Two-step continuous flow synthesis of amide via oxidative amidation of methylarene
A green and efficient method for the synthesis of amides has been developed through oxidative amidation between methylarenes with amines in a two-step continuous flow system. This method integrates methylarene oxidation and amide formation into a single operation which is usually accomplished separa...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Shi, Tingting [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020transfer abstract |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Therapeutic Advances in Pediatric Multiple Sclerosis - 2013, the international journal for the rapid publication of full original research papers and critical reviews in organic chemistry, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:76 ; year:2020 ; number:13 ; day:27 ; month:03 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1016/j.tet.2020.131044 |
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ELV049580949 |
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| 520 | |a A green and efficient method for the synthesis of amides has been developed through oxidative amidation between methylarenes with amines in a two-step continuous flow system. This method integrates methylarene oxidation and amide formation into a single operation which is usually accomplished separately. Oxidation with tert-butyl hydroperoxide (TBHP) as “green” oxidant, the synthesis of amides under mild reaction conditions in continuous flow system and the utilization of methylarenes as starting material make this methodology novel and environment friendly. The practical value of this method is highlighted through the synthesis of high-profile pharmaceutical agents, acetylprocainamide. | ||
| 520 | |a A green and efficient method for the synthesis of amides has been developed through oxidative amidation between methylarenes with amines in a two-step continuous flow system. This method integrates methylarene oxidation and amide formation into a single operation which is usually accomplished separately. Oxidation with tert-butyl hydroperoxide (TBHP) as “green” oxidant, the synthesis of amides under mild reaction conditions in continuous flow system and the utilization of methylarenes as starting material make this methodology novel and environment friendly. The practical value of this method is highlighted through the synthesis of high-profile pharmaceutical agents, acetylprocainamide. | ||
| 650 | 7 | |a Catalysts |2 Elsevier | |
| 650 | 7 | |a Continuous flow system |2 Elsevier | |
| 650 | 7 | |a Oxidative amidation |2 Elsevier | |
| 650 | 7 | |a Amides |2 Elsevier | |
| 650 | 7 | |a Methylarenes |2 Elsevier | |
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| 700 | 1 | |a Yang, Zhao |4 oth | |
| 700 | 1 | |a He, Wei |4 oth | |
| 700 | 1 | |a Liu, Chengkou |4 oth | |
| 700 | 1 | |a Fang, Zheng |4 oth | |
| 700 | 1 | |a Guo, Kai |4 oth | |
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10.1016/j.tet.2020.131044 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000932.pica (DE-627)ELV049580949 (ELSEVIER)S0040-4020(20)30154-X DE-627 ger DE-627 rakwb eng 610 VZ 150 VZ LING DE-30 fid 77.00 bkl Shi, Tingting verfasserin aut Two-step continuous flow synthesis of amide via oxidative amidation of methylarene 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A green and efficient method for the synthesis of amides has been developed through oxidative amidation between methylarenes with amines in a two-step continuous flow system. This method integrates methylarene oxidation and amide formation into a single operation which is usually accomplished separately. Oxidation with tert-butyl hydroperoxide (TBHP) as “green” oxidant, the synthesis of amides under mild reaction conditions in continuous flow system and the utilization of methylarenes as starting material make this methodology novel and environment friendly. The practical value of this method is highlighted through the synthesis of high-profile pharmaceutical agents, acetylprocainamide. A green and efficient method for the synthesis of amides has been developed through oxidative amidation between methylarenes with amines in a two-step continuous flow system. This method integrates methylarene oxidation and amide formation into a single operation which is usually accomplished separately. Oxidation with tert-butyl hydroperoxide (TBHP) as “green” oxidant, the synthesis of amides under mild reaction conditions in continuous flow system and the utilization of methylarenes as starting material make this methodology novel and environment friendly. The practical value of this method is highlighted through the synthesis of high-profile pharmaceutical agents, acetylprocainamide. Catalysts Elsevier Continuous flow system Elsevier Oxidative amidation Elsevier Amides Elsevier Methylarenes Elsevier Zhang, Zhimin oth Yang, Yuhang oth Yang, Zhao oth He, Wei oth Liu, Chengkou oth Fang, Zheng oth Guo, Kai oth Enthalten in Elsevier Science Therapeutic Advances in Pediatric Multiple Sclerosis 2013 the international journal for the rapid publication of full original research papers and critical reviews in organic chemistry Amsterdam [u.a.] (DE-627)ELV011938943 volume:76 year:2020 number:13 day:27 month:03 pages:0 https://doi.org/10.1016/j.tet.2020.131044 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-LING 77.00 Psychologie: Allgemeines VZ AR 76 2020 13 27 0327 0 |
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10.1016/j.tet.2020.131044 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000932.pica (DE-627)ELV049580949 (ELSEVIER)S0040-4020(20)30154-X DE-627 ger DE-627 rakwb eng 610 VZ 150 VZ LING DE-30 fid 77.00 bkl Shi, Tingting verfasserin aut Two-step continuous flow synthesis of amide via oxidative amidation of methylarene 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A green and efficient method for the synthesis of amides has been developed through oxidative amidation between methylarenes with amines in a two-step continuous flow system. This method integrates methylarene oxidation and amide formation into a single operation which is usually accomplished separately. Oxidation with tert-butyl hydroperoxide (TBHP) as “green” oxidant, the synthesis of amides under mild reaction conditions in continuous flow system and the utilization of methylarenes as starting material make this methodology novel and environment friendly. The practical value of this method is highlighted through the synthesis of high-profile pharmaceutical agents, acetylprocainamide. A green and efficient method for the synthesis of amides has been developed through oxidative amidation between methylarenes with amines in a two-step continuous flow system. This method integrates methylarene oxidation and amide formation into a single operation which is usually accomplished separately. Oxidation with tert-butyl hydroperoxide (TBHP) as “green” oxidant, the synthesis of amides under mild reaction conditions in continuous flow system and the utilization of methylarenes as starting material make this methodology novel and environment friendly. The practical value of this method is highlighted through the synthesis of high-profile pharmaceutical agents, acetylprocainamide. Catalysts Elsevier Continuous flow system Elsevier Oxidative amidation Elsevier Amides Elsevier Methylarenes Elsevier Zhang, Zhimin oth Yang, Yuhang oth Yang, Zhao oth He, Wei oth Liu, Chengkou oth Fang, Zheng oth Guo, Kai oth Enthalten in Elsevier Science Therapeutic Advances in Pediatric Multiple Sclerosis 2013 the international journal for the rapid publication of full original research papers and critical reviews in organic chemistry Amsterdam [u.a.] (DE-627)ELV011938943 volume:76 year:2020 number:13 day:27 month:03 pages:0 https://doi.org/10.1016/j.tet.2020.131044 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-LING 77.00 Psychologie: Allgemeines VZ AR 76 2020 13 27 0327 0 |
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10.1016/j.tet.2020.131044 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000932.pica (DE-627)ELV049580949 (ELSEVIER)S0040-4020(20)30154-X DE-627 ger DE-627 rakwb eng 610 VZ 150 VZ LING DE-30 fid 77.00 bkl Shi, Tingting verfasserin aut Two-step continuous flow synthesis of amide via oxidative amidation of methylarene 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A green and efficient method for the synthesis of amides has been developed through oxidative amidation between methylarenes with amines in a two-step continuous flow system. This method integrates methylarene oxidation and amide formation into a single operation which is usually accomplished separately. Oxidation with tert-butyl hydroperoxide (TBHP) as “green” oxidant, the synthesis of amides under mild reaction conditions in continuous flow system and the utilization of methylarenes as starting material make this methodology novel and environment friendly. The practical value of this method is highlighted through the synthesis of high-profile pharmaceutical agents, acetylprocainamide. A green and efficient method for the synthesis of amides has been developed through oxidative amidation between methylarenes with amines in a two-step continuous flow system. This method integrates methylarene oxidation and amide formation into a single operation which is usually accomplished separately. Oxidation with tert-butyl hydroperoxide (TBHP) as “green” oxidant, the synthesis of amides under mild reaction conditions in continuous flow system and the utilization of methylarenes as starting material make this methodology novel and environment friendly. The practical value of this method is highlighted through the synthesis of high-profile pharmaceutical agents, acetylprocainamide. Catalysts Elsevier Continuous flow system Elsevier Oxidative amidation Elsevier Amides Elsevier Methylarenes Elsevier Zhang, Zhimin oth Yang, Yuhang oth Yang, Zhao oth He, Wei oth Liu, Chengkou oth Fang, Zheng oth Guo, Kai oth Enthalten in Elsevier Science Therapeutic Advances in Pediatric Multiple Sclerosis 2013 the international journal for the rapid publication of full original research papers and critical reviews in organic chemistry Amsterdam [u.a.] (DE-627)ELV011938943 volume:76 year:2020 number:13 day:27 month:03 pages:0 https://doi.org/10.1016/j.tet.2020.131044 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-LING 77.00 Psychologie: Allgemeines VZ AR 76 2020 13 27 0327 0 |
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10.1016/j.tet.2020.131044 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000932.pica (DE-627)ELV049580949 (ELSEVIER)S0040-4020(20)30154-X DE-627 ger DE-627 rakwb eng 610 VZ 150 VZ LING DE-30 fid 77.00 bkl Shi, Tingting verfasserin aut Two-step continuous flow synthesis of amide via oxidative amidation of methylarene 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A green and efficient method for the synthesis of amides has been developed through oxidative amidation between methylarenes with amines in a two-step continuous flow system. This method integrates methylarene oxidation and amide formation into a single operation which is usually accomplished separately. Oxidation with tert-butyl hydroperoxide (TBHP) as “green” oxidant, the synthesis of amides under mild reaction conditions in continuous flow system and the utilization of methylarenes as starting material make this methodology novel and environment friendly. The practical value of this method is highlighted through the synthesis of high-profile pharmaceutical agents, acetylprocainamide. A green and efficient method for the synthesis of amides has been developed through oxidative amidation between methylarenes with amines in a two-step continuous flow system. This method integrates methylarene oxidation and amide formation into a single operation which is usually accomplished separately. Oxidation with tert-butyl hydroperoxide (TBHP) as “green” oxidant, the synthesis of amides under mild reaction conditions in continuous flow system and the utilization of methylarenes as starting material make this methodology novel and environment friendly. The practical value of this method is highlighted through the synthesis of high-profile pharmaceutical agents, acetylprocainamide. Catalysts Elsevier Continuous flow system Elsevier Oxidative amidation Elsevier Amides Elsevier Methylarenes Elsevier Zhang, Zhimin oth Yang, Yuhang oth Yang, Zhao oth He, Wei oth Liu, Chengkou oth Fang, Zheng oth Guo, Kai oth Enthalten in Elsevier Science Therapeutic Advances in Pediatric Multiple Sclerosis 2013 the international journal for the rapid publication of full original research papers and critical reviews in organic chemistry Amsterdam [u.a.] (DE-627)ELV011938943 volume:76 year:2020 number:13 day:27 month:03 pages:0 https://doi.org/10.1016/j.tet.2020.131044 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-LING 77.00 Psychologie: Allgemeines VZ AR 76 2020 13 27 0327 0 |
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10.1016/j.tet.2020.131044 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000932.pica (DE-627)ELV049580949 (ELSEVIER)S0040-4020(20)30154-X DE-627 ger DE-627 rakwb eng 610 VZ 150 VZ LING DE-30 fid 77.00 bkl Shi, Tingting verfasserin aut Two-step continuous flow synthesis of amide via oxidative amidation of methylarene 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A green and efficient method for the synthesis of amides has been developed through oxidative amidation between methylarenes with amines in a two-step continuous flow system. This method integrates methylarene oxidation and amide formation into a single operation which is usually accomplished separately. Oxidation with tert-butyl hydroperoxide (TBHP) as “green” oxidant, the synthesis of amides under mild reaction conditions in continuous flow system and the utilization of methylarenes as starting material make this methodology novel and environment friendly. The practical value of this method is highlighted through the synthesis of high-profile pharmaceutical agents, acetylprocainamide. A green and efficient method for the synthesis of amides has been developed through oxidative amidation between methylarenes with amines in a two-step continuous flow system. This method integrates methylarene oxidation and amide formation into a single operation which is usually accomplished separately. Oxidation with tert-butyl hydroperoxide (TBHP) as “green” oxidant, the synthesis of amides under mild reaction conditions in continuous flow system and the utilization of methylarenes as starting material make this methodology novel and environment friendly. The practical value of this method is highlighted through the synthesis of high-profile pharmaceutical agents, acetylprocainamide. Catalysts Elsevier Continuous flow system Elsevier Oxidative amidation Elsevier Amides Elsevier Methylarenes Elsevier Zhang, Zhimin oth Yang, Yuhang oth Yang, Zhao oth He, Wei oth Liu, Chengkou oth Fang, Zheng oth Guo, Kai oth Enthalten in Elsevier Science Therapeutic Advances in Pediatric Multiple Sclerosis 2013 the international journal for the rapid publication of full original research papers and critical reviews in organic chemistry Amsterdam [u.a.] (DE-627)ELV011938943 volume:76 year:2020 number:13 day:27 month:03 pages:0 https://doi.org/10.1016/j.tet.2020.131044 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-LING 77.00 Psychologie: Allgemeines VZ AR 76 2020 13 27 0327 0 |
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Two-step continuous flow synthesis of amide via oxidative amidation of methylarene |
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Two-step continuous flow synthesis of amide via oxidative amidation of methylarene |
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Therapeutic Advances in Pediatric Multiple Sclerosis |
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two-step continuous flow synthesis of amide via oxidative amidation of methylarene |
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Two-step continuous flow synthesis of amide via oxidative amidation of methylarene |
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A green and efficient method for the synthesis of amides has been developed through oxidative amidation between methylarenes with amines in a two-step continuous flow system. This method integrates methylarene oxidation and amide formation into a single operation which is usually accomplished separately. Oxidation with tert-butyl hydroperoxide (TBHP) as “green” oxidant, the synthesis of amides under mild reaction conditions in continuous flow system and the utilization of methylarenes as starting material make this methodology novel and environment friendly. The practical value of this method is highlighted through the synthesis of high-profile pharmaceutical agents, acetylprocainamide. |
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A green and efficient method for the synthesis of amides has been developed through oxidative amidation between methylarenes with amines in a two-step continuous flow system. This method integrates methylarene oxidation and amide formation into a single operation which is usually accomplished separately. Oxidation with tert-butyl hydroperoxide (TBHP) as “green” oxidant, the synthesis of amides under mild reaction conditions in continuous flow system and the utilization of methylarenes as starting material make this methodology novel and environment friendly. The practical value of this method is highlighted through the synthesis of high-profile pharmaceutical agents, acetylprocainamide. |
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A green and efficient method for the synthesis of amides has been developed through oxidative amidation between methylarenes with amines in a two-step continuous flow system. This method integrates methylarene oxidation and amide formation into a single operation which is usually accomplished separately. Oxidation with tert-butyl hydroperoxide (TBHP) as “green” oxidant, the synthesis of amides under mild reaction conditions in continuous flow system and the utilization of methylarenes as starting material make this methodology novel and environment friendly. The practical value of this method is highlighted through the synthesis of high-profile pharmaceutical agents, acetylprocainamide. |
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Two-step continuous flow synthesis of amide via oxidative amidation of methylarene |
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Zhang, Zhimin Yang, Yuhang Yang, Zhao He, Wei Liu, Chengkou Fang, Zheng Guo, Kai |
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