Missing Pieces to the Endocannabinoid Puzzle
The most bioactive ingredient of cannabis (Cannabis sativa or indica) extracts, Δ 9-tetrahydrocannabinol (THC), was identified in the 1960s as one of more than 110 phytocannabinoids. It activates receptors of chemically different endogenous ligands (endocannabinoids) that, unlike THC, are metabolize...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Maccarrone, Mauro [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020transfer abstract |
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| Schlagwörter: |
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| Umfang: |
10 |
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| Übergeordnetes Werk: |
Enthalten in: Ocean sand ridge signatures in the Bohai Sea observed by satellite ocean color and synthetic aperture radar measurements - 2011transfer abstract, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:26 ; year:2020 ; number:3 ; pages:263-272 ; extent:10 |
| Links: |
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| DOI / URN: |
10.1016/j.molmed.2019.11.002 |
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ELV049534610 |
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| 520 | |a The most bioactive ingredient of cannabis (Cannabis sativa or indica) extracts, Δ 9-tetrahydrocannabinol (THC), was identified in the 1960s as one of more than 110 phytocannabinoids. It activates receptors of chemically different endogenous ligands (endocannabinoids) that, unlike THC, are metabolized by several enzymes of the endocannabinoid system. Here, the complexity of the plant-derived and endogenous cannabinoids (eCBs) is discussed, to better appreciate the challenge of: (i) dissecting their mutual interactions; (ii) understanding their impact on human pathophysiology; and (iii) exploiting them for human disease. To this aim, missing pieces to the eCB puzzle must be urgently found, by solving the 3D structures of key components, and interrogating noncanonical modes of regulation and trafficking of these lipid signals. | ||
| 520 | |a The most bioactive ingredient of cannabis (Cannabis sativa or indica) extracts, Δ 9-tetrahydrocannabinol (THC), was identified in the 1960s as one of more than 110 phytocannabinoids. It activates receptors of chemically different endogenous ligands (endocannabinoids) that, unlike THC, are metabolized by several enzymes of the endocannabinoid system. Here, the complexity of the plant-derived and endogenous cannabinoids (eCBs) is discussed, to better appreciate the challenge of: (i) dissecting their mutual interactions; (ii) understanding their impact on human pathophysiology; and (iii) exploiting them for human disease. To this aim, missing pieces to the eCB puzzle must be urgently found, by solving the 3D structures of key components, and interrogating noncanonical modes of regulation and trafficking of these lipid signals. | ||
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10.1016/j.molmed.2019.11.002 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000945.pica (DE-627)ELV049534610 (ELSEVIER)S1471-4914(19)30293-X DE-627 ger DE-627 rakwb eng 050 VZ 550 VZ 660 VZ 660 VZ 530 600 670 VZ 51.00 bkl Maccarrone, Mauro verfasserin aut Missing Pieces to the Endocannabinoid Puzzle 2020transfer abstract 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The most bioactive ingredient of cannabis (Cannabis sativa or indica) extracts, Δ 9-tetrahydrocannabinol (THC), was identified in the 1960s as one of more than 110 phytocannabinoids. It activates receptors of chemically different endogenous ligands (endocannabinoids) that, unlike THC, are metabolized by several enzymes of the endocannabinoid system. Here, the complexity of the plant-derived and endogenous cannabinoids (eCBs) is discussed, to better appreciate the challenge of: (i) dissecting their mutual interactions; (ii) understanding their impact on human pathophysiology; and (iii) exploiting them for human disease. To this aim, missing pieces to the eCB puzzle must be urgently found, by solving the 3D structures of key components, and interrogating noncanonical modes of regulation and trafficking of these lipid signals. The most bioactive ingredient of cannabis (Cannabis sativa or indica) extracts, Δ 9-tetrahydrocannabinol (THC), was identified in the 1960s as one of more than 110 phytocannabinoids. It activates receptors of chemically different endogenous ligands (endocannabinoids) that, unlike THC, are metabolized by several enzymes of the endocannabinoid system. Here, the complexity of the plant-derived and endogenous cannabinoids (eCBs) is discussed, to better appreciate the challenge of: (i) dissecting their mutual interactions; (ii) understanding their impact on human pathophysiology; and (iii) exploiting them for human disease. To this aim, missing pieces to the eCB puzzle must be urgently found, by solving the 3D structures of key components, and interrogating noncanonical modes of regulation and trafficking of these lipid signals. membrane lipids Elsevier signal transduction Elsevier 3D structures Elsevier cannabinoids Elsevier endocannabinoids Elsevier trafficking Elsevier Enthalten in Elsevier Science Ocean sand ridge signatures in the Bohai Sea observed by satellite ocean color and synthetic aperture radar measurements 2011transfer abstract Amsterdam [u.a.] (DE-627)ELV026173794 volume:26 year:2020 number:3 pages:263-272 extent:10 https://doi.org/10.1016/j.molmed.2019.11.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_73 GBV_ILN_252 51.00 Werkstoffkunde: Allgemeines VZ AR 26 2020 3 263-272 10 |
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10.1016/j.molmed.2019.11.002 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000945.pica (DE-627)ELV049534610 (ELSEVIER)S1471-4914(19)30293-X DE-627 ger DE-627 rakwb eng 050 VZ 550 VZ 660 VZ 660 VZ 530 600 670 VZ 51.00 bkl Maccarrone, Mauro verfasserin aut Missing Pieces to the Endocannabinoid Puzzle 2020transfer abstract 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The most bioactive ingredient of cannabis (Cannabis sativa or indica) extracts, Δ 9-tetrahydrocannabinol (THC), was identified in the 1960s as one of more than 110 phytocannabinoids. It activates receptors of chemically different endogenous ligands (endocannabinoids) that, unlike THC, are metabolized by several enzymes of the endocannabinoid system. Here, the complexity of the plant-derived and endogenous cannabinoids (eCBs) is discussed, to better appreciate the challenge of: (i) dissecting their mutual interactions; (ii) understanding their impact on human pathophysiology; and (iii) exploiting them for human disease. To this aim, missing pieces to the eCB puzzle must be urgently found, by solving the 3D structures of key components, and interrogating noncanonical modes of regulation and trafficking of these lipid signals. The most bioactive ingredient of cannabis (Cannabis sativa or indica) extracts, Δ 9-tetrahydrocannabinol (THC), was identified in the 1960s as one of more than 110 phytocannabinoids. It activates receptors of chemically different endogenous ligands (endocannabinoids) that, unlike THC, are metabolized by several enzymes of the endocannabinoid system. Here, the complexity of the plant-derived and endogenous cannabinoids (eCBs) is discussed, to better appreciate the challenge of: (i) dissecting their mutual interactions; (ii) understanding their impact on human pathophysiology; and (iii) exploiting them for human disease. To this aim, missing pieces to the eCB puzzle must be urgently found, by solving the 3D structures of key components, and interrogating noncanonical modes of regulation and trafficking of these lipid signals. membrane lipids Elsevier signal transduction Elsevier 3D structures Elsevier cannabinoids Elsevier endocannabinoids Elsevier trafficking Elsevier Enthalten in Elsevier Science Ocean sand ridge signatures in the Bohai Sea observed by satellite ocean color and synthetic aperture radar measurements 2011transfer abstract Amsterdam [u.a.] (DE-627)ELV026173794 volume:26 year:2020 number:3 pages:263-272 extent:10 https://doi.org/10.1016/j.molmed.2019.11.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_73 GBV_ILN_252 51.00 Werkstoffkunde: Allgemeines VZ AR 26 2020 3 263-272 10 |
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10.1016/j.molmed.2019.11.002 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000945.pica (DE-627)ELV049534610 (ELSEVIER)S1471-4914(19)30293-X DE-627 ger DE-627 rakwb eng 050 VZ 550 VZ 660 VZ 660 VZ 530 600 670 VZ 51.00 bkl Maccarrone, Mauro verfasserin aut Missing Pieces to the Endocannabinoid Puzzle 2020transfer abstract 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The most bioactive ingredient of cannabis (Cannabis sativa or indica) extracts, Δ 9-tetrahydrocannabinol (THC), was identified in the 1960s as one of more than 110 phytocannabinoids. It activates receptors of chemically different endogenous ligands (endocannabinoids) that, unlike THC, are metabolized by several enzymes of the endocannabinoid system. Here, the complexity of the plant-derived and endogenous cannabinoids (eCBs) is discussed, to better appreciate the challenge of: (i) dissecting their mutual interactions; (ii) understanding their impact on human pathophysiology; and (iii) exploiting them for human disease. To this aim, missing pieces to the eCB puzzle must be urgently found, by solving the 3D structures of key components, and interrogating noncanonical modes of regulation and trafficking of these lipid signals. The most bioactive ingredient of cannabis (Cannabis sativa or indica) extracts, Δ 9-tetrahydrocannabinol (THC), was identified in the 1960s as one of more than 110 phytocannabinoids. It activates receptors of chemically different endogenous ligands (endocannabinoids) that, unlike THC, are metabolized by several enzymes of the endocannabinoid system. Here, the complexity of the plant-derived and endogenous cannabinoids (eCBs) is discussed, to better appreciate the challenge of: (i) dissecting their mutual interactions; (ii) understanding their impact on human pathophysiology; and (iii) exploiting them for human disease. To this aim, missing pieces to the eCB puzzle must be urgently found, by solving the 3D structures of key components, and interrogating noncanonical modes of regulation and trafficking of these lipid signals. membrane lipids Elsevier signal transduction Elsevier 3D structures Elsevier cannabinoids Elsevier endocannabinoids Elsevier trafficking Elsevier Enthalten in Elsevier Science Ocean sand ridge signatures in the Bohai Sea observed by satellite ocean color and synthetic aperture radar measurements 2011transfer abstract Amsterdam [u.a.] (DE-627)ELV026173794 volume:26 year:2020 number:3 pages:263-272 extent:10 https://doi.org/10.1016/j.molmed.2019.11.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_73 GBV_ILN_252 51.00 Werkstoffkunde: Allgemeines VZ AR 26 2020 3 263-272 10 |
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10.1016/j.molmed.2019.11.002 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000945.pica (DE-627)ELV049534610 (ELSEVIER)S1471-4914(19)30293-X DE-627 ger DE-627 rakwb eng 050 VZ 550 VZ 660 VZ 660 VZ 530 600 670 VZ 51.00 bkl Maccarrone, Mauro verfasserin aut Missing Pieces to the Endocannabinoid Puzzle 2020transfer abstract 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The most bioactive ingredient of cannabis (Cannabis sativa or indica) extracts, Δ 9-tetrahydrocannabinol (THC), was identified in the 1960s as one of more than 110 phytocannabinoids. It activates receptors of chemically different endogenous ligands (endocannabinoids) that, unlike THC, are metabolized by several enzymes of the endocannabinoid system. Here, the complexity of the plant-derived and endogenous cannabinoids (eCBs) is discussed, to better appreciate the challenge of: (i) dissecting their mutual interactions; (ii) understanding their impact on human pathophysiology; and (iii) exploiting them for human disease. To this aim, missing pieces to the eCB puzzle must be urgently found, by solving the 3D structures of key components, and interrogating noncanonical modes of regulation and trafficking of these lipid signals. The most bioactive ingredient of cannabis (Cannabis sativa or indica) extracts, Δ 9-tetrahydrocannabinol (THC), was identified in the 1960s as one of more than 110 phytocannabinoids. It activates receptors of chemically different endogenous ligands (endocannabinoids) that, unlike THC, are metabolized by several enzymes of the endocannabinoid system. Here, the complexity of the plant-derived and endogenous cannabinoids (eCBs) is discussed, to better appreciate the challenge of: (i) dissecting their mutual interactions; (ii) understanding their impact on human pathophysiology; and (iii) exploiting them for human disease. To this aim, missing pieces to the eCB puzzle must be urgently found, by solving the 3D structures of key components, and interrogating noncanonical modes of regulation and trafficking of these lipid signals. membrane lipids Elsevier signal transduction Elsevier 3D structures Elsevier cannabinoids Elsevier endocannabinoids Elsevier trafficking Elsevier Enthalten in Elsevier Science Ocean sand ridge signatures in the Bohai Sea observed by satellite ocean color and synthetic aperture radar measurements 2011transfer abstract Amsterdam [u.a.] (DE-627)ELV026173794 volume:26 year:2020 number:3 pages:263-272 extent:10 https://doi.org/10.1016/j.molmed.2019.11.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_73 GBV_ILN_252 51.00 Werkstoffkunde: Allgemeines VZ AR 26 2020 3 263-272 10 |
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10.1016/j.molmed.2019.11.002 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000945.pica (DE-627)ELV049534610 (ELSEVIER)S1471-4914(19)30293-X DE-627 ger DE-627 rakwb eng 050 VZ 550 VZ 660 VZ 660 VZ 530 600 670 VZ 51.00 bkl Maccarrone, Mauro verfasserin aut Missing Pieces to the Endocannabinoid Puzzle 2020transfer abstract 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The most bioactive ingredient of cannabis (Cannabis sativa or indica) extracts, Δ 9-tetrahydrocannabinol (THC), was identified in the 1960s as one of more than 110 phytocannabinoids. It activates receptors of chemically different endogenous ligands (endocannabinoids) that, unlike THC, are metabolized by several enzymes of the endocannabinoid system. Here, the complexity of the plant-derived and endogenous cannabinoids (eCBs) is discussed, to better appreciate the challenge of: (i) dissecting their mutual interactions; (ii) understanding their impact on human pathophysiology; and (iii) exploiting them for human disease. To this aim, missing pieces to the eCB puzzle must be urgently found, by solving the 3D structures of key components, and interrogating noncanonical modes of regulation and trafficking of these lipid signals. The most bioactive ingredient of cannabis (Cannabis sativa or indica) extracts, Δ 9-tetrahydrocannabinol (THC), was identified in the 1960s as one of more than 110 phytocannabinoids. It activates receptors of chemically different endogenous ligands (endocannabinoids) that, unlike THC, are metabolized by several enzymes of the endocannabinoid system. Here, the complexity of the plant-derived and endogenous cannabinoids (eCBs) is discussed, to better appreciate the challenge of: (i) dissecting their mutual interactions; (ii) understanding their impact on human pathophysiology; and (iii) exploiting them for human disease. To this aim, missing pieces to the eCB puzzle must be urgently found, by solving the 3D structures of key components, and interrogating noncanonical modes of regulation and trafficking of these lipid signals. membrane lipids Elsevier signal transduction Elsevier 3D structures Elsevier cannabinoids Elsevier endocannabinoids Elsevier trafficking Elsevier Enthalten in Elsevier Science Ocean sand ridge signatures in the Bohai Sea observed by satellite ocean color and synthetic aperture radar measurements 2011transfer abstract Amsterdam [u.a.] (DE-627)ELV026173794 volume:26 year:2020 number:3 pages:263-272 extent:10 https://doi.org/10.1016/j.molmed.2019.11.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_73 GBV_ILN_252 51.00 Werkstoffkunde: Allgemeines VZ AR 26 2020 3 263-272 10 |
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Ocean sand ridge signatures in the Bohai Sea observed by satellite ocean color and synthetic aperture radar measurements |
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Ocean sand ridge signatures in the Bohai Sea observed by satellite ocean color and synthetic aperture radar measurements |
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Missing Pieces to the Endocannabinoid Puzzle |
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Missing Pieces to the Endocannabinoid Puzzle |
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Ocean sand ridge signatures in the Bohai Sea observed by satellite ocean color and synthetic aperture radar measurements |
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missing pieces to the endocannabinoid puzzle |
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Missing Pieces to the Endocannabinoid Puzzle |
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The most bioactive ingredient of cannabis (Cannabis sativa or indica) extracts, Δ 9-tetrahydrocannabinol (THC), was identified in the 1960s as one of more than 110 phytocannabinoids. It activates receptors of chemically different endogenous ligands (endocannabinoids) that, unlike THC, are metabolized by several enzymes of the endocannabinoid system. Here, the complexity of the plant-derived and endogenous cannabinoids (eCBs) is discussed, to better appreciate the challenge of: (i) dissecting their mutual interactions; (ii) understanding their impact on human pathophysiology; and (iii) exploiting them for human disease. To this aim, missing pieces to the eCB puzzle must be urgently found, by solving the 3D structures of key components, and interrogating noncanonical modes of regulation and trafficking of these lipid signals. |
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The most bioactive ingredient of cannabis (Cannabis sativa or indica) extracts, Δ 9-tetrahydrocannabinol (THC), was identified in the 1960s as one of more than 110 phytocannabinoids. It activates receptors of chemically different endogenous ligands (endocannabinoids) that, unlike THC, are metabolized by several enzymes of the endocannabinoid system. Here, the complexity of the plant-derived and endogenous cannabinoids (eCBs) is discussed, to better appreciate the challenge of: (i) dissecting their mutual interactions; (ii) understanding their impact on human pathophysiology; and (iii) exploiting them for human disease. To this aim, missing pieces to the eCB puzzle must be urgently found, by solving the 3D structures of key components, and interrogating noncanonical modes of regulation and trafficking of these lipid signals. |
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The most bioactive ingredient of cannabis (Cannabis sativa or indica) extracts, Δ 9-tetrahydrocannabinol (THC), was identified in the 1960s as one of more than 110 phytocannabinoids. It activates receptors of chemically different endogenous ligands (endocannabinoids) that, unlike THC, are metabolized by several enzymes of the endocannabinoid system. Here, the complexity of the plant-derived and endogenous cannabinoids (eCBs) is discussed, to better appreciate the challenge of: (i) dissecting their mutual interactions; (ii) understanding their impact on human pathophysiology; and (iii) exploiting them for human disease. To this aim, missing pieces to the eCB puzzle must be urgently found, by solving the 3D structures of key components, and interrogating noncanonical modes of regulation and trafficking of these lipid signals. |
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