RUNX1 variant as a genetic predisposition factor for acute myeloid leukemia
Acute myeloid leukemia (AML) is the most common hematological malignancy among adults and is characterized by accumulation of immature myeloid cells. Different genetic factors have role in the occurrence of AML. Among different proteins, RUNX1 and BAALC are involved in the development AML. It has be...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Javadlar, Masoumeh [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2020transfer abstract |
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| Übergeordnetes Werk: |
Enthalten in: Chemical constituents from twigs and leaves of - Zhang, Yan ELSEVIER, 2022, Orlando, Fla |
|---|---|
| Übergeordnetes Werk: |
volume:115 ; year:2020 ; pages:0 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.yexmp.2020.104440 |
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ELV050876120 |
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| 245 | 1 | 0 | |a RUNX1 variant as a genetic predisposition factor for acute myeloid leukemia |
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| 520 | |a Acute myeloid leukemia (AML) is the most common hematological malignancy among adults and is characterized by accumulation of immature myeloid cells. Different genetic factors have role in the occurrence of AML. Among different proteins, RUNX1 and BAALC are involved in the development AML. It has been shown that BAALC overexpression is a factor that indicate shorter disease free survival in a subset of AML patients. RUNX1 has been implicated in the development of breast, prostate, lung, and skin cancers. The aim of this study is determination of the prevalence of common polymorphisms in BAALC (rs6999622 and rs62527607) and RUNX1 (rs13051066 and rs61750222) in AML patients compared with healthy subjects. A total of 100 AML patients and 100 healthy control subjects were included in our study. Genomic DNA was isolated from peripheral blood and the polymorphisms were genotyped by applying ARMS and PCR-RFLP methods. Finally, data was analyzed using SPPSS software. Our results demonstrate a significant association between the RUNX1 rs13051066 and AML in the co-dominant (odd ratio = 6.66, 95% Cl = 1.85–25, p = .006) and dominant (GT + TT versus GG: odd ratio = 6.15, 95% CI = 1.73–21.87, p = .002) models. The RUNX1 rs13051066 polymorphism is associated with risk of AML in Iranian population. Future studies should consider larger sample size for assessment of RUNX1 gene polymorphisms, and employ cytogenetic and molecular analyses in AML patients from different ethnic origins. | ||
| 520 | |a Acute myeloid leukemia (AML) is the most common hematological malignancy among adults and is characterized by accumulation of immature myeloid cells. Different genetic factors have role in the occurrence of AML. Among different proteins, RUNX1 and BAALC are involved in the development AML. It has been shown that BAALC overexpression is a factor that indicate shorter disease free survival in a subset of AML patients. RUNX1 has been implicated in the development of breast, prostate, lung, and skin cancers. The aim of this study is determination of the prevalence of common polymorphisms in BAALC (rs6999622 and rs62527607) and RUNX1 (rs13051066 and rs61750222) in AML patients compared with healthy subjects. A total of 100 AML patients and 100 healthy control subjects were included in our study. Genomic DNA was isolated from peripheral blood and the polymorphisms were genotyped by applying ARMS and PCR-RFLP methods. Finally, data was analyzed using SPPSS software. Our results demonstrate a significant association between the RUNX1 rs13051066 and AML in the co-dominant (odd ratio = 6.66, 95% Cl = 1.85–25, p = .006) and dominant (GT + TT versus GG: odd ratio = 6.15, 95% CI = 1.73–21.87, p = .002) models. The RUNX1 rs13051066 polymorphism is associated with risk of AML in Iranian population. Future studies should consider larger sample size for assessment of RUNX1 gene polymorphisms, and employ cytogenetic and molecular analyses in AML patients from different ethnic origins. | ||
| 700 | 1 | |a Dastar, Saba |4 oth | |
| 700 | 1 | |a Gharesouran, Jalal |4 oth | |
| 700 | 1 | |a Ghafouri-Fard, Soudeh |4 oth | |
| 700 | 1 | |a Hosseinzadeh, Hassan |4 oth | |
| 700 | 1 | |a Moradi, Mohsen |4 oth | |
| 700 | 1 | |a Mazraeh, Shamsi Abdi |4 oth | |
| 700 | 1 | |a Nasiri Ganjineh Ketab, Fereshteh |4 oth | |
| 700 | 1 | |a Rezamand, Azim |4 oth | |
| 700 | 1 | |a Hiradfar, Amirataollah |4 oth | |
| 700 | 1 | |a Taheri, Mohammad |4 oth | |
| 700 | 1 | |a Rezazadeh, Maryam |4 oth | |
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10.1016/j.yexmp.2020.104440 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001500.pica (DE-627)ELV050876120 (ELSEVIER)S0014-4800(20)30298-7 DE-627 ger DE-627 rakwb eng 570 VZ BIODIV DE-30 fid 42.00 bkl 35.00 bkl Javadlar, Masoumeh verfasserin aut RUNX1 variant as a genetic predisposition factor for acute myeloid leukemia 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Acute myeloid leukemia (AML) is the most common hematological malignancy among adults and is characterized by accumulation of immature myeloid cells. Different genetic factors have role in the occurrence of AML. Among different proteins, RUNX1 and BAALC are involved in the development AML. It has been shown that BAALC overexpression is a factor that indicate shorter disease free survival in a subset of AML patients. RUNX1 has been implicated in the development of breast, prostate, lung, and skin cancers. The aim of this study is determination of the prevalence of common polymorphisms in BAALC (rs6999622 and rs62527607) and RUNX1 (rs13051066 and rs61750222) in AML patients compared with healthy subjects. A total of 100 AML patients and 100 healthy control subjects were included in our study. Genomic DNA was isolated from peripheral blood and the polymorphisms were genotyped by applying ARMS and PCR-RFLP methods. Finally, data was analyzed using SPPSS software. Our results demonstrate a significant association between the RUNX1 rs13051066 and AML in the co-dominant (odd ratio = 6.66, 95% Cl = 1.85–25, p = .006) and dominant (GT + TT versus GG: odd ratio = 6.15, 95% CI = 1.73–21.87, p = .002) models. The RUNX1 rs13051066 polymorphism is associated with risk of AML in Iranian population. Future studies should consider larger sample size for assessment of RUNX1 gene polymorphisms, and employ cytogenetic and molecular analyses in AML patients from different ethnic origins. Acute myeloid leukemia (AML) is the most common hematological malignancy among adults and is characterized by accumulation of immature myeloid cells. Different genetic factors have role in the occurrence of AML. Among different proteins, RUNX1 and BAALC are involved in the development AML. It has been shown that BAALC overexpression is a factor that indicate shorter disease free survival in a subset of AML patients. RUNX1 has been implicated in the development of breast, prostate, lung, and skin cancers. The aim of this study is determination of the prevalence of common polymorphisms in BAALC (rs6999622 and rs62527607) and RUNX1 (rs13051066 and rs61750222) in AML patients compared with healthy subjects. A total of 100 AML patients and 100 healthy control subjects were included in our study. Genomic DNA was isolated from peripheral blood and the polymorphisms were genotyped by applying ARMS and PCR-RFLP methods. Finally, data was analyzed using SPPSS software. Our results demonstrate a significant association between the RUNX1 rs13051066 and AML in the co-dominant (odd ratio = 6.66, 95% Cl = 1.85–25, p = .006) and dominant (GT + TT versus GG: odd ratio = 6.15, 95% CI = 1.73–21.87, p = .002) models. The RUNX1 rs13051066 polymorphism is associated with risk of AML in Iranian population. Future studies should consider larger sample size for assessment of RUNX1 gene polymorphisms, and employ cytogenetic and molecular analyses in AML patients from different ethnic origins. Dastar, Saba oth Gharesouran, Jalal oth Ghafouri-Fard, Soudeh oth Hosseinzadeh, Hassan oth Moradi, Mohsen oth Mazraeh, Shamsi Abdi oth Nasiri Ganjineh Ketab, Fereshteh oth Rezamand, Azim oth Hiradfar, Amirataollah oth Taheri, Mohammad oth Rezazadeh, Maryam oth Enthalten in Academic Press Zhang, Yan ELSEVIER Chemical constituents from twigs and leaves of 2022 Orlando, Fla (DE-627)ELV008414009 volume:115 year:2020 pages:0 https://doi.org/10.1016/j.yexmp.2020.104440 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA 42.00 Biologie: Allgemeines VZ 35.00 Chemie: Allgemeines VZ AR 115 2020 0 |
| spelling |
10.1016/j.yexmp.2020.104440 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001500.pica (DE-627)ELV050876120 (ELSEVIER)S0014-4800(20)30298-7 DE-627 ger DE-627 rakwb eng 570 VZ BIODIV DE-30 fid 42.00 bkl 35.00 bkl Javadlar, Masoumeh verfasserin aut RUNX1 variant as a genetic predisposition factor for acute myeloid leukemia 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Acute myeloid leukemia (AML) is the most common hematological malignancy among adults and is characterized by accumulation of immature myeloid cells. Different genetic factors have role in the occurrence of AML. Among different proteins, RUNX1 and BAALC are involved in the development AML. It has been shown that BAALC overexpression is a factor that indicate shorter disease free survival in a subset of AML patients. RUNX1 has been implicated in the development of breast, prostate, lung, and skin cancers. The aim of this study is determination of the prevalence of common polymorphisms in BAALC (rs6999622 and rs62527607) and RUNX1 (rs13051066 and rs61750222) in AML patients compared with healthy subjects. A total of 100 AML patients and 100 healthy control subjects were included in our study. Genomic DNA was isolated from peripheral blood and the polymorphisms were genotyped by applying ARMS and PCR-RFLP methods. Finally, data was analyzed using SPPSS software. Our results demonstrate a significant association between the RUNX1 rs13051066 and AML in the co-dominant (odd ratio = 6.66, 95% Cl = 1.85–25, p = .006) and dominant (GT + TT versus GG: odd ratio = 6.15, 95% CI = 1.73–21.87, p = .002) models. The RUNX1 rs13051066 polymorphism is associated with risk of AML in Iranian population. Future studies should consider larger sample size for assessment of RUNX1 gene polymorphisms, and employ cytogenetic and molecular analyses in AML patients from different ethnic origins. Acute myeloid leukemia (AML) is the most common hematological malignancy among adults and is characterized by accumulation of immature myeloid cells. Different genetic factors have role in the occurrence of AML. Among different proteins, RUNX1 and BAALC are involved in the development AML. It has been shown that BAALC overexpression is a factor that indicate shorter disease free survival in a subset of AML patients. RUNX1 has been implicated in the development of breast, prostate, lung, and skin cancers. The aim of this study is determination of the prevalence of common polymorphisms in BAALC (rs6999622 and rs62527607) and RUNX1 (rs13051066 and rs61750222) in AML patients compared with healthy subjects. A total of 100 AML patients and 100 healthy control subjects were included in our study. Genomic DNA was isolated from peripheral blood and the polymorphisms were genotyped by applying ARMS and PCR-RFLP methods. Finally, data was analyzed using SPPSS software. Our results demonstrate a significant association between the RUNX1 rs13051066 and AML in the co-dominant (odd ratio = 6.66, 95% Cl = 1.85–25, p = .006) and dominant (GT + TT versus GG: odd ratio = 6.15, 95% CI = 1.73–21.87, p = .002) models. The RUNX1 rs13051066 polymorphism is associated with risk of AML in Iranian population. Future studies should consider larger sample size for assessment of RUNX1 gene polymorphisms, and employ cytogenetic and molecular analyses in AML patients from different ethnic origins. Dastar, Saba oth Gharesouran, Jalal oth Ghafouri-Fard, Soudeh oth Hosseinzadeh, Hassan oth Moradi, Mohsen oth Mazraeh, Shamsi Abdi oth Nasiri Ganjineh Ketab, Fereshteh oth Rezamand, Azim oth Hiradfar, Amirataollah oth Taheri, Mohammad oth Rezazadeh, Maryam oth Enthalten in Academic Press Zhang, Yan ELSEVIER Chemical constituents from twigs and leaves of 2022 Orlando, Fla (DE-627)ELV008414009 volume:115 year:2020 pages:0 https://doi.org/10.1016/j.yexmp.2020.104440 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA 42.00 Biologie: Allgemeines VZ 35.00 Chemie: Allgemeines VZ AR 115 2020 0 |
| allfields_unstemmed |
10.1016/j.yexmp.2020.104440 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001500.pica (DE-627)ELV050876120 (ELSEVIER)S0014-4800(20)30298-7 DE-627 ger DE-627 rakwb eng 570 VZ BIODIV DE-30 fid 42.00 bkl 35.00 bkl Javadlar, Masoumeh verfasserin aut RUNX1 variant as a genetic predisposition factor for acute myeloid leukemia 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Acute myeloid leukemia (AML) is the most common hematological malignancy among adults and is characterized by accumulation of immature myeloid cells. Different genetic factors have role in the occurrence of AML. Among different proteins, RUNX1 and BAALC are involved in the development AML. It has been shown that BAALC overexpression is a factor that indicate shorter disease free survival in a subset of AML patients. RUNX1 has been implicated in the development of breast, prostate, lung, and skin cancers. The aim of this study is determination of the prevalence of common polymorphisms in BAALC (rs6999622 and rs62527607) and RUNX1 (rs13051066 and rs61750222) in AML patients compared with healthy subjects. A total of 100 AML patients and 100 healthy control subjects were included in our study. Genomic DNA was isolated from peripheral blood and the polymorphisms were genotyped by applying ARMS and PCR-RFLP methods. Finally, data was analyzed using SPPSS software. Our results demonstrate a significant association between the RUNX1 rs13051066 and AML in the co-dominant (odd ratio = 6.66, 95% Cl = 1.85–25, p = .006) and dominant (GT + TT versus GG: odd ratio = 6.15, 95% CI = 1.73–21.87, p = .002) models. The RUNX1 rs13051066 polymorphism is associated with risk of AML in Iranian population. Future studies should consider larger sample size for assessment of RUNX1 gene polymorphisms, and employ cytogenetic and molecular analyses in AML patients from different ethnic origins. Acute myeloid leukemia (AML) is the most common hematological malignancy among adults and is characterized by accumulation of immature myeloid cells. Different genetic factors have role in the occurrence of AML. Among different proteins, RUNX1 and BAALC are involved in the development AML. It has been shown that BAALC overexpression is a factor that indicate shorter disease free survival in a subset of AML patients. RUNX1 has been implicated in the development of breast, prostate, lung, and skin cancers. The aim of this study is determination of the prevalence of common polymorphisms in BAALC (rs6999622 and rs62527607) and RUNX1 (rs13051066 and rs61750222) in AML patients compared with healthy subjects. A total of 100 AML patients and 100 healthy control subjects were included in our study. Genomic DNA was isolated from peripheral blood and the polymorphisms were genotyped by applying ARMS and PCR-RFLP methods. Finally, data was analyzed using SPPSS software. Our results demonstrate a significant association between the RUNX1 rs13051066 and AML in the co-dominant (odd ratio = 6.66, 95% Cl = 1.85–25, p = .006) and dominant (GT + TT versus GG: odd ratio = 6.15, 95% CI = 1.73–21.87, p = .002) models. The RUNX1 rs13051066 polymorphism is associated with risk of AML in Iranian population. Future studies should consider larger sample size for assessment of RUNX1 gene polymorphisms, and employ cytogenetic and molecular analyses in AML patients from different ethnic origins. Dastar, Saba oth Gharesouran, Jalal oth Ghafouri-Fard, Soudeh oth Hosseinzadeh, Hassan oth Moradi, Mohsen oth Mazraeh, Shamsi Abdi oth Nasiri Ganjineh Ketab, Fereshteh oth Rezamand, Azim oth Hiradfar, Amirataollah oth Taheri, Mohammad oth Rezazadeh, Maryam oth Enthalten in Academic Press Zhang, Yan ELSEVIER Chemical constituents from twigs and leaves of 2022 Orlando, Fla (DE-627)ELV008414009 volume:115 year:2020 pages:0 https://doi.org/10.1016/j.yexmp.2020.104440 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA 42.00 Biologie: Allgemeines VZ 35.00 Chemie: Allgemeines VZ AR 115 2020 0 |
| allfieldsGer |
10.1016/j.yexmp.2020.104440 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001500.pica (DE-627)ELV050876120 (ELSEVIER)S0014-4800(20)30298-7 DE-627 ger DE-627 rakwb eng 570 VZ BIODIV DE-30 fid 42.00 bkl 35.00 bkl Javadlar, Masoumeh verfasserin aut RUNX1 variant as a genetic predisposition factor for acute myeloid leukemia 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Acute myeloid leukemia (AML) is the most common hematological malignancy among adults and is characterized by accumulation of immature myeloid cells. Different genetic factors have role in the occurrence of AML. Among different proteins, RUNX1 and BAALC are involved in the development AML. It has been shown that BAALC overexpression is a factor that indicate shorter disease free survival in a subset of AML patients. RUNX1 has been implicated in the development of breast, prostate, lung, and skin cancers. The aim of this study is determination of the prevalence of common polymorphisms in BAALC (rs6999622 and rs62527607) and RUNX1 (rs13051066 and rs61750222) in AML patients compared with healthy subjects. A total of 100 AML patients and 100 healthy control subjects were included in our study. Genomic DNA was isolated from peripheral blood and the polymorphisms were genotyped by applying ARMS and PCR-RFLP methods. Finally, data was analyzed using SPPSS software. Our results demonstrate a significant association between the RUNX1 rs13051066 and AML in the co-dominant (odd ratio = 6.66, 95% Cl = 1.85–25, p = .006) and dominant (GT + TT versus GG: odd ratio = 6.15, 95% CI = 1.73–21.87, p = .002) models. The RUNX1 rs13051066 polymorphism is associated with risk of AML in Iranian population. Future studies should consider larger sample size for assessment of RUNX1 gene polymorphisms, and employ cytogenetic and molecular analyses in AML patients from different ethnic origins. Acute myeloid leukemia (AML) is the most common hematological malignancy among adults and is characterized by accumulation of immature myeloid cells. Different genetic factors have role in the occurrence of AML. Among different proteins, RUNX1 and BAALC are involved in the development AML. It has been shown that BAALC overexpression is a factor that indicate shorter disease free survival in a subset of AML patients. RUNX1 has been implicated in the development of breast, prostate, lung, and skin cancers. The aim of this study is determination of the prevalence of common polymorphisms in BAALC (rs6999622 and rs62527607) and RUNX1 (rs13051066 and rs61750222) in AML patients compared with healthy subjects. A total of 100 AML patients and 100 healthy control subjects were included in our study. Genomic DNA was isolated from peripheral blood and the polymorphisms were genotyped by applying ARMS and PCR-RFLP methods. Finally, data was analyzed using SPPSS software. Our results demonstrate a significant association between the RUNX1 rs13051066 and AML in the co-dominant (odd ratio = 6.66, 95% Cl = 1.85–25, p = .006) and dominant (GT + TT versus GG: odd ratio = 6.15, 95% CI = 1.73–21.87, p = .002) models. The RUNX1 rs13051066 polymorphism is associated with risk of AML in Iranian population. Future studies should consider larger sample size for assessment of RUNX1 gene polymorphisms, and employ cytogenetic and molecular analyses in AML patients from different ethnic origins. Dastar, Saba oth Gharesouran, Jalal oth Ghafouri-Fard, Soudeh oth Hosseinzadeh, Hassan oth Moradi, Mohsen oth Mazraeh, Shamsi Abdi oth Nasiri Ganjineh Ketab, Fereshteh oth Rezamand, Azim oth Hiradfar, Amirataollah oth Taheri, Mohammad oth Rezazadeh, Maryam oth Enthalten in Academic Press Zhang, Yan ELSEVIER Chemical constituents from twigs and leaves of 2022 Orlando, Fla (DE-627)ELV008414009 volume:115 year:2020 pages:0 https://doi.org/10.1016/j.yexmp.2020.104440 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA 42.00 Biologie: Allgemeines VZ 35.00 Chemie: Allgemeines VZ AR 115 2020 0 |
| allfieldsSound |
10.1016/j.yexmp.2020.104440 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001500.pica (DE-627)ELV050876120 (ELSEVIER)S0014-4800(20)30298-7 DE-627 ger DE-627 rakwb eng 570 VZ BIODIV DE-30 fid 42.00 bkl 35.00 bkl Javadlar, Masoumeh verfasserin aut RUNX1 variant as a genetic predisposition factor for acute myeloid leukemia 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Acute myeloid leukemia (AML) is the most common hematological malignancy among adults and is characterized by accumulation of immature myeloid cells. Different genetic factors have role in the occurrence of AML. Among different proteins, RUNX1 and BAALC are involved in the development AML. It has been shown that BAALC overexpression is a factor that indicate shorter disease free survival in a subset of AML patients. RUNX1 has been implicated in the development of breast, prostate, lung, and skin cancers. The aim of this study is determination of the prevalence of common polymorphisms in BAALC (rs6999622 and rs62527607) and RUNX1 (rs13051066 and rs61750222) in AML patients compared with healthy subjects. A total of 100 AML patients and 100 healthy control subjects were included in our study. Genomic DNA was isolated from peripheral blood and the polymorphisms were genotyped by applying ARMS and PCR-RFLP methods. Finally, data was analyzed using SPPSS software. Our results demonstrate a significant association between the RUNX1 rs13051066 and AML in the co-dominant (odd ratio = 6.66, 95% Cl = 1.85–25, p = .006) and dominant (GT + TT versus GG: odd ratio = 6.15, 95% CI = 1.73–21.87, p = .002) models. The RUNX1 rs13051066 polymorphism is associated with risk of AML in Iranian population. Future studies should consider larger sample size for assessment of RUNX1 gene polymorphisms, and employ cytogenetic and molecular analyses in AML patients from different ethnic origins. Acute myeloid leukemia (AML) is the most common hematological malignancy among adults and is characterized by accumulation of immature myeloid cells. Different genetic factors have role in the occurrence of AML. Among different proteins, RUNX1 and BAALC are involved in the development AML. It has been shown that BAALC overexpression is a factor that indicate shorter disease free survival in a subset of AML patients. RUNX1 has been implicated in the development of breast, prostate, lung, and skin cancers. The aim of this study is determination of the prevalence of common polymorphisms in BAALC (rs6999622 and rs62527607) and RUNX1 (rs13051066 and rs61750222) in AML patients compared with healthy subjects. A total of 100 AML patients and 100 healthy control subjects were included in our study. Genomic DNA was isolated from peripheral blood and the polymorphisms were genotyped by applying ARMS and PCR-RFLP methods. Finally, data was analyzed using SPPSS software. Our results demonstrate a significant association between the RUNX1 rs13051066 and AML in the co-dominant (odd ratio = 6.66, 95% Cl = 1.85–25, p = .006) and dominant (GT + TT versus GG: odd ratio = 6.15, 95% CI = 1.73–21.87, p = .002) models. The RUNX1 rs13051066 polymorphism is associated with risk of AML in Iranian population. Future studies should consider larger sample size for assessment of RUNX1 gene polymorphisms, and employ cytogenetic and molecular analyses in AML patients from different ethnic origins. Dastar, Saba oth Gharesouran, Jalal oth Ghafouri-Fard, Soudeh oth Hosseinzadeh, Hassan oth Moradi, Mohsen oth Mazraeh, Shamsi Abdi oth Nasiri Ganjineh Ketab, Fereshteh oth Rezamand, Azim oth Hiradfar, Amirataollah oth Taheri, Mohammad oth Rezazadeh, Maryam oth Enthalten in Academic Press Zhang, Yan ELSEVIER Chemical constituents from twigs and leaves of 2022 Orlando, Fla (DE-627)ELV008414009 volume:115 year:2020 pages:0 https://doi.org/10.1016/j.yexmp.2020.104440 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA 42.00 Biologie: Allgemeines VZ 35.00 Chemie: Allgemeines VZ AR 115 2020 0 |
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RUNX1 variant as a genetic predisposition factor for acute myeloid leukemia |
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Acute myeloid leukemia (AML) is the most common hematological malignancy among adults and is characterized by accumulation of immature myeloid cells. Different genetic factors have role in the occurrence of AML. Among different proteins, RUNX1 and BAALC are involved in the development AML. It has been shown that BAALC overexpression is a factor that indicate shorter disease free survival in a subset of AML patients. RUNX1 has been implicated in the development of breast, prostate, lung, and skin cancers. The aim of this study is determination of the prevalence of common polymorphisms in BAALC (rs6999622 and rs62527607) and RUNX1 (rs13051066 and rs61750222) in AML patients compared with healthy subjects. A total of 100 AML patients and 100 healthy control subjects were included in our study. Genomic DNA was isolated from peripheral blood and the polymorphisms were genotyped by applying ARMS and PCR-RFLP methods. Finally, data was analyzed using SPPSS software. Our results demonstrate a significant association between the RUNX1 rs13051066 and AML in the co-dominant (odd ratio = 6.66, 95% Cl = 1.85–25, p = .006) and dominant (GT + TT versus GG: odd ratio = 6.15, 95% CI = 1.73–21.87, p = .002) models. The RUNX1 rs13051066 polymorphism is associated with risk of AML in Iranian population. Future studies should consider larger sample size for assessment of RUNX1 gene polymorphisms, and employ cytogenetic and molecular analyses in AML patients from different ethnic origins. |
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Acute myeloid leukemia (AML) is the most common hematological malignancy among adults and is characterized by accumulation of immature myeloid cells. Different genetic factors have role in the occurrence of AML. Among different proteins, RUNX1 and BAALC are involved in the development AML. It has been shown that BAALC overexpression is a factor that indicate shorter disease free survival in a subset of AML patients. RUNX1 has been implicated in the development of breast, prostate, lung, and skin cancers. The aim of this study is determination of the prevalence of common polymorphisms in BAALC (rs6999622 and rs62527607) and RUNX1 (rs13051066 and rs61750222) in AML patients compared with healthy subjects. A total of 100 AML patients and 100 healthy control subjects were included in our study. Genomic DNA was isolated from peripheral blood and the polymorphisms were genotyped by applying ARMS and PCR-RFLP methods. Finally, data was analyzed using SPPSS software. Our results demonstrate a significant association between the RUNX1 rs13051066 and AML in the co-dominant (odd ratio = 6.66, 95% Cl = 1.85–25, p = .006) and dominant (GT + TT versus GG: odd ratio = 6.15, 95% CI = 1.73–21.87, p = .002) models. The RUNX1 rs13051066 polymorphism is associated with risk of AML in Iranian population. Future studies should consider larger sample size for assessment of RUNX1 gene polymorphisms, and employ cytogenetic and molecular analyses in AML patients from different ethnic origins. |
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Acute myeloid leukemia (AML) is the most common hematological malignancy among adults and is characterized by accumulation of immature myeloid cells. Different genetic factors have role in the occurrence of AML. Among different proteins, RUNX1 and BAALC are involved in the development AML. It has been shown that BAALC overexpression is a factor that indicate shorter disease free survival in a subset of AML patients. RUNX1 has been implicated in the development of breast, prostate, lung, and skin cancers. The aim of this study is determination of the prevalence of common polymorphisms in BAALC (rs6999622 and rs62527607) and RUNX1 (rs13051066 and rs61750222) in AML patients compared with healthy subjects. A total of 100 AML patients and 100 healthy control subjects were included in our study. Genomic DNA was isolated from peripheral blood and the polymorphisms were genotyped by applying ARMS and PCR-RFLP methods. Finally, data was analyzed using SPPSS software. Our results demonstrate a significant association between the RUNX1 rs13051066 and AML in the co-dominant (odd ratio = 6.66, 95% Cl = 1.85–25, p = .006) and dominant (GT + TT versus GG: odd ratio = 6.15, 95% CI = 1.73–21.87, p = .002) models. The RUNX1 rs13051066 polymorphism is associated with risk of AML in Iranian population. Future studies should consider larger sample size for assessment of RUNX1 gene polymorphisms, and employ cytogenetic and molecular analyses in AML patients from different ethnic origins. |
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|
| score |
7.40221 |