Cytogenetic and molecular genetic characterization of KMT2A-PTD positive acute myeloid leukemia in comparison to KMT2A-Rearranged acute myeloid leukemia
• To define the biological differences in acute myeloid leukaemia (AML) with KMT2A gene involvement and their prognostic impact, we compared 190 de novo AML patients at diagnosis, 95 harbouring KMT2A-rearrangement (KMT2Ar) and 95 KMT2A-PTD, performing cytogenetic and molecular genetic analyses. Both...
Ausführliche Beschreibung
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| Autor*in: |
Vetro, Calogero [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020transfer abstract |
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| Umfang: |
8 |
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| Übergeordnetes Werk: |
Enthalten in: 0488: Assessment of aortic regurgitation severity: a cardiac magnetic resonance and echocardiographic comparison study - Mohty, Dania ELSEVIER, 2016, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:240 ; year:2020 ; pages:15-22 ; extent:8 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.cancergen.2019.10.006 |
|---|
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| 245 | 1 | 0 | |a Cytogenetic and molecular genetic characterization of KMT2A-PTD positive acute myeloid leukemia in comparison to KMT2A-Rearranged acute myeloid leukemia |
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| 520 | |a • To define the biological differences in acute myeloid leukaemia (AML) with KMT2A gene involvement and their prognostic impact, we compared 190 de novo AML patients at diagnosis, 95 harbouring KMT2A-rearrangement (KMT2Ar) and 95 KMT2A-PTD, performing cytogenetic and molecular genetic analyses. Both AML subtypes had an unfavourable outcome, particularly in patients older than 60. Patients with KMT2Ar were younger compared to patients with KMT2A-PTD (mean 52 vs 65 years, p < 0.001) and had a higher rate of additional cytogenetic abnormalities (ACA) (46% vs 25% of cases). • In both groups, occurrence of ACA did not influence the overall survival (OS). Regarding molecular genetics, 66% of patients with KMT2Ar and 99% of patients with KMT2A-PTD had additional gene mutations. In multivariate analysis, KRAS mutations and 10p12 rearrangement resulted as adverse prognostic factors in KMT2Ar subgroup. In the KMT2A-PTD group, apart from age, only the occurrence of DNMT3A non-R882 mutations correlated with shorter OS. | ||
| 520 | |a • To define the biological differences in acute myeloid leukaemia (AML) with KMT2A gene involvement and their prognostic impact, we compared 190 de novo AML patients at diagnosis, 95 harbouring KMT2A-rearrangement (KMT2Ar) and 95 KMT2A-PTD, performing cytogenetic and molecular genetic analyses. Both AML subtypes had an unfavourable outcome, particularly in patients older than 60. Patients with KMT2Ar were younger compared to patients with KMT2A-PTD (mean 52 vs 65 years, p < 0.001) and had a higher rate of additional cytogenetic abnormalities (ACA) (46% vs 25% of cases). • In both groups, occurrence of ACA did not influence the overall survival (OS). Regarding molecular genetics, 66% of patients with KMT2Ar and 99% of patients with KMT2A-PTD had additional gene mutations. In multivariate analysis, KRAS mutations and 10p12 rearrangement resulted as adverse prognostic factors in KMT2Ar subgroup. In the KMT2A-PTD group, apart from age, only the occurrence of DNMT3A non-R882 mutations correlated with shorter OS. | ||
| 700 | 1 | |a Haferlach, Torsten |4 oth | |
| 700 | 1 | |a Meggendorfer, Manja |4 oth | |
| 700 | 1 | |a Stengel, Anna |4 oth | |
| 700 | 1 | |a Jeromin, Sabine |4 oth | |
| 700 | 1 | |a Kern, Wolfgang |4 oth | |
| 700 | 1 | |a Haferlach, Claudia |4 oth | |
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10.1016/j.cancergen.2019.10.006 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000836.pica (DE-627)ELV04876048X (ELSEVIER)S2210-7762(19)30470-3 DE-627 ger DE-627 rakwb eng 610 VZ 380 VZ 55.82 bkl Vetro, Calogero verfasserin aut Cytogenetic and molecular genetic characterization of KMT2A-PTD positive acute myeloid leukemia in comparison to KMT2A-Rearranged acute myeloid leukemia 2020transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • To define the biological differences in acute myeloid leukaemia (AML) with KMT2A gene involvement and their prognostic impact, we compared 190 de novo AML patients at diagnosis, 95 harbouring KMT2A-rearrangement (KMT2Ar) and 95 KMT2A-PTD, performing cytogenetic and molecular genetic analyses. Both AML subtypes had an unfavourable outcome, particularly in patients older than 60. Patients with KMT2Ar were younger compared to patients with KMT2A-PTD (mean 52 vs 65 years, p < 0.001) and had a higher rate of additional cytogenetic abnormalities (ACA) (46% vs 25% of cases). • In both groups, occurrence of ACA did not influence the overall survival (OS). Regarding molecular genetics, 66% of patients with KMT2Ar and 99% of patients with KMT2A-PTD had additional gene mutations. In multivariate analysis, KRAS mutations and 10p12 rearrangement resulted as adverse prognostic factors in KMT2Ar subgroup. In the KMT2A-PTD group, apart from age, only the occurrence of DNMT3A non-R882 mutations correlated with shorter OS. • To define the biological differences in acute myeloid leukaemia (AML) with KMT2A gene involvement and their prognostic impact, we compared 190 de novo AML patients at diagnosis, 95 harbouring KMT2A-rearrangement (KMT2Ar) and 95 KMT2A-PTD, performing cytogenetic and molecular genetic analyses. Both AML subtypes had an unfavourable outcome, particularly in patients older than 60. Patients with KMT2Ar were younger compared to patients with KMT2A-PTD (mean 52 vs 65 years, p < 0.001) and had a higher rate of additional cytogenetic abnormalities (ACA) (46% vs 25% of cases). • In both groups, occurrence of ACA did not influence the overall survival (OS). Regarding molecular genetics, 66% of patients with KMT2Ar and 99% of patients with KMT2A-PTD had additional gene mutations. In multivariate analysis, KRAS mutations and 10p12 rearrangement resulted as adverse prognostic factors in KMT2Ar subgroup. In the KMT2A-PTD group, apart from age, only the occurrence of DNMT3A non-R882 mutations correlated with shorter OS. Haferlach, Torsten oth Meggendorfer, Manja oth Stengel, Anna oth Jeromin, Sabine oth Kern, Wolfgang oth Haferlach, Claudia oth Enthalten in Elsevier Science Mohty, Dania ELSEVIER 0488: Assessment of aortic regurgitation severity: a cardiac magnetic resonance and echocardiographic comparison study 2016 Amsterdam [u.a.] (DE-627)ELV019379730 volume:240 year:2020 pages:15-22 extent:8 https://doi.org/10.1016/j.cancergen.2019.10.006 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 55.82 Güterverkehr VZ AR 240 2020 15-22 8 |
| spelling |
10.1016/j.cancergen.2019.10.006 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000836.pica (DE-627)ELV04876048X (ELSEVIER)S2210-7762(19)30470-3 DE-627 ger DE-627 rakwb eng 610 VZ 380 VZ 55.82 bkl Vetro, Calogero verfasserin aut Cytogenetic and molecular genetic characterization of KMT2A-PTD positive acute myeloid leukemia in comparison to KMT2A-Rearranged acute myeloid leukemia 2020transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • To define the biological differences in acute myeloid leukaemia (AML) with KMT2A gene involvement and their prognostic impact, we compared 190 de novo AML patients at diagnosis, 95 harbouring KMT2A-rearrangement (KMT2Ar) and 95 KMT2A-PTD, performing cytogenetic and molecular genetic analyses. Both AML subtypes had an unfavourable outcome, particularly in patients older than 60. Patients with KMT2Ar were younger compared to patients with KMT2A-PTD (mean 52 vs 65 years, p < 0.001) and had a higher rate of additional cytogenetic abnormalities (ACA) (46% vs 25% of cases). • In both groups, occurrence of ACA did not influence the overall survival (OS). Regarding molecular genetics, 66% of patients with KMT2Ar and 99% of patients with KMT2A-PTD had additional gene mutations. In multivariate analysis, KRAS mutations and 10p12 rearrangement resulted as adverse prognostic factors in KMT2Ar subgroup. In the KMT2A-PTD group, apart from age, only the occurrence of DNMT3A non-R882 mutations correlated with shorter OS. • To define the biological differences in acute myeloid leukaemia (AML) with KMT2A gene involvement and their prognostic impact, we compared 190 de novo AML patients at diagnosis, 95 harbouring KMT2A-rearrangement (KMT2Ar) and 95 KMT2A-PTD, performing cytogenetic and molecular genetic analyses. Both AML subtypes had an unfavourable outcome, particularly in patients older than 60. Patients with KMT2Ar were younger compared to patients with KMT2A-PTD (mean 52 vs 65 years, p < 0.001) and had a higher rate of additional cytogenetic abnormalities (ACA) (46% vs 25% of cases). • In both groups, occurrence of ACA did not influence the overall survival (OS). Regarding molecular genetics, 66% of patients with KMT2Ar and 99% of patients with KMT2A-PTD had additional gene mutations. In multivariate analysis, KRAS mutations and 10p12 rearrangement resulted as adverse prognostic factors in KMT2Ar subgroup. In the KMT2A-PTD group, apart from age, only the occurrence of DNMT3A non-R882 mutations correlated with shorter OS. Haferlach, Torsten oth Meggendorfer, Manja oth Stengel, Anna oth Jeromin, Sabine oth Kern, Wolfgang oth Haferlach, Claudia oth Enthalten in Elsevier Science Mohty, Dania ELSEVIER 0488: Assessment of aortic regurgitation severity: a cardiac magnetic resonance and echocardiographic comparison study 2016 Amsterdam [u.a.] (DE-627)ELV019379730 volume:240 year:2020 pages:15-22 extent:8 https://doi.org/10.1016/j.cancergen.2019.10.006 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 55.82 Güterverkehr VZ AR 240 2020 15-22 8 |
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10.1016/j.cancergen.2019.10.006 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000836.pica (DE-627)ELV04876048X (ELSEVIER)S2210-7762(19)30470-3 DE-627 ger DE-627 rakwb eng 610 VZ 380 VZ 55.82 bkl Vetro, Calogero verfasserin aut Cytogenetic and molecular genetic characterization of KMT2A-PTD positive acute myeloid leukemia in comparison to KMT2A-Rearranged acute myeloid leukemia 2020transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • To define the biological differences in acute myeloid leukaemia (AML) with KMT2A gene involvement and their prognostic impact, we compared 190 de novo AML patients at diagnosis, 95 harbouring KMT2A-rearrangement (KMT2Ar) and 95 KMT2A-PTD, performing cytogenetic and molecular genetic analyses. Both AML subtypes had an unfavourable outcome, particularly in patients older than 60. Patients with KMT2Ar were younger compared to patients with KMT2A-PTD (mean 52 vs 65 years, p < 0.001) and had a higher rate of additional cytogenetic abnormalities (ACA) (46% vs 25% of cases). • In both groups, occurrence of ACA did not influence the overall survival (OS). Regarding molecular genetics, 66% of patients with KMT2Ar and 99% of patients with KMT2A-PTD had additional gene mutations. In multivariate analysis, KRAS mutations and 10p12 rearrangement resulted as adverse prognostic factors in KMT2Ar subgroup. In the KMT2A-PTD group, apart from age, only the occurrence of DNMT3A non-R882 mutations correlated with shorter OS. • To define the biological differences in acute myeloid leukaemia (AML) with KMT2A gene involvement and their prognostic impact, we compared 190 de novo AML patients at diagnosis, 95 harbouring KMT2A-rearrangement (KMT2Ar) and 95 KMT2A-PTD, performing cytogenetic and molecular genetic analyses. Both AML subtypes had an unfavourable outcome, particularly in patients older than 60. Patients with KMT2Ar were younger compared to patients with KMT2A-PTD (mean 52 vs 65 years, p < 0.001) and had a higher rate of additional cytogenetic abnormalities (ACA) (46% vs 25% of cases). • In both groups, occurrence of ACA did not influence the overall survival (OS). Regarding molecular genetics, 66% of patients with KMT2Ar and 99% of patients with KMT2A-PTD had additional gene mutations. In multivariate analysis, KRAS mutations and 10p12 rearrangement resulted as adverse prognostic factors in KMT2Ar subgroup. In the KMT2A-PTD group, apart from age, only the occurrence of DNMT3A non-R882 mutations correlated with shorter OS. Haferlach, Torsten oth Meggendorfer, Manja oth Stengel, Anna oth Jeromin, Sabine oth Kern, Wolfgang oth Haferlach, Claudia oth Enthalten in Elsevier Science Mohty, Dania ELSEVIER 0488: Assessment of aortic regurgitation severity: a cardiac magnetic resonance and echocardiographic comparison study 2016 Amsterdam [u.a.] (DE-627)ELV019379730 volume:240 year:2020 pages:15-22 extent:8 https://doi.org/10.1016/j.cancergen.2019.10.006 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 55.82 Güterverkehr VZ AR 240 2020 15-22 8 |
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10.1016/j.cancergen.2019.10.006 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000836.pica (DE-627)ELV04876048X (ELSEVIER)S2210-7762(19)30470-3 DE-627 ger DE-627 rakwb eng 610 VZ 380 VZ 55.82 bkl Vetro, Calogero verfasserin aut Cytogenetic and molecular genetic characterization of KMT2A-PTD positive acute myeloid leukemia in comparison to KMT2A-Rearranged acute myeloid leukemia 2020transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • To define the biological differences in acute myeloid leukaemia (AML) with KMT2A gene involvement and their prognostic impact, we compared 190 de novo AML patients at diagnosis, 95 harbouring KMT2A-rearrangement (KMT2Ar) and 95 KMT2A-PTD, performing cytogenetic and molecular genetic analyses. Both AML subtypes had an unfavourable outcome, particularly in patients older than 60. Patients with KMT2Ar were younger compared to patients with KMT2A-PTD (mean 52 vs 65 years, p < 0.001) and had a higher rate of additional cytogenetic abnormalities (ACA) (46% vs 25% of cases). • In both groups, occurrence of ACA did not influence the overall survival (OS). Regarding molecular genetics, 66% of patients with KMT2Ar and 99% of patients with KMT2A-PTD had additional gene mutations. In multivariate analysis, KRAS mutations and 10p12 rearrangement resulted as adverse prognostic factors in KMT2Ar subgroup. In the KMT2A-PTD group, apart from age, only the occurrence of DNMT3A non-R882 mutations correlated with shorter OS. • To define the biological differences in acute myeloid leukaemia (AML) with KMT2A gene involvement and their prognostic impact, we compared 190 de novo AML patients at diagnosis, 95 harbouring KMT2A-rearrangement (KMT2Ar) and 95 KMT2A-PTD, performing cytogenetic and molecular genetic analyses. Both AML subtypes had an unfavourable outcome, particularly in patients older than 60. Patients with KMT2Ar were younger compared to patients with KMT2A-PTD (mean 52 vs 65 years, p < 0.001) and had a higher rate of additional cytogenetic abnormalities (ACA) (46% vs 25% of cases). • In both groups, occurrence of ACA did not influence the overall survival (OS). Regarding molecular genetics, 66% of patients with KMT2Ar and 99% of patients with KMT2A-PTD had additional gene mutations. In multivariate analysis, KRAS mutations and 10p12 rearrangement resulted as adverse prognostic factors in KMT2Ar subgroup. In the KMT2A-PTD group, apart from age, only the occurrence of DNMT3A non-R882 mutations correlated with shorter OS. Haferlach, Torsten oth Meggendorfer, Manja oth Stengel, Anna oth Jeromin, Sabine oth Kern, Wolfgang oth Haferlach, Claudia oth Enthalten in Elsevier Science Mohty, Dania ELSEVIER 0488: Assessment of aortic regurgitation severity: a cardiac magnetic resonance and echocardiographic comparison study 2016 Amsterdam [u.a.] (DE-627)ELV019379730 volume:240 year:2020 pages:15-22 extent:8 https://doi.org/10.1016/j.cancergen.2019.10.006 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 55.82 Güterverkehr VZ AR 240 2020 15-22 8 |
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10.1016/j.cancergen.2019.10.006 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000836.pica (DE-627)ELV04876048X (ELSEVIER)S2210-7762(19)30470-3 DE-627 ger DE-627 rakwb eng 610 VZ 380 VZ 55.82 bkl Vetro, Calogero verfasserin aut Cytogenetic and molecular genetic characterization of KMT2A-PTD positive acute myeloid leukemia in comparison to KMT2A-Rearranged acute myeloid leukemia 2020transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • To define the biological differences in acute myeloid leukaemia (AML) with KMT2A gene involvement and their prognostic impact, we compared 190 de novo AML patients at diagnosis, 95 harbouring KMT2A-rearrangement (KMT2Ar) and 95 KMT2A-PTD, performing cytogenetic and molecular genetic analyses. Both AML subtypes had an unfavourable outcome, particularly in patients older than 60. Patients with KMT2Ar were younger compared to patients with KMT2A-PTD (mean 52 vs 65 years, p < 0.001) and had a higher rate of additional cytogenetic abnormalities (ACA) (46% vs 25% of cases). • In both groups, occurrence of ACA did not influence the overall survival (OS). Regarding molecular genetics, 66% of patients with KMT2Ar and 99% of patients with KMT2A-PTD had additional gene mutations. In multivariate analysis, KRAS mutations and 10p12 rearrangement resulted as adverse prognostic factors in KMT2Ar subgroup. In the KMT2A-PTD group, apart from age, only the occurrence of DNMT3A non-R882 mutations correlated with shorter OS. • To define the biological differences in acute myeloid leukaemia (AML) with KMT2A gene involvement and their prognostic impact, we compared 190 de novo AML patients at diagnosis, 95 harbouring KMT2A-rearrangement (KMT2Ar) and 95 KMT2A-PTD, performing cytogenetic and molecular genetic analyses. Both AML subtypes had an unfavourable outcome, particularly in patients older than 60. Patients with KMT2Ar were younger compared to patients with KMT2A-PTD (mean 52 vs 65 years, p < 0.001) and had a higher rate of additional cytogenetic abnormalities (ACA) (46% vs 25% of cases). • In both groups, occurrence of ACA did not influence the overall survival (OS). Regarding molecular genetics, 66% of patients with KMT2Ar and 99% of patients with KMT2A-PTD had additional gene mutations. In multivariate analysis, KRAS mutations and 10p12 rearrangement resulted as adverse prognostic factors in KMT2Ar subgroup. In the KMT2A-PTD group, apart from age, only the occurrence of DNMT3A non-R882 mutations correlated with shorter OS. Haferlach, Torsten oth Meggendorfer, Manja oth Stengel, Anna oth Jeromin, Sabine oth Kern, Wolfgang oth Haferlach, Claudia oth Enthalten in Elsevier Science Mohty, Dania ELSEVIER 0488: Assessment of aortic regurgitation severity: a cardiac magnetic resonance and echocardiographic comparison study 2016 Amsterdam [u.a.] (DE-627)ELV019379730 volume:240 year:2020 pages:15-22 extent:8 https://doi.org/10.1016/j.cancergen.2019.10.006 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 55.82 Güterverkehr VZ AR 240 2020 15-22 8 |
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Enthalten in 0488: Assessment of aortic regurgitation severity: a cardiac magnetic resonance and echocardiographic comparison study Amsterdam [u.a.] volume:240 year:2020 pages:15-22 extent:8 |
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Both AML subtypes had an unfavourable outcome, particularly in patients older than 60. Patients with KMT2Ar were younger compared to patients with KMT2A-PTD (mean 52 vs 65 years, p < 0.001) and had a higher rate of additional cytogenetic abnormalities (ACA) (46% vs 25% of cases). • In both groups, occurrence of ACA did not influence the overall survival (OS). Regarding molecular genetics, 66% of patients with KMT2Ar and 99% of patients with KMT2A-PTD had additional gene mutations. In multivariate analysis, KRAS mutations and 10p12 rearrangement resulted as adverse prognostic factors in KMT2Ar subgroup. 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cytogenetic and molecular genetic characterization of kmt2a-ptd positive acute myeloid leukemia in comparison to kmt2a-rearranged acute myeloid leukemia |
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Cytogenetic and molecular genetic characterization of KMT2A-PTD positive acute myeloid leukemia in comparison to KMT2A-Rearranged acute myeloid leukemia |
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• To define the biological differences in acute myeloid leukaemia (AML) with KMT2A gene involvement and their prognostic impact, we compared 190 de novo AML patients at diagnosis, 95 harbouring KMT2A-rearrangement (KMT2Ar) and 95 KMT2A-PTD, performing cytogenetic and molecular genetic analyses. Both AML subtypes had an unfavourable outcome, particularly in patients older than 60. Patients with KMT2Ar were younger compared to patients with KMT2A-PTD (mean 52 vs 65 years, p < 0.001) and had a higher rate of additional cytogenetic abnormalities (ACA) (46% vs 25% of cases). • In both groups, occurrence of ACA did not influence the overall survival (OS). Regarding molecular genetics, 66% of patients with KMT2Ar and 99% of patients with KMT2A-PTD had additional gene mutations. In multivariate analysis, KRAS mutations and 10p12 rearrangement resulted as adverse prognostic factors in KMT2Ar subgroup. In the KMT2A-PTD group, apart from age, only the occurrence of DNMT3A non-R882 mutations correlated with shorter OS. |
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• To define the biological differences in acute myeloid leukaemia (AML) with KMT2A gene involvement and their prognostic impact, we compared 190 de novo AML patients at diagnosis, 95 harbouring KMT2A-rearrangement (KMT2Ar) and 95 KMT2A-PTD, performing cytogenetic and molecular genetic analyses. Both AML subtypes had an unfavourable outcome, particularly in patients older than 60. Patients with KMT2Ar were younger compared to patients with KMT2A-PTD (mean 52 vs 65 years, p < 0.001) and had a higher rate of additional cytogenetic abnormalities (ACA) (46% vs 25% of cases). • In both groups, occurrence of ACA did not influence the overall survival (OS). Regarding molecular genetics, 66% of patients with KMT2Ar and 99% of patients with KMT2A-PTD had additional gene mutations. In multivariate analysis, KRAS mutations and 10p12 rearrangement resulted as adverse prognostic factors in KMT2Ar subgroup. In the KMT2A-PTD group, apart from age, only the occurrence of DNMT3A non-R882 mutations correlated with shorter OS. |
| abstract_unstemmed |
• To define the biological differences in acute myeloid leukaemia (AML) with KMT2A gene involvement and their prognostic impact, we compared 190 de novo AML patients at diagnosis, 95 harbouring KMT2A-rearrangement (KMT2Ar) and 95 KMT2A-PTD, performing cytogenetic and molecular genetic analyses. Both AML subtypes had an unfavourable outcome, particularly in patients older than 60. Patients with KMT2Ar were younger compared to patients with KMT2A-PTD (mean 52 vs 65 years, p < 0.001) and had a higher rate of additional cytogenetic abnormalities (ACA) (46% vs 25% of cases). • In both groups, occurrence of ACA did not influence the overall survival (OS). Regarding molecular genetics, 66% of patients with KMT2Ar and 99% of patients with KMT2A-PTD had additional gene mutations. In multivariate analysis, KRAS mutations and 10p12 rearrangement resulted as adverse prognostic factors in KMT2Ar subgroup. In the KMT2A-PTD group, apart from age, only the occurrence of DNMT3A non-R882 mutations correlated with shorter OS. |
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Cytogenetic and molecular genetic characterization of KMT2A-PTD positive acute myeloid leukemia in comparison to KMT2A-Rearranged acute myeloid leukemia |
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Haferlach, Torsten Meggendorfer, Manja Stengel, Anna Jeromin, Sabine Kern, Wolfgang Haferlach, Claudia |
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