Cellulose based nanocomposite hydrogel films consisting of sodium carboxymethylcellulose–grapefruit seed extract nanoparticles for potential wound healing applications
The impact of grapefruit seed extract (GFSE) as an antibacterial agent on citric acid (CA) crosslinked sodium carboxymethylcellulose (NaCMC)/hydroxypropylmethylcellulose (HPMC) hydrogel films has been studied by incorporating different quantities of GFSE. The prepared films were examined for their p...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Koneru, Aditya [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020transfer abstract |
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| Umfang: |
10 |
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| Übergeordnetes Werk: |
Enthalten in: Automated DNA hybridization transfer with movable super-paramagnetic microbeads in a microflow reactor - Penchovsky, Robert ELSEVIER, 2019, structure, function and interactions, New York, NY [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:148 ; year:2020 ; day:1 ; month:04 ; pages:833-842 ; extent:10 |
| Links: |
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| DOI / URN: |
10.1016/j.ijbiomac.2020.01.018 |
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| 520 | |a The impact of grapefruit seed extract (GFSE) as an antibacterial agent on citric acid (CA) crosslinked sodium carboxymethylcellulose (NaCMC)/hydroxypropylmethylcellulose (HPMC) hydrogel films has been studied by incorporating different quantities of GFSE. The prepared films were examined for their physical, thermal, mechanical and antibacterial properties. It was observed that crystallinity and initial decomposition temperature of hydrogel films decreased with GFSE concentration. Furthermore, the swelling degree and tensile strength of hydrogel films were found to be 257.29 ± 5.08%–162.06 ± 1.78% and 11.61 ± 0.27–2.21 ± 0.94 MPa for increasing GFSE concentration varying from 0.25% - 1.5% (v/v). The presence of nanoparticles in the films was observed by FESEM and FETEM analysis. It was confirmed that the formation of nanoparticles (micelles) is due to the addition of NaCMC and GFSE, probably glycerides, which is one of the main components in GFSE. The hydrogel films have demonstrated excellent antimicrobial activity and elongation at break (%). Moreover, zeta potential of nanoparticles was recorded to be −55.26 mV ascertaining their stability in water that contributed to a higher antimicrobial activity against gram negative bacteria. All these outcomes prove the nanocomposite films to be a potential substitute for hydrogels loaded with synthetic drugs in wound healing and other biological applications. | ||
| 520 | |a The impact of grapefruit seed extract (GFSE) as an antibacterial agent on citric acid (CA) crosslinked sodium carboxymethylcellulose (NaCMC)/hydroxypropylmethylcellulose (HPMC) hydrogel films has been studied by incorporating different quantities of GFSE. The prepared films were examined for their physical, thermal, mechanical and antibacterial properties. It was observed that crystallinity and initial decomposition temperature of hydrogel films decreased with GFSE concentration. Furthermore, the swelling degree and tensile strength of hydrogel films were found to be 257.29 ± 5.08%–162.06 ± 1.78% and 11.61 ± 0.27–2.21 ± 0.94 MPa for increasing GFSE concentration varying from 0.25% - 1.5% (v/v). The presence of nanoparticles in the films was observed by FESEM and FETEM analysis. It was confirmed that the formation of nanoparticles (micelles) is due to the addition of NaCMC and GFSE, probably glycerides, which is one of the main components in GFSE. The hydrogel films have demonstrated excellent antimicrobial activity and elongation at break (%). Moreover, zeta potential of nanoparticles was recorded to be −55.26 mV ascertaining their stability in water that contributed to a higher antimicrobial activity against gram negative bacteria. All these outcomes prove the nanocomposite films to be a potential substitute for hydrogels loaded with synthetic drugs in wound healing and other biological applications. | ||
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10.1016/j.ijbiomac.2020.01.018 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000934.pica (DE-627)ELV049606107 (ELSEVIER)S0141-8130(19)37246-0 DE-627 ger DE-627 rakwb eng 570 610 VZ 58.30 bkl 50.22 bkl 44.09 bkl Koneru, Aditya verfasserin aut Cellulose based nanocomposite hydrogel films consisting of sodium carboxymethylcellulose–grapefruit seed extract nanoparticles for potential wound healing applications 2020transfer abstract 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The impact of grapefruit seed extract (GFSE) as an antibacterial agent on citric acid (CA) crosslinked sodium carboxymethylcellulose (NaCMC)/hydroxypropylmethylcellulose (HPMC) hydrogel films has been studied by incorporating different quantities of GFSE. The prepared films were examined for their physical, thermal, mechanical and antibacterial properties. It was observed that crystallinity and initial decomposition temperature of hydrogel films decreased with GFSE concentration. Furthermore, the swelling degree and tensile strength of hydrogel films were found to be 257.29 ± 5.08%–162.06 ± 1.78% and 11.61 ± 0.27–2.21 ± 0.94 MPa for increasing GFSE concentration varying from 0.25% - 1.5% (v/v). The presence of nanoparticles in the films was observed by FESEM and FETEM analysis. It was confirmed that the formation of nanoparticles (micelles) is due to the addition of NaCMC and GFSE, probably glycerides, which is one of the main components in GFSE. The hydrogel films have demonstrated excellent antimicrobial activity and elongation at break (%). Moreover, zeta potential of nanoparticles was recorded to be −55.26 mV ascertaining their stability in water that contributed to a higher antimicrobial activity against gram negative bacteria. All these outcomes prove the nanocomposite films to be a potential substitute for hydrogels loaded with synthetic drugs in wound healing and other biological applications. The impact of grapefruit seed extract (GFSE) as an antibacterial agent on citric acid (CA) crosslinked sodium carboxymethylcellulose (NaCMC)/hydroxypropylmethylcellulose (HPMC) hydrogel films has been studied by incorporating different quantities of GFSE. The prepared films were examined for their physical, thermal, mechanical and antibacterial properties. It was observed that crystallinity and initial decomposition temperature of hydrogel films decreased with GFSE concentration. Furthermore, the swelling degree and tensile strength of hydrogel films were found to be 257.29 ± 5.08%–162.06 ± 1.78% and 11.61 ± 0.27–2.21 ± 0.94 MPa for increasing GFSE concentration varying from 0.25% - 1.5% (v/v). The presence of nanoparticles in the films was observed by FESEM and FETEM analysis. It was confirmed that the formation of nanoparticles (micelles) is due to the addition of NaCMC and GFSE, probably glycerides, which is one of the main components in GFSE. The hydrogel films have demonstrated excellent antimicrobial activity and elongation at break (%). Moreover, zeta potential of nanoparticles was recorded to be −55.26 mV ascertaining their stability in water that contributed to a higher antimicrobial activity against gram negative bacteria. All these outcomes prove the nanocomposite films to be a potential substitute for hydrogels loaded with synthetic drugs in wound healing and other biological applications. Dharmalingam, K. oth Anandalakshmi, R. oth Enthalten in Elsevier Penchovsky, Robert ELSEVIER Automated DNA hybridization transfer with movable super-paramagnetic microbeads in a microflow reactor 2019 structure, function and interactions New York, NY [u.a.] (DE-627)ELV002200198 volume:148 year:2020 day:1 month:04 pages:833-842 extent:10 https://doi.org/10.1016/j.ijbiomac.2020.01.018 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 58.30 Biotechnologie VZ 50.22 Sensorik VZ 44.09 Medizintechnik VZ AR 148 2020 1 0401 833-842 10 |
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10.1016/j.ijbiomac.2020.01.018 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000934.pica (DE-627)ELV049606107 (ELSEVIER)S0141-8130(19)37246-0 DE-627 ger DE-627 rakwb eng 570 610 VZ 58.30 bkl 50.22 bkl 44.09 bkl Koneru, Aditya verfasserin aut Cellulose based nanocomposite hydrogel films consisting of sodium carboxymethylcellulose–grapefruit seed extract nanoparticles for potential wound healing applications 2020transfer abstract 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The impact of grapefruit seed extract (GFSE) as an antibacterial agent on citric acid (CA) crosslinked sodium carboxymethylcellulose (NaCMC)/hydroxypropylmethylcellulose (HPMC) hydrogel films has been studied by incorporating different quantities of GFSE. The prepared films were examined for their physical, thermal, mechanical and antibacterial properties. It was observed that crystallinity and initial decomposition temperature of hydrogel films decreased with GFSE concentration. Furthermore, the swelling degree and tensile strength of hydrogel films were found to be 257.29 ± 5.08%–162.06 ± 1.78% and 11.61 ± 0.27–2.21 ± 0.94 MPa for increasing GFSE concentration varying from 0.25% - 1.5% (v/v). The presence of nanoparticles in the films was observed by FESEM and FETEM analysis. It was confirmed that the formation of nanoparticles (micelles) is due to the addition of NaCMC and GFSE, probably glycerides, which is one of the main components in GFSE. The hydrogel films have demonstrated excellent antimicrobial activity and elongation at break (%). Moreover, zeta potential of nanoparticles was recorded to be −55.26 mV ascertaining their stability in water that contributed to a higher antimicrobial activity against gram negative bacteria. All these outcomes prove the nanocomposite films to be a potential substitute for hydrogels loaded with synthetic drugs in wound healing and other biological applications. The impact of grapefruit seed extract (GFSE) as an antibacterial agent on citric acid (CA) crosslinked sodium carboxymethylcellulose (NaCMC)/hydroxypropylmethylcellulose (HPMC) hydrogel films has been studied by incorporating different quantities of GFSE. The prepared films were examined for their physical, thermal, mechanical and antibacterial properties. It was observed that crystallinity and initial decomposition temperature of hydrogel films decreased with GFSE concentration. Furthermore, the swelling degree and tensile strength of hydrogel films were found to be 257.29 ± 5.08%–162.06 ± 1.78% and 11.61 ± 0.27–2.21 ± 0.94 MPa for increasing GFSE concentration varying from 0.25% - 1.5% (v/v). The presence of nanoparticles in the films was observed by FESEM and FETEM analysis. It was confirmed that the formation of nanoparticles (micelles) is due to the addition of NaCMC and GFSE, probably glycerides, which is one of the main components in GFSE. The hydrogel films have demonstrated excellent antimicrobial activity and elongation at break (%). Moreover, zeta potential of nanoparticles was recorded to be −55.26 mV ascertaining their stability in water that contributed to a higher antimicrobial activity against gram negative bacteria. All these outcomes prove the nanocomposite films to be a potential substitute for hydrogels loaded with synthetic drugs in wound healing and other biological applications. Dharmalingam, K. oth Anandalakshmi, R. oth Enthalten in Elsevier Penchovsky, Robert ELSEVIER Automated DNA hybridization transfer with movable super-paramagnetic microbeads in a microflow reactor 2019 structure, function and interactions New York, NY [u.a.] (DE-627)ELV002200198 volume:148 year:2020 day:1 month:04 pages:833-842 extent:10 https://doi.org/10.1016/j.ijbiomac.2020.01.018 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 58.30 Biotechnologie VZ 50.22 Sensorik VZ 44.09 Medizintechnik VZ AR 148 2020 1 0401 833-842 10 |
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10.1016/j.ijbiomac.2020.01.018 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000934.pica (DE-627)ELV049606107 (ELSEVIER)S0141-8130(19)37246-0 DE-627 ger DE-627 rakwb eng 570 610 VZ 58.30 bkl 50.22 bkl 44.09 bkl Koneru, Aditya verfasserin aut Cellulose based nanocomposite hydrogel films consisting of sodium carboxymethylcellulose–grapefruit seed extract nanoparticles for potential wound healing applications 2020transfer abstract 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The impact of grapefruit seed extract (GFSE) as an antibacterial agent on citric acid (CA) crosslinked sodium carboxymethylcellulose (NaCMC)/hydroxypropylmethylcellulose (HPMC) hydrogel films has been studied by incorporating different quantities of GFSE. The prepared films were examined for their physical, thermal, mechanical and antibacterial properties. It was observed that crystallinity and initial decomposition temperature of hydrogel films decreased with GFSE concentration. Furthermore, the swelling degree and tensile strength of hydrogel films were found to be 257.29 ± 5.08%–162.06 ± 1.78% and 11.61 ± 0.27–2.21 ± 0.94 MPa for increasing GFSE concentration varying from 0.25% - 1.5% (v/v). The presence of nanoparticles in the films was observed by FESEM and FETEM analysis. It was confirmed that the formation of nanoparticles (micelles) is due to the addition of NaCMC and GFSE, probably glycerides, which is one of the main components in GFSE. The hydrogel films have demonstrated excellent antimicrobial activity and elongation at break (%). Moreover, zeta potential of nanoparticles was recorded to be −55.26 mV ascertaining their stability in water that contributed to a higher antimicrobial activity against gram negative bacteria. All these outcomes prove the nanocomposite films to be a potential substitute for hydrogels loaded with synthetic drugs in wound healing and other biological applications. The impact of grapefruit seed extract (GFSE) as an antibacterial agent on citric acid (CA) crosslinked sodium carboxymethylcellulose (NaCMC)/hydroxypropylmethylcellulose (HPMC) hydrogel films has been studied by incorporating different quantities of GFSE. The prepared films were examined for their physical, thermal, mechanical and antibacterial properties. It was observed that crystallinity and initial decomposition temperature of hydrogel films decreased with GFSE concentration. Furthermore, the swelling degree and tensile strength of hydrogel films were found to be 257.29 ± 5.08%–162.06 ± 1.78% and 11.61 ± 0.27–2.21 ± 0.94 MPa for increasing GFSE concentration varying from 0.25% - 1.5% (v/v). The presence of nanoparticles in the films was observed by FESEM and FETEM analysis. It was confirmed that the formation of nanoparticles (micelles) is due to the addition of NaCMC and GFSE, probably glycerides, which is one of the main components in GFSE. The hydrogel films have demonstrated excellent antimicrobial activity and elongation at break (%). Moreover, zeta potential of nanoparticles was recorded to be −55.26 mV ascertaining their stability in water that contributed to a higher antimicrobial activity against gram negative bacteria. All these outcomes prove the nanocomposite films to be a potential substitute for hydrogels loaded with synthetic drugs in wound healing and other biological applications. Dharmalingam, K. oth Anandalakshmi, R. oth Enthalten in Elsevier Penchovsky, Robert ELSEVIER Automated DNA hybridization transfer with movable super-paramagnetic microbeads in a microflow reactor 2019 structure, function and interactions New York, NY [u.a.] (DE-627)ELV002200198 volume:148 year:2020 day:1 month:04 pages:833-842 extent:10 https://doi.org/10.1016/j.ijbiomac.2020.01.018 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 58.30 Biotechnologie VZ 50.22 Sensorik VZ 44.09 Medizintechnik VZ AR 148 2020 1 0401 833-842 10 |
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10.1016/j.ijbiomac.2020.01.018 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000934.pica (DE-627)ELV049606107 (ELSEVIER)S0141-8130(19)37246-0 DE-627 ger DE-627 rakwb eng 570 610 VZ 58.30 bkl 50.22 bkl 44.09 bkl Koneru, Aditya verfasserin aut Cellulose based nanocomposite hydrogel films consisting of sodium carboxymethylcellulose–grapefruit seed extract nanoparticles for potential wound healing applications 2020transfer abstract 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The impact of grapefruit seed extract (GFSE) as an antibacterial agent on citric acid (CA) crosslinked sodium carboxymethylcellulose (NaCMC)/hydroxypropylmethylcellulose (HPMC) hydrogel films has been studied by incorporating different quantities of GFSE. The prepared films were examined for their physical, thermal, mechanical and antibacterial properties. It was observed that crystallinity and initial decomposition temperature of hydrogel films decreased with GFSE concentration. Furthermore, the swelling degree and tensile strength of hydrogel films were found to be 257.29 ± 5.08%–162.06 ± 1.78% and 11.61 ± 0.27–2.21 ± 0.94 MPa for increasing GFSE concentration varying from 0.25% - 1.5% (v/v). The presence of nanoparticles in the films was observed by FESEM and FETEM analysis. It was confirmed that the formation of nanoparticles (micelles) is due to the addition of NaCMC and GFSE, probably glycerides, which is one of the main components in GFSE. The hydrogel films have demonstrated excellent antimicrobial activity and elongation at break (%). Moreover, zeta potential of nanoparticles was recorded to be −55.26 mV ascertaining their stability in water that contributed to a higher antimicrobial activity against gram negative bacteria. All these outcomes prove the nanocomposite films to be a potential substitute for hydrogels loaded with synthetic drugs in wound healing and other biological applications. The impact of grapefruit seed extract (GFSE) as an antibacterial agent on citric acid (CA) crosslinked sodium carboxymethylcellulose (NaCMC)/hydroxypropylmethylcellulose (HPMC) hydrogel films has been studied by incorporating different quantities of GFSE. The prepared films were examined for their physical, thermal, mechanical and antibacterial properties. It was observed that crystallinity and initial decomposition temperature of hydrogel films decreased with GFSE concentration. Furthermore, the swelling degree and tensile strength of hydrogel films were found to be 257.29 ± 5.08%–162.06 ± 1.78% and 11.61 ± 0.27–2.21 ± 0.94 MPa for increasing GFSE concentration varying from 0.25% - 1.5% (v/v). The presence of nanoparticles in the films was observed by FESEM and FETEM analysis. It was confirmed that the formation of nanoparticles (micelles) is due to the addition of NaCMC and GFSE, probably glycerides, which is one of the main components in GFSE. The hydrogel films have demonstrated excellent antimicrobial activity and elongation at break (%). Moreover, zeta potential of nanoparticles was recorded to be −55.26 mV ascertaining their stability in water that contributed to a higher antimicrobial activity against gram negative bacteria. All these outcomes prove the nanocomposite films to be a potential substitute for hydrogels loaded with synthetic drugs in wound healing and other biological applications. Dharmalingam, K. oth Anandalakshmi, R. oth Enthalten in Elsevier Penchovsky, Robert ELSEVIER Automated DNA hybridization transfer with movable super-paramagnetic microbeads in a microflow reactor 2019 structure, function and interactions New York, NY [u.a.] (DE-627)ELV002200198 volume:148 year:2020 day:1 month:04 pages:833-842 extent:10 https://doi.org/10.1016/j.ijbiomac.2020.01.018 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 58.30 Biotechnologie VZ 50.22 Sensorik VZ 44.09 Medizintechnik VZ AR 148 2020 1 0401 833-842 10 |
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10.1016/j.ijbiomac.2020.01.018 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000934.pica (DE-627)ELV049606107 (ELSEVIER)S0141-8130(19)37246-0 DE-627 ger DE-627 rakwb eng 570 610 VZ 58.30 bkl 50.22 bkl 44.09 bkl Koneru, Aditya verfasserin aut Cellulose based nanocomposite hydrogel films consisting of sodium carboxymethylcellulose–grapefruit seed extract nanoparticles for potential wound healing applications 2020transfer abstract 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The impact of grapefruit seed extract (GFSE) as an antibacterial agent on citric acid (CA) crosslinked sodium carboxymethylcellulose (NaCMC)/hydroxypropylmethylcellulose (HPMC) hydrogel films has been studied by incorporating different quantities of GFSE. The prepared films were examined for their physical, thermal, mechanical and antibacterial properties. It was observed that crystallinity and initial decomposition temperature of hydrogel films decreased with GFSE concentration. Furthermore, the swelling degree and tensile strength of hydrogel films were found to be 257.29 ± 5.08%–162.06 ± 1.78% and 11.61 ± 0.27–2.21 ± 0.94 MPa for increasing GFSE concentration varying from 0.25% - 1.5% (v/v). The presence of nanoparticles in the films was observed by FESEM and FETEM analysis. It was confirmed that the formation of nanoparticles (micelles) is due to the addition of NaCMC and GFSE, probably glycerides, which is one of the main components in GFSE. The hydrogel films have demonstrated excellent antimicrobial activity and elongation at break (%). Moreover, zeta potential of nanoparticles was recorded to be −55.26 mV ascertaining their stability in water that contributed to a higher antimicrobial activity against gram negative bacteria. All these outcomes prove the nanocomposite films to be a potential substitute for hydrogels loaded with synthetic drugs in wound healing and other biological applications. The impact of grapefruit seed extract (GFSE) as an antibacterial agent on citric acid (CA) crosslinked sodium carboxymethylcellulose (NaCMC)/hydroxypropylmethylcellulose (HPMC) hydrogel films has been studied by incorporating different quantities of GFSE. The prepared films were examined for their physical, thermal, mechanical and antibacterial properties. It was observed that crystallinity and initial decomposition temperature of hydrogel films decreased with GFSE concentration. Furthermore, the swelling degree and tensile strength of hydrogel films were found to be 257.29 ± 5.08%–162.06 ± 1.78% and 11.61 ± 0.27–2.21 ± 0.94 MPa for increasing GFSE concentration varying from 0.25% - 1.5% (v/v). The presence of nanoparticles in the films was observed by FESEM and FETEM analysis. It was confirmed that the formation of nanoparticles (micelles) is due to the addition of NaCMC and GFSE, probably glycerides, which is one of the main components in GFSE. The hydrogel films have demonstrated excellent antimicrobial activity and elongation at break (%). Moreover, zeta potential of nanoparticles was recorded to be −55.26 mV ascertaining their stability in water that contributed to a higher antimicrobial activity against gram negative bacteria. All these outcomes prove the nanocomposite films to be a potential substitute for hydrogels loaded with synthetic drugs in wound healing and other biological applications. Dharmalingam, K. oth Anandalakshmi, R. oth Enthalten in Elsevier Penchovsky, Robert ELSEVIER Automated DNA hybridization transfer with movable super-paramagnetic microbeads in a microflow reactor 2019 structure, function and interactions New York, NY [u.a.] (DE-627)ELV002200198 volume:148 year:2020 day:1 month:04 pages:833-842 extent:10 https://doi.org/10.1016/j.ijbiomac.2020.01.018 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 58.30 Biotechnologie VZ 50.22 Sensorik VZ 44.09 Medizintechnik VZ AR 148 2020 1 0401 833-842 10 |
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cellulose based nanocomposite hydrogel films consisting of sodium carboxymethylcellulose–grapefruit seed extract nanoparticles for potential wound healing applications |
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Cellulose based nanocomposite hydrogel films consisting of sodium carboxymethylcellulose–grapefruit seed extract nanoparticles for potential wound healing applications |
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The impact of grapefruit seed extract (GFSE) as an antibacterial agent on citric acid (CA) crosslinked sodium carboxymethylcellulose (NaCMC)/hydroxypropylmethylcellulose (HPMC) hydrogel films has been studied by incorporating different quantities of GFSE. The prepared films were examined for their physical, thermal, mechanical and antibacterial properties. It was observed that crystallinity and initial decomposition temperature of hydrogel films decreased with GFSE concentration. Furthermore, the swelling degree and tensile strength of hydrogel films were found to be 257.29 ± 5.08%–162.06 ± 1.78% and 11.61 ± 0.27–2.21 ± 0.94 MPa for increasing GFSE concentration varying from 0.25% - 1.5% (v/v). The presence of nanoparticles in the films was observed by FESEM and FETEM analysis. It was confirmed that the formation of nanoparticles (micelles) is due to the addition of NaCMC and GFSE, probably glycerides, which is one of the main components in GFSE. The hydrogel films have demonstrated excellent antimicrobial activity and elongation at break (%). Moreover, zeta potential of nanoparticles was recorded to be −55.26 mV ascertaining their stability in water that contributed to a higher antimicrobial activity against gram negative bacteria. All these outcomes prove the nanocomposite films to be a potential substitute for hydrogels loaded with synthetic drugs in wound healing and other biological applications. |
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The impact of grapefruit seed extract (GFSE) as an antibacterial agent on citric acid (CA) crosslinked sodium carboxymethylcellulose (NaCMC)/hydroxypropylmethylcellulose (HPMC) hydrogel films has been studied by incorporating different quantities of GFSE. The prepared films were examined for their physical, thermal, mechanical and antibacterial properties. It was observed that crystallinity and initial decomposition temperature of hydrogel films decreased with GFSE concentration. Furthermore, the swelling degree and tensile strength of hydrogel films were found to be 257.29 ± 5.08%–162.06 ± 1.78% and 11.61 ± 0.27–2.21 ± 0.94 MPa for increasing GFSE concentration varying from 0.25% - 1.5% (v/v). The presence of nanoparticles in the films was observed by FESEM and FETEM analysis. It was confirmed that the formation of nanoparticles (micelles) is due to the addition of NaCMC and GFSE, probably glycerides, which is one of the main components in GFSE. The hydrogel films have demonstrated excellent antimicrobial activity and elongation at break (%). Moreover, zeta potential of nanoparticles was recorded to be −55.26 mV ascertaining their stability in water that contributed to a higher antimicrobial activity against gram negative bacteria. All these outcomes prove the nanocomposite films to be a potential substitute for hydrogels loaded with synthetic drugs in wound healing and other biological applications. |
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The impact of grapefruit seed extract (GFSE) as an antibacterial agent on citric acid (CA) crosslinked sodium carboxymethylcellulose (NaCMC)/hydroxypropylmethylcellulose (HPMC) hydrogel films has been studied by incorporating different quantities of GFSE. The prepared films were examined for their physical, thermal, mechanical and antibacterial properties. It was observed that crystallinity and initial decomposition temperature of hydrogel films decreased with GFSE concentration. Furthermore, the swelling degree and tensile strength of hydrogel films were found to be 257.29 ± 5.08%–162.06 ± 1.78% and 11.61 ± 0.27–2.21 ± 0.94 MPa for increasing GFSE concentration varying from 0.25% - 1.5% (v/v). The presence of nanoparticles in the films was observed by FESEM and FETEM analysis. It was confirmed that the formation of nanoparticles (micelles) is due to the addition of NaCMC and GFSE, probably glycerides, which is one of the main components in GFSE. The hydrogel films have demonstrated excellent antimicrobial activity and elongation at break (%). Moreover, zeta potential of nanoparticles was recorded to be −55.26 mV ascertaining their stability in water that contributed to a higher antimicrobial activity against gram negative bacteria. All these outcomes prove the nanocomposite films to be a potential substitute for hydrogels loaded with synthetic drugs in wound healing and other biological applications. |
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