Electrospun fibrous membranes of poly (lactic-co-glycolic acid) with β-tricalcium phosphate for guided bone regeneration application
Guided bone regeneration (GBR) have been proved great success for the treatment of bone defects in oral implantology. Bone defects are reconstructed by the use of a barrier membrane which prevents the invasion of soft tissue and create a space for guiding new bone growth into the bone defect. To dev...
Ausführliche Beschreibung
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| Autor*in: |
Castro, Vanessa Oliveira [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020transfer abstract |
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| Übergeordnetes Werk: |
Enthalten in: USE OF NOVEL OBSERVATIONAL METHODOLOGY FOR MEASURING AFFECT AND BEHAVIORS IN A BEHAVIORAL INTERVENTION FOR PERSONS WITH DEMENTIA HOSPITALIZED FOR BEHAVIORAL SYMPTOMS - Marx, Katherine A. ELSEVIER, 2016, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:86 ; year:2020 ; pages:0 |
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| DOI / URN: |
10.1016/j.polymertesting.2020.106489 |
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| 520 | |a Guided bone regeneration (GBR) have been proved great success for the treatment of bone defects in oral implantology. Bone defects are reconstructed by the use of a barrier membrane which prevents the invasion of soft tissue and create a space for guiding new bone growth into the bone defect. To develop GBR membranes with higher bioactivity, poly (lactic-co-glycolic acid) (PLGA) fibrous membranes containing β-tricalcium phosphate (β-TCP) were fabricated via electrospinning. The presence of 5 wt% and 10 wt% of β-TCP in the fibers improved mechanical properties. In vitro biocompatibility results have shown that all membranes are non-cytotoxic and the presence of β-TCP increased cell adhesion and proliferation. Furthermore, cell viability results demonstrated that the presence of 5 wt% β-TCP is advantageous for osteoblast proliferation. Therefore, the results suggest that PLGA with 5 wt% β-TCP fibrous membranes meet the requirement of morphological, physical, mechanical and bioactive properties for an effective GBR membrane. | ||
| 520 | |a Guided bone regeneration (GBR) have been proved great success for the treatment of bone defects in oral implantology. Bone defects are reconstructed by the use of a barrier membrane which prevents the invasion of soft tissue and create a space for guiding new bone growth into the bone defect. To develop GBR membranes with higher bioactivity, poly (lactic-co-glycolic acid) (PLGA) fibrous membranes containing β-tricalcium phosphate (β-TCP) were fabricated via electrospinning. The presence of 5 wt% and 10 wt% of β-TCP in the fibers improved mechanical properties. In vitro biocompatibility results have shown that all membranes are non-cytotoxic and the presence of β-TCP increased cell adhesion and proliferation. Furthermore, cell viability results demonstrated that the presence of 5 wt% β-TCP is advantageous for osteoblast proliferation. Therefore, the results suggest that PLGA with 5 wt% β-TCP fibrous membranes meet the requirement of morphological, physical, mechanical and bioactive properties for an effective GBR membrane. | ||
| 650 | 7 | |a Electrospinning |2 Elsevier | |
| 650 | 7 | |a Membrane |2 Elsevier | |
| 650 | 7 | |a Guided bone regeneration |2 Elsevier | |
| 650 | 7 | |a Poly (lactic-co-glycolic acid) and β-tricalcium phosphate |2 Elsevier | |
| 700 | 1 | |a Fredel, Márcio Celso |4 oth | |
| 700 | 1 | |a Aragones, Águedo |4 oth | |
| 700 | 1 | |a de Oliveira Barra, Guilherme Mariz |4 oth | |
| 700 | 1 | |a Cesca, Karina |4 oth | |
| 700 | 1 | |a Merlini, Claudia |4 oth | |
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10.1016/j.polymertesting.2020.106489 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001223.pica (DE-627)ELV050145010 (ELSEVIER)S0142-9418(19)32386-4 DE-627 ger DE-627 rakwb eng 610 VZ 530 VZ 52.56 bkl Castro, Vanessa Oliveira verfasserin aut Electrospun fibrous membranes of poly (lactic-co-glycolic acid) with β-tricalcium phosphate for guided bone regeneration application 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Guided bone regeneration (GBR) have been proved great success for the treatment of bone defects in oral implantology. Bone defects are reconstructed by the use of a barrier membrane which prevents the invasion of soft tissue and create a space for guiding new bone growth into the bone defect. To develop GBR membranes with higher bioactivity, poly (lactic-co-glycolic acid) (PLGA) fibrous membranes containing β-tricalcium phosphate (β-TCP) were fabricated via electrospinning. The presence of 5 wt% and 10 wt% of β-TCP in the fibers improved mechanical properties. In vitro biocompatibility results have shown that all membranes are non-cytotoxic and the presence of β-TCP increased cell adhesion and proliferation. Furthermore, cell viability results demonstrated that the presence of 5 wt% β-TCP is advantageous for osteoblast proliferation. Therefore, the results suggest that PLGA with 5 wt% β-TCP fibrous membranes meet the requirement of morphological, physical, mechanical and bioactive properties for an effective GBR membrane. Guided bone regeneration (GBR) have been proved great success for the treatment of bone defects in oral implantology. Bone defects are reconstructed by the use of a barrier membrane which prevents the invasion of soft tissue and create a space for guiding new bone growth into the bone defect. To develop GBR membranes with higher bioactivity, poly (lactic-co-glycolic acid) (PLGA) fibrous membranes containing β-tricalcium phosphate (β-TCP) were fabricated via electrospinning. The presence of 5 wt% and 10 wt% of β-TCP in the fibers improved mechanical properties. In vitro biocompatibility results have shown that all membranes are non-cytotoxic and the presence of β-TCP increased cell adhesion and proliferation. Furthermore, cell viability results demonstrated that the presence of 5 wt% β-TCP is advantageous for osteoblast proliferation. Therefore, the results suggest that PLGA with 5 wt% β-TCP fibrous membranes meet the requirement of morphological, physical, mechanical and bioactive properties for an effective GBR membrane. Electrospinning Elsevier Membrane Elsevier Guided bone regeneration Elsevier Poly (lactic-co-glycolic acid) and β-tricalcium phosphate Elsevier Fredel, Márcio Celso oth Aragones, Águedo oth de Oliveira Barra, Guilherme Mariz oth Cesca, Karina oth Merlini, Claudia oth Enthalten in Elsevier Science Marx, Katherine A. ELSEVIER USE OF NOVEL OBSERVATIONAL METHODOLOGY FOR MEASURING AFFECT AND BEHAVIORS IN A BEHAVIORAL INTERVENTION FOR PERSONS WITH DEMENTIA HOSPITALIZED FOR BEHAVIORAL SYMPTOMS 2016 Amsterdam [u.a.] (DE-627)ELV013776983 volume:86 year:2020 pages:0 https://doi.org/10.1016/j.polymertesting.2020.106489 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_40 52.56 Regenerative Energieformen alternative Energieformen VZ AR 86 2020 0 |
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10.1016/j.polymertesting.2020.106489 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001223.pica (DE-627)ELV050145010 (ELSEVIER)S0142-9418(19)32386-4 DE-627 ger DE-627 rakwb eng 610 VZ 530 VZ 52.56 bkl Castro, Vanessa Oliveira verfasserin aut Electrospun fibrous membranes of poly (lactic-co-glycolic acid) with β-tricalcium phosphate for guided bone regeneration application 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Guided bone regeneration (GBR) have been proved great success for the treatment of bone defects in oral implantology. Bone defects are reconstructed by the use of a barrier membrane which prevents the invasion of soft tissue and create a space for guiding new bone growth into the bone defect. To develop GBR membranes with higher bioactivity, poly (lactic-co-glycolic acid) (PLGA) fibrous membranes containing β-tricalcium phosphate (β-TCP) were fabricated via electrospinning. The presence of 5 wt% and 10 wt% of β-TCP in the fibers improved mechanical properties. In vitro biocompatibility results have shown that all membranes are non-cytotoxic and the presence of β-TCP increased cell adhesion and proliferation. Furthermore, cell viability results demonstrated that the presence of 5 wt% β-TCP is advantageous for osteoblast proliferation. Therefore, the results suggest that PLGA with 5 wt% β-TCP fibrous membranes meet the requirement of morphological, physical, mechanical and bioactive properties for an effective GBR membrane. Guided bone regeneration (GBR) have been proved great success for the treatment of bone defects in oral implantology. Bone defects are reconstructed by the use of a barrier membrane which prevents the invasion of soft tissue and create a space for guiding new bone growth into the bone defect. To develop GBR membranes with higher bioactivity, poly (lactic-co-glycolic acid) (PLGA) fibrous membranes containing β-tricalcium phosphate (β-TCP) were fabricated via electrospinning. The presence of 5 wt% and 10 wt% of β-TCP in the fibers improved mechanical properties. In vitro biocompatibility results have shown that all membranes are non-cytotoxic and the presence of β-TCP increased cell adhesion and proliferation. Furthermore, cell viability results demonstrated that the presence of 5 wt% β-TCP is advantageous for osteoblast proliferation. Therefore, the results suggest that PLGA with 5 wt% β-TCP fibrous membranes meet the requirement of morphological, physical, mechanical and bioactive properties for an effective GBR membrane. Electrospinning Elsevier Membrane Elsevier Guided bone regeneration Elsevier Poly (lactic-co-glycolic acid) and β-tricalcium phosphate Elsevier Fredel, Márcio Celso oth Aragones, Águedo oth de Oliveira Barra, Guilherme Mariz oth Cesca, Karina oth Merlini, Claudia oth Enthalten in Elsevier Science Marx, Katherine A. ELSEVIER USE OF NOVEL OBSERVATIONAL METHODOLOGY FOR MEASURING AFFECT AND BEHAVIORS IN A BEHAVIORAL INTERVENTION FOR PERSONS WITH DEMENTIA HOSPITALIZED FOR BEHAVIORAL SYMPTOMS 2016 Amsterdam [u.a.] (DE-627)ELV013776983 volume:86 year:2020 pages:0 https://doi.org/10.1016/j.polymertesting.2020.106489 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_40 52.56 Regenerative Energieformen alternative Energieformen VZ AR 86 2020 0 |
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10.1016/j.polymertesting.2020.106489 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001223.pica (DE-627)ELV050145010 (ELSEVIER)S0142-9418(19)32386-4 DE-627 ger DE-627 rakwb eng 610 VZ 530 VZ 52.56 bkl Castro, Vanessa Oliveira verfasserin aut Electrospun fibrous membranes of poly (lactic-co-glycolic acid) with β-tricalcium phosphate for guided bone regeneration application 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Guided bone regeneration (GBR) have been proved great success for the treatment of bone defects in oral implantology. Bone defects are reconstructed by the use of a barrier membrane which prevents the invasion of soft tissue and create a space for guiding new bone growth into the bone defect. To develop GBR membranes with higher bioactivity, poly (lactic-co-glycolic acid) (PLGA) fibrous membranes containing β-tricalcium phosphate (β-TCP) were fabricated via electrospinning. The presence of 5 wt% and 10 wt% of β-TCP in the fibers improved mechanical properties. In vitro biocompatibility results have shown that all membranes are non-cytotoxic and the presence of β-TCP increased cell adhesion and proliferation. Furthermore, cell viability results demonstrated that the presence of 5 wt% β-TCP is advantageous for osteoblast proliferation. Therefore, the results suggest that PLGA with 5 wt% β-TCP fibrous membranes meet the requirement of morphological, physical, mechanical and bioactive properties for an effective GBR membrane. Guided bone regeneration (GBR) have been proved great success for the treatment of bone defects in oral implantology. Bone defects are reconstructed by the use of a barrier membrane which prevents the invasion of soft tissue and create a space for guiding new bone growth into the bone defect. To develop GBR membranes with higher bioactivity, poly (lactic-co-glycolic acid) (PLGA) fibrous membranes containing β-tricalcium phosphate (β-TCP) were fabricated via electrospinning. The presence of 5 wt% and 10 wt% of β-TCP in the fibers improved mechanical properties. In vitro biocompatibility results have shown that all membranes are non-cytotoxic and the presence of β-TCP increased cell adhesion and proliferation. Furthermore, cell viability results demonstrated that the presence of 5 wt% β-TCP is advantageous for osteoblast proliferation. Therefore, the results suggest that PLGA with 5 wt% β-TCP fibrous membranes meet the requirement of morphological, physical, mechanical and bioactive properties for an effective GBR membrane. Electrospinning Elsevier Membrane Elsevier Guided bone regeneration Elsevier Poly (lactic-co-glycolic acid) and β-tricalcium phosphate Elsevier Fredel, Márcio Celso oth Aragones, Águedo oth de Oliveira Barra, Guilherme Mariz oth Cesca, Karina oth Merlini, Claudia oth Enthalten in Elsevier Science Marx, Katherine A. ELSEVIER USE OF NOVEL OBSERVATIONAL METHODOLOGY FOR MEASURING AFFECT AND BEHAVIORS IN A BEHAVIORAL INTERVENTION FOR PERSONS WITH DEMENTIA HOSPITALIZED FOR BEHAVIORAL SYMPTOMS 2016 Amsterdam [u.a.] (DE-627)ELV013776983 volume:86 year:2020 pages:0 https://doi.org/10.1016/j.polymertesting.2020.106489 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_40 52.56 Regenerative Energieformen alternative Energieformen VZ AR 86 2020 0 |
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10.1016/j.polymertesting.2020.106489 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001223.pica (DE-627)ELV050145010 (ELSEVIER)S0142-9418(19)32386-4 DE-627 ger DE-627 rakwb eng 610 VZ 530 VZ 52.56 bkl Castro, Vanessa Oliveira verfasserin aut Electrospun fibrous membranes of poly (lactic-co-glycolic acid) with β-tricalcium phosphate for guided bone regeneration application 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Guided bone regeneration (GBR) have been proved great success for the treatment of bone defects in oral implantology. Bone defects are reconstructed by the use of a barrier membrane which prevents the invasion of soft tissue and create a space for guiding new bone growth into the bone defect. To develop GBR membranes with higher bioactivity, poly (lactic-co-glycolic acid) (PLGA) fibrous membranes containing β-tricalcium phosphate (β-TCP) were fabricated via electrospinning. The presence of 5 wt% and 10 wt% of β-TCP in the fibers improved mechanical properties. In vitro biocompatibility results have shown that all membranes are non-cytotoxic and the presence of β-TCP increased cell adhesion and proliferation. Furthermore, cell viability results demonstrated that the presence of 5 wt% β-TCP is advantageous for osteoblast proliferation. Therefore, the results suggest that PLGA with 5 wt% β-TCP fibrous membranes meet the requirement of morphological, physical, mechanical and bioactive properties for an effective GBR membrane. Guided bone regeneration (GBR) have been proved great success for the treatment of bone defects in oral implantology. Bone defects are reconstructed by the use of a barrier membrane which prevents the invasion of soft tissue and create a space for guiding new bone growth into the bone defect. To develop GBR membranes with higher bioactivity, poly (lactic-co-glycolic acid) (PLGA) fibrous membranes containing β-tricalcium phosphate (β-TCP) were fabricated via electrospinning. The presence of 5 wt% and 10 wt% of β-TCP in the fibers improved mechanical properties. In vitro biocompatibility results have shown that all membranes are non-cytotoxic and the presence of β-TCP increased cell adhesion and proliferation. Furthermore, cell viability results demonstrated that the presence of 5 wt% β-TCP is advantageous for osteoblast proliferation. Therefore, the results suggest that PLGA with 5 wt% β-TCP fibrous membranes meet the requirement of morphological, physical, mechanical and bioactive properties for an effective GBR membrane. Electrospinning Elsevier Membrane Elsevier Guided bone regeneration Elsevier Poly (lactic-co-glycolic acid) and β-tricalcium phosphate Elsevier Fredel, Márcio Celso oth Aragones, Águedo oth de Oliveira Barra, Guilherme Mariz oth Cesca, Karina oth Merlini, Claudia oth Enthalten in Elsevier Science Marx, Katherine A. ELSEVIER USE OF NOVEL OBSERVATIONAL METHODOLOGY FOR MEASURING AFFECT AND BEHAVIORS IN A BEHAVIORAL INTERVENTION FOR PERSONS WITH DEMENTIA HOSPITALIZED FOR BEHAVIORAL SYMPTOMS 2016 Amsterdam [u.a.] (DE-627)ELV013776983 volume:86 year:2020 pages:0 https://doi.org/10.1016/j.polymertesting.2020.106489 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_40 52.56 Regenerative Energieformen alternative Energieformen VZ AR 86 2020 0 |
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10.1016/j.polymertesting.2020.106489 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001223.pica (DE-627)ELV050145010 (ELSEVIER)S0142-9418(19)32386-4 DE-627 ger DE-627 rakwb eng 610 VZ 530 VZ 52.56 bkl Castro, Vanessa Oliveira verfasserin aut Electrospun fibrous membranes of poly (lactic-co-glycolic acid) with β-tricalcium phosphate for guided bone regeneration application 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Guided bone regeneration (GBR) have been proved great success for the treatment of bone defects in oral implantology. Bone defects are reconstructed by the use of a barrier membrane which prevents the invasion of soft tissue and create a space for guiding new bone growth into the bone defect. To develop GBR membranes with higher bioactivity, poly (lactic-co-glycolic acid) (PLGA) fibrous membranes containing β-tricalcium phosphate (β-TCP) were fabricated via electrospinning. The presence of 5 wt% and 10 wt% of β-TCP in the fibers improved mechanical properties. In vitro biocompatibility results have shown that all membranes are non-cytotoxic and the presence of β-TCP increased cell adhesion and proliferation. Furthermore, cell viability results demonstrated that the presence of 5 wt% β-TCP is advantageous for osteoblast proliferation. Therefore, the results suggest that PLGA with 5 wt% β-TCP fibrous membranes meet the requirement of morphological, physical, mechanical and bioactive properties for an effective GBR membrane. Guided bone regeneration (GBR) have been proved great success for the treatment of bone defects in oral implantology. Bone defects are reconstructed by the use of a barrier membrane which prevents the invasion of soft tissue and create a space for guiding new bone growth into the bone defect. To develop GBR membranes with higher bioactivity, poly (lactic-co-glycolic acid) (PLGA) fibrous membranes containing β-tricalcium phosphate (β-TCP) were fabricated via electrospinning. The presence of 5 wt% and 10 wt% of β-TCP in the fibers improved mechanical properties. In vitro biocompatibility results have shown that all membranes are non-cytotoxic and the presence of β-TCP increased cell adhesion and proliferation. Furthermore, cell viability results demonstrated that the presence of 5 wt% β-TCP is advantageous for osteoblast proliferation. Therefore, the results suggest that PLGA with 5 wt% β-TCP fibrous membranes meet the requirement of morphological, physical, mechanical and bioactive properties for an effective GBR membrane. Electrospinning Elsevier Membrane Elsevier Guided bone regeneration Elsevier Poly (lactic-co-glycolic acid) and β-tricalcium phosphate Elsevier Fredel, Márcio Celso oth Aragones, Águedo oth de Oliveira Barra, Guilherme Mariz oth Cesca, Karina oth Merlini, Claudia oth Enthalten in Elsevier Science Marx, Katherine A. ELSEVIER USE OF NOVEL OBSERVATIONAL METHODOLOGY FOR MEASURING AFFECT AND BEHAVIORS IN A BEHAVIORAL INTERVENTION FOR PERSONS WITH DEMENTIA HOSPITALIZED FOR BEHAVIORAL SYMPTOMS 2016 Amsterdam [u.a.] (DE-627)ELV013776983 volume:86 year:2020 pages:0 https://doi.org/10.1016/j.polymertesting.2020.106489 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_40 52.56 Regenerative Energieformen alternative Energieformen VZ AR 86 2020 0 |
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Enthalten in USE OF NOVEL OBSERVATIONAL METHODOLOGY FOR MEASURING AFFECT AND BEHAVIORS IN A BEHAVIORAL INTERVENTION FOR PERSONS WITH DEMENTIA HOSPITALIZED FOR BEHAVIORAL SYMPTOMS Amsterdam [u.a.] volume:86 year:2020 pages:0 |
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Enthalten in USE OF NOVEL OBSERVATIONAL METHODOLOGY FOR MEASURING AFFECT AND BEHAVIORS IN A BEHAVIORAL INTERVENTION FOR PERSONS WITH DEMENTIA HOSPITALIZED FOR BEHAVIORAL SYMPTOMS Amsterdam [u.a.] volume:86 year:2020 pages:0 |
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Electrospinning Membrane Guided bone regeneration Poly (lactic-co-glycolic acid) and β-tricalcium phosphate |
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USE OF NOVEL OBSERVATIONAL METHODOLOGY FOR MEASURING AFFECT AND BEHAVIORS IN A BEHAVIORAL INTERVENTION FOR PERSONS WITH DEMENTIA HOSPITALIZED FOR BEHAVIORAL SYMPTOMS |
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Castro, Vanessa Oliveira @@aut@@ Fredel, Márcio Celso @@oth@@ Aragones, Águedo @@oth@@ de Oliveira Barra, Guilherme Mariz @@oth@@ Cesca, Karina @@oth@@ Merlini, Claudia @@oth@@ |
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electrospun fibrous membranes of poly (lactic-co-glycolic acid) with β-tricalcium phosphate for guided bone regeneration application |
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Electrospun fibrous membranes of poly (lactic-co-glycolic acid) with β-tricalcium phosphate for guided bone regeneration application |
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Guided bone regeneration (GBR) have been proved great success for the treatment of bone defects in oral implantology. Bone defects are reconstructed by the use of a barrier membrane which prevents the invasion of soft tissue and create a space for guiding new bone growth into the bone defect. To develop GBR membranes with higher bioactivity, poly (lactic-co-glycolic acid) (PLGA) fibrous membranes containing β-tricalcium phosphate (β-TCP) were fabricated via electrospinning. The presence of 5 wt% and 10 wt% of β-TCP in the fibers improved mechanical properties. In vitro biocompatibility results have shown that all membranes are non-cytotoxic and the presence of β-TCP increased cell adhesion and proliferation. Furthermore, cell viability results demonstrated that the presence of 5 wt% β-TCP is advantageous for osteoblast proliferation. Therefore, the results suggest that PLGA with 5 wt% β-TCP fibrous membranes meet the requirement of morphological, physical, mechanical and bioactive properties for an effective GBR membrane. |
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Guided bone regeneration (GBR) have been proved great success for the treatment of bone defects in oral implantology. Bone defects are reconstructed by the use of a barrier membrane which prevents the invasion of soft tissue and create a space for guiding new bone growth into the bone defect. To develop GBR membranes with higher bioactivity, poly (lactic-co-glycolic acid) (PLGA) fibrous membranes containing β-tricalcium phosphate (β-TCP) were fabricated via electrospinning. The presence of 5 wt% and 10 wt% of β-TCP in the fibers improved mechanical properties. In vitro biocompatibility results have shown that all membranes are non-cytotoxic and the presence of β-TCP increased cell adhesion and proliferation. Furthermore, cell viability results demonstrated that the presence of 5 wt% β-TCP is advantageous for osteoblast proliferation. Therefore, the results suggest that PLGA with 5 wt% β-TCP fibrous membranes meet the requirement of morphological, physical, mechanical and bioactive properties for an effective GBR membrane. |
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Guided bone regeneration (GBR) have been proved great success for the treatment of bone defects in oral implantology. Bone defects are reconstructed by the use of a barrier membrane which prevents the invasion of soft tissue and create a space for guiding new bone growth into the bone defect. To develop GBR membranes with higher bioactivity, poly (lactic-co-glycolic acid) (PLGA) fibrous membranes containing β-tricalcium phosphate (β-TCP) were fabricated via electrospinning. The presence of 5 wt% and 10 wt% of β-TCP in the fibers improved mechanical properties. In vitro biocompatibility results have shown that all membranes are non-cytotoxic and the presence of β-TCP increased cell adhesion and proliferation. Furthermore, cell viability results demonstrated that the presence of 5 wt% β-TCP is advantageous for osteoblast proliferation. Therefore, the results suggest that PLGA with 5 wt% β-TCP fibrous membranes meet the requirement of morphological, physical, mechanical and bioactive properties for an effective GBR membrane. |
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