Long-term efficacy and safety of eculizumab in Japanese patients with generalized myasthenia gravis: A subgroup analysis of the REGAIN open-label extension study
The terminal complement inhibitor eculizumab was shown to improve myasthenia gravis-related symptoms in the 26-week, phase 3, randomized, double-blind, placebo-controlled REGAIN study (NCT01997229). In this 52-week sub-analysis of the open-label extension of REGAIN (NCT02301624), eculizumab’s effica...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Murai, Hiroyuki [verfasserIn] Alves de Siqueira Carvalho, Alzira Ananias Morita, Maria da Penha Gomes da Silva, Tamires Cristina Rodriguez de Rivera, Francisco Javier |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2019transfer abstract |
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| Übergeordnetes Werk: |
Enthalten in: A new global analytical potential energy surface of NaH - Yuan, Meiling ELSEVIER, 2018, official journal of the World Federation of Neurology, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:407 ; year:2019 ; day:15 ; month:12 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1016/j.jns.2019.08.004 |
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| Katalog-ID: |
ELV048649120 |
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| 100 | 1 | |a Murai, Hiroyuki |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Long-term efficacy and safety of eculizumab in Japanese patients with generalized myasthenia gravis: A subgroup analysis of the REGAIN open-label extension study |
| 264 | 1 | |c 2019transfer abstract | |
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a nicht spezifiziert |b z |2 rdamedia | ||
| 338 | |a nicht spezifiziert |b zu |2 rdacarrier | ||
| 520 | |a The terminal complement inhibitor eculizumab was shown to improve myasthenia gravis-related symptoms in the 26-week, phase 3, randomized, double-blind, placebo-controlled REGAIN study (NCT01997229). In this 52-week sub-analysis of the open-label extension of REGAIN (NCT02301624), eculizumab’s efficacy and safety were assessed in 11 Japanese and 88 Caucasian patients with anti-acetylcholine receptor antibody-positive refractory generalized myasthenia gravis. For patients who had received placebo during REGAIN, treatment with open-label eculizumab resulted in generally similar outcomes in the Japanese and Caucasian populations. Rapid improvements were maintained for 52 weeks, assessed by change in score from open-label extension baseline to week 52 (mean [standard error]) using the following scales (in Japanese and Caucasian patients, respectively): Myasthenia Gravis Activities of Daily Living (−2.4 [1.34] and − 3.3 [0.65]); Quantitative Myasthenia Gravis (−2.9 [1.98] and − 4.3 [0.79]); Myasthenia Gravis Composite (−4.5 [2.63] and − 4.9 [1.19]); and Myasthenia Gravis Quality of Life 15-item questionnaire (−8.6 [5.68] and − 6.5 [1.93]). Overall, the safety of eculizumab was consistent with its known safety profile. In this interim sub-analysis, the efficacy and safety of eculizumab in Japanese and Caucasian patients were generally similar, and consistent with the overall REGAIN population. | ||
| 520 | |a The terminal complement inhibitor eculizumab was shown to improve myasthenia gravis-related symptoms in the 26-week, phase 3, randomized, double-blind, placebo-controlled REGAIN study (NCT01997229). In this 52-week sub-analysis of the open-label extension of REGAIN (NCT02301624), eculizumab’s efficacy and safety were assessed in 11 Japanese and 88 Caucasian patients with anti-acetylcholine receptor antibody-positive refractory generalized myasthenia gravis. For patients who had received placebo during REGAIN, treatment with open-label eculizumab resulted in generally similar outcomes in the Japanese and Caucasian populations. Rapid improvements were maintained for 52 weeks, assessed by change in score from open-label extension baseline to week 52 (mean [standard error]) using the following scales (in Japanese and Caucasian patients, respectively): Myasthenia Gravis Activities of Daily Living (−2.4 [1.34] and − 3.3 [0.65]); Quantitative Myasthenia Gravis (−2.9 [1.98] and − 4.3 [0.79]); Myasthenia Gravis Composite (−4.5 [2.63] and − 4.9 [1.19]); and Myasthenia Gravis Quality of Life 15-item questionnaire (−8.6 [5.68] and − 6.5 [1.93]). Overall, the safety of eculizumab was consistent with its known safety profile. In this interim sub-analysis, the efficacy and safety of eculizumab in Japanese and Caucasian patients were generally similar, and consistent with the overall REGAIN population. | ||
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| 700 | 1 | |a Massey, Janice |4 oth | |
| 700 | 1 | |a Beck, Kate |4 oth | |
| 700 | 1 | |a Carnes, Donna |4 oth | |
| 700 | 1 | |a Loor, John |4 oth | |
| 700 | 1 | |a Anderson, Amanda |4 oth | |
| 700 | 1 | |a Pascuzzi, Robert |4 oth | |
| 700 | 1 | |a Bodkin, Cynthia |4 oth | |
| 700 | 1 | |a Kincaid, John |4 oth | |
| 700 | 1 | |a Snook, Riley |4 oth | |
| 700 | 1 | |a Guingrich, Sandra |4 oth | |
| 700 | 1 | |a Micheels, Angela |4 oth | |
| 700 | 1 | |a Chaudhry, Vinay |4 oth | |
| 700 | 1 | |a Corse, Andrea |4 oth | |
| 700 | 1 | |a Mosmiller, Betsy |4 oth | |
| 700 | 1 | |a Kelley, Andrea |4 oth | |
| 700 | 1 | |a Ho, Doreen |4 oth | |
| 700 | 1 | |a Srinivasan, Jayashri |4 oth | |
| 700 | 1 | |a Vytopil, Michal |4 oth | |
| 700 | 1 | |a Jara, Jordan |4 oth | |
| 700 | 1 | |a Ventura, Nicholas |4 oth | |
| 700 | 1 | |a Scala, Stephanie |4 oth | |
| 700 | 1 | |a Carter, Cynthia |4 oth | |
| 700 | 1 | |a Donahue, Craig |4 oth | |
| 700 | 1 | |a Herbert, Carol |4 oth | |
| 700 | 1 | |a Weiner, Elaine |4 oth | |
| 700 | 1 | |a Alam, Sharmeen |4 oth | |
| 700 | 1 | |a McKinnon, Jonathan |4 oth | |
| 700 | 1 | |a Haar, Laura |4 oth | |
| 700 | 1 | |a McKinnon, Naya |4 oth | |
| 700 | 1 | |a Alcon, Karan |4 oth | |
| 700 | 1 | |a McKenna, Kaitlyn |4 oth | |
| 700 | 1 | |a Sattar, Nadia |4 oth | |
| 700 | 1 | |a Daniels, Kevin |4 oth | |
| 700 | 1 | |a Jeffery, Dennis |4 oth | |
| 700 | 1 | |a Freimer, Miriam |4 oth | |
| 700 | 1 | |a Hoyle, Joseph Chad |4 oth | |
| 700 | 1 | |a Kissel, John |4 oth | |
| 700 | 1 | |a Agriesti, Julie |4 oth | |
| 700 | 1 | |a Chelnick, Sharon |4 oth | |
| 700 | 1 | |a Mezache, Louisa |4 oth | |
| 700 | 1 | |a Pineda, Colleen |4 oth | |
| 700 | 1 | |a Muharrem, Filiz |4 oth | |
| 700 | 1 | |a Karam, Chafic |4 oth | |
| 700 | 1 | |a Khoury, Julie |4 oth | |
| 700 | 1 | |a Marburger, Tessa |4 oth | |
| 700 | 1 | |a Kaur, Harpreet |4 oth | |
| 700 | 1 | |a Dimitrova, Diana |4 oth | |
| 700 | 1 | |a Gilchrist, James |4 oth | |
| 700 | 1 | |a Agrawal, Brajesh |4 oth | |
| 700 | 1 | |a Elsayed, Mona |4 oth | |
| 700 | 1 | |a Kohlrus, Stephanie |4 oth | |
| 700 | 1 | |a Andoin, Angela |4 oth | |
| 700 | 1 | |a Darnell, Taylor |4 oth | |
| 700 | 1 | |a Golden, Laura |4 oth | |
| 700 | 1 | |a Lokaitis, Barbara |4 oth | |
| 700 | 1 | |a Seelback, Jenna |4 oth | |
| 700 | 1 | |a Muppidi, Srikanth |4 oth | |
| 700 | 1 | |a Goyal, Neelam |4 oth | |
| 700 | 1 | |a Sakamuri, Sarada |4 oth | |
| 700 | 1 | |a So, Yuen T. |4 oth | |
| 700 | 1 | |a Paulose, Shirley |4 oth | |
| 700 | 1 | |a Pol, Sabrina |4 oth | |
| 700 | 1 | |a Welsh, Lesly |4 oth | |
| 700 | 1 | |a Bhavaraju-Sanka, Ratna |4 oth | |
| 700 | 1 | |a Tobon Gonzales, Alejandro |4 oth | |
| 700 | 1 | |a Dishman, Lorraine |4 oth | |
| 700 | 1 | |a Jones, Floyd |4 oth | |
| 700 | 1 | |a Gonzalez, Anna |4 oth | |
| 700 | 1 | |a Padilla, Patricia |4 oth | |
| 700 | 1 | |a Saklad, Amy |4 oth | |
| 700 | 1 | |a Silva, Marcela |4 oth | |
| 700 | 1 | |a Kazamel, Mohamed |4 oth | |
| 700 | 1 | |a Alsharabati, Mohammad |4 oth | |
| 700 | 1 | |a Lu, Liang |4 oth | |
| 700 | 1 | |a Nozaki, Kenkichi |4 oth | |
| 700 | 1 | |a Mumfrey-Thomas, Sandi |4 oth | |
| 700 | 1 | |a Woodall, Amy |4 oth | |
| 700 | 1 | |a Mozaffar, Tahseen |4 oth | |
| 700 | 1 | |a Cash, Tiyonnoh |4 oth | |
| 700 | 1 | |a Goyal, Namita |4 oth | |
| 700 | 1 | |a Roy, Gulmohor |4 oth | |
| 700 | 1 | |a Mathew, Veena |4 oth | |
| 700 | 1 | |a Maqsood, Fatima |4 oth | |
| 700 | 1 | |a Minton, Brian |4 oth | |
| 700 | 1 | |a Jones, H. James |4 oth | |
| 700 | 1 | |a Rosenfeld, Jeffrey |4 oth | |
| 700 | 1 | |a Garcia, Rebekah |4 oth | |
| 700 | 1 | |a Echevarria, Laura |4 oth | |
| 700 | 1 | |a Garcia, Sonia |4 oth | |
| 700 | 1 | |a Pulley, Michael |4 oth | |
| 700 | 1 | |a Aranke, Shachie |4 oth | |
| 700 | 1 | |a Berger, Alan Ross |4 oth | |
| 700 | 1 | |a Shah, Jaimin |4 oth | |
| 700 | 1 | |a Shabbir, Yasmeen |4 oth | |
| 700 | 1 | |a Smith, Lisa |4 oth | |
| 700 | 1 | |a Varghese, Mary |4 oth | |
| 700 | 1 | |a Gutmann, Laurie |4 oth | |
| 700 | 1 | |a Gutmann, Ludwig |4 oth | |
| 700 | 1 | |a Jerath, Nivedita |4 oth | |
| 700 | 1 | |a Nance, Christopher |4 oth | |
| 700 | 1 | |a Swenson, Andrea |4 oth | |
| 700 | 1 | |a Olalde, Heena |4 oth | |
| 700 | 1 | |a Kressin, Nicole |4 oth | |
| 700 | 1 | |a Sieren, Jeri |4 oth | |
| 700 | 1 | |a Barohn, Richard |4 oth | |
| 700 | 1 | |a Dimachkie, Mazen |4 oth | |
| 700 | 1 | |a Glenn, Melanie |4 oth | |
| 700 | 1 | |a McVey, April |4 oth | |
| 700 | 1 | |a Pasnoor, Mamatha |4 oth | |
| 700 | 1 | |a Statland, Jeffery |4 oth | |
| 700 | 1 | |a Wang, Yunxia |4 oth | |
| 700 | 1 | |a Liu, Tina |4 oth | |
| 700 | 1 | |a Emmons, Kelley |4 oth | |
| 700 | 1 | |a Jenci, Nicole |4 oth | |
| 700 | 1 | |a Locheke, Jerry |4 oth | |
| 700 | 1 | |a Fondaw, Alex |4 oth | |
| 700 | 1 | |a Johns, Kathryn |4 oth | |
| 700 | 1 | |a Rico, Gabrielle |4 oth | |
| 700 | 1 | |a Walsh, Maureen |4 oth | |
| 700 | 1 | |a Herbelin, Laura |4 oth | |
| 700 | 1 | |a Hafer-Macko, Charlene |4 oth | |
| 700 | 1 | |a Kwan, Justin |4 oth | |
| 700 | 1 | |a Zilliox, Lindsay |4 oth | |
| 700 | 1 | |a Callison, Karen |4 oth | |
| 700 | 1 | |a Young, Valerie |4 oth | |
| 700 | 1 | |a DiSanzo, Beth |4 oth | |
| 700 | 1 | |a Naunton, Kerry |4 oth | |
| 700 | 1 | |a Benatar, Michael |4 oth | |
| 700 | 1 | |a Bilsker, Martin |4 oth | |
| 700 | 1 | |a Sharma, Khema |4 oth | |
| 700 | 1 | |a Cooley, Anne |4 oth | |
| 700 | 1 | |a Reyes, Eliana |4 oth | |
| 700 | 1 | |a Michon, Sara-Claude |4 oth | |
| 700 | 1 | |a Sheldon, Danielle |4 oth | |
| 700 | 1 | |a Steele, Julie |4 oth | |
| 700 | 1 | |a Howard Jr, James |4 oth | |
| 700 | 1 | |a Karam, Chafic |4 oth | |
| 700 | 1 | |a Chopra, Manisha |4 oth | |
| 700 | 1 | |a Traub, Rebecca |4 oth | |
| 700 | 1 | |a Vu, Tuan |4 oth | |
| 700 | 1 | |a Katzin, Lara |4 oth | |
| 700 | 1 | |a McClain, Terry |4 oth | |
| 700 | 1 | |a Harvey, Brittany |4 oth | |
| 700 | 1 | |a Hart, Adam |4 oth | |
| 700 | 1 | |a Huynh, Kristin |4 oth | |
| 700 | 1 | |a Beydoun, Said |4 oth | |
| 700 | 1 | |a Chilingaryan, Amaiak |4 oth | |
| 700 | 1 | |a Doan, Victor |4 oth | |
| 700 | 1 | |a Droker, Brian |4 oth | |
| 700 | 1 | |a Gong, Hui |4 oth | |
| 700 | 1 | |a Karimi, Sanaz |4 oth | |
| 700 | 1 | |a Lin, Frank |4 oth | |
| 700 | 1 | |a McClain, Terry |4 oth | |
| 700 | 1 | |a Pokala, Krishna |4 oth | |
| 700 | 1 | |a Shah, Akshay |4 oth | |
| 700 | 1 | |a Tran, Anh |4 oth | |
| 700 | 1 | |a Akhter, Salma |4 oth | |
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| 773 | 0 | 8 | |i Enthalten in |n Elsevier Science |a Yuan, Meiling ELSEVIER |t A new global analytical potential energy surface of NaH |d 2018 |d official journal of the World Federation of Neurology |g Amsterdam [u.a.] |w (DE-627)ELV001315870 |
| 773 | 1 | 8 | |g volume:407 |g year:2019 |g day:15 |g month:12 |g pages:0 |
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10.1016/j.jns.2019.08.004 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000826.pica (DE-627)ELV048649120 (ELSEVIER)S0022-510X(19)30340-5 DE-627 ger DE-627 rakwb eng 540 VZ 35.10 bkl Murai, Hiroyuki verfasserin aut Long-term efficacy and safety of eculizumab in Japanese patients with generalized myasthenia gravis: A subgroup analysis of the REGAIN open-label extension study 2019transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The terminal complement inhibitor eculizumab was shown to improve myasthenia gravis-related symptoms in the 26-week, phase 3, randomized, double-blind, placebo-controlled REGAIN study (NCT01997229). In this 52-week sub-analysis of the open-label extension of REGAIN (NCT02301624), eculizumab’s efficacy and safety were assessed in 11 Japanese and 88 Caucasian patients with anti-acetylcholine receptor antibody-positive refractory generalized myasthenia gravis. For patients who had received placebo during REGAIN, treatment with open-label eculizumab resulted in generally similar outcomes in the Japanese and Caucasian populations. Rapid improvements were maintained for 52 weeks, assessed by change in score from open-label extension baseline to week 52 (mean [standard error]) using the following scales (in Japanese and Caucasian patients, respectively): Myasthenia Gravis Activities of Daily Living (−2.4 [1.34] and − 3.3 [0.65]); Quantitative Myasthenia Gravis (−2.9 [1.98] and − 4.3 [0.79]); Myasthenia Gravis Composite (−4.5 [2.63] and − 4.9 [1.19]); and Myasthenia Gravis Quality of Life 15-item questionnaire (−8.6 [5.68] and − 6.5 [1.93]). Overall, the safety of eculizumab was consistent with its known safety profile. In this interim sub-analysis, the efficacy and safety of eculizumab in Japanese and Caucasian patients were generally similar, and consistent with the overall REGAIN population. The terminal complement inhibitor eculizumab was shown to improve myasthenia gravis-related symptoms in the 26-week, phase 3, randomized, double-blind, placebo-controlled REGAIN study (NCT01997229). In this 52-week sub-analysis of the open-label extension of REGAIN (NCT02301624), eculizumab’s efficacy and safety were assessed in 11 Japanese and 88 Caucasian patients with anti-acetylcholine receptor antibody-positive refractory generalized myasthenia gravis. For patients who had received placebo during REGAIN, treatment with open-label eculizumab resulted in generally similar outcomes in the Japanese and Caucasian populations. Rapid improvements were maintained for 52 weeks, assessed by change in score from open-label extension baseline to week 52 (mean [standard error]) using the following scales (in Japanese and Caucasian patients, respectively): Myasthenia Gravis Activities of Daily Living (−2.4 [1.34] and − 3.3 [0.65]); Quantitative Myasthenia Gravis (−2.9 [1.98] and − 4.3 [0.79]); Myasthenia Gravis Composite (−4.5 [2.63] and − 4.9 [1.19]); and Myasthenia Gravis Quality of Life 15-item questionnaire (−8.6 [5.68] and − 6.5 [1.93]). Overall, the safety of eculizumab was consistent with its known safety profile. In this interim sub-analysis, the efficacy and safety of eculizumab in Japanese and Caucasian patients were generally similar, and consistent with the overall REGAIN population. Uzawa, Akiyuki oth Suzuki, Yasushi oth Imai, Tomihiro oth Shiraishi, Hirokazu oth Suzuki, Hidekazu oth Okumura, Meinoshin oth O’Brien, Fanny oth Wang, Jing-Jing oth Fujita, Kenji P. oth Utsugisawa, Kimiaki oth Mazia, Claudio Gabriel oth Wilken, Miguel oth Barroso, Fabio oth Saba, Juliet oth Rugiero, Marcelo oth Bettini, Mariela oth Chaves, Marcelo oth Vidal, Gonzalo oth Garcia, Alejandra Dalila oth De Bleecker, Jan oth Van den Abeele, Guy oth de Koning, Kathy oth De Mey, Katrien oth Mercelis, Rudy oth Mahieu, Délphine oth Wagemaekers, Linda oth Van Damme, Philip oth Depreitere, Annelies oth Schotte, Caroline oth Smetcoren, Charlotte oth Stevens, Olivier oth Van Daele, Sien oth Vandenbussche, Nicolas oth Vanhee, Annelies oth Verjans, Sarah oth Vynckier, Jan oth D'Hondt, Ann oth Tilkin, Petra oth Alves de Siqueira Carvalho, Alzira oth Dias Brockhausen, Igor oth Feder, David oth Ambrosio, Daniel oth César, Pamela oth Melo, Ana Paula oth Martins Ribeiro, Renata oth Rocha, Rosana oth Bezerra Rosa, Bruno oth Veiga, Thabata oth da Silva, Luiz Augusto oth Santos Engel, Murilo oth Gonçalves Geraldo, Jordana oth Ananias Morita, Maria da Penha oth Nogueira Coelho, Erica oth Paiva, Gabriel oth Pozo, Marina oth Prando, Natalia oth Martineli Torres, Debora Dada oth Butinhao, Cristiani Fernanda oth Duran, Gustavo oth Gomes da Silva, Tamires Cristina oth Otavio Maia Gonçalves, Luiz oth Pazetto, Lucas Eduardo oth Fialho, Tomás Augusto Suriane oth Renata Cubas Volpe, Luciana oth Souza Duca, Luciana oth Souza Bulle Oliveira, Acary oth Amaral Andrade, Ana Carolina oth Annes, Marcelo oth Duarte Silva, Liene oth Cavalcante Lino, Valeria oth Pinto, Wladimir oth Assis, Natália oth Carrara, Fernanda oth Miranda, Carolina oth Souza, Iandra oth Fernandes, Patricia oth Siddiqi, Zaeem oth Phan, Cecile oth Narayan, Jeffrey oth Blackmore, Derrick oth Mallon, Ashley oth Roderus, Rikki oth Watt, Elizabeth oth Junkerova, Jana oth Kurkova, Barbora oth Reguliova, Katarina oth Zapletalova, Olga oth Pitha, Jiri oth Novakova, Iveta oth Tyblova, Michaela oth Jurajdova, Ivana oth Wolfova, Marcela oth Andersen, Henning oth Harbo, Thomas oth Vinge, Lotte oth Krogh, Susanne oth Mogensen, Anita oth Vissing, John oth Højgaard, Joan oth Witting, Nanna oth Mette Ostergaard Autzen, Anne oth Pedersen, Jane oth Eralinna, Juha-Pekka oth Laaksonen, Mikko oth Oksaranta, Olli oth Harrison, Tuula oth Eriksson, Jaana oth Rozsa, Csilla oth Horvath, Melinda oth Lovas, Gabor oth Matolcsi, Judit oth Szabo, Gyorgyi oth Jakab, Gedeonne oth Szabadosne, Brigitta oth Antonini, Giovanni oth Di Pasquale, Antonella oth Garibaldi, Matteo oth Morino, Stefania oth Troili, Fernanda oth Fionda, Laura oth Filla, Allessandro oth Costabile, Teresa oth Marano, Enrico oth Saccà, Francesco oth Fasanaro, Angiola oth Marsili, Angela oth Puorro, Giorgia oth Mantegazza, Renato oth Antozzi, Carlo oth Bonanno, Silvia oth Camera, Giorgia oth Locatelli, Alberta oth Maggi, Lorenzo oth Pasanisi, Maria oth Campanella, Angela oth Evoli, Amelia oth Alboini, Paolo Emilio oth D'Amato, Valentina oth Iorio, Raffaele oth Kanai, Tetsuya oth Kawaguchi, Naoki oth Mori, Masahiro oth Kaneko, Yoko oth Kanzaki, Akiko oth Kobayashi, Eri oth Masaki, Katsuhisa oth Matsuse, Dai oth Matsushita, Takuya oth Uehara, Taira oth Shimpo, Misa oth Jingu, Maki oth Kikutake, Keiko oth Nakamura, Yumiko oth Sano, Yoshiko oth Nagane, Yuriko oth Kamegamori, Ikuko oth Tsuda, Tomoko oth Fujii, Yuko oth Futono, Kazumi oth Ozawa, Yukiko oth Mizugami, Aya oth Saito, Yuka oth Morikawa, Miyuki oth Samukawa, Makoto oth Kamakura, Sachiko oth Miyawaki, Eriko oth Mitazaki, Teiichiro oth Motomura, Masakatsu oth Mukaino, Akihiro oth Yoshimura, Shunsuke oth Asada, Shizuka oth Yoshida, Seiko oth Amamoto, Shoko oth Kobashikawa, Tomomi oth Koga, Megumi oth Maeda, Yasuko oth Takada, Kazumi oth Takada, Mihoko oth Tsurumaru, Masako oth Yamashita, Yumi oth Akiyama, Tetsuya oth Narikawa, Koichi oth Tano, Ohito oth Tsukita, Kenichi oth Kurihara, Rikako oth Meguro, Fumie oth Fukuda, Yusuke oth Sato, Miwako oth Funaka, Soichiro oth Kawamura, Tomohiro oth Makamori, Masayuki oth Takahashi, Masanori oth Taichi, Namie oth Hasuike, Tomoya oth Higuchi, Eriko oth Kobayashi, Hisako oth Osakada, Kaori oth Tsuda, Emiko oth Shimohama, Shun oth Hayashi, Takashi oth Hisahara, Shin oth Kawamata, Jun oth Murahara, Takashi oth Saitoh, Masaki oth Suzuki, Shuichiro oth Yamamoto, Daisuke oth Ishiyama, Yoko oth Ishiyama, Naoko oth Noshiro, Mayuko oth Takeyama, Rumi oth Uwasa, Kaori oth Yasuda, Ikuko oth van der Kooi, Anneke oth de Visser, Marianne oth Gibson, Tamar oth Casasnovas, Carlos oth Alberti Aguilo, Maria Antonia oth Homedes-Pedret, Christian oth Julia Palacios, Natalia oth Diez Porras, Laura oth Velez Santamaria, Valentina oth Lazaro, Ana oth Diez Tejedor, Exuperio oth Gomez Salcedo, Pilar oth Fernandez-Fournier, Mireya oth Lopez Ruiz, Pedro oth Rodriguez de Rivera, Francisco Javier oth Sastre, Maria oth Gamez, Josep oth Sune, Pilar oth Salvado, Maria oth Gili, Gisela oth Mazuela, Gonzalo oth Illa, Isabel oth Cortes Vicente, Elena oth Diaz-Manera, Jordi oth Querol Gutierrez, Luis Antonio oth Rojas Garcia, Ricardo oth Vidal, Nuria oth Arribas-Ibar, Elisabet oth Piehl, Fredrik oth Hietala, Albert oth Bjarbo, Lena oth Sengun, Ihsan oth Meherremova, Arzu oth Ozcelik, Pinar oth Balkan, Bengu oth Tuga, Celal oth Ugur, Muzeyyen oth Erdem-Ozdamar, Sevim oth Bekircan-Kurt, Can Ebru oth Acar, Nazire Pinar oth Yilmaz, Ezgi oth Caliskan, Yagmur oth Orsel, Gulsah oth Efendi, Husnu oth Aydinlik, Seda oth Cavus, Hakan oth Kutlu, Ayse oth Becerikli, Gulsah oth Semiz, Cansu oth Tun, Ozlem oth Terzi, Murat oth Dogan, Baki oth Onar, Musa Kazim oth Sen, Sedat oth Kirbas Cavdar, Tugce oth Veske, Adife oth Norwood, Fiona oth Dimitriou, Aikaterini oth Gollogly, Jakit oth Mahdi-Rogers, Mohamed oth Seddigh, Arshira oth Sokratous, Giannis oth Maier, Gal oth Sohail, Faisal oth Jacob, Saiju oth Sadalage, Girija oth Torane, Pravin oth Brown, Claire oth Shah, Amna oth Sathasivam, Sivakumar oth Arndt, Heike oth Davies, Debbie oth Watling, Dave oth Amato, Anthony oth Cochrane, Thomas oth Salajegheh, Mohammed oth Roe, Kristen oth Amato, Katherine oth Toska, Shirli oth Wolfe, Gil oth Silvestri, Nicholas oth Patrick, Kara oth Zakalik, Karen oth Katz, Jonathan oth Miller, Robert oth Engel, Marguerite oth Forshew, Dallas oth Bravver, Elena oth Brooks, Benjamin oth Plevka, Sarah oth Burdette, Maryanne oth Cunningham, Scott oth Sanjak, Mohammad oth Kramer, Megan oth Nemeth, Joanne oth Schommer, Clara oth Tierney, Scott oth Juel, Vern oth Guptill, Jeffrey oth Hobson-Webb, Lisa oth Massey, Janice oth Beck, Kate oth Carnes, Donna oth Loor, John oth Anderson, Amanda oth Pascuzzi, Robert oth Bodkin, Cynthia oth Kincaid, John oth Snook, Riley oth Guingrich, Sandra oth Micheels, Angela oth Chaudhry, Vinay oth Corse, Andrea oth Mosmiller, Betsy oth Kelley, Andrea oth Ho, Doreen oth Srinivasan, Jayashri oth Vytopil, Michal oth Jara, Jordan oth Ventura, Nicholas oth Scala, Stephanie oth Carter, Cynthia oth Donahue, Craig oth Herbert, Carol oth Weiner, Elaine oth Alam, Sharmeen oth McKinnon, Jonathan oth Haar, Laura oth McKinnon, Naya oth Alcon, Karan oth McKenna, Kaitlyn oth Sattar, Nadia oth Daniels, Kevin oth Jeffery, Dennis oth Freimer, Miriam oth Hoyle, Joseph Chad oth Kissel, John oth Agriesti, Julie oth Chelnick, Sharon oth Mezache, Louisa oth Pineda, Colleen oth Muharrem, Filiz oth Karam, Chafic oth Khoury, Julie oth Marburger, Tessa oth Kaur, Harpreet oth Dimitrova, Diana oth Gilchrist, James oth Agrawal, Brajesh oth Elsayed, Mona oth Kohlrus, Stephanie oth Andoin, Angela oth Darnell, Taylor oth Golden, Laura oth Lokaitis, Barbara oth Seelback, Jenna oth Muppidi, Srikanth oth Goyal, Neelam oth Sakamuri, Sarada oth So, Yuen T. oth Paulose, Shirley oth Pol, Sabrina oth Welsh, Lesly oth Bhavaraju-Sanka, Ratna oth Tobon Gonzales, Alejandro oth Dishman, Lorraine oth Jones, Floyd oth Gonzalez, Anna oth Padilla, Patricia oth Saklad, Amy oth Silva, Marcela oth Kazamel, Mohamed oth Alsharabati, Mohammad oth Lu, Liang oth Nozaki, Kenkichi oth Mumfrey-Thomas, Sandi oth Woodall, Amy oth Mozaffar, Tahseen oth Cash, Tiyonnoh oth Goyal, Namita oth Roy, Gulmohor oth Mathew, Veena oth Maqsood, Fatima oth Minton, Brian oth Jones, H. James oth Rosenfeld, Jeffrey oth Garcia, Rebekah oth Echevarria, Laura oth Garcia, Sonia oth Pulley, Michael oth Aranke, Shachie oth Berger, Alan Ross oth Shah, Jaimin oth Shabbir, Yasmeen oth Smith, Lisa oth Varghese, Mary oth Gutmann, Laurie oth Gutmann, Ludwig oth Jerath, Nivedita oth Nance, Christopher oth Swenson, Andrea oth Olalde, Heena oth Kressin, Nicole oth Sieren, Jeri oth Barohn, Richard oth Dimachkie, Mazen oth Glenn, Melanie oth McVey, April oth Pasnoor, Mamatha oth Statland, Jeffery oth Wang, Yunxia oth Liu, Tina oth Emmons, Kelley oth Jenci, Nicole oth Locheke, Jerry oth Fondaw, Alex oth Johns, Kathryn oth Rico, Gabrielle oth Walsh, Maureen oth Herbelin, Laura oth Hafer-Macko, Charlene oth Kwan, Justin oth Zilliox, Lindsay oth Callison, Karen oth Young, Valerie oth DiSanzo, Beth oth Naunton, Kerry oth Benatar, Michael oth Bilsker, Martin oth Sharma, Khema oth Cooley, Anne oth Reyes, Eliana oth Michon, Sara-Claude oth Sheldon, Danielle oth Steele, Julie oth Howard Jr, James oth Karam, Chafic oth Chopra, Manisha oth Traub, Rebecca oth Vu, Tuan oth Katzin, Lara oth McClain, Terry oth Harvey, Brittany oth Hart, Adam oth Huynh, Kristin oth Beydoun, Said oth Chilingaryan, Amaiak oth Doan, Victor oth Droker, Brian oth Gong, Hui oth Karimi, Sanaz oth Lin, Frank oth McClain, Terry oth Pokala, Krishna oth Shah, Akshay oth Tran, Anh oth Akhter, Salma oth Malekniazi, Ali oth Tandan, Rup oth Hehir, Michael oth Waheed, Waqar oth Lucy, Shannon oth Weiss, Michael oth Distad, Jane oth Strom, Susan oth Downing, Sharon oth Kim, Bryan oth Nowak, Richard oth Dicapua, Daniel oth Keung, Benison oth Kumar, Aditya oth Patwa, Huned oth Robeson, Kimberly oth Yang, Irene oth Nye, Joan oth Vu, Hong oth Enthalten in Elsevier Science Yuan, Meiling ELSEVIER A new global analytical potential energy surface of NaH 2018 official journal of the World Federation of Neurology Amsterdam [u.a.] (DE-627)ELV001315870 volume:407 year:2019 day:15 month:12 pages:0 https://doi.org/10.1016/j.jns.2019.08.004 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 35.10 Physikalische Chemie: Allgemeines VZ AR 407 2019 15 1215 0 |
| spelling |
10.1016/j.jns.2019.08.004 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000826.pica (DE-627)ELV048649120 (ELSEVIER)S0022-510X(19)30340-5 DE-627 ger DE-627 rakwb eng 540 VZ 35.10 bkl Murai, Hiroyuki verfasserin aut Long-term efficacy and safety of eculizumab in Japanese patients with generalized myasthenia gravis: A subgroup analysis of the REGAIN open-label extension study 2019transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The terminal complement inhibitor eculizumab was shown to improve myasthenia gravis-related symptoms in the 26-week, phase 3, randomized, double-blind, placebo-controlled REGAIN study (NCT01997229). In this 52-week sub-analysis of the open-label extension of REGAIN (NCT02301624), eculizumab’s efficacy and safety were assessed in 11 Japanese and 88 Caucasian patients with anti-acetylcholine receptor antibody-positive refractory generalized myasthenia gravis. For patients who had received placebo during REGAIN, treatment with open-label eculizumab resulted in generally similar outcomes in the Japanese and Caucasian populations. Rapid improvements were maintained for 52 weeks, assessed by change in score from open-label extension baseline to week 52 (mean [standard error]) using the following scales (in Japanese and Caucasian patients, respectively): Myasthenia Gravis Activities of Daily Living (−2.4 [1.34] and − 3.3 [0.65]); Quantitative Myasthenia Gravis (−2.9 [1.98] and − 4.3 [0.79]); Myasthenia Gravis Composite (−4.5 [2.63] and − 4.9 [1.19]); and Myasthenia Gravis Quality of Life 15-item questionnaire (−8.6 [5.68] and − 6.5 [1.93]). Overall, the safety of eculizumab was consistent with its known safety profile. In this interim sub-analysis, the efficacy and safety of eculizumab in Japanese and Caucasian patients were generally similar, and consistent with the overall REGAIN population. The terminal complement inhibitor eculizumab was shown to improve myasthenia gravis-related symptoms in the 26-week, phase 3, randomized, double-blind, placebo-controlled REGAIN study (NCT01997229). In this 52-week sub-analysis of the open-label extension of REGAIN (NCT02301624), eculizumab’s efficacy and safety were assessed in 11 Japanese and 88 Caucasian patients with anti-acetylcholine receptor antibody-positive refractory generalized myasthenia gravis. For patients who had received placebo during REGAIN, treatment with open-label eculizumab resulted in generally similar outcomes in the Japanese and Caucasian populations. Rapid improvements were maintained for 52 weeks, assessed by change in score from open-label extension baseline to week 52 (mean [standard error]) using the following scales (in Japanese and Caucasian patients, respectively): Myasthenia Gravis Activities of Daily Living (−2.4 [1.34] and − 3.3 [0.65]); Quantitative Myasthenia Gravis (−2.9 [1.98] and − 4.3 [0.79]); Myasthenia Gravis Composite (−4.5 [2.63] and − 4.9 [1.19]); and Myasthenia Gravis Quality of Life 15-item questionnaire (−8.6 [5.68] and − 6.5 [1.93]). Overall, the safety of eculizumab was consistent with its known safety profile. In this interim sub-analysis, the efficacy and safety of eculizumab in Japanese and Caucasian patients were generally similar, and consistent with the overall REGAIN population. Uzawa, Akiyuki oth Suzuki, Yasushi oth Imai, Tomihiro oth Shiraishi, Hirokazu oth Suzuki, Hidekazu oth Okumura, Meinoshin oth O’Brien, Fanny oth Wang, Jing-Jing oth Fujita, Kenji P. oth Utsugisawa, Kimiaki oth Mazia, Claudio Gabriel oth Wilken, Miguel oth Barroso, Fabio oth Saba, Juliet oth Rugiero, Marcelo oth Bettini, Mariela oth Chaves, Marcelo oth Vidal, Gonzalo oth Garcia, Alejandra Dalila oth De Bleecker, Jan oth Van den Abeele, Guy oth de Koning, Kathy oth De Mey, Katrien oth Mercelis, Rudy oth Mahieu, Délphine oth Wagemaekers, Linda oth Van Damme, Philip oth Depreitere, Annelies oth Schotte, Caroline oth Smetcoren, Charlotte oth Stevens, Olivier oth Van Daele, Sien oth Vandenbussche, Nicolas oth Vanhee, Annelies oth Verjans, Sarah oth Vynckier, Jan oth D'Hondt, Ann oth Tilkin, Petra oth Alves de Siqueira Carvalho, Alzira oth Dias Brockhausen, Igor oth Feder, David oth Ambrosio, Daniel oth César, Pamela oth Melo, Ana Paula oth Martins Ribeiro, Renata oth Rocha, Rosana oth Bezerra Rosa, Bruno oth Veiga, Thabata oth da Silva, Luiz Augusto oth Santos Engel, Murilo oth Gonçalves Geraldo, Jordana oth Ananias Morita, Maria da Penha oth Nogueira Coelho, Erica oth Paiva, Gabriel oth Pozo, Marina oth Prando, Natalia oth Martineli Torres, Debora Dada oth Butinhao, Cristiani Fernanda oth Duran, Gustavo oth Gomes da Silva, Tamires Cristina oth Otavio Maia Gonçalves, Luiz oth Pazetto, Lucas Eduardo oth Fialho, Tomás Augusto Suriane oth Renata Cubas Volpe, Luciana oth Souza Duca, Luciana oth Souza Bulle Oliveira, Acary oth Amaral Andrade, Ana Carolina oth Annes, Marcelo oth Duarte Silva, Liene oth Cavalcante Lino, Valeria oth Pinto, Wladimir oth Assis, Natália oth Carrara, Fernanda oth Miranda, Carolina oth Souza, Iandra oth Fernandes, Patricia oth Siddiqi, Zaeem oth Phan, Cecile oth Narayan, Jeffrey oth Blackmore, Derrick oth Mallon, Ashley oth Roderus, Rikki oth Watt, Elizabeth oth Junkerova, Jana oth Kurkova, Barbora oth Reguliova, Katarina oth Zapletalova, Olga oth Pitha, Jiri oth Novakova, Iveta oth Tyblova, Michaela oth Jurajdova, Ivana oth Wolfova, Marcela oth Andersen, Henning oth Harbo, Thomas oth Vinge, Lotte oth Krogh, Susanne oth Mogensen, Anita oth Vissing, John oth Højgaard, Joan oth Witting, Nanna oth Mette Ostergaard Autzen, Anne oth Pedersen, Jane oth Eralinna, Juha-Pekka oth Laaksonen, Mikko oth Oksaranta, Olli oth Harrison, Tuula oth Eriksson, Jaana oth Rozsa, Csilla oth Horvath, Melinda oth Lovas, Gabor oth Matolcsi, Judit oth Szabo, Gyorgyi oth Jakab, Gedeonne oth Szabadosne, Brigitta oth Antonini, Giovanni oth Di Pasquale, Antonella oth Garibaldi, Matteo oth Morino, Stefania oth Troili, Fernanda oth Fionda, Laura oth Filla, Allessandro oth Costabile, Teresa oth Marano, Enrico oth Saccà, Francesco oth Fasanaro, Angiola oth Marsili, Angela oth Puorro, Giorgia oth Mantegazza, Renato oth Antozzi, Carlo oth Bonanno, Silvia oth Camera, Giorgia oth Locatelli, Alberta oth Maggi, Lorenzo oth Pasanisi, Maria oth Campanella, Angela oth Evoli, Amelia oth Alboini, Paolo Emilio oth D'Amato, Valentina oth Iorio, Raffaele oth Kanai, Tetsuya oth Kawaguchi, Naoki oth Mori, Masahiro oth Kaneko, Yoko oth Kanzaki, Akiko oth Kobayashi, Eri oth Masaki, Katsuhisa oth Matsuse, Dai oth Matsushita, Takuya oth Uehara, Taira oth Shimpo, Misa oth Jingu, Maki oth Kikutake, Keiko oth Nakamura, Yumiko oth Sano, Yoshiko oth Nagane, Yuriko oth Kamegamori, Ikuko oth Tsuda, Tomoko oth Fujii, Yuko oth Futono, Kazumi oth Ozawa, Yukiko oth Mizugami, Aya oth Saito, Yuka oth Morikawa, Miyuki oth Samukawa, Makoto oth Kamakura, Sachiko oth Miyawaki, Eriko oth Mitazaki, Teiichiro oth Motomura, Masakatsu oth Mukaino, Akihiro oth Yoshimura, Shunsuke oth Asada, Shizuka oth Yoshida, Seiko oth Amamoto, Shoko oth Kobashikawa, Tomomi oth Koga, Megumi oth Maeda, Yasuko oth Takada, Kazumi oth Takada, Mihoko oth Tsurumaru, Masako oth Yamashita, Yumi oth Akiyama, Tetsuya oth Narikawa, Koichi oth Tano, Ohito oth Tsukita, Kenichi oth Kurihara, Rikako oth Meguro, Fumie oth Fukuda, Yusuke oth Sato, Miwako oth Funaka, Soichiro oth Kawamura, Tomohiro oth Makamori, Masayuki oth Takahashi, Masanori oth Taichi, Namie oth Hasuike, Tomoya oth Higuchi, Eriko oth Kobayashi, Hisako oth Osakada, Kaori oth Tsuda, Emiko oth Shimohama, Shun oth Hayashi, Takashi oth Hisahara, Shin oth Kawamata, Jun oth Murahara, Takashi oth Saitoh, Masaki oth Suzuki, Shuichiro oth Yamamoto, Daisuke oth Ishiyama, Yoko oth Ishiyama, Naoko oth Noshiro, Mayuko oth Takeyama, Rumi oth Uwasa, Kaori oth Yasuda, Ikuko oth van der Kooi, Anneke oth de Visser, Marianne oth Gibson, Tamar oth Casasnovas, Carlos oth Alberti Aguilo, Maria Antonia oth Homedes-Pedret, Christian oth Julia Palacios, Natalia oth Diez Porras, Laura oth Velez Santamaria, Valentina oth Lazaro, Ana oth Diez Tejedor, Exuperio oth Gomez Salcedo, Pilar oth Fernandez-Fournier, Mireya oth Lopez Ruiz, Pedro oth Rodriguez de Rivera, Francisco Javier oth Sastre, Maria oth Gamez, Josep oth Sune, Pilar oth Salvado, Maria oth Gili, Gisela oth Mazuela, Gonzalo oth Illa, Isabel oth Cortes Vicente, Elena oth Diaz-Manera, Jordi oth Querol Gutierrez, Luis Antonio oth Rojas Garcia, Ricardo oth Vidal, Nuria oth Arribas-Ibar, Elisabet oth Piehl, Fredrik oth Hietala, Albert oth Bjarbo, Lena oth Sengun, Ihsan oth Meherremova, Arzu oth Ozcelik, Pinar oth Balkan, Bengu oth Tuga, Celal oth Ugur, Muzeyyen oth Erdem-Ozdamar, Sevim oth Bekircan-Kurt, Can Ebru oth Acar, Nazire Pinar oth Yilmaz, Ezgi oth Caliskan, Yagmur oth Orsel, Gulsah oth Efendi, Husnu oth Aydinlik, Seda oth Cavus, Hakan oth Kutlu, Ayse oth Becerikli, Gulsah oth Semiz, Cansu oth Tun, Ozlem oth Terzi, Murat oth Dogan, Baki oth Onar, Musa Kazim oth Sen, Sedat oth Kirbas Cavdar, Tugce oth Veske, Adife oth Norwood, Fiona oth Dimitriou, Aikaterini oth Gollogly, Jakit oth Mahdi-Rogers, Mohamed oth Seddigh, Arshira oth Sokratous, Giannis oth Maier, Gal oth Sohail, Faisal oth Jacob, Saiju oth Sadalage, Girija oth Torane, Pravin oth Brown, Claire oth Shah, Amna oth Sathasivam, Sivakumar oth Arndt, Heike oth Davies, Debbie oth Watling, Dave oth Amato, Anthony oth Cochrane, Thomas oth Salajegheh, Mohammed oth Roe, Kristen oth Amato, Katherine oth Toska, Shirli oth Wolfe, Gil oth Silvestri, Nicholas oth Patrick, Kara oth Zakalik, Karen oth Katz, Jonathan oth Miller, Robert oth Engel, Marguerite oth Forshew, Dallas oth Bravver, Elena oth Brooks, Benjamin oth Plevka, Sarah oth Burdette, Maryanne oth Cunningham, Scott oth Sanjak, Mohammad oth Kramer, Megan oth Nemeth, Joanne oth Schommer, Clara oth Tierney, Scott oth Juel, Vern oth Guptill, Jeffrey oth Hobson-Webb, Lisa oth Massey, Janice oth Beck, Kate oth Carnes, Donna oth Loor, John oth Anderson, Amanda oth Pascuzzi, Robert oth Bodkin, Cynthia oth Kincaid, John oth Snook, Riley oth Guingrich, Sandra oth Micheels, Angela oth Chaudhry, Vinay oth Corse, Andrea oth Mosmiller, Betsy oth Kelley, Andrea oth Ho, Doreen oth Srinivasan, Jayashri oth Vytopil, Michal oth Jara, Jordan oth Ventura, Nicholas oth Scala, Stephanie oth Carter, Cynthia oth Donahue, Craig oth Herbert, Carol oth Weiner, Elaine oth Alam, Sharmeen oth McKinnon, Jonathan oth Haar, Laura oth McKinnon, Naya oth Alcon, Karan oth McKenna, Kaitlyn oth Sattar, Nadia oth Daniels, Kevin oth Jeffery, Dennis oth Freimer, Miriam oth Hoyle, Joseph Chad oth Kissel, John oth Agriesti, Julie oth Chelnick, Sharon oth Mezache, Louisa oth Pineda, Colleen oth Muharrem, Filiz oth Karam, Chafic oth Khoury, Julie oth Marburger, Tessa oth Kaur, Harpreet oth Dimitrova, Diana oth Gilchrist, James oth Agrawal, Brajesh oth Elsayed, Mona oth Kohlrus, Stephanie oth Andoin, Angela oth Darnell, Taylor oth Golden, Laura oth Lokaitis, Barbara oth Seelback, Jenna oth Muppidi, Srikanth oth Goyal, Neelam oth Sakamuri, Sarada oth So, Yuen T. oth Paulose, Shirley oth Pol, Sabrina oth Welsh, Lesly oth Bhavaraju-Sanka, Ratna oth Tobon Gonzales, Alejandro oth Dishman, Lorraine oth Jones, Floyd oth Gonzalez, Anna oth Padilla, Patricia oth Saklad, Amy oth Silva, Marcela oth Kazamel, Mohamed oth Alsharabati, Mohammad oth Lu, Liang oth Nozaki, Kenkichi oth Mumfrey-Thomas, Sandi oth Woodall, Amy oth Mozaffar, Tahseen oth Cash, Tiyonnoh oth Goyal, Namita oth Roy, Gulmohor oth Mathew, Veena oth Maqsood, Fatima oth Minton, Brian oth Jones, H. James oth Rosenfeld, Jeffrey oth Garcia, Rebekah oth Echevarria, Laura oth Garcia, Sonia oth Pulley, Michael oth Aranke, Shachie oth Berger, Alan Ross oth Shah, Jaimin oth Shabbir, Yasmeen oth Smith, Lisa oth Varghese, Mary oth Gutmann, Laurie oth Gutmann, Ludwig oth Jerath, Nivedita oth Nance, Christopher oth Swenson, Andrea oth Olalde, Heena oth Kressin, Nicole oth Sieren, Jeri oth Barohn, Richard oth Dimachkie, Mazen oth Glenn, Melanie oth McVey, April oth Pasnoor, Mamatha oth Statland, Jeffery oth Wang, Yunxia oth Liu, Tina oth Emmons, Kelley oth Jenci, Nicole oth Locheke, Jerry oth Fondaw, Alex oth Johns, Kathryn oth Rico, Gabrielle oth Walsh, Maureen oth Herbelin, Laura oth Hafer-Macko, Charlene oth Kwan, Justin oth Zilliox, Lindsay oth Callison, Karen oth Young, Valerie oth DiSanzo, Beth oth Naunton, Kerry oth Benatar, Michael oth Bilsker, Martin oth Sharma, Khema oth Cooley, Anne oth Reyes, Eliana oth Michon, Sara-Claude oth Sheldon, Danielle oth Steele, Julie oth Howard Jr, James oth Karam, Chafic oth Chopra, Manisha oth Traub, Rebecca oth Vu, Tuan oth Katzin, Lara oth McClain, Terry oth Harvey, Brittany oth Hart, Adam oth Huynh, Kristin oth Beydoun, Said oth Chilingaryan, Amaiak oth Doan, Victor oth Droker, Brian oth Gong, Hui oth Karimi, Sanaz oth Lin, Frank oth McClain, Terry oth Pokala, Krishna oth Shah, Akshay oth Tran, Anh oth Akhter, Salma oth Malekniazi, Ali oth Tandan, Rup oth Hehir, Michael oth Waheed, Waqar oth Lucy, Shannon oth Weiss, Michael oth Distad, Jane oth Strom, Susan oth Downing, Sharon oth Kim, Bryan oth Nowak, Richard oth Dicapua, Daniel oth Keung, Benison oth Kumar, Aditya oth Patwa, Huned oth Robeson, Kimberly oth Yang, Irene oth Nye, Joan oth Vu, Hong oth Enthalten in Elsevier Science Yuan, Meiling ELSEVIER A new global analytical potential energy surface of NaH 2018 official journal of the World Federation of Neurology Amsterdam [u.a.] (DE-627)ELV001315870 volume:407 year:2019 day:15 month:12 pages:0 https://doi.org/10.1016/j.jns.2019.08.004 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 35.10 Physikalische Chemie: Allgemeines VZ AR 407 2019 15 1215 0 |
| allfields_unstemmed |
10.1016/j.jns.2019.08.004 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000826.pica (DE-627)ELV048649120 (ELSEVIER)S0022-510X(19)30340-5 DE-627 ger DE-627 rakwb eng 540 VZ 35.10 bkl Murai, Hiroyuki verfasserin aut Long-term efficacy and safety of eculizumab in Japanese patients with generalized myasthenia gravis: A subgroup analysis of the REGAIN open-label extension study 2019transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The terminal complement inhibitor eculizumab was shown to improve myasthenia gravis-related symptoms in the 26-week, phase 3, randomized, double-blind, placebo-controlled REGAIN study (NCT01997229). In this 52-week sub-analysis of the open-label extension of REGAIN (NCT02301624), eculizumab’s efficacy and safety were assessed in 11 Japanese and 88 Caucasian patients with anti-acetylcholine receptor antibody-positive refractory generalized myasthenia gravis. For patients who had received placebo during REGAIN, treatment with open-label eculizumab resulted in generally similar outcomes in the Japanese and Caucasian populations. Rapid improvements were maintained for 52 weeks, assessed by change in score from open-label extension baseline to week 52 (mean [standard error]) using the following scales (in Japanese and Caucasian patients, respectively): Myasthenia Gravis Activities of Daily Living (−2.4 [1.34] and − 3.3 [0.65]); Quantitative Myasthenia Gravis (−2.9 [1.98] and − 4.3 [0.79]); Myasthenia Gravis Composite (−4.5 [2.63] and − 4.9 [1.19]); and Myasthenia Gravis Quality of Life 15-item questionnaire (−8.6 [5.68] and − 6.5 [1.93]). Overall, the safety of eculizumab was consistent with its known safety profile. In this interim sub-analysis, the efficacy and safety of eculizumab in Japanese and Caucasian patients were generally similar, and consistent with the overall REGAIN population. The terminal complement inhibitor eculizumab was shown to improve myasthenia gravis-related symptoms in the 26-week, phase 3, randomized, double-blind, placebo-controlled REGAIN study (NCT01997229). In this 52-week sub-analysis of the open-label extension of REGAIN (NCT02301624), eculizumab’s efficacy and safety were assessed in 11 Japanese and 88 Caucasian patients with anti-acetylcholine receptor antibody-positive refractory generalized myasthenia gravis. For patients who had received placebo during REGAIN, treatment with open-label eculizumab resulted in generally similar outcomes in the Japanese and Caucasian populations. Rapid improvements were maintained for 52 weeks, assessed by change in score from open-label extension baseline to week 52 (mean [standard error]) using the following scales (in Japanese and Caucasian patients, respectively): Myasthenia Gravis Activities of Daily Living (−2.4 [1.34] and − 3.3 [0.65]); Quantitative Myasthenia Gravis (−2.9 [1.98] and − 4.3 [0.79]); Myasthenia Gravis Composite (−4.5 [2.63] and − 4.9 [1.19]); and Myasthenia Gravis Quality of Life 15-item questionnaire (−8.6 [5.68] and − 6.5 [1.93]). Overall, the safety of eculizumab was consistent with its known safety profile. In this interim sub-analysis, the efficacy and safety of eculizumab in Japanese and Caucasian patients were generally similar, and consistent with the overall REGAIN population. Uzawa, Akiyuki oth Suzuki, Yasushi oth Imai, Tomihiro oth Shiraishi, Hirokazu oth Suzuki, Hidekazu oth Okumura, Meinoshin oth O’Brien, Fanny oth Wang, Jing-Jing oth Fujita, Kenji P. oth Utsugisawa, Kimiaki oth Mazia, Claudio Gabriel oth Wilken, Miguel oth Barroso, Fabio oth Saba, Juliet oth Rugiero, Marcelo oth Bettini, Mariela oth Chaves, Marcelo oth Vidal, Gonzalo oth Garcia, Alejandra Dalila oth De Bleecker, Jan oth Van den Abeele, Guy oth de Koning, Kathy oth De Mey, Katrien oth Mercelis, Rudy oth Mahieu, Délphine oth Wagemaekers, Linda oth Van Damme, Philip oth Depreitere, Annelies oth Schotte, Caroline oth Smetcoren, Charlotte oth Stevens, Olivier oth Van Daele, Sien oth Vandenbussche, Nicolas oth Vanhee, Annelies oth Verjans, Sarah oth Vynckier, Jan oth D'Hondt, Ann oth Tilkin, Petra oth Alves de Siqueira Carvalho, Alzira oth Dias Brockhausen, Igor oth Feder, David oth Ambrosio, Daniel oth César, Pamela oth Melo, Ana Paula oth Martins Ribeiro, Renata oth Rocha, Rosana oth Bezerra Rosa, Bruno oth Veiga, Thabata oth da Silva, Luiz Augusto oth Santos Engel, Murilo oth Gonçalves Geraldo, Jordana oth Ananias Morita, Maria da Penha oth Nogueira Coelho, Erica oth Paiva, Gabriel oth Pozo, Marina oth Prando, Natalia oth Martineli Torres, Debora Dada oth Butinhao, Cristiani Fernanda oth Duran, Gustavo oth Gomes da Silva, Tamires Cristina oth Otavio Maia Gonçalves, Luiz oth Pazetto, Lucas Eduardo oth Fialho, Tomás Augusto Suriane oth Renata Cubas Volpe, Luciana oth Souza Duca, Luciana oth Souza Bulle Oliveira, Acary oth Amaral Andrade, Ana Carolina oth Annes, Marcelo oth Duarte Silva, Liene oth Cavalcante Lino, Valeria oth Pinto, Wladimir oth Assis, Natália oth Carrara, Fernanda oth Miranda, Carolina oth Souza, Iandra oth Fernandes, Patricia oth Siddiqi, Zaeem oth Phan, Cecile oth Narayan, Jeffrey oth Blackmore, Derrick oth Mallon, Ashley oth Roderus, Rikki oth Watt, Elizabeth oth Junkerova, Jana oth Kurkova, Barbora oth Reguliova, Katarina oth Zapletalova, Olga oth Pitha, Jiri oth Novakova, Iveta oth Tyblova, Michaela oth Jurajdova, Ivana oth Wolfova, Marcela oth Andersen, Henning oth Harbo, Thomas oth Vinge, Lotte oth Krogh, Susanne oth Mogensen, Anita oth Vissing, John oth Højgaard, Joan oth Witting, Nanna oth Mette Ostergaard Autzen, Anne oth Pedersen, Jane oth Eralinna, Juha-Pekka oth Laaksonen, Mikko oth Oksaranta, Olli oth Harrison, Tuula oth Eriksson, Jaana oth Rozsa, Csilla oth Horvath, Melinda oth Lovas, Gabor oth Matolcsi, Judit oth Szabo, Gyorgyi oth Jakab, Gedeonne oth Szabadosne, Brigitta oth Antonini, Giovanni oth Di Pasquale, Antonella oth Garibaldi, Matteo oth Morino, Stefania oth Troili, Fernanda oth Fionda, Laura oth Filla, Allessandro oth Costabile, Teresa oth Marano, Enrico oth Saccà, Francesco oth Fasanaro, Angiola oth Marsili, Angela oth Puorro, Giorgia oth Mantegazza, Renato oth Antozzi, Carlo oth Bonanno, Silvia oth Camera, Giorgia oth Locatelli, Alberta oth Maggi, Lorenzo oth Pasanisi, Maria oth Campanella, Angela oth Evoli, Amelia oth Alboini, Paolo Emilio oth D'Amato, Valentina oth Iorio, Raffaele oth Kanai, Tetsuya oth Kawaguchi, Naoki oth Mori, Masahiro oth Kaneko, Yoko oth Kanzaki, Akiko oth Kobayashi, Eri oth Masaki, Katsuhisa oth Matsuse, Dai oth Matsushita, Takuya oth Uehara, Taira oth Shimpo, Misa oth Jingu, Maki oth Kikutake, Keiko oth Nakamura, Yumiko oth Sano, Yoshiko oth Nagane, Yuriko oth Kamegamori, Ikuko oth Tsuda, Tomoko oth Fujii, Yuko oth Futono, Kazumi oth Ozawa, Yukiko oth Mizugami, Aya oth Saito, Yuka oth Morikawa, Miyuki oth Samukawa, Makoto oth Kamakura, Sachiko oth Miyawaki, Eriko oth Mitazaki, Teiichiro oth Motomura, Masakatsu oth Mukaino, Akihiro oth Yoshimura, Shunsuke oth Asada, Shizuka oth Yoshida, Seiko oth Amamoto, Shoko oth Kobashikawa, Tomomi oth Koga, Megumi oth Maeda, Yasuko oth Takada, Kazumi oth Takada, Mihoko oth Tsurumaru, Masako oth Yamashita, Yumi oth Akiyama, Tetsuya oth Narikawa, Koichi oth Tano, Ohito oth Tsukita, Kenichi oth Kurihara, Rikako oth Meguro, Fumie oth Fukuda, Yusuke oth Sato, Miwako oth Funaka, Soichiro oth Kawamura, Tomohiro oth Makamori, Masayuki oth Takahashi, Masanori oth Taichi, Namie oth Hasuike, Tomoya oth Higuchi, Eriko oth Kobayashi, Hisako oth Osakada, Kaori oth Tsuda, Emiko oth Shimohama, Shun oth Hayashi, Takashi oth Hisahara, Shin oth Kawamata, Jun oth Murahara, Takashi oth Saitoh, Masaki oth Suzuki, Shuichiro oth Yamamoto, Daisuke oth Ishiyama, Yoko oth Ishiyama, Naoko oth Noshiro, Mayuko oth Takeyama, Rumi oth Uwasa, Kaori oth Yasuda, Ikuko oth van der Kooi, Anneke oth de Visser, Marianne oth Gibson, Tamar oth Casasnovas, Carlos oth Alberti Aguilo, Maria Antonia oth Homedes-Pedret, Christian oth Julia Palacios, Natalia oth Diez Porras, Laura oth Velez Santamaria, Valentina oth Lazaro, Ana oth Diez Tejedor, Exuperio oth Gomez Salcedo, Pilar oth Fernandez-Fournier, Mireya oth Lopez Ruiz, Pedro oth Rodriguez de Rivera, Francisco Javier oth Sastre, Maria oth Gamez, Josep oth Sune, Pilar oth Salvado, Maria oth Gili, Gisela oth Mazuela, Gonzalo oth Illa, Isabel oth Cortes Vicente, Elena oth Diaz-Manera, Jordi oth Querol Gutierrez, Luis Antonio oth Rojas Garcia, Ricardo oth Vidal, Nuria oth Arribas-Ibar, Elisabet oth Piehl, Fredrik oth Hietala, Albert oth Bjarbo, Lena oth Sengun, Ihsan oth Meherremova, Arzu oth Ozcelik, Pinar oth Balkan, Bengu oth Tuga, Celal oth Ugur, Muzeyyen oth Erdem-Ozdamar, Sevim oth Bekircan-Kurt, Can Ebru oth Acar, Nazire Pinar oth Yilmaz, Ezgi oth Caliskan, Yagmur oth Orsel, Gulsah oth Efendi, Husnu oth Aydinlik, Seda oth Cavus, Hakan oth Kutlu, Ayse oth Becerikli, Gulsah oth Semiz, Cansu oth Tun, Ozlem oth Terzi, Murat oth Dogan, Baki oth Onar, Musa Kazim oth Sen, Sedat oth Kirbas Cavdar, Tugce oth Veske, Adife oth Norwood, Fiona oth Dimitriou, Aikaterini oth Gollogly, Jakit oth Mahdi-Rogers, Mohamed oth Seddigh, Arshira oth Sokratous, Giannis oth Maier, Gal oth Sohail, Faisal oth Jacob, Saiju oth Sadalage, Girija oth Torane, Pravin oth Brown, Claire oth Shah, Amna oth Sathasivam, Sivakumar oth Arndt, Heike oth Davies, Debbie oth Watling, Dave oth Amato, Anthony oth Cochrane, Thomas oth Salajegheh, Mohammed oth Roe, Kristen oth Amato, Katherine oth Toska, Shirli oth Wolfe, Gil oth Silvestri, Nicholas oth Patrick, Kara oth Zakalik, Karen oth Katz, Jonathan oth Miller, Robert oth Engel, Marguerite oth Forshew, Dallas oth Bravver, Elena oth Brooks, Benjamin oth Plevka, Sarah oth Burdette, Maryanne oth Cunningham, Scott oth Sanjak, Mohammad oth Kramer, Megan oth Nemeth, Joanne oth Schommer, Clara oth Tierney, Scott oth Juel, Vern oth Guptill, Jeffrey oth Hobson-Webb, Lisa oth Massey, Janice oth Beck, Kate oth Carnes, Donna oth Loor, John oth Anderson, Amanda oth Pascuzzi, Robert oth Bodkin, Cynthia oth Kincaid, John oth Snook, Riley oth Guingrich, Sandra oth Micheels, Angela oth Chaudhry, Vinay oth Corse, Andrea oth Mosmiller, Betsy oth Kelley, Andrea oth Ho, Doreen oth Srinivasan, Jayashri oth Vytopil, Michal oth Jara, Jordan oth Ventura, Nicholas oth Scala, Stephanie oth Carter, Cynthia oth Donahue, Craig oth Herbert, Carol oth Weiner, Elaine oth Alam, Sharmeen oth McKinnon, Jonathan oth Haar, Laura oth McKinnon, Naya oth Alcon, Karan oth McKenna, Kaitlyn oth Sattar, Nadia oth Daniels, Kevin oth Jeffery, Dennis oth Freimer, Miriam oth Hoyle, Joseph Chad oth Kissel, John oth Agriesti, Julie oth Chelnick, Sharon oth Mezache, Louisa oth Pineda, Colleen oth Muharrem, Filiz oth Karam, Chafic oth Khoury, Julie oth Marburger, Tessa oth Kaur, Harpreet oth Dimitrova, Diana oth Gilchrist, James oth Agrawal, Brajesh oth Elsayed, Mona oth Kohlrus, Stephanie oth Andoin, Angela oth Darnell, Taylor oth Golden, Laura oth Lokaitis, Barbara oth Seelback, Jenna oth Muppidi, Srikanth oth Goyal, Neelam oth Sakamuri, Sarada oth So, Yuen T. oth Paulose, Shirley oth Pol, Sabrina oth Welsh, Lesly oth Bhavaraju-Sanka, Ratna oth Tobon Gonzales, Alejandro oth Dishman, Lorraine oth Jones, Floyd oth Gonzalez, Anna oth Padilla, Patricia oth Saklad, Amy oth Silva, Marcela oth Kazamel, Mohamed oth Alsharabati, Mohammad oth Lu, Liang oth Nozaki, Kenkichi oth Mumfrey-Thomas, Sandi oth Woodall, Amy oth Mozaffar, Tahseen oth Cash, Tiyonnoh oth Goyal, Namita oth Roy, Gulmohor oth Mathew, Veena oth Maqsood, Fatima oth Minton, Brian oth Jones, H. James oth Rosenfeld, Jeffrey oth Garcia, Rebekah oth Echevarria, Laura oth Garcia, Sonia oth Pulley, Michael oth Aranke, Shachie oth Berger, Alan Ross oth Shah, Jaimin oth Shabbir, Yasmeen oth Smith, Lisa oth Varghese, Mary oth Gutmann, Laurie oth Gutmann, Ludwig oth Jerath, Nivedita oth Nance, Christopher oth Swenson, Andrea oth Olalde, Heena oth Kressin, Nicole oth Sieren, Jeri oth Barohn, Richard oth Dimachkie, Mazen oth Glenn, Melanie oth McVey, April oth Pasnoor, Mamatha oth Statland, Jeffery oth Wang, Yunxia oth Liu, Tina oth Emmons, Kelley oth Jenci, Nicole oth Locheke, Jerry oth Fondaw, Alex oth Johns, Kathryn oth Rico, Gabrielle oth Walsh, Maureen oth Herbelin, Laura oth Hafer-Macko, Charlene oth Kwan, Justin oth Zilliox, Lindsay oth Callison, Karen oth Young, Valerie oth DiSanzo, Beth oth Naunton, Kerry oth Benatar, Michael oth Bilsker, Martin oth Sharma, Khema oth Cooley, Anne oth Reyes, Eliana oth Michon, Sara-Claude oth Sheldon, Danielle oth Steele, Julie oth Howard Jr, James oth Karam, Chafic oth Chopra, Manisha oth Traub, Rebecca oth Vu, Tuan oth Katzin, Lara oth McClain, Terry oth Harvey, Brittany oth Hart, Adam oth Huynh, Kristin oth Beydoun, Said oth Chilingaryan, Amaiak oth Doan, Victor oth Droker, Brian oth Gong, Hui oth Karimi, Sanaz oth Lin, Frank oth McClain, Terry oth Pokala, Krishna oth Shah, Akshay oth Tran, Anh oth Akhter, Salma oth Malekniazi, Ali oth Tandan, Rup oth Hehir, Michael oth Waheed, Waqar oth Lucy, Shannon oth Weiss, Michael oth Distad, Jane oth Strom, Susan oth Downing, Sharon oth Kim, Bryan oth Nowak, Richard oth Dicapua, Daniel oth Keung, Benison oth Kumar, Aditya oth Patwa, Huned oth Robeson, Kimberly oth Yang, Irene oth Nye, Joan oth Vu, Hong oth Enthalten in Elsevier Science Yuan, Meiling ELSEVIER A new global analytical potential energy surface of NaH 2018 official journal of the World Federation of Neurology Amsterdam [u.a.] (DE-627)ELV001315870 volume:407 year:2019 day:15 month:12 pages:0 https://doi.org/10.1016/j.jns.2019.08.004 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 35.10 Physikalische Chemie: Allgemeines VZ AR 407 2019 15 1215 0 |
| allfieldsGer |
10.1016/j.jns.2019.08.004 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000826.pica (DE-627)ELV048649120 (ELSEVIER)S0022-510X(19)30340-5 DE-627 ger DE-627 rakwb eng 540 VZ 35.10 bkl Murai, Hiroyuki verfasserin aut Long-term efficacy and safety of eculizumab in Japanese patients with generalized myasthenia gravis: A subgroup analysis of the REGAIN open-label extension study 2019transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The terminal complement inhibitor eculizumab was shown to improve myasthenia gravis-related symptoms in the 26-week, phase 3, randomized, double-blind, placebo-controlled REGAIN study (NCT01997229). In this 52-week sub-analysis of the open-label extension of REGAIN (NCT02301624), eculizumab’s efficacy and safety were assessed in 11 Japanese and 88 Caucasian patients with anti-acetylcholine receptor antibody-positive refractory generalized myasthenia gravis. For patients who had received placebo during REGAIN, treatment with open-label eculizumab resulted in generally similar outcomes in the Japanese and Caucasian populations. Rapid improvements were maintained for 52 weeks, assessed by change in score from open-label extension baseline to week 52 (mean [standard error]) using the following scales (in Japanese and Caucasian patients, respectively): Myasthenia Gravis Activities of Daily Living (−2.4 [1.34] and − 3.3 [0.65]); Quantitative Myasthenia Gravis (−2.9 [1.98] and − 4.3 [0.79]); Myasthenia Gravis Composite (−4.5 [2.63] and − 4.9 [1.19]); and Myasthenia Gravis Quality of Life 15-item questionnaire (−8.6 [5.68] and − 6.5 [1.93]). Overall, the safety of eculizumab was consistent with its known safety profile. In this interim sub-analysis, the efficacy and safety of eculizumab in Japanese and Caucasian patients were generally similar, and consistent with the overall REGAIN population. The terminal complement inhibitor eculizumab was shown to improve myasthenia gravis-related symptoms in the 26-week, phase 3, randomized, double-blind, placebo-controlled REGAIN study (NCT01997229). In this 52-week sub-analysis of the open-label extension of REGAIN (NCT02301624), eculizumab’s efficacy and safety were assessed in 11 Japanese and 88 Caucasian patients with anti-acetylcholine receptor antibody-positive refractory generalized myasthenia gravis. For patients who had received placebo during REGAIN, treatment with open-label eculizumab resulted in generally similar outcomes in the Japanese and Caucasian populations. Rapid improvements were maintained for 52 weeks, assessed by change in score from open-label extension baseline to week 52 (mean [standard error]) using the following scales (in Japanese and Caucasian patients, respectively): Myasthenia Gravis Activities of Daily Living (−2.4 [1.34] and − 3.3 [0.65]); Quantitative Myasthenia Gravis (−2.9 [1.98] and − 4.3 [0.79]); Myasthenia Gravis Composite (−4.5 [2.63] and − 4.9 [1.19]); and Myasthenia Gravis Quality of Life 15-item questionnaire (−8.6 [5.68] and − 6.5 [1.93]). Overall, the safety of eculizumab was consistent with its known safety profile. In this interim sub-analysis, the efficacy and safety of eculizumab in Japanese and Caucasian patients were generally similar, and consistent with the overall REGAIN population. Uzawa, Akiyuki oth Suzuki, Yasushi oth Imai, Tomihiro oth Shiraishi, Hirokazu oth Suzuki, Hidekazu oth Okumura, Meinoshin oth O’Brien, Fanny oth Wang, Jing-Jing oth Fujita, Kenji P. oth Utsugisawa, Kimiaki oth Mazia, Claudio Gabriel oth Wilken, Miguel oth Barroso, Fabio oth Saba, Juliet oth Rugiero, Marcelo oth Bettini, Mariela oth Chaves, Marcelo oth Vidal, Gonzalo oth Garcia, Alejandra Dalila oth De Bleecker, Jan oth Van den Abeele, Guy oth de Koning, Kathy oth De Mey, Katrien oth Mercelis, Rudy oth Mahieu, Délphine oth Wagemaekers, Linda oth Van Damme, Philip oth Depreitere, Annelies oth Schotte, Caroline oth Smetcoren, Charlotte oth Stevens, Olivier oth Van Daele, Sien oth Vandenbussche, Nicolas oth Vanhee, Annelies oth Verjans, Sarah oth Vynckier, Jan oth D'Hondt, Ann oth Tilkin, Petra oth Alves de Siqueira Carvalho, Alzira oth Dias Brockhausen, Igor oth Feder, David oth Ambrosio, Daniel oth César, Pamela oth Melo, Ana Paula oth Martins Ribeiro, Renata oth Rocha, Rosana oth Bezerra Rosa, Bruno oth Veiga, Thabata oth da Silva, Luiz Augusto oth Santos Engel, Murilo oth Gonçalves Geraldo, Jordana oth Ananias Morita, Maria da Penha oth Nogueira Coelho, Erica oth Paiva, Gabriel oth Pozo, Marina oth Prando, Natalia oth Martineli Torres, Debora Dada oth Butinhao, Cristiani Fernanda oth Duran, Gustavo oth Gomes da Silva, Tamires Cristina oth Otavio Maia Gonçalves, Luiz oth Pazetto, Lucas Eduardo oth Fialho, Tomás Augusto Suriane oth Renata Cubas Volpe, Luciana oth Souza Duca, Luciana oth Souza Bulle Oliveira, Acary oth Amaral Andrade, Ana Carolina oth Annes, Marcelo oth Duarte Silva, Liene oth Cavalcante Lino, Valeria oth Pinto, Wladimir oth Assis, Natália oth Carrara, Fernanda oth Miranda, Carolina oth Souza, Iandra oth Fernandes, Patricia oth Siddiqi, Zaeem oth Phan, Cecile oth Narayan, Jeffrey oth Blackmore, Derrick oth Mallon, Ashley oth Roderus, Rikki oth Watt, Elizabeth oth Junkerova, Jana oth Kurkova, Barbora oth Reguliova, Katarina oth Zapletalova, Olga oth Pitha, Jiri oth Novakova, Iveta oth Tyblova, Michaela oth Jurajdova, Ivana oth Wolfova, Marcela oth Andersen, Henning oth Harbo, Thomas oth Vinge, Lotte oth Krogh, Susanne oth Mogensen, Anita oth Vissing, John oth Højgaard, Joan oth Witting, Nanna oth Mette Ostergaard Autzen, Anne oth Pedersen, Jane oth Eralinna, Juha-Pekka oth Laaksonen, Mikko oth Oksaranta, Olli oth Harrison, Tuula oth Eriksson, Jaana oth Rozsa, Csilla oth Horvath, Melinda oth Lovas, Gabor oth Matolcsi, Judit oth Szabo, Gyorgyi oth Jakab, Gedeonne oth Szabadosne, Brigitta oth Antonini, Giovanni oth Di Pasquale, Antonella oth Garibaldi, Matteo oth Morino, Stefania oth Troili, Fernanda oth Fionda, Laura oth Filla, Allessandro oth Costabile, Teresa oth Marano, Enrico oth Saccà, Francesco oth Fasanaro, Angiola oth Marsili, Angela oth Puorro, Giorgia oth Mantegazza, Renato oth Antozzi, Carlo oth Bonanno, Silvia oth Camera, Giorgia oth Locatelli, Alberta oth Maggi, Lorenzo oth Pasanisi, Maria oth Campanella, Angela oth Evoli, Amelia oth Alboini, Paolo Emilio oth D'Amato, Valentina oth Iorio, Raffaele oth Kanai, Tetsuya oth Kawaguchi, Naoki oth Mori, Masahiro oth Kaneko, Yoko oth Kanzaki, Akiko oth Kobayashi, Eri oth Masaki, Katsuhisa oth Matsuse, Dai oth Matsushita, Takuya oth Uehara, Taira oth Shimpo, Misa oth Jingu, Maki oth Kikutake, Keiko oth Nakamura, Yumiko oth Sano, Yoshiko oth Nagane, Yuriko oth Kamegamori, Ikuko oth Tsuda, Tomoko oth Fujii, Yuko oth Futono, Kazumi oth Ozawa, Yukiko oth Mizugami, Aya oth Saito, Yuka oth Morikawa, Miyuki oth Samukawa, Makoto oth Kamakura, Sachiko oth Miyawaki, Eriko oth Mitazaki, Teiichiro oth Motomura, Masakatsu oth Mukaino, Akihiro oth Yoshimura, Shunsuke oth Asada, Shizuka oth Yoshida, Seiko oth Amamoto, Shoko oth Kobashikawa, Tomomi oth Koga, Megumi oth Maeda, Yasuko oth Takada, Kazumi oth Takada, Mihoko oth Tsurumaru, Masako oth Yamashita, Yumi oth Akiyama, Tetsuya oth Narikawa, Koichi oth Tano, Ohito oth Tsukita, Kenichi oth Kurihara, Rikako oth Meguro, Fumie oth Fukuda, Yusuke oth Sato, Miwako oth Funaka, Soichiro oth Kawamura, Tomohiro oth Makamori, Masayuki oth Takahashi, Masanori oth Taichi, Namie oth Hasuike, Tomoya oth Higuchi, Eriko oth Kobayashi, Hisako oth Osakada, Kaori oth Tsuda, Emiko oth Shimohama, Shun oth Hayashi, Takashi oth Hisahara, Shin oth Kawamata, Jun oth Murahara, Takashi oth Saitoh, Masaki oth Suzuki, Shuichiro oth Yamamoto, Daisuke oth Ishiyama, Yoko oth Ishiyama, Naoko oth Noshiro, Mayuko oth Takeyama, Rumi oth Uwasa, Kaori oth Yasuda, Ikuko oth van der Kooi, Anneke oth de Visser, Marianne oth Gibson, Tamar oth Casasnovas, Carlos oth Alberti Aguilo, Maria Antonia oth Homedes-Pedret, Christian oth Julia Palacios, Natalia oth Diez Porras, Laura oth Velez Santamaria, Valentina oth Lazaro, Ana oth Diez Tejedor, Exuperio oth Gomez Salcedo, Pilar oth Fernandez-Fournier, Mireya oth Lopez Ruiz, Pedro oth Rodriguez de Rivera, Francisco Javier oth Sastre, Maria oth Gamez, Josep oth Sune, Pilar oth Salvado, Maria oth Gili, Gisela oth Mazuela, Gonzalo oth Illa, Isabel oth Cortes Vicente, Elena oth Diaz-Manera, Jordi oth Querol Gutierrez, Luis Antonio oth Rojas Garcia, Ricardo oth Vidal, Nuria oth Arribas-Ibar, Elisabet oth Piehl, Fredrik oth Hietala, Albert oth Bjarbo, Lena oth Sengun, Ihsan oth Meherremova, Arzu oth Ozcelik, Pinar oth Balkan, Bengu oth Tuga, Celal oth Ugur, Muzeyyen oth Erdem-Ozdamar, Sevim oth Bekircan-Kurt, Can Ebru oth Acar, Nazire Pinar oth Yilmaz, Ezgi oth Caliskan, Yagmur oth Orsel, Gulsah oth Efendi, Husnu oth Aydinlik, Seda oth Cavus, Hakan oth Kutlu, Ayse oth Becerikli, Gulsah oth Semiz, Cansu oth Tun, Ozlem oth Terzi, Murat oth Dogan, Baki oth Onar, Musa Kazim oth Sen, Sedat oth Kirbas Cavdar, Tugce oth Veske, Adife oth Norwood, Fiona oth Dimitriou, Aikaterini oth Gollogly, Jakit oth Mahdi-Rogers, Mohamed oth Seddigh, Arshira oth Sokratous, Giannis oth Maier, Gal oth Sohail, Faisal oth Jacob, Saiju oth Sadalage, Girija oth Torane, Pravin oth Brown, Claire oth Shah, Amna oth Sathasivam, Sivakumar oth Arndt, Heike oth Davies, Debbie oth Watling, Dave oth Amato, Anthony oth Cochrane, Thomas oth Salajegheh, Mohammed oth Roe, Kristen oth Amato, Katherine oth Toska, Shirli oth Wolfe, Gil oth Silvestri, Nicholas oth Patrick, Kara oth Zakalik, Karen oth Katz, Jonathan oth Miller, Robert oth Engel, Marguerite oth Forshew, Dallas oth Bravver, Elena oth Brooks, Benjamin oth Plevka, Sarah oth Burdette, Maryanne oth Cunningham, Scott oth Sanjak, Mohammad oth Kramer, Megan oth Nemeth, Joanne oth Schommer, Clara oth Tierney, Scott oth Juel, Vern oth Guptill, Jeffrey oth Hobson-Webb, Lisa oth Massey, Janice oth Beck, Kate oth Carnes, Donna oth Loor, John oth Anderson, Amanda oth Pascuzzi, Robert oth Bodkin, Cynthia oth Kincaid, John oth Snook, Riley oth Guingrich, Sandra oth Micheels, Angela oth Chaudhry, Vinay oth Corse, Andrea oth Mosmiller, Betsy oth Kelley, Andrea oth Ho, Doreen oth Srinivasan, Jayashri oth Vytopil, Michal oth Jara, Jordan oth Ventura, Nicholas oth Scala, Stephanie oth Carter, Cynthia oth Donahue, Craig oth Herbert, Carol oth Weiner, Elaine oth Alam, Sharmeen oth McKinnon, Jonathan oth Haar, Laura oth McKinnon, Naya oth Alcon, Karan oth McKenna, Kaitlyn oth Sattar, Nadia oth Daniels, Kevin oth Jeffery, Dennis oth Freimer, Miriam oth Hoyle, Joseph Chad oth Kissel, John oth Agriesti, Julie oth Chelnick, Sharon oth Mezache, Louisa oth Pineda, Colleen oth Muharrem, Filiz oth Karam, Chafic oth Khoury, Julie oth Marburger, Tessa oth Kaur, Harpreet oth Dimitrova, Diana oth Gilchrist, James oth Agrawal, Brajesh oth Elsayed, Mona oth Kohlrus, Stephanie oth Andoin, Angela oth Darnell, Taylor oth Golden, Laura oth Lokaitis, Barbara oth Seelback, Jenna oth Muppidi, Srikanth oth Goyal, Neelam oth Sakamuri, Sarada oth So, Yuen T. oth Paulose, Shirley oth Pol, Sabrina oth Welsh, Lesly oth Bhavaraju-Sanka, Ratna oth Tobon Gonzales, Alejandro oth Dishman, Lorraine oth Jones, Floyd oth Gonzalez, Anna oth Padilla, Patricia oth Saklad, Amy oth Silva, Marcela oth Kazamel, Mohamed oth Alsharabati, Mohammad oth Lu, Liang oth Nozaki, Kenkichi oth Mumfrey-Thomas, Sandi oth Woodall, Amy oth Mozaffar, Tahseen oth Cash, Tiyonnoh oth Goyal, Namita oth Roy, Gulmohor oth Mathew, Veena oth Maqsood, Fatima oth Minton, Brian oth Jones, H. James oth Rosenfeld, Jeffrey oth Garcia, Rebekah oth Echevarria, Laura oth Garcia, Sonia oth Pulley, Michael oth Aranke, Shachie oth Berger, Alan Ross oth Shah, Jaimin oth Shabbir, Yasmeen oth Smith, Lisa oth Varghese, Mary oth Gutmann, Laurie oth Gutmann, Ludwig oth Jerath, Nivedita oth Nance, Christopher oth Swenson, Andrea oth Olalde, Heena oth Kressin, Nicole oth Sieren, Jeri oth Barohn, Richard oth Dimachkie, Mazen oth Glenn, Melanie oth McVey, April oth Pasnoor, Mamatha oth Statland, Jeffery oth Wang, Yunxia oth Liu, Tina oth Emmons, Kelley oth Jenci, Nicole oth Locheke, Jerry oth Fondaw, Alex oth Johns, Kathryn oth Rico, Gabrielle oth Walsh, Maureen oth Herbelin, Laura oth Hafer-Macko, Charlene oth Kwan, Justin oth Zilliox, Lindsay oth Callison, Karen oth Young, Valerie oth DiSanzo, Beth oth Naunton, Kerry oth Benatar, Michael oth Bilsker, Martin oth Sharma, Khema oth Cooley, Anne oth Reyes, Eliana oth Michon, Sara-Claude oth Sheldon, Danielle oth Steele, Julie oth Howard Jr, James oth Karam, Chafic oth Chopra, Manisha oth Traub, Rebecca oth Vu, Tuan oth Katzin, Lara oth McClain, Terry oth Harvey, Brittany oth Hart, Adam oth Huynh, Kristin oth Beydoun, Said oth Chilingaryan, Amaiak oth Doan, Victor oth Droker, Brian oth Gong, Hui oth Karimi, Sanaz oth Lin, Frank oth McClain, Terry oth Pokala, Krishna oth Shah, Akshay oth Tran, Anh oth Akhter, Salma oth Malekniazi, Ali oth Tandan, Rup oth Hehir, Michael oth Waheed, Waqar oth Lucy, Shannon oth Weiss, Michael oth Distad, Jane oth Strom, Susan oth Downing, Sharon oth Kim, Bryan oth Nowak, Richard oth Dicapua, Daniel oth Keung, Benison oth Kumar, Aditya oth Patwa, Huned oth Robeson, Kimberly oth Yang, Irene oth Nye, Joan oth Vu, Hong oth Enthalten in Elsevier Science Yuan, Meiling ELSEVIER A new global analytical potential energy surface of NaH 2018 official journal of the World Federation of Neurology Amsterdam [u.a.] (DE-627)ELV001315870 volume:407 year:2019 day:15 month:12 pages:0 https://doi.org/10.1016/j.jns.2019.08.004 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 35.10 Physikalische Chemie: Allgemeines VZ AR 407 2019 15 1215 0 |
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10.1016/j.jns.2019.08.004 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000826.pica (DE-627)ELV048649120 (ELSEVIER)S0022-510X(19)30340-5 DE-627 ger DE-627 rakwb eng 540 VZ 35.10 bkl Murai, Hiroyuki verfasserin aut Long-term efficacy and safety of eculizumab in Japanese patients with generalized myasthenia gravis: A subgroup analysis of the REGAIN open-label extension study 2019transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The terminal complement inhibitor eculizumab was shown to improve myasthenia gravis-related symptoms in the 26-week, phase 3, randomized, double-blind, placebo-controlled REGAIN study (NCT01997229). In this 52-week sub-analysis of the open-label extension of REGAIN (NCT02301624), eculizumab’s efficacy and safety were assessed in 11 Japanese and 88 Caucasian patients with anti-acetylcholine receptor antibody-positive refractory generalized myasthenia gravis. For patients who had received placebo during REGAIN, treatment with open-label eculizumab resulted in generally similar outcomes in the Japanese and Caucasian populations. Rapid improvements were maintained for 52 weeks, assessed by change in score from open-label extension baseline to week 52 (mean [standard error]) using the following scales (in Japanese and Caucasian patients, respectively): Myasthenia Gravis Activities of Daily Living (−2.4 [1.34] and − 3.3 [0.65]); Quantitative Myasthenia Gravis (−2.9 [1.98] and − 4.3 [0.79]); Myasthenia Gravis Composite (−4.5 [2.63] and − 4.9 [1.19]); and Myasthenia Gravis Quality of Life 15-item questionnaire (−8.6 [5.68] and − 6.5 [1.93]). Overall, the safety of eculizumab was consistent with its known safety profile. In this interim sub-analysis, the efficacy and safety of eculizumab in Japanese and Caucasian patients were generally similar, and consistent with the overall REGAIN population. The terminal complement inhibitor eculizumab was shown to improve myasthenia gravis-related symptoms in the 26-week, phase 3, randomized, double-blind, placebo-controlled REGAIN study (NCT01997229). In this 52-week sub-analysis of the open-label extension of REGAIN (NCT02301624), eculizumab’s efficacy and safety were assessed in 11 Japanese and 88 Caucasian patients with anti-acetylcholine receptor antibody-positive refractory generalized myasthenia gravis. For patients who had received placebo during REGAIN, treatment with open-label eculizumab resulted in generally similar outcomes in the Japanese and Caucasian populations. Rapid improvements were maintained for 52 weeks, assessed by change in score from open-label extension baseline to week 52 (mean [standard error]) using the following scales (in Japanese and Caucasian patients, respectively): Myasthenia Gravis Activities of Daily Living (−2.4 [1.34] and − 3.3 [0.65]); Quantitative Myasthenia Gravis (−2.9 [1.98] and − 4.3 [0.79]); Myasthenia Gravis Composite (−4.5 [2.63] and − 4.9 [1.19]); and Myasthenia Gravis Quality of Life 15-item questionnaire (−8.6 [5.68] and − 6.5 [1.93]). Overall, the safety of eculizumab was consistent with its known safety profile. In this interim sub-analysis, the efficacy and safety of eculizumab in Japanese and Caucasian patients were generally similar, and consistent with the overall REGAIN population. Uzawa, Akiyuki oth Suzuki, Yasushi oth Imai, Tomihiro oth Shiraishi, Hirokazu oth Suzuki, Hidekazu oth Okumura, Meinoshin oth O’Brien, Fanny oth Wang, Jing-Jing oth Fujita, Kenji P. oth Utsugisawa, Kimiaki oth Mazia, Claudio Gabriel oth Wilken, Miguel oth Barroso, Fabio oth Saba, Juliet oth Rugiero, Marcelo oth Bettini, Mariela oth Chaves, Marcelo oth Vidal, Gonzalo oth Garcia, Alejandra Dalila oth De Bleecker, Jan oth Van den Abeele, Guy oth de Koning, Kathy oth De Mey, Katrien oth Mercelis, Rudy oth Mahieu, Délphine oth Wagemaekers, Linda oth Van Damme, Philip oth Depreitere, Annelies oth Schotte, Caroline oth Smetcoren, Charlotte oth Stevens, Olivier oth Van Daele, Sien oth Vandenbussche, Nicolas oth Vanhee, Annelies oth Verjans, Sarah oth Vynckier, Jan oth D'Hondt, Ann oth Tilkin, Petra oth Alves de Siqueira Carvalho, Alzira oth Dias Brockhausen, Igor oth Feder, David oth Ambrosio, Daniel oth César, Pamela oth Melo, Ana Paula oth Martins Ribeiro, Renata oth Rocha, Rosana oth Bezerra Rosa, Bruno oth Veiga, Thabata oth da Silva, Luiz Augusto oth Santos Engel, Murilo oth Gonçalves Geraldo, Jordana oth Ananias Morita, Maria da Penha oth Nogueira Coelho, Erica oth Paiva, Gabriel oth Pozo, Marina oth Prando, Natalia oth Martineli Torres, Debora Dada oth Butinhao, Cristiani Fernanda oth Duran, Gustavo oth Gomes da Silva, Tamires Cristina oth Otavio Maia Gonçalves, Luiz oth Pazetto, Lucas Eduardo oth Fialho, Tomás Augusto Suriane oth Renata Cubas Volpe, Luciana oth Souza Duca, Luciana oth Souza Bulle Oliveira, Acary oth Amaral Andrade, Ana Carolina oth Annes, Marcelo oth Duarte Silva, Liene oth Cavalcante Lino, Valeria oth Pinto, Wladimir oth Assis, Natália oth Carrara, Fernanda oth Miranda, Carolina oth Souza, Iandra oth Fernandes, Patricia oth Siddiqi, Zaeem oth Phan, Cecile oth Narayan, Jeffrey oth Blackmore, Derrick oth Mallon, Ashley oth Roderus, Rikki oth Watt, Elizabeth oth Junkerova, Jana oth Kurkova, Barbora oth Reguliova, Katarina oth Zapletalova, Olga oth Pitha, Jiri oth Novakova, Iveta oth Tyblova, Michaela oth Jurajdova, Ivana oth Wolfova, Marcela oth Andersen, Henning oth Harbo, Thomas oth Vinge, Lotte oth Krogh, Susanne oth Mogensen, Anita oth Vissing, John oth Højgaard, Joan oth Witting, Nanna oth Mette Ostergaard Autzen, Anne oth Pedersen, Jane oth Eralinna, Juha-Pekka oth Laaksonen, Mikko oth Oksaranta, Olli oth Harrison, Tuula oth Eriksson, Jaana oth Rozsa, Csilla oth Horvath, Melinda oth Lovas, Gabor oth Matolcsi, Judit oth Szabo, Gyorgyi oth Jakab, Gedeonne oth Szabadosne, Brigitta oth Antonini, Giovanni oth Di Pasquale, Antonella oth Garibaldi, Matteo oth Morino, Stefania oth Troili, Fernanda oth Fionda, Laura oth Filla, Allessandro oth Costabile, Teresa oth Marano, Enrico oth Saccà, Francesco oth Fasanaro, Angiola oth Marsili, Angela oth Puorro, Giorgia oth Mantegazza, Renato oth Antozzi, Carlo oth Bonanno, Silvia oth Camera, Giorgia oth Locatelli, Alberta oth Maggi, Lorenzo oth Pasanisi, Maria oth Campanella, Angela oth Evoli, Amelia oth Alboini, Paolo Emilio oth D'Amato, Valentina oth Iorio, Raffaele oth Kanai, Tetsuya oth Kawaguchi, Naoki oth Mori, Masahiro oth Kaneko, Yoko oth Kanzaki, Akiko oth Kobayashi, Eri oth Masaki, Katsuhisa oth Matsuse, Dai oth Matsushita, Takuya oth Uehara, Taira oth Shimpo, Misa oth Jingu, Maki oth Kikutake, Keiko oth Nakamura, Yumiko oth Sano, Yoshiko oth Nagane, Yuriko oth Kamegamori, Ikuko oth Tsuda, Tomoko oth Fujii, Yuko oth Futono, Kazumi oth Ozawa, Yukiko oth Mizugami, Aya oth Saito, Yuka oth Morikawa, Miyuki oth Samukawa, Makoto oth Kamakura, Sachiko oth Miyawaki, Eriko oth Mitazaki, Teiichiro oth Motomura, Masakatsu oth Mukaino, Akihiro oth Yoshimura, Shunsuke oth Asada, Shizuka oth Yoshida, Seiko oth Amamoto, Shoko oth Kobashikawa, Tomomi oth Koga, Megumi oth Maeda, Yasuko oth Takada, Kazumi oth Takada, Mihoko oth Tsurumaru, Masako oth Yamashita, Yumi oth Akiyama, Tetsuya oth Narikawa, Koichi oth Tano, Ohito oth Tsukita, Kenichi oth Kurihara, Rikako oth Meguro, Fumie oth Fukuda, Yusuke oth Sato, Miwako oth Funaka, Soichiro oth Kawamura, Tomohiro oth Makamori, Masayuki oth Takahashi, Masanori oth Taichi, Namie oth Hasuike, Tomoya oth Higuchi, Eriko oth Kobayashi, Hisako oth Osakada, Kaori oth Tsuda, Emiko oth Shimohama, Shun oth Hayashi, Takashi oth Hisahara, Shin oth Kawamata, Jun oth Murahara, Takashi oth Saitoh, Masaki oth Suzuki, Shuichiro oth Yamamoto, Daisuke oth Ishiyama, Yoko oth Ishiyama, Naoko oth Noshiro, Mayuko oth Takeyama, Rumi oth Uwasa, Kaori oth Yasuda, Ikuko oth van der Kooi, Anneke oth de Visser, Marianne oth Gibson, Tamar oth Casasnovas, Carlos oth Alberti Aguilo, Maria Antonia oth Homedes-Pedret, Christian oth Julia Palacios, Natalia oth Diez Porras, Laura oth Velez Santamaria, Valentina oth Lazaro, Ana oth Diez Tejedor, Exuperio oth Gomez Salcedo, Pilar oth Fernandez-Fournier, Mireya oth Lopez Ruiz, Pedro oth Rodriguez de Rivera, Francisco Javier oth Sastre, Maria oth Gamez, Josep oth Sune, Pilar oth Salvado, Maria oth Gili, Gisela oth Mazuela, Gonzalo oth Illa, Isabel oth Cortes Vicente, Elena oth Diaz-Manera, Jordi oth Querol Gutierrez, Luis Antonio oth Rojas Garcia, Ricardo oth Vidal, Nuria oth Arribas-Ibar, Elisabet oth Piehl, Fredrik oth Hietala, Albert oth Bjarbo, Lena oth Sengun, Ihsan oth Meherremova, Arzu oth Ozcelik, Pinar oth Balkan, Bengu oth Tuga, Celal oth Ugur, Muzeyyen oth Erdem-Ozdamar, Sevim oth Bekircan-Kurt, Can Ebru oth Acar, Nazire Pinar oth Yilmaz, Ezgi oth Caliskan, Yagmur oth Orsel, Gulsah oth Efendi, Husnu oth Aydinlik, Seda oth Cavus, Hakan oth Kutlu, Ayse oth Becerikli, Gulsah oth Semiz, Cansu oth Tun, Ozlem oth Terzi, Murat oth Dogan, Baki oth Onar, Musa Kazim oth Sen, Sedat oth Kirbas Cavdar, Tugce oth Veske, Adife oth Norwood, Fiona oth Dimitriou, Aikaterini oth Gollogly, Jakit oth Mahdi-Rogers, Mohamed oth Seddigh, Arshira oth Sokratous, Giannis oth Maier, Gal oth Sohail, Faisal oth Jacob, Saiju oth Sadalage, Girija oth Torane, Pravin oth Brown, Claire oth Shah, Amna oth Sathasivam, Sivakumar oth Arndt, Heike oth Davies, Debbie oth Watling, Dave oth Amato, Anthony oth Cochrane, Thomas oth Salajegheh, Mohammed oth Roe, Kristen oth Amato, Katherine oth Toska, Shirli oth Wolfe, Gil oth Silvestri, Nicholas oth Patrick, Kara oth Zakalik, Karen oth Katz, Jonathan oth Miller, Robert oth Engel, Marguerite oth Forshew, Dallas oth Bravver, Elena oth Brooks, Benjamin oth Plevka, Sarah oth Burdette, Maryanne oth Cunningham, Scott oth Sanjak, Mohammad oth Kramer, Megan oth Nemeth, Joanne oth Schommer, Clara oth Tierney, Scott oth Juel, Vern oth Guptill, Jeffrey oth Hobson-Webb, Lisa oth Massey, Janice oth Beck, Kate oth Carnes, Donna oth Loor, John oth Anderson, Amanda oth Pascuzzi, Robert oth Bodkin, Cynthia oth Kincaid, John oth Snook, Riley oth Guingrich, Sandra oth Micheels, Angela oth Chaudhry, Vinay oth Corse, Andrea oth Mosmiller, Betsy oth Kelley, Andrea oth Ho, Doreen oth Srinivasan, Jayashri oth Vytopil, Michal oth Jara, Jordan oth Ventura, Nicholas oth Scala, Stephanie oth Carter, Cynthia oth Donahue, Craig oth Herbert, Carol oth Weiner, Elaine oth Alam, Sharmeen oth McKinnon, Jonathan oth Haar, Laura oth McKinnon, Naya oth Alcon, Karan oth McKenna, Kaitlyn oth Sattar, Nadia oth Daniels, Kevin oth Jeffery, Dennis oth Freimer, Miriam oth Hoyle, Joseph Chad oth Kissel, John oth Agriesti, Julie oth Chelnick, Sharon oth Mezache, Louisa oth Pineda, Colleen oth Muharrem, Filiz oth Karam, Chafic oth Khoury, Julie oth Marburger, Tessa oth Kaur, Harpreet oth Dimitrova, Diana oth Gilchrist, James oth Agrawal, Brajesh oth Elsayed, Mona oth Kohlrus, Stephanie oth Andoin, Angela oth Darnell, Taylor oth Golden, Laura oth Lokaitis, Barbara oth Seelback, Jenna oth Muppidi, Srikanth oth Goyal, Neelam oth Sakamuri, Sarada oth So, Yuen T. oth Paulose, Shirley oth Pol, Sabrina oth Welsh, Lesly oth Bhavaraju-Sanka, Ratna oth Tobon Gonzales, Alejandro oth Dishman, Lorraine oth Jones, Floyd oth Gonzalez, Anna oth Padilla, Patricia oth Saklad, Amy oth Silva, Marcela oth Kazamel, Mohamed oth Alsharabati, Mohammad oth Lu, Liang oth Nozaki, Kenkichi oth Mumfrey-Thomas, Sandi oth Woodall, Amy oth Mozaffar, Tahseen oth Cash, Tiyonnoh oth Goyal, Namita oth Roy, Gulmohor oth Mathew, Veena oth Maqsood, Fatima oth Minton, Brian oth Jones, H. James oth Rosenfeld, Jeffrey oth Garcia, Rebekah oth Echevarria, Laura oth Garcia, Sonia oth Pulley, Michael oth Aranke, Shachie oth Berger, Alan Ross oth Shah, Jaimin oth Shabbir, Yasmeen oth Smith, Lisa oth Varghese, Mary oth Gutmann, Laurie oth Gutmann, Ludwig oth Jerath, Nivedita oth Nance, Christopher oth Swenson, Andrea oth Olalde, Heena oth Kressin, Nicole oth Sieren, Jeri oth Barohn, Richard oth Dimachkie, Mazen oth Glenn, Melanie oth McVey, April oth Pasnoor, Mamatha oth Statland, Jeffery oth Wang, Yunxia oth Liu, Tina oth Emmons, Kelley oth Jenci, Nicole oth Locheke, Jerry oth Fondaw, Alex oth Johns, Kathryn oth Rico, Gabrielle oth Walsh, Maureen oth Herbelin, Laura oth Hafer-Macko, Charlene oth Kwan, Justin oth Zilliox, Lindsay oth Callison, Karen oth Young, Valerie oth DiSanzo, Beth oth Naunton, Kerry oth Benatar, Michael oth Bilsker, Martin oth Sharma, Khema oth Cooley, Anne oth Reyes, Eliana oth Michon, Sara-Claude oth Sheldon, Danielle oth Steele, Julie oth Howard Jr, James oth Karam, Chafic oth Chopra, Manisha oth Traub, Rebecca oth Vu, Tuan oth Katzin, Lara oth McClain, Terry oth Harvey, Brittany oth Hart, Adam oth Huynh, Kristin oth Beydoun, Said oth Chilingaryan, Amaiak oth Doan, Victor oth Droker, Brian oth Gong, Hui oth Karimi, Sanaz oth Lin, Frank oth McClain, Terry oth Pokala, Krishna oth Shah, Akshay oth Tran, Anh oth Akhter, Salma oth Malekniazi, Ali oth Tandan, Rup oth Hehir, Michael oth Waheed, Waqar oth Lucy, Shannon oth Weiss, Michael oth Distad, Jane oth Strom, Susan oth Downing, Sharon oth Kim, Bryan oth Nowak, Richard oth Dicapua, Daniel oth Keung, Benison oth Kumar, Aditya oth Patwa, Huned oth Robeson, Kimberly oth Yang, Irene oth Nye, Joan oth Vu, Hong oth Enthalten in Elsevier Science Yuan, Meiling ELSEVIER A new global analytical potential energy surface of NaH 2018 official journal of the World Federation of Neurology Amsterdam [u.a.] (DE-627)ELV001315870 volume:407 year:2019 day:15 month:12 pages:0 https://doi.org/10.1016/j.jns.2019.08.004 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 35.10 Physikalische Chemie: Allgemeines VZ AR 407 2019 15 1215 0 |
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A new global analytical potential energy surface of NaH |
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Murai, Hiroyuki @@aut@@ Uzawa, Akiyuki @@oth@@ Suzuki, Yasushi @@oth@@ Imai, Tomihiro @@oth@@ Shiraishi, Hirokazu @@oth@@ Suzuki, Hidekazu @@oth@@ Okumura, Meinoshin @@oth@@ O’Brien, Fanny @@oth@@ Wang, Jing-Jing @@oth@@ Fujita, Kenji P. @@oth@@ Utsugisawa, Kimiaki @@oth@@ Mazia, Claudio Gabriel @@oth@@ Wilken, Miguel @@oth@@ Barroso, Fabio @@oth@@ Saba, Juliet @@oth@@ Rugiero, Marcelo @@oth@@ Bettini, Mariela @@oth@@ Chaves, Marcelo @@oth@@ Vidal, Gonzalo @@oth@@ Garcia, Alejandra Dalila @@oth@@ De Bleecker, Jan @@oth@@ Van den Abeele, Guy @@oth@@ de Koning, Kathy @@oth@@ De Mey, Katrien @@oth@@ Mercelis, Rudy @@oth@@ Mahieu, Délphine @@oth@@ Wagemaekers, Linda @@oth@@ Van Damme, Philip @@oth@@ Depreitere, Annelies @@oth@@ Schotte, Caroline @@oth@@ Smetcoren, Charlotte @@oth@@ Stevens, Olivier @@oth@@ Van Daele, Sien @@oth@@ Vandenbussche, Nicolas @@oth@@ Vanhee, Annelies @@oth@@ Verjans, Sarah @@oth@@ Vynckier, Jan @@oth@@ D'Hondt, Ann @@oth@@ Tilkin, Petra @@oth@@ Alves de Siqueira Carvalho, Alzira @@oth@@ Dias Brockhausen, Igor @@oth@@ Feder, David @@oth@@ Ambrosio, Daniel @@oth@@ César, Pamela @@oth@@ Melo, Ana Paula @@oth@@ Martins Ribeiro, Renata @@oth@@ Rocha, Rosana @@oth@@ Bezerra Rosa, Bruno @@oth@@ Veiga, Thabata @@oth@@ da Silva, Luiz Augusto @@oth@@ Santos Engel, Murilo @@oth@@ Gonçalves Geraldo, Jordana @@oth@@ Ananias Morita, Maria da Penha @@oth@@ Nogueira Coelho, Erica @@oth@@ Paiva, Gabriel @@oth@@ Pozo, Marina @@oth@@ Prando, Natalia @@oth@@ Martineli Torres, Debora Dada @@oth@@ Butinhao, Cristiani Fernanda @@oth@@ Duran, Gustavo @@oth@@ Gomes da Silva, Tamires Cristina @@oth@@ Otavio Maia Gonçalves, Luiz @@oth@@ Pazetto, Lucas Eduardo @@oth@@ Fialho, Tomás Augusto Suriane @@oth@@ Renata Cubas Volpe, Luciana @@oth@@ Souza Duca, Luciana @@oth@@ Souza Bulle Oliveira, Acary @@oth@@ Amaral Andrade, Ana Carolina @@oth@@ Annes, Marcelo @@oth@@ Duarte Silva, Liene @@oth@@ Cavalcante Lino, Valeria @@oth@@ Pinto, Wladimir @@oth@@ Assis, Natália @@oth@@ Carrara, Fernanda @@oth@@ Miranda, Carolina @@oth@@ Souza, Iandra @@oth@@ Fernandes, Patricia @@oth@@ Siddiqi, Zaeem @@oth@@ Phan, Cecile @@oth@@ Narayan, Jeffrey @@oth@@ Blackmore, Derrick @@oth@@ Mallon, Ashley @@oth@@ Roderus, Rikki @@oth@@ Watt, Elizabeth @@oth@@ Junkerova, Jana @@oth@@ Kurkova, Barbora @@oth@@ Reguliova, Katarina @@oth@@ Zapletalova, Olga @@oth@@ Pitha, Jiri @@oth@@ Novakova, Iveta @@oth@@ Tyblova, Michaela @@oth@@ Jurajdova, Ivana @@oth@@ Wolfova, Marcela @@oth@@ Andersen, Henning @@oth@@ Harbo, Thomas @@oth@@ Vinge, Lotte @@oth@@ Krogh, Susanne @@oth@@ Mogensen, Anita @@oth@@ Vissing, John @@oth@@ Højgaard, Joan @@oth@@ Witting, Nanna @@oth@@ Mette Ostergaard Autzen, Anne @@oth@@ Pedersen, Jane @@oth@@ Eralinna, Juha-Pekka @@oth@@ Laaksonen, Mikko @@oth@@ Oksaranta, Olli @@oth@@ Harrison, Tuula @@oth@@ Eriksson, Jaana @@oth@@ Rozsa, Csilla @@oth@@ Horvath, Melinda @@oth@@ Lovas, Gabor @@oth@@ Matolcsi, Judit @@oth@@ Szabo, Gyorgyi @@oth@@ Jakab, Gedeonne @@oth@@ Szabadosne, Brigitta @@oth@@ Antonini, Giovanni @@oth@@ Di Pasquale, Antonella @@oth@@ Garibaldi, Matteo @@oth@@ Morino, Stefania @@oth@@ Troili, Fernanda @@oth@@ Fionda, Laura @@oth@@ Filla, Allessandro @@oth@@ Costabile, Teresa @@oth@@ Marano, Enrico @@oth@@ Saccà, Francesco @@oth@@ Fasanaro, Angiola @@oth@@ Marsili, Angela @@oth@@ Puorro, Giorgia @@oth@@ Mantegazza, Renato @@oth@@ Antozzi, Carlo @@oth@@ Bonanno, Silvia @@oth@@ Camera, Giorgia @@oth@@ Locatelli, Alberta @@oth@@ Maggi, Lorenzo @@oth@@ Pasanisi, Maria @@oth@@ Campanella, Angela @@oth@@ Evoli, Amelia @@oth@@ Alboini, Paolo Emilio @@oth@@ D'Amato, Valentina @@oth@@ Iorio, Raffaele @@oth@@ Kanai, Tetsuya @@oth@@ Kawaguchi, Naoki @@oth@@ Mori, Masahiro @@oth@@ Kaneko, Yoko @@oth@@ Kanzaki, Akiko @@oth@@ Kobayashi, Eri @@oth@@ Masaki, Katsuhisa @@oth@@ Matsuse, Dai @@oth@@ Matsushita, Takuya @@oth@@ Uehara, Taira @@oth@@ Shimpo, Misa @@oth@@ Jingu, Maki @@oth@@ Kikutake, Keiko @@oth@@ Nakamura, Yumiko @@oth@@ Sano, Yoshiko @@oth@@ Nagane, Yuriko @@oth@@ Kamegamori, Ikuko @@oth@@ Tsuda, Tomoko @@oth@@ Fujii, Yuko @@oth@@ Futono, Kazumi @@oth@@ Ozawa, Yukiko @@oth@@ Mizugami, Aya @@oth@@ Saito, Yuka @@oth@@ Morikawa, Miyuki @@oth@@ Samukawa, Makoto @@oth@@ Kamakura, Sachiko @@oth@@ Miyawaki, Eriko @@oth@@ Mitazaki, Teiichiro @@oth@@ Motomura, Masakatsu @@oth@@ Mukaino, Akihiro @@oth@@ Yoshimura, Shunsuke @@oth@@ Asada, Shizuka @@oth@@ Yoshida, Seiko @@oth@@ Amamoto, Shoko @@oth@@ Kobashikawa, Tomomi @@oth@@ Koga, Megumi @@oth@@ Maeda, Yasuko @@oth@@ Takada, Kazumi @@oth@@ Takada, Mihoko @@oth@@ Tsurumaru, Masako @@oth@@ Yamashita, Yumi @@oth@@ Akiyama, Tetsuya @@oth@@ Narikawa, Koichi @@oth@@ Tano, Ohito @@oth@@ Tsukita, Kenichi @@oth@@ Kurihara, Rikako @@oth@@ Meguro, Fumie @@oth@@ Fukuda, Yusuke @@oth@@ Sato, Miwako @@oth@@ Funaka, Soichiro @@oth@@ Kawamura, Tomohiro @@oth@@ Makamori, Masayuki @@oth@@ Takahashi, Masanori @@oth@@ Taichi, Namie @@oth@@ Hasuike, Tomoya @@oth@@ Higuchi, Eriko @@oth@@ Kobayashi, Hisako @@oth@@ Osakada, Kaori @@oth@@ Tsuda, Emiko @@oth@@ Shimohama, Shun @@oth@@ Hayashi, Takashi @@oth@@ Hisahara, Shin @@oth@@ Kawamata, Jun @@oth@@ Murahara, Takashi @@oth@@ Saitoh, Masaki @@oth@@ Suzuki, Shuichiro @@oth@@ Yamamoto, Daisuke @@oth@@ Ishiyama, Yoko @@oth@@ Ishiyama, Naoko @@oth@@ Noshiro, Mayuko @@oth@@ Takeyama, Rumi @@oth@@ Uwasa, Kaori @@oth@@ Yasuda, Ikuko @@oth@@ van der Kooi, Anneke @@oth@@ de Visser, Marianne @@oth@@ Gibson, Tamar @@oth@@ Casasnovas, Carlos @@oth@@ Alberti Aguilo, Maria Antonia @@oth@@ Homedes-Pedret, Christian @@oth@@ Julia Palacios, Natalia @@oth@@ Diez Porras, Laura @@oth@@ Velez Santamaria, Valentina @@oth@@ Lazaro, Ana @@oth@@ Diez Tejedor, Exuperio @@oth@@ Gomez Salcedo, Pilar @@oth@@ Fernandez-Fournier, Mireya @@oth@@ Lopez Ruiz, Pedro @@oth@@ Rodriguez de Rivera, Francisco Javier @@oth@@ Sastre, Maria @@oth@@ Gamez, Josep @@oth@@ Sune, Pilar @@oth@@ Salvado, Maria @@oth@@ Gili, Gisela @@oth@@ Mazuela, Gonzalo @@oth@@ Illa, Isabel @@oth@@ Cortes Vicente, Elena @@oth@@ Diaz-Manera, Jordi @@oth@@ Querol Gutierrez, Luis Antonio @@oth@@ Rojas Garcia, Ricardo @@oth@@ Vidal, Nuria @@oth@@ Arribas-Ibar, Elisabet @@oth@@ Piehl, Fredrik @@oth@@ Hietala, Albert @@oth@@ Bjarbo, Lena @@oth@@ Sengun, Ihsan @@oth@@ Meherremova, Arzu @@oth@@ Ozcelik, Pinar @@oth@@ Balkan, Bengu @@oth@@ Tuga, Celal @@oth@@ Ugur, Muzeyyen @@oth@@ Erdem-Ozdamar, Sevim @@oth@@ Bekircan-Kurt, Can Ebru @@oth@@ Acar, Nazire Pinar @@oth@@ Yilmaz, Ezgi @@oth@@ Caliskan, Yagmur @@oth@@ Orsel, Gulsah @@oth@@ Efendi, Husnu @@oth@@ Aydinlik, Seda @@oth@@ Cavus, Hakan @@oth@@ Kutlu, Ayse @@oth@@ Becerikli, Gulsah @@oth@@ Semiz, Cansu @@oth@@ Tun, Ozlem @@oth@@ Terzi, Murat @@oth@@ Dogan, Baki @@oth@@ Onar, Musa Kazim @@oth@@ Sen, Sedat @@oth@@ Kirbas Cavdar, Tugce @@oth@@ Veske, Adife @@oth@@ Norwood, Fiona @@oth@@ Dimitriou, Aikaterini @@oth@@ Gollogly, Jakit @@oth@@ Mahdi-Rogers, Mohamed @@oth@@ Seddigh, Arshira @@oth@@ Sokratous, Giannis @@oth@@ Maier, Gal @@oth@@ Sohail, Faisal @@oth@@ Jacob, Saiju @@oth@@ Sadalage, Girija @@oth@@ Torane, Pravin @@oth@@ Brown, Claire @@oth@@ Shah, Amna @@oth@@ Sathasivam, Sivakumar @@oth@@ Arndt, Heike @@oth@@ Davies, Debbie @@oth@@ Watling, Dave @@oth@@ Amato, Anthony @@oth@@ Cochrane, Thomas @@oth@@ Salajegheh, Mohammed @@oth@@ Roe, Kristen @@oth@@ Amato, Katherine @@oth@@ Toska, Shirli @@oth@@ Wolfe, Gil @@oth@@ Silvestri, Nicholas @@oth@@ Patrick, Kara @@oth@@ Zakalik, Karen @@oth@@ Katz, Jonathan @@oth@@ Miller, Robert @@oth@@ Engel, Marguerite @@oth@@ Forshew, Dallas @@oth@@ Bravver, Elena @@oth@@ Brooks, Benjamin @@oth@@ Plevka, Sarah @@oth@@ Burdette, Maryanne @@oth@@ Cunningham, Scott @@oth@@ Sanjak, Mohammad @@oth@@ Kramer, Megan @@oth@@ Nemeth, Joanne @@oth@@ Schommer, Clara @@oth@@ Tierney, Scott @@oth@@ Juel, Vern @@oth@@ Guptill, Jeffrey @@oth@@ Hobson-Webb, Lisa @@oth@@ Massey, Janice @@oth@@ Beck, Kate @@oth@@ Carnes, Donna @@oth@@ Loor, John @@oth@@ Anderson, Amanda @@oth@@ Pascuzzi, Robert @@oth@@ Bodkin, Cynthia @@oth@@ Kincaid, John @@oth@@ Snook, Riley @@oth@@ Guingrich, Sandra @@oth@@ Micheels, Angela @@oth@@ Chaudhry, Vinay @@oth@@ Corse, Andrea @@oth@@ Mosmiller, Betsy @@oth@@ Kelley, Andrea @@oth@@ Ho, Doreen @@oth@@ Srinivasan, Jayashri @@oth@@ Vytopil, Michal @@oth@@ Jara, Jordan @@oth@@ Ventura, Nicholas @@oth@@ Scala, Stephanie @@oth@@ Carter, Cynthia @@oth@@ Donahue, Craig @@oth@@ Herbert, Carol @@oth@@ Weiner, Elaine @@oth@@ Alam, Sharmeen @@oth@@ McKinnon, Jonathan @@oth@@ Haar, Laura @@oth@@ McKinnon, Naya @@oth@@ Alcon, Karan @@oth@@ McKenna, Kaitlyn @@oth@@ Sattar, Nadia @@oth@@ Daniels, Kevin @@oth@@ Jeffery, Dennis @@oth@@ Freimer, Miriam @@oth@@ Hoyle, Joseph Chad @@oth@@ Kissel, John @@oth@@ Agriesti, Julie @@oth@@ Chelnick, Sharon @@oth@@ Mezache, Louisa @@oth@@ Pineda, Colleen @@oth@@ Muharrem, Filiz @@oth@@ Karam, Chafic @@oth@@ Khoury, Julie @@oth@@ Marburger, Tessa @@oth@@ Kaur, Harpreet @@oth@@ Dimitrova, Diana @@oth@@ Gilchrist, James @@oth@@ Agrawal, Brajesh @@oth@@ Elsayed, Mona @@oth@@ Kohlrus, Stephanie @@oth@@ Andoin, Angela @@oth@@ Darnell, Taylor @@oth@@ Golden, Laura @@oth@@ Lokaitis, Barbara @@oth@@ Seelback, Jenna @@oth@@ Muppidi, Srikanth @@oth@@ Goyal, Neelam @@oth@@ Sakamuri, Sarada @@oth@@ So, Yuen T. @@oth@@ Paulose, Shirley @@oth@@ Pol, Sabrina @@oth@@ Welsh, Lesly @@oth@@ Bhavaraju-Sanka, Ratna @@oth@@ Tobon Gonzales, Alejandro @@oth@@ Dishman, Lorraine @@oth@@ Jones, Floyd @@oth@@ Gonzalez, Anna @@oth@@ Padilla, Patricia @@oth@@ Saklad, Amy @@oth@@ Silva, Marcela @@oth@@ Kazamel, Mohamed @@oth@@ Alsharabati, Mohammad @@oth@@ Lu, Liang @@oth@@ Nozaki, Kenkichi @@oth@@ Mumfrey-Thomas, Sandi @@oth@@ Woodall, Amy @@oth@@ Mozaffar, Tahseen @@oth@@ Cash, Tiyonnoh @@oth@@ Goyal, Namita @@oth@@ Roy, Gulmohor @@oth@@ Mathew, Veena @@oth@@ Maqsood, Fatima @@oth@@ Minton, Brian @@oth@@ Jones, H. James @@oth@@ Rosenfeld, Jeffrey @@oth@@ Garcia, Rebekah @@oth@@ Echevarria, Laura @@oth@@ Garcia, Sonia @@oth@@ Pulley, Michael @@oth@@ Aranke, Shachie @@oth@@ Berger, Alan Ross @@oth@@ Shah, Jaimin @@oth@@ Shabbir, Yasmeen @@oth@@ Smith, Lisa @@oth@@ Varghese, Mary @@oth@@ Gutmann, Laurie @@oth@@ Gutmann, Ludwig @@oth@@ Jerath, Nivedita @@oth@@ Nance, Christopher @@oth@@ Swenson, Andrea @@oth@@ Olalde, Heena @@oth@@ Kressin, Nicole @@oth@@ Sieren, Jeri @@oth@@ Barohn, Richard @@oth@@ Dimachkie, Mazen @@oth@@ Glenn, Melanie @@oth@@ McVey, April @@oth@@ Pasnoor, Mamatha @@oth@@ Statland, Jeffery @@oth@@ Wang, Yunxia @@oth@@ Liu, Tina @@oth@@ Emmons, Kelley @@oth@@ Jenci, Nicole @@oth@@ Locheke, Jerry @@oth@@ Fondaw, Alex @@oth@@ Johns, Kathryn @@oth@@ Rico, Gabrielle @@oth@@ Walsh, Maureen @@oth@@ Herbelin, Laura @@oth@@ Hafer-Macko, Charlene @@oth@@ Kwan, Justin @@oth@@ Zilliox, Lindsay @@oth@@ Callison, Karen @@oth@@ Young, Valerie @@oth@@ DiSanzo, Beth @@oth@@ Naunton, Kerry @@oth@@ Benatar, Michael @@oth@@ Bilsker, Martin @@oth@@ Sharma, Khema @@oth@@ Cooley, Anne @@oth@@ Reyes, Eliana @@oth@@ Michon, Sara-Claude @@oth@@ Sheldon, Danielle @@oth@@ Steele, Julie @@oth@@ Howard Jr, James @@oth@@ Chopra, Manisha @@oth@@ Traub, Rebecca @@oth@@ Vu, Tuan @@oth@@ Katzin, Lara @@oth@@ McClain, Terry @@oth@@ Harvey, Brittany @@oth@@ Hart, Adam @@oth@@ Huynh, Kristin @@oth@@ Beydoun, Said @@oth@@ Chilingaryan, Amaiak @@oth@@ Doan, Victor @@oth@@ Droker, Brian @@oth@@ Gong, Hui @@oth@@ Karimi, Sanaz @@oth@@ Lin, Frank @@oth@@ Pokala, Krishna @@oth@@ Shah, Akshay @@oth@@ Tran, Anh @@oth@@ Akhter, Salma @@oth@@ Malekniazi, Ali @@oth@@ Tandan, Rup @@oth@@ Hehir, Michael @@oth@@ Waheed, Waqar @@oth@@ Lucy, Shannon @@oth@@ Weiss, Michael @@oth@@ Distad, Jane @@oth@@ Strom, Susan @@oth@@ Downing, Sharon @@oth@@ Kim, Bryan @@oth@@ Nowak, Richard @@oth@@ Dicapua, Daniel @@oth@@ Keung, Benison @@oth@@ Kumar, Aditya @@oth@@ Patwa, Huned @@oth@@ Robeson, Kimberly @@oth@@ Yang, Irene @@oth@@ Nye, Joan @@oth@@ Vu, Hong @@oth@@ |
| publishDateDaySort_date |
2019-01-15T00:00:00Z |
| hierarchy_top_id |
ELV001315870 |
| dewey-sort |
3540 |
| id |
ELV048649120 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV048649120</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230626022458.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">200108s2019 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.jns.2019.08.004</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">/cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000826.pica</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV048649120</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0022-510X(19)30340-5</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">540</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">35.10</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Murai, Hiroyuki</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Long-term efficacy and safety of eculizumab in Japanese patients with generalized myasthenia gravis: A subgroup analysis of the REGAIN open-label extension study</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2019transfer abstract</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The terminal complement inhibitor eculizumab was shown to improve myasthenia gravis-related symptoms in the 26-week, phase 3, randomized, double-blind, placebo-controlled REGAIN study (NCT01997229). In this 52-week sub-analysis of the open-label extension of REGAIN (NCT02301624), eculizumab’s efficacy and safety were assessed in 11 Japanese and 88 Caucasian patients with anti-acetylcholine receptor antibody-positive refractory generalized myasthenia gravis. For patients who had received placebo during REGAIN, treatment with open-label eculizumab resulted in generally similar outcomes in the Japanese and Caucasian populations. Rapid improvements were maintained for 52 weeks, assessed by change in score from open-label extension baseline to week 52 (mean [standard error]) using the following scales (in Japanese and Caucasian patients, respectively): Myasthenia Gravis Activities of Daily Living (−2.4 [1.34] and − 3.3 [0.65]); Quantitative Myasthenia Gravis (−2.9 [1.98] and − 4.3 [0.79]); Myasthenia Gravis Composite (−4.5 [2.63] and − 4.9 [1.19]); and Myasthenia Gravis Quality of Life 15-item questionnaire (−8.6 [5.68] and − 6.5 [1.93]). Overall, the safety of eculizumab was consistent with its known safety profile. In this interim sub-analysis, the efficacy and safety of eculizumab in Japanese and Caucasian patients were generally similar, and consistent with the overall REGAIN population.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The terminal complement inhibitor eculizumab was shown to improve myasthenia gravis-related symptoms in the 26-week, phase 3, randomized, double-blind, placebo-controlled REGAIN study (NCT01997229). In this 52-week sub-analysis of the open-label extension of REGAIN (NCT02301624), eculizumab’s efficacy and safety were assessed in 11 Japanese and 88 Caucasian patients with anti-acetylcholine receptor antibody-positive refractory generalized myasthenia gravis. For patients who had received placebo during REGAIN, treatment with open-label eculizumab resulted in generally similar outcomes in the Japanese and Caucasian populations. Rapid improvements were maintained for 52 weeks, assessed by change in score from open-label extension baseline to week 52 (mean [standard error]) using the following scales (in Japanese and Caucasian patients, respectively): Myasthenia Gravis Activities of Daily Living (−2.4 [1.34] and − 3.3 [0.65]); Quantitative Myasthenia Gravis (−2.9 [1.98] and − 4.3 [0.79]); Myasthenia Gravis Composite (−4.5 [2.63] and − 4.9 [1.19]); and Myasthenia Gravis Quality of Life 15-item questionnaire (−8.6 [5.68] and − 6.5 [1.93]). Overall, the safety of eculizumab was consistent with its known safety profile. In this interim sub-analysis, the efficacy and safety of eculizumab in Japanese and Caucasian patients were generally similar, and consistent with the overall REGAIN population.</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Uzawa, Akiyuki</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Suzuki, Yasushi</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Imai, Tomihiro</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Shiraishi, Hirokazu</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Suzuki, Hidekazu</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Okumura, Meinoshin</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" 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| author |
Murai, Hiroyuki |
| spellingShingle |
Murai, Hiroyuki ddc 540 bkl 35.10 Long-term efficacy and safety of eculizumab in Japanese patients with generalized myasthenia gravis: A subgroup analysis of the REGAIN open-label extension study |
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Murai, Hiroyuki |
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540 - Chemistry & allied sciences |
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Not Illustrated |
| topic_title |
540 VZ 35.10 bkl Long-term efficacy and safety of eculizumab in Japanese patients with generalized myasthenia gravis: A subgroup analysis of the REGAIN open-label extension study |
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ddc 540 bkl 35.10 |
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Elektronische Aufsätze Aufsätze Elektronische Ressource |
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A new global analytical potential energy surface of NaH |
| hierarchy_parent_id |
ELV001315870 |
| dewey-tens |
540 - Chemistry |
| hierarchy_top_title |
A new global analytical potential energy surface of NaH |
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false |
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(DE-627)ELV001315870 |
| title |
Long-term efficacy and safety of eculizumab in Japanese patients with generalized myasthenia gravis: A subgroup analysis of the REGAIN open-label extension study |
| ctrlnum |
(DE-627)ELV048649120 (ELSEVIER)S0022-510X(19)30340-5 |
| title_full |
Long-term efficacy and safety of eculizumab in Japanese patients with generalized myasthenia gravis: A subgroup analysis of the REGAIN open-label extension study |
| author_sort |
Murai, Hiroyuki |
| journal |
A new global analytical potential energy surface of NaH |
| journalStr |
A new global analytical potential energy surface of NaH |
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eng |
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500 - Science |
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marc |
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2019 |
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zzz |
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0 |
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Murai, Hiroyuki |
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407 |
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540 VZ 35.10 bkl |
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Elektronische Aufsätze |
| author-letter |
Murai, Hiroyuki |
| doi_str_mv |
10.1016/j.jns.2019.08.004 |
| dewey-full |
540 |
| title_sort |
long-term efficacy and safety of eculizumab in japanese patients with generalized myasthenia gravis: a subgroup analysis of the regain open-label extension study |
| title_auth |
Long-term efficacy and safety of eculizumab in Japanese patients with generalized myasthenia gravis: A subgroup analysis of the REGAIN open-label extension study |
| abstract |
The terminal complement inhibitor eculizumab was shown to improve myasthenia gravis-related symptoms in the 26-week, phase 3, randomized, double-blind, placebo-controlled REGAIN study (NCT01997229). In this 52-week sub-analysis of the open-label extension of REGAIN (NCT02301624), eculizumab’s efficacy and safety were assessed in 11 Japanese and 88 Caucasian patients with anti-acetylcholine receptor antibody-positive refractory generalized myasthenia gravis. For patients who had received placebo during REGAIN, treatment with open-label eculizumab resulted in generally similar outcomes in the Japanese and Caucasian populations. Rapid improvements were maintained for 52 weeks, assessed by change in score from open-label extension baseline to week 52 (mean [standard error]) using the following scales (in Japanese and Caucasian patients, respectively): Myasthenia Gravis Activities of Daily Living (−2.4 [1.34] and − 3.3 [0.65]); Quantitative Myasthenia Gravis (−2.9 [1.98] and − 4.3 [0.79]); Myasthenia Gravis Composite (−4.5 [2.63] and − 4.9 [1.19]); and Myasthenia Gravis Quality of Life 15-item questionnaire (−8.6 [5.68] and − 6.5 [1.93]). Overall, the safety of eculizumab was consistent with its known safety profile. In this interim sub-analysis, the efficacy and safety of eculizumab in Japanese and Caucasian patients were generally similar, and consistent with the overall REGAIN population. |
| abstractGer |
The terminal complement inhibitor eculizumab was shown to improve myasthenia gravis-related symptoms in the 26-week, phase 3, randomized, double-blind, placebo-controlled REGAIN study (NCT01997229). In this 52-week sub-analysis of the open-label extension of REGAIN (NCT02301624), eculizumab’s efficacy and safety were assessed in 11 Japanese and 88 Caucasian patients with anti-acetylcholine receptor antibody-positive refractory generalized myasthenia gravis. For patients who had received placebo during REGAIN, treatment with open-label eculizumab resulted in generally similar outcomes in the Japanese and Caucasian populations. Rapid improvements were maintained for 52 weeks, assessed by change in score from open-label extension baseline to week 52 (mean [standard error]) using the following scales (in Japanese and Caucasian patients, respectively): Myasthenia Gravis Activities of Daily Living (−2.4 [1.34] and − 3.3 [0.65]); Quantitative Myasthenia Gravis (−2.9 [1.98] and − 4.3 [0.79]); Myasthenia Gravis Composite (−4.5 [2.63] and − 4.9 [1.19]); and Myasthenia Gravis Quality of Life 15-item questionnaire (−8.6 [5.68] and − 6.5 [1.93]). Overall, the safety of eculizumab was consistent with its known safety profile. In this interim sub-analysis, the efficacy and safety of eculizumab in Japanese and Caucasian patients were generally similar, and consistent with the overall REGAIN population. |
| abstract_unstemmed |
The terminal complement inhibitor eculizumab was shown to improve myasthenia gravis-related symptoms in the 26-week, phase 3, randomized, double-blind, placebo-controlled REGAIN study (NCT01997229). In this 52-week sub-analysis of the open-label extension of REGAIN (NCT02301624), eculizumab’s efficacy and safety were assessed in 11 Japanese and 88 Caucasian patients with anti-acetylcholine receptor antibody-positive refractory generalized myasthenia gravis. For patients who had received placebo during REGAIN, treatment with open-label eculizumab resulted in generally similar outcomes in the Japanese and Caucasian populations. Rapid improvements were maintained for 52 weeks, assessed by change in score from open-label extension baseline to week 52 (mean [standard error]) using the following scales (in Japanese and Caucasian patients, respectively): Myasthenia Gravis Activities of Daily Living (−2.4 [1.34] and − 3.3 [0.65]); Quantitative Myasthenia Gravis (−2.9 [1.98] and − 4.3 [0.79]); Myasthenia Gravis Composite (−4.5 [2.63] and − 4.9 [1.19]); and Myasthenia Gravis Quality of Life 15-item questionnaire (−8.6 [5.68] and − 6.5 [1.93]). Overall, the safety of eculizumab was consistent with its known safety profile. In this interim sub-analysis, the efficacy and safety of eculizumab in Japanese and Caucasian patients were generally similar, and consistent with the overall REGAIN population. |
| collection_details |
GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA |
| title_short |
Long-term efficacy and safety of eculizumab in Japanese patients with generalized myasthenia gravis: A subgroup analysis of the REGAIN open-label extension study |
| url |
https://doi.org/10.1016/j.jns.2019.08.004 |
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Uzawa, Akiyuki Suzuki, Yasushi Imai, Tomihiro Shiraishi, Hirokazu Suzuki, Hidekazu Okumura, Meinoshin O’Brien, Fanny Wang, Jing-Jing Fujita, Kenji P. Utsugisawa, Kimiaki Mazia, Claudio Gabriel Wilken, Miguel Barroso, Fabio Saba, Juliet Rugiero, Marcelo Bettini, Mariela Chaves, Marcelo Vidal, Gonzalo Garcia, Alejandra Dalila De Bleecker, Jan Van den Abeele, Guy de Koning, Kathy De Mey, Katrien Mercelis, Rudy Mahieu, Délphine Wagemaekers, Linda Van Damme, Philip Depreitere, Annelies Schotte, Caroline Smetcoren, Charlotte Stevens, Olivier Van Daele, Sien Vandenbussche, Nicolas Vanhee, Annelies Verjans, Sarah Vynckier, Jan D'Hondt, Ann Tilkin, Petra Alves de Siqueira Carvalho, Alzira Dias Brockhausen, Igor Feder, David Ambrosio, Daniel César, Pamela Melo, Ana Paula Martins Ribeiro, Renata Rocha, Rosana Bezerra Rosa, Bruno Veiga, Thabata da Silva, Luiz Augusto Santos Engel, Murilo Gonçalves Geraldo, Jordana Ananias Morita, Maria da Penha Nogueira Coelho, Erica Paiva, Gabriel Pozo, Marina Prando, Natalia Martineli Torres, Debora Dada Butinhao, Cristiani Fernanda Duran, Gustavo Gomes da Silva, Tamires Cristina Otavio Maia Gonçalves, Luiz Pazetto, Lucas Eduardo Fialho, Tomás Augusto Suriane Renata Cubas Volpe, Luciana Souza Duca, Luciana Souza Bulle Oliveira, Acary Amaral Andrade, Ana Carolina Annes, Marcelo Duarte Silva, Liene Cavalcante Lino, Valeria Pinto, Wladimir Assis, Natália Carrara, Fernanda Miranda, Carolina Souza, Iandra Fernandes, Patricia Siddiqi, Zaeem Phan, Cecile Narayan, Jeffrey Blackmore, Derrick Mallon, Ashley Roderus, Rikki Watt, Elizabeth Junkerova, Jana Kurkova, Barbora Reguliova, Katarina Zapletalova, Olga Pitha, Jiri Novakova, Iveta Tyblova, Michaela Jurajdova, Ivana Wolfova, Marcela Andersen, Henning Harbo, Thomas Vinge, Lotte Krogh, Susanne Mogensen, Anita Vissing, John Højgaard, Joan Witting, Nanna Mette Ostergaard Autzen, Anne Pedersen, Jane Eralinna, Juha-Pekka Laaksonen, Mikko Oksaranta, Olli Harrison, Tuula Eriksson, Jaana Rozsa, Csilla Horvath, Melinda Lovas, Gabor Matolcsi, Judit Szabo, Gyorgyi Jakab, Gedeonne Szabadosne, Brigitta Antonini, Giovanni Di Pasquale, Antonella Garibaldi, 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Mona Kohlrus, Stephanie Andoin, Angela Darnell, Taylor Golden, Laura Lokaitis, Barbara Seelback, Jenna Muppidi, Srikanth Goyal, Neelam Sakamuri, Sarada So, Yuen T. Paulose, Shirley Pol, Sabrina Welsh, Lesly Bhavaraju-Sanka, Ratna Tobon Gonzales, Alejandro Dishman, Lorraine Jones, Floyd Gonzalez, Anna Padilla, Patricia Saklad, Amy Silva, Marcela Kazamel, Mohamed Alsharabati, Mohammad Lu, Liang Nozaki, Kenkichi Mumfrey-Thomas, Sandi Woodall, Amy Mozaffar, Tahseen Cash, Tiyonnoh Goyal, Namita Roy, Gulmohor Mathew, Veena Maqsood, Fatima Minton, Brian Jones, H. 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| doi_str |
10.1016/j.jns.2019.08.004 |
| up_date |
2024-07-06T19:25:26.652Z |
| _version_ |
1803858924441436160 |
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Rapid improvements were maintained for 52 weeks, assessed by change in score from open-label extension baseline to week 52 (mean [standard error]) using the following scales (in Japanese and Caucasian patients, respectively): Myasthenia Gravis Activities of Daily Living (−2.4 [1.34] and − 3.3 [0.65]); Quantitative Myasthenia Gravis (−2.9 [1.98] and − 4.3 [0.79]); Myasthenia Gravis Composite (−4.5 [2.63] and − 4.9 [1.19]); and Myasthenia Gravis Quality of Life 15-item questionnaire (−8.6 [5.68] and − 6.5 [1.93]). Overall, the safety of eculizumab was consistent with its known safety profile. 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