Seizure-induced neuronal apoptosis is related to dysregulation of the RNA-edited GluR2 subunit in the developing mouse brain
• Expression kinetics of AMPAR subunits and their mRNA-editing adenosine deaminases are developmentally regulated. • Recurrent neonatal seizures significantly reduce GluR2 mRNA-editing enzymes ADAR1 and ADAR2 in a time- and region-specific manner. • Seizure-induced ADAR2 downregulation is related to...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Jung, Susan [verfasserIn] |
|---|
| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: DNA methylation mediates gonadal development via regulating the expression levels of - Su, Junxiao ELSEVIER, 2023, an international multidisciplinary journal devoted to fundamental research in the brain sciences, Amsterdam |
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| Übergeordnetes Werk: |
volume:1735 ; year:2020 ; day:15 ; month:05 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1016/j.brainres.2020.146760 |
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Seizure-induced neuronal apoptosis is related to dysregulation of the RNA-edited GluR2 subunit in the developing mouse brain |
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• Expression kinetics of AMPAR subunits and their mRNA-editing adenosine deaminases are developmentally regulated. • Recurrent neonatal seizures significantly reduce GluR2 mRNA-editing enzymes ADAR1 and ADAR2 in a time- and region-specific manner. • Seizure-induced ADAR2 downregulation is related to region-specific activation of apoptosis. |
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• Expression kinetics of AMPAR subunits and their mRNA-editing adenosine deaminases are developmentally regulated. • Recurrent neonatal seizures significantly reduce GluR2 mRNA-editing enzymes ADAR1 and ADAR2 in a time- and region-specific manner. • Seizure-induced ADAR2 downregulation is related to region-specific activation of apoptosis. |
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• Expression kinetics of AMPAR subunits and their mRNA-editing adenosine deaminases are developmentally regulated. • Recurrent neonatal seizures significantly reduce GluR2 mRNA-editing enzymes ADAR1 and ADAR2 in a time- and region-specific manner. • Seizure-induced ADAR2 downregulation is related to region-specific activation of apoptosis. |
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Seizure-induced neuronal apoptosis is related to dysregulation of the RNA-edited GluR2 subunit in the developing mouse brain |
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https://doi.org/10.1016/j.brainres.2020.146760 |
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Ballheimer, Yili E. Brackmann, Florian Zoglauer, Daniel Geppert, Carol-Immanuel Hartmann, Arndt Trollmann, Regina |
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Ballheimer, Yili E. Brackmann, Florian Zoglauer, Daniel Geppert, Carol-Immanuel Hartmann, Arndt Trollmann, Regina |
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10.1016/j.brainres.2020.146760 |
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2024-07-06T22:18:19.758Z |
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