MMPs and ADAMs/ADAMTS inhibition therapy of abdominal aortic aneurysm
Abdominal aortic aneurysm (AAA) is a chronic vascular degenerative disease featured by progressive dilation and remodeling of the vascular wall, which may lead to aortic rupture and high mortality. The occurrence and development of AAA involve multiple mechanisms, including extracellular matrix degr...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Li, Yongqi [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020transfer abstract |
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| Übergeordnetes Werk: |
Enthalten in: Transition of convective heat transfer to subcooled flow boiling due to crystallization fouling - Abd-Elhady, M.S. ELSEVIER, 2016, including pharmacology letters, New York, NY [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:253 ; year:2020 ; day:15 ; month:07 ; pages:0 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.lfs.2020.117659 |
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ELV050453793 |
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| 520 | |a Abdominal aortic aneurysm (AAA) is a chronic vascular degenerative disease featured by progressive dilation and remodeling of the vascular wall, which may lead to aortic rupture and high mortality. The occurrence and development of AAA involve multiple mechanisms, including extracellular matrix degradation, chronic inflammation, oxidative stress, apoptosis of vascular smooth muscle cells and innate immunity. Extracellular matrix degradation is considered as the most important mechanism causing AAA. Matrix metalloproteinases (MMPs) are key factors in this process, contributing greatly to the occurrence and development of AAA. But whether the zinc-dependent endopeptidases (ADAM/ADAMTS) are involved in this process is very little known. This study is a review about the role of MMPs and ADAM/ADAMT as well as the existing MMP inhibitors in abdominal aortic aneurysm, with the purpose of providing reference for the clinical treatment of abdominal aortic aneurysm. | ||
| 520 | |a Abdominal aortic aneurysm (AAA) is a chronic vascular degenerative disease featured by progressive dilation and remodeling of the vascular wall, which may lead to aortic rupture and high mortality. The occurrence and development of AAA involve multiple mechanisms, including extracellular matrix degradation, chronic inflammation, oxidative stress, apoptosis of vascular smooth muscle cells and innate immunity. Extracellular matrix degradation is considered as the most important mechanism causing AAA. Matrix metalloproteinases (MMPs) are key factors in this process, contributing greatly to the occurrence and development of AAA. But whether the zinc-dependent endopeptidases (ADAM/ADAMTS) are involved in this process is very little known. This study is a review about the role of MMPs and ADAM/ADAMT as well as the existing MMP inhibitors in abdominal aortic aneurysm, with the purpose of providing reference for the clinical treatment of abdominal aortic aneurysm. | ||
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10.1016/j.lfs.2020.117659 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001023.pica (DE-627)ELV050453793 (ELSEVIER)S0024-3205(20)30407-0 DE-627 ger DE-627 rakwb eng 690 VZ 530 620 VZ 52.56 bkl Li, Yongqi verfasserin aut MMPs and ADAMs/ADAMTS inhibition therapy of abdominal aortic aneurysm 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abdominal aortic aneurysm (AAA) is a chronic vascular degenerative disease featured by progressive dilation and remodeling of the vascular wall, which may lead to aortic rupture and high mortality. The occurrence and development of AAA involve multiple mechanisms, including extracellular matrix degradation, chronic inflammation, oxidative stress, apoptosis of vascular smooth muscle cells and innate immunity. Extracellular matrix degradation is considered as the most important mechanism causing AAA. Matrix metalloproteinases (MMPs) are key factors in this process, contributing greatly to the occurrence and development of AAA. But whether the zinc-dependent endopeptidases (ADAM/ADAMTS) are involved in this process is very little known. This study is a review about the role of MMPs and ADAM/ADAMT as well as the existing MMP inhibitors in abdominal aortic aneurysm, with the purpose of providing reference for the clinical treatment of abdominal aortic aneurysm. Abdominal aortic aneurysm (AAA) is a chronic vascular degenerative disease featured by progressive dilation and remodeling of the vascular wall, which may lead to aortic rupture and high mortality. The occurrence and development of AAA involve multiple mechanisms, including extracellular matrix degradation, chronic inflammation, oxidative stress, apoptosis of vascular smooth muscle cells and innate immunity. Extracellular matrix degradation is considered as the most important mechanism causing AAA. Matrix metalloproteinases (MMPs) are key factors in this process, contributing greatly to the occurrence and development of AAA. But whether the zinc-dependent endopeptidases (ADAM/ADAMTS) are involved in this process is very little known. This study is a review about the role of MMPs and ADAM/ADAMT as well as the existing MMP inhibitors in abdominal aortic aneurysm, with the purpose of providing reference for the clinical treatment of abdominal aortic aneurysm. Wang, Weicheng oth Li, Lei oth Khalil, Raouf A. oth Enthalten in Elsevier Science Abd-Elhady, M.S. ELSEVIER Transition of convective heat transfer to subcooled flow boiling due to crystallization fouling 2016 including pharmacology letters New York, NY [u.a.] (DE-627)ELV014481960 volume:253 year:2020 day:15 month:07 pages:0 https://doi.org/10.1016/j.lfs.2020.117659 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_40 52.56 Regenerative Energieformen alternative Energieformen VZ AR 253 2020 15 0715 0 |
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10.1016/j.lfs.2020.117659 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001023.pica (DE-627)ELV050453793 (ELSEVIER)S0024-3205(20)30407-0 DE-627 ger DE-627 rakwb eng 690 VZ 530 620 VZ 52.56 bkl Li, Yongqi verfasserin aut MMPs and ADAMs/ADAMTS inhibition therapy of abdominal aortic aneurysm 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abdominal aortic aneurysm (AAA) is a chronic vascular degenerative disease featured by progressive dilation and remodeling of the vascular wall, which may lead to aortic rupture and high mortality. The occurrence and development of AAA involve multiple mechanisms, including extracellular matrix degradation, chronic inflammation, oxidative stress, apoptosis of vascular smooth muscle cells and innate immunity. Extracellular matrix degradation is considered as the most important mechanism causing AAA. Matrix metalloproteinases (MMPs) are key factors in this process, contributing greatly to the occurrence and development of AAA. But whether the zinc-dependent endopeptidases (ADAM/ADAMTS) are involved in this process is very little known. This study is a review about the role of MMPs and ADAM/ADAMT as well as the existing MMP inhibitors in abdominal aortic aneurysm, with the purpose of providing reference for the clinical treatment of abdominal aortic aneurysm. Abdominal aortic aneurysm (AAA) is a chronic vascular degenerative disease featured by progressive dilation and remodeling of the vascular wall, which may lead to aortic rupture and high mortality. The occurrence and development of AAA involve multiple mechanisms, including extracellular matrix degradation, chronic inflammation, oxidative stress, apoptosis of vascular smooth muscle cells and innate immunity. Extracellular matrix degradation is considered as the most important mechanism causing AAA. Matrix metalloproteinases (MMPs) are key factors in this process, contributing greatly to the occurrence and development of AAA. But whether the zinc-dependent endopeptidases (ADAM/ADAMTS) are involved in this process is very little known. This study is a review about the role of MMPs and ADAM/ADAMT as well as the existing MMP inhibitors in abdominal aortic aneurysm, with the purpose of providing reference for the clinical treatment of abdominal aortic aneurysm. Wang, Weicheng oth Li, Lei oth Khalil, Raouf A. oth Enthalten in Elsevier Science Abd-Elhady, M.S. ELSEVIER Transition of convective heat transfer to subcooled flow boiling due to crystallization fouling 2016 including pharmacology letters New York, NY [u.a.] (DE-627)ELV014481960 volume:253 year:2020 day:15 month:07 pages:0 https://doi.org/10.1016/j.lfs.2020.117659 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_40 52.56 Regenerative Energieformen alternative Energieformen VZ AR 253 2020 15 0715 0 |
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10.1016/j.lfs.2020.117659 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001023.pica (DE-627)ELV050453793 (ELSEVIER)S0024-3205(20)30407-0 DE-627 ger DE-627 rakwb eng 690 VZ 530 620 VZ 52.56 bkl Li, Yongqi verfasserin aut MMPs and ADAMs/ADAMTS inhibition therapy of abdominal aortic aneurysm 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abdominal aortic aneurysm (AAA) is a chronic vascular degenerative disease featured by progressive dilation and remodeling of the vascular wall, which may lead to aortic rupture and high mortality. The occurrence and development of AAA involve multiple mechanisms, including extracellular matrix degradation, chronic inflammation, oxidative stress, apoptosis of vascular smooth muscle cells and innate immunity. Extracellular matrix degradation is considered as the most important mechanism causing AAA. Matrix metalloproteinases (MMPs) are key factors in this process, contributing greatly to the occurrence and development of AAA. But whether the zinc-dependent endopeptidases (ADAM/ADAMTS) are involved in this process is very little known. This study is a review about the role of MMPs and ADAM/ADAMT as well as the existing MMP inhibitors in abdominal aortic aneurysm, with the purpose of providing reference for the clinical treatment of abdominal aortic aneurysm. Abdominal aortic aneurysm (AAA) is a chronic vascular degenerative disease featured by progressive dilation and remodeling of the vascular wall, which may lead to aortic rupture and high mortality. The occurrence and development of AAA involve multiple mechanisms, including extracellular matrix degradation, chronic inflammation, oxidative stress, apoptosis of vascular smooth muscle cells and innate immunity. Extracellular matrix degradation is considered as the most important mechanism causing AAA. Matrix metalloproteinases (MMPs) are key factors in this process, contributing greatly to the occurrence and development of AAA. But whether the zinc-dependent endopeptidases (ADAM/ADAMTS) are involved in this process is very little known. This study is a review about the role of MMPs and ADAM/ADAMT as well as the existing MMP inhibitors in abdominal aortic aneurysm, with the purpose of providing reference for the clinical treatment of abdominal aortic aneurysm. Wang, Weicheng oth Li, Lei oth Khalil, Raouf A. oth Enthalten in Elsevier Science Abd-Elhady, M.S. ELSEVIER Transition of convective heat transfer to subcooled flow boiling due to crystallization fouling 2016 including pharmacology letters New York, NY [u.a.] (DE-627)ELV014481960 volume:253 year:2020 day:15 month:07 pages:0 https://doi.org/10.1016/j.lfs.2020.117659 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_40 52.56 Regenerative Energieformen alternative Energieformen VZ AR 253 2020 15 0715 0 |
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10.1016/j.lfs.2020.117659 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001023.pica (DE-627)ELV050453793 (ELSEVIER)S0024-3205(20)30407-0 DE-627 ger DE-627 rakwb eng 690 VZ 530 620 VZ 52.56 bkl Li, Yongqi verfasserin aut MMPs and ADAMs/ADAMTS inhibition therapy of abdominal aortic aneurysm 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abdominal aortic aneurysm (AAA) is a chronic vascular degenerative disease featured by progressive dilation and remodeling of the vascular wall, which may lead to aortic rupture and high mortality. The occurrence and development of AAA involve multiple mechanisms, including extracellular matrix degradation, chronic inflammation, oxidative stress, apoptosis of vascular smooth muscle cells and innate immunity. Extracellular matrix degradation is considered as the most important mechanism causing AAA. Matrix metalloproteinases (MMPs) are key factors in this process, contributing greatly to the occurrence and development of AAA. But whether the zinc-dependent endopeptidases (ADAM/ADAMTS) are involved in this process is very little known. This study is a review about the role of MMPs and ADAM/ADAMT as well as the existing MMP inhibitors in abdominal aortic aneurysm, with the purpose of providing reference for the clinical treatment of abdominal aortic aneurysm. Abdominal aortic aneurysm (AAA) is a chronic vascular degenerative disease featured by progressive dilation and remodeling of the vascular wall, which may lead to aortic rupture and high mortality. The occurrence and development of AAA involve multiple mechanisms, including extracellular matrix degradation, chronic inflammation, oxidative stress, apoptosis of vascular smooth muscle cells and innate immunity. Extracellular matrix degradation is considered as the most important mechanism causing AAA. Matrix metalloproteinases (MMPs) are key factors in this process, contributing greatly to the occurrence and development of AAA. But whether the zinc-dependent endopeptidases (ADAM/ADAMTS) are involved in this process is very little known. This study is a review about the role of MMPs and ADAM/ADAMT as well as the existing MMP inhibitors in abdominal aortic aneurysm, with the purpose of providing reference for the clinical treatment of abdominal aortic aneurysm. Wang, Weicheng oth Li, Lei oth Khalil, Raouf A. oth Enthalten in Elsevier Science Abd-Elhady, M.S. ELSEVIER Transition of convective heat transfer to subcooled flow boiling due to crystallization fouling 2016 including pharmacology letters New York, NY [u.a.] (DE-627)ELV014481960 volume:253 year:2020 day:15 month:07 pages:0 https://doi.org/10.1016/j.lfs.2020.117659 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_40 52.56 Regenerative Energieformen alternative Energieformen VZ AR 253 2020 15 0715 0 |
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MMPs and ADAMs/ADAMTS inhibition therapy of abdominal aortic aneurysm |
| author_sort |
Li, Yongqi |
| journal |
Transition of convective heat transfer to subcooled flow boiling due to crystallization fouling |
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Transition of convective heat transfer to subcooled flow boiling due to crystallization fouling |
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eng |
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600 - Technology 500 - Science |
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2020 |
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Li, Yongqi |
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Elektronische Aufsätze |
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Li, Yongqi |
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10.1016/j.lfs.2020.117659 |
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690 530 620 |
| title_sort |
mmps and adams/adamts inhibition therapy of abdominal aortic aneurysm |
| title_auth |
MMPs and ADAMs/ADAMTS inhibition therapy of abdominal aortic aneurysm |
| abstract |
Abdominal aortic aneurysm (AAA) is a chronic vascular degenerative disease featured by progressive dilation and remodeling of the vascular wall, which may lead to aortic rupture and high mortality. The occurrence and development of AAA involve multiple mechanisms, including extracellular matrix degradation, chronic inflammation, oxidative stress, apoptosis of vascular smooth muscle cells and innate immunity. Extracellular matrix degradation is considered as the most important mechanism causing AAA. Matrix metalloproteinases (MMPs) are key factors in this process, contributing greatly to the occurrence and development of AAA. But whether the zinc-dependent endopeptidases (ADAM/ADAMTS) are involved in this process is very little known. This study is a review about the role of MMPs and ADAM/ADAMT as well as the existing MMP inhibitors in abdominal aortic aneurysm, with the purpose of providing reference for the clinical treatment of abdominal aortic aneurysm. |
| abstractGer |
Abdominal aortic aneurysm (AAA) is a chronic vascular degenerative disease featured by progressive dilation and remodeling of the vascular wall, which may lead to aortic rupture and high mortality. The occurrence and development of AAA involve multiple mechanisms, including extracellular matrix degradation, chronic inflammation, oxidative stress, apoptosis of vascular smooth muscle cells and innate immunity. Extracellular matrix degradation is considered as the most important mechanism causing AAA. Matrix metalloproteinases (MMPs) are key factors in this process, contributing greatly to the occurrence and development of AAA. But whether the zinc-dependent endopeptidases (ADAM/ADAMTS) are involved in this process is very little known. This study is a review about the role of MMPs and ADAM/ADAMT as well as the existing MMP inhibitors in abdominal aortic aneurysm, with the purpose of providing reference for the clinical treatment of abdominal aortic aneurysm. |
| abstract_unstemmed |
Abdominal aortic aneurysm (AAA) is a chronic vascular degenerative disease featured by progressive dilation and remodeling of the vascular wall, which may lead to aortic rupture and high mortality. The occurrence and development of AAA involve multiple mechanisms, including extracellular matrix degradation, chronic inflammation, oxidative stress, apoptosis of vascular smooth muscle cells and innate immunity. Extracellular matrix degradation is considered as the most important mechanism causing AAA. Matrix metalloproteinases (MMPs) are key factors in this process, contributing greatly to the occurrence and development of AAA. But whether the zinc-dependent endopeptidases (ADAM/ADAMTS) are involved in this process is very little known. This study is a review about the role of MMPs and ADAM/ADAMT as well as the existing MMP inhibitors in abdominal aortic aneurysm, with the purpose of providing reference for the clinical treatment of abdominal aortic aneurysm. |
| collection_details |
GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_40 |
| title_short |
MMPs and ADAMs/ADAMTS inhibition therapy of abdominal aortic aneurysm |
| url |
https://doi.org/10.1016/j.lfs.2020.117659 |
| remote_bool |
true |
| author2 |
Wang, Weicheng Li, Lei Khalil, Raouf A. |
| author2Str |
Wang, Weicheng Li, Lei Khalil, Raouf A. |
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10.1016/j.lfs.2020.117659 |
| up_date |
2024-07-06T17:34:50.049Z |
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