Structural characterization and antiviral activity of pectin isolated from Inga spp.
Several studies have been conducted on polysaccharides derived from natural sources, and their different biological properties have been reported. Their low toxicity and antiviral effects i.e., their action on several steps of viral replication, have been extensively examined. In this work, pectin i...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
de Godoi, Ananda Marques [verfasserIn] Rechenchoski, Daniele Zendrini Arruda, Tathilene Bezerra Mota Gomes Rodrigues, Francisco Eduardo Arruda |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2019transfer abstract |
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| Umfang: |
7 |
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| Übergeordnetes Werk: |
Enthalten in: Automated DNA hybridization transfer with movable super-paramagnetic microbeads in a microflow reactor - Penchovsky, Robert ELSEVIER, 2019, structure, function and interactions, New York, NY [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:139 ; year:2019 ; day:15 ; month:10 ; pages:925-931 ; extent:7 |
| Links: |
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| DOI / URN: |
10.1016/j.ijbiomac.2019.07.212 |
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| 520 | |a Several studies have been conducted on polysaccharides derived from natural sources, and their different biological properties have been reported. Their low toxicity and antiviral effects i.e., their action on several steps of viral replication, have been extensively examined. In this work, pectin isolated from Inga spp. fruit pulp was first characterized and evaluated using HEp-2 cells against the herpes simplex virus type 1 (HSV-1) and the poliovirus (PV). The isolated pectin (denoted as PDTS) was characterized by infrared spectroscopy, NMR and Gel permeation chromatography. The cytotoxicity was analyzed by the MTT method and antiviral activity by plaque reduction assay, immunofluorescence assay (IF) and polymerase chain reaction (PCR). The cytotoxic concentration (CC50) of PDTS was 870 μg.mL−1 and the inhibitory concentrations (IC50) were 179 μg.mL−1 and 58 μg.mL−1 for HSV-1 and PV, respectively. Greater inhibitory effect was observed when the cells were simultaneously treated with PDTS and infected, suggesting that PDTS inhibited the initial viral replication stages, revealing its antiviral potential. | ||
| 520 | |a Several studies have been conducted on polysaccharides derived from natural sources, and their different biological properties have been reported. Their low toxicity and antiviral effects i.e., their action on several steps of viral replication, have been extensively examined. In this work, pectin isolated from Inga spp. fruit pulp was first characterized and evaluated using HEp-2 cells against the herpes simplex virus type 1 (HSV-1) and the poliovirus (PV). The isolated pectin (denoted as PDTS) was characterized by infrared spectroscopy, NMR and Gel permeation chromatography. The cytotoxicity was analyzed by the MTT method and antiviral activity by plaque reduction assay, immunofluorescence assay (IF) and polymerase chain reaction (PCR). The cytotoxic concentration (CC50) of PDTS was 870 μg.mL−1 and the inhibitory concentrations (IC50) were 179 μg.mL−1 and 58 μg.mL−1 for HSV-1 and PV, respectively. Greater inhibitory effect was observed when the cells were simultaneously treated with PDTS and infected, suggesting that PDTS inhibited the initial viral replication stages, revealing its antiviral potential. | ||
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10.1016/j.ijbiomac.2019.07.212 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000823.pica (DE-627)ELV048605530 (ELSEVIER)S0141-8130(19)30437-4 DE-627 ger DE-627 rakwb eng 570 610 VZ 58.30 bkl 50.22 bkl 44.09 bkl de Godoi, Ananda Marques verfasserin aut Structural characterization and antiviral activity of pectin isolated from Inga spp. 2019transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Several studies have been conducted on polysaccharides derived from natural sources, and their different biological properties have been reported. Their low toxicity and antiviral effects i.e., their action on several steps of viral replication, have been extensively examined. In this work, pectin isolated from Inga spp. fruit pulp was first characterized and evaluated using HEp-2 cells against the herpes simplex virus type 1 (HSV-1) and the poliovirus (PV). The isolated pectin (denoted as PDTS) was characterized by infrared spectroscopy, NMR and Gel permeation chromatography. The cytotoxicity was analyzed by the MTT method and antiviral activity by plaque reduction assay, immunofluorescence assay (IF) and polymerase chain reaction (PCR). The cytotoxic concentration (CC50) of PDTS was 870 μg.mL−1 and the inhibitory concentrations (IC50) were 179 μg.mL−1 and 58 μg.mL−1 for HSV-1 and PV, respectively. Greater inhibitory effect was observed when the cells were simultaneously treated with PDTS and infected, suggesting that PDTS inhibited the initial viral replication stages, revealing its antiviral potential. Several studies have been conducted on polysaccharides derived from natural sources, and their different biological properties have been reported. Their low toxicity and antiviral effects i.e., their action on several steps of viral replication, have been extensively examined. In this work, pectin isolated from Inga spp. fruit pulp was first characterized and evaluated using HEp-2 cells against the herpes simplex virus type 1 (HSV-1) and the poliovirus (PV). The isolated pectin (denoted as PDTS) was characterized by infrared spectroscopy, NMR and Gel permeation chromatography. The cytotoxicity was analyzed by the MTT method and antiviral activity by plaque reduction assay, immunofluorescence assay (IF) and polymerase chain reaction (PCR). The cytotoxic concentration (CC50) of PDTS was 870 μg.mL−1 and the inhibitory concentrations (IC50) were 179 μg.mL−1 and 58 μg.mL−1 for HSV-1 and PV, respectively. Greater inhibitory effect was observed when the cells were simultaneously treated with PDTS and infected, suggesting that PDTS inhibited the initial viral replication stages, revealing its antiviral potential. Faccin-Galhardi, Ligia Carla oth Rechenchoski, Daniele Zendrini oth Arruda, Tathilene Bezerra Mota Gomes oth Cunha, Arcelina Pacheco oth de Almeida, Raimundo Rafael oth Rodrigues, Francisco Eduardo Arruda oth Ricardo, Nágila Maria Pontes Silva oth Nozawa, Carlos oth Linhares, Rosa Elisa Carvalho oth Enthalten in Elsevier Penchovsky, Robert ELSEVIER Automated DNA hybridization transfer with movable super-paramagnetic microbeads in a microflow reactor 2019 structure, function and interactions New York, NY [u.a.] (DE-627)ELV002200198 volume:139 year:2019 day:15 month:10 pages:925-931 extent:7 https://doi.org/10.1016/j.ijbiomac.2019.07.212 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 58.30 Biotechnologie VZ 50.22 Sensorik VZ 44.09 Medizintechnik VZ AR 139 2019 15 1015 925-931 7 |
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10.1016/j.ijbiomac.2019.07.212 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000823.pica (DE-627)ELV048605530 (ELSEVIER)S0141-8130(19)30437-4 DE-627 ger DE-627 rakwb eng 570 610 VZ 58.30 bkl 50.22 bkl 44.09 bkl de Godoi, Ananda Marques verfasserin aut Structural characterization and antiviral activity of pectin isolated from Inga spp. 2019transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Several studies have been conducted on polysaccharides derived from natural sources, and their different biological properties have been reported. Their low toxicity and antiviral effects i.e., their action on several steps of viral replication, have been extensively examined. In this work, pectin isolated from Inga spp. fruit pulp was first characterized and evaluated using HEp-2 cells against the herpes simplex virus type 1 (HSV-1) and the poliovirus (PV). The isolated pectin (denoted as PDTS) was characterized by infrared spectroscopy, NMR and Gel permeation chromatography. The cytotoxicity was analyzed by the MTT method and antiviral activity by plaque reduction assay, immunofluorescence assay (IF) and polymerase chain reaction (PCR). The cytotoxic concentration (CC50) of PDTS was 870 μg.mL−1 and the inhibitory concentrations (IC50) were 179 μg.mL−1 and 58 μg.mL−1 for HSV-1 and PV, respectively. Greater inhibitory effect was observed when the cells were simultaneously treated with PDTS and infected, suggesting that PDTS inhibited the initial viral replication stages, revealing its antiviral potential. Several studies have been conducted on polysaccharides derived from natural sources, and their different biological properties have been reported. Their low toxicity and antiviral effects i.e., their action on several steps of viral replication, have been extensively examined. In this work, pectin isolated from Inga spp. fruit pulp was first characterized and evaluated using HEp-2 cells against the herpes simplex virus type 1 (HSV-1) and the poliovirus (PV). The isolated pectin (denoted as PDTS) was characterized by infrared spectroscopy, NMR and Gel permeation chromatography. The cytotoxicity was analyzed by the MTT method and antiviral activity by plaque reduction assay, immunofluorescence assay (IF) and polymerase chain reaction (PCR). The cytotoxic concentration (CC50) of PDTS was 870 μg.mL−1 and the inhibitory concentrations (IC50) were 179 μg.mL−1 and 58 μg.mL−1 for HSV-1 and PV, respectively. Greater inhibitory effect was observed when the cells were simultaneously treated with PDTS and infected, suggesting that PDTS inhibited the initial viral replication stages, revealing its antiviral potential. Faccin-Galhardi, Ligia Carla oth Rechenchoski, Daniele Zendrini oth Arruda, Tathilene Bezerra Mota Gomes oth Cunha, Arcelina Pacheco oth de Almeida, Raimundo Rafael oth Rodrigues, Francisco Eduardo Arruda oth Ricardo, Nágila Maria Pontes Silva oth Nozawa, Carlos oth Linhares, Rosa Elisa Carvalho oth Enthalten in Elsevier Penchovsky, Robert ELSEVIER Automated DNA hybridization transfer with movable super-paramagnetic microbeads in a microflow reactor 2019 structure, function and interactions New York, NY [u.a.] (DE-627)ELV002200198 volume:139 year:2019 day:15 month:10 pages:925-931 extent:7 https://doi.org/10.1016/j.ijbiomac.2019.07.212 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 58.30 Biotechnologie VZ 50.22 Sensorik VZ 44.09 Medizintechnik VZ AR 139 2019 15 1015 925-931 7 |
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10.1016/j.ijbiomac.2019.07.212 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000823.pica (DE-627)ELV048605530 (ELSEVIER)S0141-8130(19)30437-4 DE-627 ger DE-627 rakwb eng 570 610 VZ 58.30 bkl 50.22 bkl 44.09 bkl de Godoi, Ananda Marques verfasserin aut Structural characterization and antiviral activity of pectin isolated from Inga spp. 2019transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Several studies have been conducted on polysaccharides derived from natural sources, and their different biological properties have been reported. Their low toxicity and antiviral effects i.e., their action on several steps of viral replication, have been extensively examined. In this work, pectin isolated from Inga spp. fruit pulp was first characterized and evaluated using HEp-2 cells against the herpes simplex virus type 1 (HSV-1) and the poliovirus (PV). The isolated pectin (denoted as PDTS) was characterized by infrared spectroscopy, NMR and Gel permeation chromatography. The cytotoxicity was analyzed by the MTT method and antiviral activity by plaque reduction assay, immunofluorescence assay (IF) and polymerase chain reaction (PCR). The cytotoxic concentration (CC50) of PDTS was 870 μg.mL−1 and the inhibitory concentrations (IC50) were 179 μg.mL−1 and 58 μg.mL−1 for HSV-1 and PV, respectively. Greater inhibitory effect was observed when the cells were simultaneously treated with PDTS and infected, suggesting that PDTS inhibited the initial viral replication stages, revealing its antiviral potential. Several studies have been conducted on polysaccharides derived from natural sources, and their different biological properties have been reported. Their low toxicity and antiviral effects i.e., their action on several steps of viral replication, have been extensively examined. In this work, pectin isolated from Inga spp. fruit pulp was first characterized and evaluated using HEp-2 cells against the herpes simplex virus type 1 (HSV-1) and the poliovirus (PV). The isolated pectin (denoted as PDTS) was characterized by infrared spectroscopy, NMR and Gel permeation chromatography. The cytotoxicity was analyzed by the MTT method and antiviral activity by plaque reduction assay, immunofluorescence assay (IF) and polymerase chain reaction (PCR). The cytotoxic concentration (CC50) of PDTS was 870 μg.mL−1 and the inhibitory concentrations (IC50) were 179 μg.mL−1 and 58 μg.mL−1 for HSV-1 and PV, respectively. Greater inhibitory effect was observed when the cells were simultaneously treated with PDTS and infected, suggesting that PDTS inhibited the initial viral replication stages, revealing its antiviral potential. Faccin-Galhardi, Ligia Carla oth Rechenchoski, Daniele Zendrini oth Arruda, Tathilene Bezerra Mota Gomes oth Cunha, Arcelina Pacheco oth de Almeida, Raimundo Rafael oth Rodrigues, Francisco Eduardo Arruda oth Ricardo, Nágila Maria Pontes Silva oth Nozawa, Carlos oth Linhares, Rosa Elisa Carvalho oth Enthalten in Elsevier Penchovsky, Robert ELSEVIER Automated DNA hybridization transfer with movable super-paramagnetic microbeads in a microflow reactor 2019 structure, function and interactions New York, NY [u.a.] (DE-627)ELV002200198 volume:139 year:2019 day:15 month:10 pages:925-931 extent:7 https://doi.org/10.1016/j.ijbiomac.2019.07.212 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 58.30 Biotechnologie VZ 50.22 Sensorik VZ 44.09 Medizintechnik VZ AR 139 2019 15 1015 925-931 7 |
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10.1016/j.ijbiomac.2019.07.212 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000823.pica (DE-627)ELV048605530 (ELSEVIER)S0141-8130(19)30437-4 DE-627 ger DE-627 rakwb eng 570 610 VZ 58.30 bkl 50.22 bkl 44.09 bkl de Godoi, Ananda Marques verfasserin aut Structural characterization and antiviral activity of pectin isolated from Inga spp. 2019transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Several studies have been conducted on polysaccharides derived from natural sources, and their different biological properties have been reported. Their low toxicity and antiviral effects i.e., their action on several steps of viral replication, have been extensively examined. In this work, pectin isolated from Inga spp. fruit pulp was first characterized and evaluated using HEp-2 cells against the herpes simplex virus type 1 (HSV-1) and the poliovirus (PV). The isolated pectin (denoted as PDTS) was characterized by infrared spectroscopy, NMR and Gel permeation chromatography. The cytotoxicity was analyzed by the MTT method and antiviral activity by plaque reduction assay, immunofluorescence assay (IF) and polymerase chain reaction (PCR). The cytotoxic concentration (CC50) of PDTS was 870 μg.mL−1 and the inhibitory concentrations (IC50) were 179 μg.mL−1 and 58 μg.mL−1 for HSV-1 and PV, respectively. Greater inhibitory effect was observed when the cells were simultaneously treated with PDTS and infected, suggesting that PDTS inhibited the initial viral replication stages, revealing its antiviral potential. Several studies have been conducted on polysaccharides derived from natural sources, and their different biological properties have been reported. Their low toxicity and antiviral effects i.e., their action on several steps of viral replication, have been extensively examined. In this work, pectin isolated from Inga spp. fruit pulp was first characterized and evaluated using HEp-2 cells against the herpes simplex virus type 1 (HSV-1) and the poliovirus (PV). The isolated pectin (denoted as PDTS) was characterized by infrared spectroscopy, NMR and Gel permeation chromatography. The cytotoxicity was analyzed by the MTT method and antiviral activity by plaque reduction assay, immunofluorescence assay (IF) and polymerase chain reaction (PCR). The cytotoxic concentration (CC50) of PDTS was 870 μg.mL−1 and the inhibitory concentrations (IC50) were 179 μg.mL−1 and 58 μg.mL−1 for HSV-1 and PV, respectively. Greater inhibitory effect was observed when the cells were simultaneously treated with PDTS and infected, suggesting that PDTS inhibited the initial viral replication stages, revealing its antiviral potential. Faccin-Galhardi, Ligia Carla oth Rechenchoski, Daniele Zendrini oth Arruda, Tathilene Bezerra Mota Gomes oth Cunha, Arcelina Pacheco oth de Almeida, Raimundo Rafael oth Rodrigues, Francisco Eduardo Arruda oth Ricardo, Nágila Maria Pontes Silva oth Nozawa, Carlos oth Linhares, Rosa Elisa Carvalho oth Enthalten in Elsevier Penchovsky, Robert ELSEVIER Automated DNA hybridization transfer with movable super-paramagnetic microbeads in a microflow reactor 2019 structure, function and interactions New York, NY [u.a.] (DE-627)ELV002200198 volume:139 year:2019 day:15 month:10 pages:925-931 extent:7 https://doi.org/10.1016/j.ijbiomac.2019.07.212 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 58.30 Biotechnologie VZ 50.22 Sensorik VZ 44.09 Medizintechnik VZ AR 139 2019 15 1015 925-931 7 |
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10.1016/j.ijbiomac.2019.07.212 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000823.pica (DE-627)ELV048605530 (ELSEVIER)S0141-8130(19)30437-4 DE-627 ger DE-627 rakwb eng 570 610 VZ 58.30 bkl 50.22 bkl 44.09 bkl de Godoi, Ananda Marques verfasserin aut Structural characterization and antiviral activity of pectin isolated from Inga spp. 2019transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Several studies have been conducted on polysaccharides derived from natural sources, and their different biological properties have been reported. Their low toxicity and antiviral effects i.e., their action on several steps of viral replication, have been extensively examined. In this work, pectin isolated from Inga spp. fruit pulp was first characterized and evaluated using HEp-2 cells against the herpes simplex virus type 1 (HSV-1) and the poliovirus (PV). The isolated pectin (denoted as PDTS) was characterized by infrared spectroscopy, NMR and Gel permeation chromatography. The cytotoxicity was analyzed by the MTT method and antiviral activity by plaque reduction assay, immunofluorescence assay (IF) and polymerase chain reaction (PCR). The cytotoxic concentration (CC50) of PDTS was 870 μg.mL−1 and the inhibitory concentrations (IC50) were 179 μg.mL−1 and 58 μg.mL−1 for HSV-1 and PV, respectively. Greater inhibitory effect was observed when the cells were simultaneously treated with PDTS and infected, suggesting that PDTS inhibited the initial viral replication stages, revealing its antiviral potential. Several studies have been conducted on polysaccharides derived from natural sources, and their different biological properties have been reported. Their low toxicity and antiviral effects i.e., their action on several steps of viral replication, have been extensively examined. In this work, pectin isolated from Inga spp. fruit pulp was first characterized and evaluated using HEp-2 cells against the herpes simplex virus type 1 (HSV-1) and the poliovirus (PV). The isolated pectin (denoted as PDTS) was characterized by infrared spectroscopy, NMR and Gel permeation chromatography. The cytotoxicity was analyzed by the MTT method and antiviral activity by plaque reduction assay, immunofluorescence assay (IF) and polymerase chain reaction (PCR). The cytotoxic concentration (CC50) of PDTS was 870 μg.mL−1 and the inhibitory concentrations (IC50) were 179 μg.mL−1 and 58 μg.mL−1 for HSV-1 and PV, respectively. Greater inhibitory effect was observed when the cells were simultaneously treated with PDTS and infected, suggesting that PDTS inhibited the initial viral replication stages, revealing its antiviral potential. Faccin-Galhardi, Ligia Carla oth Rechenchoski, Daniele Zendrini oth Arruda, Tathilene Bezerra Mota Gomes oth Cunha, Arcelina Pacheco oth de Almeida, Raimundo Rafael oth Rodrigues, Francisco Eduardo Arruda oth Ricardo, Nágila Maria Pontes Silva oth Nozawa, Carlos oth Linhares, Rosa Elisa Carvalho oth Enthalten in Elsevier Penchovsky, Robert ELSEVIER Automated DNA hybridization transfer with movable super-paramagnetic microbeads in a microflow reactor 2019 structure, function and interactions New York, NY [u.a.] (DE-627)ELV002200198 volume:139 year:2019 day:15 month:10 pages:925-931 extent:7 https://doi.org/10.1016/j.ijbiomac.2019.07.212 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 58.30 Biotechnologie VZ 50.22 Sensorik VZ 44.09 Medizintechnik VZ AR 139 2019 15 1015 925-931 7 |
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Enthalten in Automated DNA hybridization transfer with movable super-paramagnetic microbeads in a microflow reactor New York, NY [u.a.] volume:139 year:2019 day:15 month:10 pages:925-931 extent:7 |
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Enthalten in Automated DNA hybridization transfer with movable super-paramagnetic microbeads in a microflow reactor New York, NY [u.a.] volume:139 year:2019 day:15 month:10 pages:925-931 extent:7 |
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de Godoi, Ananda Marques @@aut@@ Faccin-Galhardi, Ligia Carla @@oth@@ Rechenchoski, Daniele Zendrini @@oth@@ Arruda, Tathilene Bezerra Mota Gomes @@oth@@ Cunha, Arcelina Pacheco @@oth@@ de Almeida, Raimundo Rafael @@oth@@ Rodrigues, Francisco Eduardo Arruda @@oth@@ Ricardo, Nágila Maria Pontes Silva @@oth@@ Nozawa, Carlos @@oth@@ Linhares, Rosa Elisa Carvalho @@oth@@ |
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structural characterization and antiviral activity of pectin isolated from inga spp |
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Structural characterization and antiviral activity of pectin isolated from Inga spp. |
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Several studies have been conducted on polysaccharides derived from natural sources, and their different biological properties have been reported. Their low toxicity and antiviral effects i.e., their action on several steps of viral replication, have been extensively examined. In this work, pectin isolated from Inga spp. fruit pulp was first characterized and evaluated using HEp-2 cells against the herpes simplex virus type 1 (HSV-1) and the poliovirus (PV). The isolated pectin (denoted as PDTS) was characterized by infrared spectroscopy, NMR and Gel permeation chromatography. The cytotoxicity was analyzed by the MTT method and antiviral activity by plaque reduction assay, immunofluorescence assay (IF) and polymerase chain reaction (PCR). The cytotoxic concentration (CC50) of PDTS was 870 μg.mL−1 and the inhibitory concentrations (IC50) were 179 μg.mL−1 and 58 μg.mL−1 for HSV-1 and PV, respectively. Greater inhibitory effect was observed when the cells were simultaneously treated with PDTS and infected, suggesting that PDTS inhibited the initial viral replication stages, revealing its antiviral potential. |
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Several studies have been conducted on polysaccharides derived from natural sources, and their different biological properties have been reported. Their low toxicity and antiviral effects i.e., their action on several steps of viral replication, have been extensively examined. In this work, pectin isolated from Inga spp. fruit pulp was first characterized and evaluated using HEp-2 cells against the herpes simplex virus type 1 (HSV-1) and the poliovirus (PV). The isolated pectin (denoted as PDTS) was characterized by infrared spectroscopy, NMR and Gel permeation chromatography. The cytotoxicity was analyzed by the MTT method and antiviral activity by plaque reduction assay, immunofluorescence assay (IF) and polymerase chain reaction (PCR). The cytotoxic concentration (CC50) of PDTS was 870 μg.mL−1 and the inhibitory concentrations (IC50) were 179 μg.mL−1 and 58 μg.mL−1 for HSV-1 and PV, respectively. Greater inhibitory effect was observed when the cells were simultaneously treated with PDTS and infected, suggesting that PDTS inhibited the initial viral replication stages, revealing its antiviral potential. |
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Several studies have been conducted on polysaccharides derived from natural sources, and their different biological properties have been reported. Their low toxicity and antiviral effects i.e., their action on several steps of viral replication, have been extensively examined. In this work, pectin isolated from Inga spp. fruit pulp was first characterized and evaluated using HEp-2 cells against the herpes simplex virus type 1 (HSV-1) and the poliovirus (PV). The isolated pectin (denoted as PDTS) was characterized by infrared spectroscopy, NMR and Gel permeation chromatography. The cytotoxicity was analyzed by the MTT method and antiviral activity by plaque reduction assay, immunofluorescence assay (IF) and polymerase chain reaction (PCR). The cytotoxic concentration (CC50) of PDTS was 870 μg.mL−1 and the inhibitory concentrations (IC50) were 179 μg.mL−1 and 58 μg.mL−1 for HSV-1 and PV, respectively. Greater inhibitory effect was observed when the cells were simultaneously treated with PDTS and infected, suggesting that PDTS inhibited the initial viral replication stages, revealing its antiviral potential. |
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