Iron overload regulate the cytokine of mesenchymal stromal cells through ROS/HIF-1α pathway in Myelodysplastic syndromes
• MDS-MSC possess high level of apoptosis and disorganized morphology, especially in iron overload group. • MDS-MSCs uptake and accumulate excessive iron due to prolonged iron exposure, resulted in up-regulating ROS level. • High level of ROS increases the expression of HIF-1a through inhibiting PHD...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Hu, Jiaxin [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: N - Li, Danyang ELSEVIER, 2019, clinical and laboratory studies, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:93 ; year:2020 ; pages:0 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.leukres.2020.106354 |
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ELV050232444 |
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| 520 | |a • MDS-MSC possess high level of apoptosis and disorganized morphology, especially in iron overload group. • MDS-MSCs uptake and accumulate excessive iron due to prolonged iron exposure, resulted in up-regulating ROS level. • High level of ROS increases the expression of HIF-1a through inhibiting PHD2. • Increased HIF-1a promote the expression of IL-6, IL-8, VEGF and TGF-β in MSC. • Iron chelation and antioxidant treatment can reverse above process in iron overload MDS-MSC. | ||
| 650 | 7 | |a Iron overload |2 Elsevier | |
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| 700 | 1 | |a Hu, Xian |4 oth | |
| 700 | 1 | |a Huang, Lei |4 oth | |
| 700 | 1 | |a Liu, Hui |4 oth | |
| 700 | 1 | |a Liu, Zhaoyun |4 oth | |
| 700 | 1 | |a Li, Lijuanli |4 oth | |
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10.1016/j.leukres.2020.106354 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001003.pica (DE-627)ELV050232444 (ELSEVIER)S0145-2126(20)30059-X DE-627 ger DE-627 rakwb eng 333.7 610 VZ 43.12 bkl 43.13 bkl 44.13 bkl Hu, Jiaxin verfasserin aut Iron overload regulate the cytokine of mesenchymal stromal cells through ROS/HIF-1α pathway in Myelodysplastic syndromes 2020 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • MDS-MSC possess high level of apoptosis and disorganized morphology, especially in iron overload group. • MDS-MSCs uptake and accumulate excessive iron due to prolonged iron exposure, resulted in up-regulating ROS level. • High level of ROS increases the expression of HIF-1a through inhibiting PHD2. • Increased HIF-1a promote the expression of IL-6, IL-8, VEGF and TGF-β in MSC. • Iron chelation and antioxidant treatment can reverse above process in iron overload MDS-MSC. Iron overload Elsevier Hypoxia inducible factor-1 Elsevier Mesenchymal stromal cells Elsevier Myelodysplastic syndromes Elsevier Meng, Fanqiao oth Hu, Xian oth Huang, Lei oth Liu, Hui oth Liu, Zhaoyun oth Li, Lijuanli oth Enthalten in Elsevier Science Li, Danyang ELSEVIER N 2019 clinical and laboratory studies Amsterdam [u.a.] (DE-627)ELV002185202 volume:93 year:2020 pages:0 https://doi.org/10.1016/j.leukres.2020.106354 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-GGO 43.12 Umweltchemie VZ 43.13 Umwelttoxikologie VZ 44.13 Medizinische Ökologie VZ AR 93 2020 0 |
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10.1016/j.leukres.2020.106354 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001003.pica (DE-627)ELV050232444 (ELSEVIER)S0145-2126(20)30059-X DE-627 ger DE-627 rakwb eng 333.7 610 VZ 43.12 bkl 43.13 bkl 44.13 bkl Hu, Jiaxin verfasserin aut Iron overload regulate the cytokine of mesenchymal stromal cells through ROS/HIF-1α pathway in Myelodysplastic syndromes 2020 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • MDS-MSC possess high level of apoptosis and disorganized morphology, especially in iron overload group. • MDS-MSCs uptake and accumulate excessive iron due to prolonged iron exposure, resulted in up-regulating ROS level. • High level of ROS increases the expression of HIF-1a through inhibiting PHD2. • Increased HIF-1a promote the expression of IL-6, IL-8, VEGF and TGF-β in MSC. • Iron chelation and antioxidant treatment can reverse above process in iron overload MDS-MSC. Iron overload Elsevier Hypoxia inducible factor-1 Elsevier Mesenchymal stromal cells Elsevier Myelodysplastic syndromes Elsevier Meng, Fanqiao oth Hu, Xian oth Huang, Lei oth Liu, Hui oth Liu, Zhaoyun oth Li, Lijuanli oth Enthalten in Elsevier Science Li, Danyang ELSEVIER N 2019 clinical and laboratory studies Amsterdam [u.a.] (DE-627)ELV002185202 volume:93 year:2020 pages:0 https://doi.org/10.1016/j.leukres.2020.106354 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-GGO 43.12 Umweltchemie VZ 43.13 Umwelttoxikologie VZ 44.13 Medizinische Ökologie VZ AR 93 2020 0 |
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10.1016/j.leukres.2020.106354 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001003.pica (DE-627)ELV050232444 (ELSEVIER)S0145-2126(20)30059-X DE-627 ger DE-627 rakwb eng 333.7 610 VZ 43.12 bkl 43.13 bkl 44.13 bkl Hu, Jiaxin verfasserin aut Iron overload regulate the cytokine of mesenchymal stromal cells through ROS/HIF-1α pathway in Myelodysplastic syndromes 2020 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • MDS-MSC possess high level of apoptosis and disorganized morphology, especially in iron overload group. • MDS-MSCs uptake and accumulate excessive iron due to prolonged iron exposure, resulted in up-regulating ROS level. • High level of ROS increases the expression of HIF-1a through inhibiting PHD2. • Increased HIF-1a promote the expression of IL-6, IL-8, VEGF and TGF-β in MSC. • Iron chelation and antioxidant treatment can reverse above process in iron overload MDS-MSC. Iron overload Elsevier Hypoxia inducible factor-1 Elsevier Mesenchymal stromal cells Elsevier Myelodysplastic syndromes Elsevier Meng, Fanqiao oth Hu, Xian oth Huang, Lei oth Liu, Hui oth Liu, Zhaoyun oth Li, Lijuanli oth Enthalten in Elsevier Science Li, Danyang ELSEVIER N 2019 clinical and laboratory studies Amsterdam [u.a.] (DE-627)ELV002185202 volume:93 year:2020 pages:0 https://doi.org/10.1016/j.leukres.2020.106354 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-GGO 43.12 Umweltchemie VZ 43.13 Umwelttoxikologie VZ 44.13 Medizinische Ökologie VZ AR 93 2020 0 |
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10.1016/j.leukres.2020.106354 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001003.pica (DE-627)ELV050232444 (ELSEVIER)S0145-2126(20)30059-X DE-627 ger DE-627 rakwb eng 333.7 610 VZ 43.12 bkl 43.13 bkl 44.13 bkl Hu, Jiaxin verfasserin aut Iron overload regulate the cytokine of mesenchymal stromal cells through ROS/HIF-1α pathway in Myelodysplastic syndromes 2020 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • MDS-MSC possess high level of apoptosis and disorganized morphology, especially in iron overload group. • MDS-MSCs uptake and accumulate excessive iron due to prolonged iron exposure, resulted in up-regulating ROS level. • High level of ROS increases the expression of HIF-1a through inhibiting PHD2. • Increased HIF-1a promote the expression of IL-6, IL-8, VEGF and TGF-β in MSC. • Iron chelation and antioxidant treatment can reverse above process in iron overload MDS-MSC. Iron overload Elsevier Hypoxia inducible factor-1 Elsevier Mesenchymal stromal cells Elsevier Myelodysplastic syndromes Elsevier Meng, Fanqiao oth Hu, Xian oth Huang, Lei oth Liu, Hui oth Liu, Zhaoyun oth Li, Lijuanli oth Enthalten in Elsevier Science Li, Danyang ELSEVIER N 2019 clinical and laboratory studies Amsterdam [u.a.] (DE-627)ELV002185202 volume:93 year:2020 pages:0 https://doi.org/10.1016/j.leukres.2020.106354 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-GGO 43.12 Umweltchemie VZ 43.13 Umwelttoxikologie VZ 44.13 Medizinische Ökologie VZ AR 93 2020 0 |
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Iron overload regulate the cytokine of mesenchymal stromal cells through ROS/HIF-1α pathway in Myelodysplastic syndromes |
| abstract |
• MDS-MSC possess high level of apoptosis and disorganized morphology, especially in iron overload group. • MDS-MSCs uptake and accumulate excessive iron due to prolonged iron exposure, resulted in up-regulating ROS level. • High level of ROS increases the expression of HIF-1a through inhibiting PHD2. • Increased HIF-1a promote the expression of IL-6, IL-8, VEGF and TGF-β in MSC. • Iron chelation and antioxidant treatment can reverse above process in iron overload MDS-MSC. |
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• MDS-MSC possess high level of apoptosis and disorganized morphology, especially in iron overload group. • MDS-MSCs uptake and accumulate excessive iron due to prolonged iron exposure, resulted in up-regulating ROS level. • High level of ROS increases the expression of HIF-1a through inhibiting PHD2. • Increased HIF-1a promote the expression of IL-6, IL-8, VEGF and TGF-β in MSC. • Iron chelation and antioxidant treatment can reverse above process in iron overload MDS-MSC. |
| abstract_unstemmed |
• MDS-MSC possess high level of apoptosis and disorganized morphology, especially in iron overload group. • MDS-MSCs uptake and accumulate excessive iron due to prolonged iron exposure, resulted in up-regulating ROS level. • High level of ROS increases the expression of HIF-1a through inhibiting PHD2. • Increased HIF-1a promote the expression of IL-6, IL-8, VEGF and TGF-β in MSC. • Iron chelation and antioxidant treatment can reverse above process in iron overload MDS-MSC. |
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| title_short |
Iron overload regulate the cytokine of mesenchymal stromal cells through ROS/HIF-1α pathway in Myelodysplastic syndromes |
| url |
https://doi.org/10.1016/j.leukres.2020.106354 |
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Meng, Fanqiao Hu, Xian Huang, Lei Liu, Hui Liu, Zhaoyun Li, Lijuanli |
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10.1016/j.leukres.2020.106354 |
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2024-07-06T16:58:33.407Z |
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