Synthesis, biological evaluation and molecular docking studies of novel 2-alkylthiopyrimidino-tacrines as anticholinesterase agents and their DFT calculations

To search for effective and selective inhibitors of cholinesterases (AChE and BuChE), a series of poly-functionalized Tacrine-derived compounds specifically 2-(alkylthio)-4-aryl-6,7,8,9-tetrahydropyrimido[4,5-b]quinolin-5-amines were designed an synthesized via Friedlander reaction. The structures o...
Ausführliche Beschreibung

Gespeichert in:
Autor*in:

Derabli, Chamseddine [verfasserIn]

Boulebd, Houssem

Abdelwahab, Ahmed B.

Boucheraine, Celia

Zerrouki, Sarah

Bensouici, Chawki

Kirsch, Gilbert

Boulcina, Raouf

Debache, Abdelmadjid

Format:

E-Artikel

Sprache:

Englisch

Erschienen:

2020transfer abstract

Schlagwörter:

Alzheimer’s disease

Inhibitors of cholinesterases

2-Alkylthiopyrimidino-Tacrines

Molecular docking

DFT calculations

Übergeordnetes Werk:

Enthalten in: Artificial neural network modelling of amido black dye sorption on iron composite nano material: Kinetics and thermodynamics studies - Ali, Imran ELSEVIER, 2017, New York, NY [u.a.]

Übergeordnetes Werk:

volume:1209 ; year:2020 ; day:5 ; month:06 ; pages:0

Links:

Volltext

DOI / URN:

10.1016/j.molstruc.2020.127902

Katalog-ID:

ELV049823728

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