A T cell–myeloid IL-10 axis regulates pathogenic IFN-γ–dependent immunity in a mouse model of type 2–low asthma
Although originally defined as a type 2 (T2) immune-mediated condition, non-T2 cytokines, such as IFN-γ and IL-17A, have been implicated in asthma pathogenesis, particularly in patients with severe disease. IL-10 regulates TH cell phenotypes and can dampen T2 immunity to allergens, but its functions...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Branchett, William J. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Schlagwörter: |
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6124 |
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Enthalten in: Antidiabetic treatment in elderly patients with low performance status admitted to internal medicine ward - Papakitsou, I. ELSEVIER, 2022, official publication of the American Academy of Allergy, Asthma and Immunology, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:145 ; year:2020 ; number:2 ; pages:666-6789 ; extent:6124 |
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| DOI / URN: |
10.1016/j.jaci.2019.08.006 |
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10.1016/j.jaci.2019.08.006 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001149.pica (DE-627)ELV049293028 (ELSEVIER)S0091-6749(19)31079-6 DE-627 ger DE-627 rakwb eng 610 VZ 44.85 bkl Branchett, William J. verfasserin aut A T cell–myeloid IL-10 axis regulates pathogenic IFN-γ–dependent immunity in a mouse model of type 2–low asthma 2020 6124 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Although originally defined as a type 2 (T2) immune-mediated condition, non-T2 cytokines, such as IFN-γ and IL-17A, have been implicated in asthma pathogenesis, particularly in patients with severe disease. IL-10 regulates TH cell phenotypes and can dampen T2 immunity to allergens, but its functions in controlling non-T2 cytokine responses in asthmatic patients are unclear. IFN-γ Elsevier T cell Elsevier type 2–low asthma Elsevier macrophage Elsevier Severe asthma Elsevier IL-10 Elsevier immune regulation Elsevier dendritic cell Elsevier Stölting, Helen oth Oliver, Robert A. oth Walker, Simone A. oth Puttur, Franz oth Gregory, Lisa G. oth Gabryšová, Leona oth Wilson, Mark S. oth O'Garra, Anne oth Lloyd, Clare M. oth Enthalten in Elsevier Papakitsou, I. ELSEVIER Antidiabetic treatment in elderly patients with low performance status admitted to internal medicine ward 2022 official publication of the American Academy of Allergy, Asthma and Immunology Amsterdam [u.a.] (DE-627)ELV000021164 volume:145 year:2020 number:2 pages:666-6789 extent:6124 https://doi.org/10.1016/j.jaci.2019.08.006 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.85 Kardiologie Angiologie VZ AR 145 2020 2 666-6789 6124 |
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Branchett, William J. |
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10.1016/j.jaci.2019.08.006 |
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610 |
| title_sort |
a t cell–myeloid il-10 axis regulates pathogenic ifn-γ–dependent immunity in a mouse model of type 2–low asthma |
| title_auth |
A T cell–myeloid IL-10 axis regulates pathogenic IFN-γ–dependent immunity in a mouse model of type 2–low asthma |
| abstract |
Although originally defined as a type 2 (T2) immune-mediated condition, non-T2 cytokines, such as IFN-γ and IL-17A, have been implicated in asthma pathogenesis, particularly in patients with severe disease. IL-10 regulates TH cell phenotypes and can dampen T2 immunity to allergens, but its functions in controlling non-T2 cytokine responses in asthmatic patients are unclear. |
| abstractGer |
Although originally defined as a type 2 (T2) immune-mediated condition, non-T2 cytokines, such as IFN-γ and IL-17A, have been implicated in asthma pathogenesis, particularly in patients with severe disease. IL-10 regulates TH cell phenotypes and can dampen T2 immunity to allergens, but its functions in controlling non-T2 cytokine responses in asthmatic patients are unclear. |
| abstract_unstemmed |
Although originally defined as a type 2 (T2) immune-mediated condition, non-T2 cytokines, such as IFN-γ and IL-17A, have been implicated in asthma pathogenesis, particularly in patients with severe disease. IL-10 regulates TH cell phenotypes and can dampen T2 immunity to allergens, but its functions in controlling non-T2 cytokine responses in asthmatic patients are unclear. |
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| title_short |
A T cell–myeloid IL-10 axis regulates pathogenic IFN-γ–dependent immunity in a mouse model of type 2–low asthma |
| url |
https://doi.org/10.1016/j.jaci.2019.08.006 |
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Stölting, Helen Oliver, Robert A. Walker, Simone A. Puttur, Franz Gregory, Lisa G. Gabryšová, Leona Wilson, Mark S. O'Garra, Anne Lloyd, Clare M. |
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Stölting, Helen Oliver, Robert A. Walker, Simone A. Puttur, Franz Gregory, Lisa G. Gabryšová, Leona Wilson, Mark S. O'Garra, Anne Lloyd, Clare M. |
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| doi_str |
10.1016/j.jaci.2019.08.006 |
| up_date |
2024-07-06T21:10:20.782Z |
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