSG-OPC-PHA 44.40 Pharmazie Pharmazeutika VZ AR 107 2020 0
spelling	10.1016/j.pmatsci.2019.100599 doi GBV00000000000776.pica (DE-627)ELV048151564 (ELSEVIER)S0079-6425(19)30081-7 DE-627 ger DE-627 rakwb eng 610 VZ 15,3 ssgn PHARM DE-84 fid 44.40 bkl Guo, Xing verfasserin aut Multifunctional nanoplatforms for subcellular delivery of drugs in cancer therapy 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier To achieve highly effective treatment to diseases, successful delivery of drugs with a carrier into the specific organelles (nucleus, mitochondria, lysosomes, etc.) is of great importance. Targeted delivery based on nanoparticle (NP)-based drug delivery systems (NDDSs) is mainly focused on cell-membrane targeting. In this review we summarize researches on organelle-specific drug delivery with multifunctional NPs. Many effective strategies are introduced for functionalizing these NPs by altering their chemical composition or by grafting functional groups onto their surface for improving organelle-targeting ability. Only when the concentrationof released drugs becomes high enough will they interact with molecular targets on specific organelles to induce tumor cell apoptosis. Organelle-specific delivery will become one of the primary goals for targeted drug delivery research. To achieve highly effective treatment to diseases, successful delivery of drugs with a carrier into the specific organelles (nucleus, mitochondria, lysosomes, etc.) is of great importance. Targeted delivery based on nanoparticle (NP)-based drug delivery systems (NDDSs) is mainly focused on cell-membrane targeting. In this review we summarize researches on organelle-specific drug delivery with multifunctional NPs. Many effective strategies are introduced for functionalizing these NPs by altering their chemical composition or by grafting functional groups onto their surface for improving organelle-targeting ability. Only when the concentrationof released drugs becomes high enough will they interact with molecular targets on specific organelles to induce tumor cell apoptosis. Organelle-specific delivery will become one of the primary goals for targeted drug delivery research. TfR Elsevier BBB Elsevier PS Elsevier EPR Elsevier MHC Elsevier HT Elsevier OLL Elsevier GLS Elsevier Nups Elsevier PI3K Elsevier UPR Elsevier IA Elsevier CME Elsevier NDDSs Elsevier R8 Elsevier DOX Elsevier OMM Elsevier PAMAM Elsevier AR Elsevier DLCs Elsevier SV40 Elsevier LCST Elsevier Ab Elsevier ABC Elsevier Ad Elsevier MCF-7 Elsevier Ir Elsevier CvME Elsevier CPPs Elsevier HeLa Elsevier DQA Elsevier LSDs Elsevier TPP Elsevier NCs Elsevier B55 Elsevier Phis Elsevier HIV Elsevier ICP Elsevier NER Elsevier ATP Elsevier CPT Elsevier TAT Elsevier HNPs Elsevier LRP Elsevier VNB Elsevier ELS Elsevier MTS Elsevier IUSs Elsevier Tf Elsevier MD Elsevier mTOR Elsevier SNPs Elsevier Gb3 Elsevier IDS Elsevier MDR Elsevier NLSs Elsevier PSD Elsevier P-gp Elsevier VAMP Elsevier IMM Elsevier N9 Elsevier MAPK Elsevier ER Elsevier IMS Elsevier RGD Elsevier ERHNPs Elsevier LCVs Elsevier NE Elsevier ROS Elsevier PCL Elsevier ANG Elsevier HPMA Elsevier QDs Elsevier NP Elsevier LIMP Elsevier PLA Elsevier GILT Elsevier EGFP Elsevier FR Elsevier MSNP Elsevier STxB Elsevier EGFR Elsevier PLL Elsevier AuNPs Elsevier HepG2 Elsevier GA Elsevier GSH Elsevier DOPE Elsevier ApDCs Elsevier GI Elsevier EGF Elsevier Fab Elsevier M6P Elsevier FPs Elsevier RAW 264.7 Elsevier SNAP Elsevier GALA Elsevier LMP Elsevier PEG Elsevier PLGA Elsevier PEI Elsevier NPCs Elsevier DOTAP Elsevier LAMP Elsevier DMMA Elsevier Wei, Xiao oth Chen, Zi oth Zhang, Xiaobin oth Yang, Guang oth Zhou, Shaobing oth Enthalten in Elsevier Science Medarević, Djordje ELSEVIER Assessing the potential of solid dispersions to improve dissolution rate and bioavailability of valsartan: 2018 Amsterdam [u.a.] (DE-627)ELV000698369 volume:107 year:2020 pages:0 https://doi.org/10.1016/j.pmatsci.2019.100599 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-PHARM SSG-OLC-PHA SSG-OPC-PHA 44.40 Pharmazie Pharmazeutika VZ AR 107 2020 0
allfields_unstemmed	10.1016/j.pmatsci.2019.100599 doi GBV00000000000776.pica (DE-627)ELV048151564 (ELSEVIER)S0079-6425(19)30081-7 DE-627 ger DE-627 rakwb eng 610 VZ 15,3 ssgn PHARM DE-84 fid 44.40 bkl Guo, Xing verfasserin aut Multifunctional nanoplatforms for subcellular delivery of drugs in cancer therapy 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier To achieve highly effective treatment to diseases, successful delivery of drugs with a carrier into the specific organelles (nucleus, mitochondria, lysosomes, etc.) is of great importance. Targeted delivery based on nanoparticle (NP)-based drug delivery systems (NDDSs) is mainly focused on cell-membrane targeting. In this review we summarize researches on organelle-specific drug delivery with multifunctional NPs. Many effective strategies are introduced for functionalizing these NPs by altering their chemical composition or by grafting functional groups onto their surface for improving organelle-targeting ability. Only when the concentrationof released drugs becomes high enough will they interact with molecular targets on specific organelles to induce tumor cell apoptosis. Organelle-specific delivery will become one of the primary goals for targeted drug delivery research. To achieve highly effective treatment to diseases, successful delivery of drugs with a carrier into the specific organelles (nucleus, mitochondria, lysosomes, etc.) is of great importance. Targeted delivery based on nanoparticle (NP)-based drug delivery systems (NDDSs) is mainly focused on cell-membrane targeting. In this review we summarize researches on organelle-specific drug delivery with multifunctional NPs. Many effective strategies are introduced for functionalizing these NPs by altering their chemical composition or by grafting functional groups onto their surface for improving organelle-targeting ability. Only when the concentrationof released drugs becomes high enough will they interact with molecular targets on specific organelles to induce tumor cell apoptosis. Organelle-specific delivery will become one of the primary goals for targeted drug delivery research. TfR Elsevier BBB Elsevier PS Elsevier EPR Elsevier MHC Elsevier HT Elsevier OLL Elsevier GLS Elsevier Nups Elsevier PI3K Elsevier UPR Elsevier IA Elsevier CME Elsevier NDDSs Elsevier R8 Elsevier DOX Elsevier OMM Elsevier PAMAM Elsevier AR Elsevier DLCs Elsevier SV40 Elsevier LCST Elsevier Ab Elsevier ABC Elsevier Ad Elsevier MCF-7 Elsevier Ir Elsevier CvME Elsevier CPPs Elsevier HeLa Elsevier DQA Elsevier LSDs Elsevier TPP Elsevier NCs Elsevier B55 Elsevier Phis Elsevier HIV Elsevier ICP Elsevier NER Elsevier ATP Elsevier CPT Elsevier TAT Elsevier HNPs Elsevier LRP Elsevier VNB Elsevier ELS Elsevier MTS Elsevier IUSs Elsevier Tf Elsevier MD Elsevier mTOR Elsevier SNPs Elsevier Gb3 Elsevier IDS Elsevier MDR Elsevier NLSs Elsevier PSD Elsevier P-gp Elsevier VAMP Elsevier IMM Elsevier N9 Elsevier MAPK Elsevier ER Elsevier IMS Elsevier RGD Elsevier ERHNPs Elsevier LCVs Elsevier NE Elsevier ROS Elsevier PCL Elsevier ANG Elsevier HPMA Elsevier QDs Elsevier NP Elsevier LIMP Elsevier PLA Elsevier GILT Elsevier EGFP Elsevier FR Elsevier MSNP Elsevier STxB Elsevier EGFR Elsevier PLL Elsevier AuNPs Elsevier HepG2 Elsevier GA Elsevier GSH Elsevier DOPE Elsevier ApDCs Elsevier GI Elsevier EGF Elsevier Fab Elsevier M6P Elsevier FPs Elsevier RAW 264.7 Elsevier SNAP Elsevier GALA Elsevier LMP Elsevier PEG Elsevier PLGA Elsevier PEI Elsevier NPCs Elsevier DOTAP Elsevier LAMP Elsevier DMMA Elsevier Wei, Xiao oth Chen, Zi oth Zhang, Xiaobin oth Yang, Guang oth Zhou, Shaobing oth Enthalten in Elsevier Science Medarević, Djordje ELSEVIER Assessing the potential of solid dispersions to improve dissolution rate and bioavailability of valsartan: 2018 Amsterdam [u.a.] (DE-627)ELV000698369 volume:107 year:2020 pages:0 https://doi.org/10.1016/j.pmatsci.2019.100599 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-PHARM SSG-OLC-PHA SSG-OPC-PHA 44.40 Pharmazie Pharmazeutika VZ AR 107 2020 0
allfieldsGer	10.1016/j.pmatsci.2019.100599 doi GBV00000000000776.pica (DE-627)ELV048151564 (ELSEVIER)S0079-6425(19)30081-7 DE-627 ger DE-627 rakwb eng 610 VZ 15,3 ssgn PHARM DE-84 fid 44.40 bkl Guo, Xing verfasserin aut Multifunctional nanoplatforms for subcellular delivery of drugs in cancer therapy 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier To achieve highly effective treatment to diseases, successful delivery of drugs with a carrier into the specific organelles (nucleus, mitochondria, lysosomes, etc.) is of great importance. Targeted delivery based on nanoparticle (NP)-based drug delivery systems (NDDSs) is mainly focused on cell-membrane targeting. In this review we summarize researches on organelle-specific drug delivery with multifunctional NPs. Many effective strategies are introduced for functionalizing these NPs by altering their chemical composition or by grafting functional groups onto their surface for improving organelle-targeting ability. Only when the concentrationof released drugs becomes high enough will they interact with molecular targets on specific organelles to induce tumor cell apoptosis. Organelle-specific delivery will become one of the primary goals for targeted drug delivery research. To achieve highly effective treatment to diseases, successful delivery of drugs with a carrier into the specific organelles (nucleus, mitochondria, lysosomes, etc.) is of great importance. Targeted delivery based on nanoparticle (NP)-based drug delivery systems (NDDSs) is mainly focused on cell-membrane targeting. In this review we summarize researches on organelle-specific drug delivery with multifunctional NPs. Many effective strategies are introduced for functionalizing these NPs by altering their chemical composition or by grafting functional groups onto their surface for improving organelle-targeting ability. Only when the concentrationof released drugs becomes high enough will they interact with molecular targets on specific organelles to induce tumor cell apoptosis. Organelle-specific delivery will become one of the primary goals for targeted drug delivery research. TfR Elsevier BBB Elsevier PS Elsevier EPR Elsevier MHC Elsevier HT Elsevier OLL Elsevier GLS Elsevier Nups Elsevier PI3K Elsevier UPR Elsevier IA Elsevier CME Elsevier NDDSs Elsevier R8 Elsevier DOX Elsevier OMM Elsevier PAMAM Elsevier AR Elsevier DLCs Elsevier SV40 Elsevier LCST Elsevier Ab Elsevier ABC Elsevier Ad Elsevier MCF-7 Elsevier Ir Elsevier CvME Elsevier CPPs Elsevier HeLa Elsevier DQA Elsevier LSDs Elsevier TPP Elsevier NCs Elsevier B55 Elsevier Phis Elsevier HIV Elsevier ICP Elsevier NER Elsevier ATP Elsevier CPT Elsevier TAT Elsevier HNPs Elsevier LRP Elsevier VNB Elsevier ELS Elsevier MTS Elsevier IUSs Elsevier Tf Elsevier MD Elsevier mTOR Elsevier SNPs Elsevier Gb3 Elsevier IDS Elsevier MDR Elsevier NLSs Elsevier PSD Elsevier P-gp Elsevier VAMP Elsevier IMM Elsevier N9 Elsevier MAPK Elsevier ER Elsevier IMS Elsevier RGD Elsevier ERHNPs Elsevier LCVs Elsevier NE Elsevier ROS Elsevier PCL Elsevier ANG Elsevier HPMA Elsevier QDs Elsevier NP Elsevier LIMP Elsevier PLA Elsevier GILT Elsevier EGFP Elsevier FR Elsevier MSNP Elsevier STxB Elsevier EGFR Elsevier PLL Elsevier AuNPs Elsevier HepG2 Elsevier GA Elsevier GSH Elsevier DOPE Elsevier ApDCs Elsevier GI Elsevier EGF Elsevier Fab Elsevier M6P Elsevier FPs Elsevier RAW 264.7 Elsevier SNAP Elsevier GALA Elsevier LMP Elsevier PEG Elsevier PLGA Elsevier PEI Elsevier NPCs Elsevier DOTAP Elsevier LAMP Elsevier DMMA Elsevier Wei, Xiao oth Chen, Zi oth Zhang, Xiaobin oth Yang, Guang oth Zhou, Shaobing oth Enthalten in Elsevier Science Medarević, Djordje ELSEVIER Assessing the potential of solid dispersions to improve dissolution rate and bioavailability of valsartan: 2018 Amsterdam [u.a.] (DE-627)ELV000698369 volume:107 year:2020 pages:0 https://doi.org/10.1016/j.pmatsci.2019.100599 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-PHARM SSG-OLC-PHA SSG-OPC-PHA 44.40 Pharmazie Pharmazeutika VZ AR 107 2020 0
allfieldsSound	10.1016/j.pmatsci.2019.100599 doi GBV00000000000776.pica (DE-627)ELV048151564 (ELSEVIER)S0079-6425(19)30081-7 DE-627 ger DE-627 rakwb eng 610 VZ 15,3 ssgn PHARM DE-84 fid 44.40 bkl Guo, Xing verfasserin aut Multifunctional nanoplatforms for subcellular delivery of drugs in cancer therapy 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier To achieve highly effective treatment to diseases, successful delivery of drugs with a carrier into the specific organelles (nucleus, mitochondria, lysosomes, etc.) is of great importance. Targeted delivery based on nanoparticle (NP)-based drug delivery systems (NDDSs) is mainly focused on cell-membrane targeting. In this review we summarize researches on organelle-specific drug delivery with multifunctional NPs. Many effective strategies are introduced for functionalizing these NPs by altering their chemical composition or by grafting functional groups onto their surface for improving organelle-targeting ability. Only when the concentrationof released drugs becomes high enough will they interact with molecular targets on specific organelles to induce tumor cell apoptosis. Organelle-specific delivery will become one of the primary goals for targeted drug delivery research. To achieve highly effective treatment to diseases, successful delivery of drugs with a carrier into the specific organelles (nucleus, mitochondria, lysosomes, etc.) is of great importance. Targeted delivery based on nanoparticle (NP)-based drug delivery systems (NDDSs) is mainly focused on cell-membrane targeting. In this review we summarize researches on organelle-specific drug delivery with multifunctional NPs. Many effective strategies are introduced for functionalizing these NPs by altering their chemical composition or by grafting functional groups onto their surface for improving organelle-targeting ability. Only when the concentrationof released drugs becomes high enough will they interact with molecular targets on specific organelles to induce tumor cell apoptosis. Organelle-specific delivery will become one of the primary goals for targeted drug delivery research. TfR Elsevier BBB Elsevier PS Elsevier EPR Elsevier MHC Elsevier HT Elsevier OLL Elsevier GLS Elsevier Nups Elsevier PI3K Elsevier UPR Elsevier IA Elsevier CME Elsevier NDDSs Elsevier R8 Elsevier DOX Elsevier OMM Elsevier PAMAM Elsevier AR Elsevier DLCs Elsevier SV40 Elsevier LCST Elsevier Ab Elsevier ABC Elsevier Ad Elsevier MCF-7 Elsevier Ir Elsevier CvME Elsevier CPPs Elsevier HeLa Elsevier DQA Elsevier LSDs Elsevier TPP Elsevier NCs Elsevier B55 Elsevier Phis Elsevier HIV Elsevier ICP Elsevier NER Elsevier ATP Elsevier CPT Elsevier TAT Elsevier HNPs Elsevier LRP Elsevier VNB Elsevier ELS Elsevier MTS Elsevier IUSs Elsevier Tf Elsevier MD Elsevier mTOR Elsevier SNPs Elsevier Gb3 Elsevier IDS Elsevier MDR Elsevier NLSs Elsevier PSD Elsevier P-gp Elsevier VAMP Elsevier IMM Elsevier N9 Elsevier MAPK Elsevier ER Elsevier IMS Elsevier RGD Elsevier ERHNPs Elsevier LCVs Elsevier NE Elsevier ROS Elsevier PCL Elsevier ANG Elsevier HPMA Elsevier QDs Elsevier NP Elsevier LIMP Elsevier PLA Elsevier GILT Elsevier EGFP Elsevier FR Elsevier MSNP Elsevier STxB Elsevier EGFR Elsevier PLL Elsevier AuNPs Elsevier HepG2 Elsevier GA Elsevier GSH Elsevier DOPE Elsevier ApDCs Elsevier GI Elsevier EGF Elsevier Fab Elsevier M6P Elsevier FPs Elsevier RAW 264.7 Elsevier SNAP Elsevier GALA Elsevier LMP Elsevier PEG Elsevier PLGA Elsevier PEI Elsevier NPCs Elsevier DOTAP Elsevier LAMP Elsevier DMMA Elsevier Wei, Xiao oth Chen, Zi oth Zhang, Xiaobin oth Yang, Guang oth Zhou, Shaobing oth Enthalten in Elsevier Science Medarević, Djordje ELSEVIER Assessing the potential of solid dispersions to improve dissolution rate and bioavailability of valsartan: 2018 Amsterdam [u.a.] (DE-627)ELV000698369 volume:107 year:2020 pages:0 https://doi.org/10.1016/j.pmatsci.2019.100599 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-PHARM SSG-OLC-PHA SSG-OPC-PHA 44.40 Pharmazie Pharmazeutika VZ AR 107 2020 0
language	English
source	Enthalten in Assessing the potential of solid dispersions to improve dissolution rate and bioavailability of valsartan: Amsterdam [u.a.] volume:107 year:2020 pages:0
sourceStr	Enthalten in Assessing the potential of solid dispersions to improve dissolution rate and bioavailability of valsartan: Amsterdam [u.a.] volume:107 year:2020 pages:0
format_phy_str_mv	Article
bklname	Pharmazie Pharmazeutika
institution	findex.gbv.de
topic_facet	TfR BBB PS EPR MHC HT OLL GLS Nups PI3K UPR IA CME NDDSs R8 DOX OMM PAMAM AR DLCs SV40 LCST Ab ABC Ad MCF-7 Ir CvME CPPs HeLa DQA LSDs TPP NCs B55 Phis HIV ICP NER ATP CPT TAT HNPs LRP VNB ELS MTS IUSs Tf MD mTOR SNPs Gb3 IDS MDR NLSs PSD P-gp VAMP IMM N9 MAPK ER IMS RGD ERHNPs LCVs NE ROS PCL ANG HPMA QDs NP LIMP PLA GILT EGFP FR MSNP STxB EGFR PLL AuNPs HepG2 GA GSH DOPE ApDCs GI EGF Fab M6P FPs RAW 264.7 SNAP GALA LMP PEG PLGA PEI NPCs DOTAP LAMP DMMA
dewey-raw	610
isfreeaccess_bool	false
container_title	Assessing the potential of solid dispersions to improve dissolution rate and bioavailability of valsartan:
authorswithroles_txt_mv	Guo, Xing @@aut@@ Wei, Xiao @@oth@@ Chen, Zi @@oth@@ Zhang, Xiaobin @@oth@@ Yang, Guang @@oth@@ Zhou, Shaobing @@oth@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	ELV000698369
dewey-sort	3610
id	ELV048151564
language_de	englisch
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topic_title	610 VZ 15,3 ssgn PHARM DE-84 fid 44.40 bkl Multifunctional nanoplatforms for subcellular delivery of drugs in cancer therapy TfR Elsevier BBB Elsevier PS Elsevier EPR Elsevier MHC Elsevier HT Elsevier OLL Elsevier GLS Elsevier Nups Elsevier PI3K Elsevier UPR Elsevier IA Elsevier CME Elsevier NDDSs Elsevier R8 Elsevier DOX Elsevier OMM Elsevier PAMAM Elsevier AR Elsevier DLCs Elsevier SV40 Elsevier LCST Elsevier Ab Elsevier ABC Elsevier Ad Elsevier MCF-7 Elsevier Ir Elsevier CvME Elsevier CPPs Elsevier HeLa Elsevier DQA Elsevier LSDs Elsevier TPP Elsevier NCs Elsevier B55 Elsevier Phis Elsevier HIV Elsevier ICP Elsevier NER Elsevier ATP Elsevier CPT Elsevier TAT Elsevier HNPs Elsevier LRP Elsevier VNB Elsevier ELS Elsevier MTS Elsevier IUSs Elsevier Tf Elsevier MD Elsevier mTOR Elsevier SNPs Elsevier Gb3 Elsevier IDS Elsevier MDR Elsevier NLSs Elsevier PSD Elsevier P-gp Elsevier VAMP Elsevier IMM Elsevier N9 Elsevier MAPK Elsevier ER Elsevier IMS Elsevier RGD Elsevier ERHNPs Elsevier LCVs Elsevier NE Elsevier ROS Elsevier PCL Elsevier ANG Elsevier HPMA Elsevier QDs Elsevier NP Elsevier LIMP Elsevier PLA Elsevier GILT Elsevier EGFP Elsevier FR Elsevier MSNP Elsevier STxB Elsevier EGFR Elsevier PLL Elsevier AuNPs Elsevier HepG2 Elsevier GA Elsevier GSH Elsevier DOPE Elsevier ApDCs Elsevier GI Elsevier EGF Elsevier Fab Elsevier M6P Elsevier FPs Elsevier RAW 264.7 Elsevier SNAP Elsevier GALA Elsevier LMP Elsevier PEG Elsevier PLGA Elsevier PEI Elsevier NPCs Elsevier DOTAP Elsevier LAMP Elsevier DMMA Elsevier
topic	ddc 610 ssgn 15,3 fid PHARM bkl 44.40 Elsevier TfR Elsevier BBB Elsevier PS Elsevier EPR Elsevier MHC Elsevier HT Elsevier OLL Elsevier GLS Elsevier Nups Elsevier PI3K Elsevier UPR Elsevier IA Elsevier CME Elsevier NDDSs Elsevier R8 Elsevier DOX Elsevier OMM Elsevier PAMAM Elsevier AR Elsevier DLCs Elsevier SV40 Elsevier LCST Elsevier Ab Elsevier ABC Elsevier Ad Elsevier MCF-7 Elsevier Ir Elsevier CvME Elsevier CPPs Elsevier HeLa Elsevier DQA Elsevier LSDs Elsevier TPP Elsevier NCs Elsevier B55 Elsevier Phis Elsevier HIV Elsevier ICP Elsevier NER Elsevier ATP Elsevier CPT Elsevier TAT Elsevier HNPs Elsevier LRP Elsevier VNB Elsevier ELS Elsevier MTS Elsevier IUSs Elsevier Tf Elsevier MD Elsevier mTOR Elsevier SNPs Elsevier Gb3 Elsevier IDS Elsevier MDR Elsevier NLSs Elsevier PSD Elsevier P-gp Elsevier VAMP Elsevier IMM Elsevier N9 Elsevier MAPK Elsevier ER Elsevier IMS Elsevier RGD Elsevier ERHNPs Elsevier LCVs Elsevier NE Elsevier ROS Elsevier PCL Elsevier ANG Elsevier HPMA Elsevier QDs Elsevier NP Elsevier LIMP Elsevier PLA Elsevier GILT Elsevier EGFP Elsevier FR Elsevier MSNP Elsevier STxB Elsevier EGFR Elsevier PLL Elsevier AuNPs Elsevier HepG2 Elsevier GA Elsevier GSH Elsevier DOPE Elsevier ApDCs Elsevier GI Elsevier EGF Elsevier Fab Elsevier M6P Elsevier FPs Elsevier RAW 264.7 Elsevier SNAP Elsevier GALA Elsevier LMP Elsevier PEG Elsevier PLGA Elsevier PEI Elsevier NPCs Elsevier DOTAP Elsevier LAMP Elsevier DMMA
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title	Multifunctional nanoplatforms for subcellular delivery of drugs in cancer therapy
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title_full	Multifunctional nanoplatforms for subcellular delivery of drugs in cancer therapy
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title_sort	multifunctional nanoplatforms for subcellular delivery of drugs in cancer therapy
title_auth	Multifunctional nanoplatforms for subcellular delivery of drugs in cancer therapy
abstract	To achieve highly effective treatment to diseases, successful delivery of drugs with a carrier into the specific organelles (nucleus, mitochondria, lysosomes, etc.) is of great importance. Targeted delivery based on nanoparticle (NP)-based drug delivery systems (NDDSs) is mainly focused on cell-membrane targeting. In this review we summarize researches on organelle-specific drug delivery with multifunctional NPs. Many effective strategies are introduced for functionalizing these NPs by altering their chemical composition or by grafting functional groups onto their surface for improving organelle-targeting ability. Only when the concentrationof released drugs becomes high enough will they interact with molecular targets on specific organelles to induce tumor cell apoptosis. Organelle-specific delivery will become one of the primary goals for targeted drug delivery research.
abstractGer	To achieve highly effective treatment to diseases, successful delivery of drugs with a carrier into the specific organelles (nucleus, mitochondria, lysosomes, etc.) is of great importance. Targeted delivery based on nanoparticle (NP)-based drug delivery systems (NDDSs) is mainly focused on cell-membrane targeting. In this review we summarize researches on organelle-specific drug delivery with multifunctional NPs. Many effective strategies are introduced for functionalizing these NPs by altering their chemical composition or by grafting functional groups onto their surface for improving organelle-targeting ability. Only when the concentrationof released drugs becomes high enough will they interact with molecular targets on specific organelles to induce tumor cell apoptosis. Organelle-specific delivery will become one of the primary goals for targeted drug delivery research.
abstract_unstemmed	To achieve highly effective treatment to diseases, successful delivery of drugs with a carrier into the specific organelles (nucleus, mitochondria, lysosomes, etc.) is of great importance. Targeted delivery based on nanoparticle (NP)-based drug delivery systems (NDDSs) is mainly focused on cell-membrane targeting. In this review we summarize researches on organelle-specific drug delivery with multifunctional NPs. Many effective strategies are introduced for functionalizing these NPs by altering their chemical composition or by grafting functional groups onto their surface for improving organelle-targeting ability. Only when the concentrationof released drugs becomes high enough will they interact with molecular targets on specific organelles to induce tumor cell apoptosis. Organelle-specific delivery will become one of the primary goals for targeted drug delivery research.
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title_short	Multifunctional nanoplatforms for subcellular delivery of drugs in cancer therapy
url	https://doi.org/10.1016/j.pmatsci.2019.100599
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author2	Wei, Xiao Chen, Zi Zhang, Xiaobin Yang, Guang Zhou, Shaobing
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Targeted delivery based on nanoparticle (NP)-based drug delivery systems (NDDSs) is mainly focused on cell-membrane targeting. In this review we summarize researches on organelle-specific drug delivery with multifunctional NPs. Many effective strategies are introduced for functionalizing these NPs by altering their chemical composition or by grafting functional groups onto their surface for improving organelle-targeting ability. Only when the concentrationof released drugs becomes high enough will they interact with molecular targets on specific organelles to induce tumor cell apoptosis. 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Multifunctional nanoplatforms for subcellular delivery of drugs in cancer therapy

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