Somatostatin receptor-2 negative meningioma: pathologic correlation and imaging implications
Meningiomas are the most common non-malignant primary intracranial tumors, accounting for nearly 40% of all primary brain tumors, usually expressing high levels of somatostatin receptors (SSTR), particularly SSTR2. Because 68Ga-DOTATATE targets SSTR2, it is increasingly used clinically for meningiom...
Ausführliche Beschreibung
Autor*in: |
Roytman, Michelle [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
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2020transfer abstract |
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Umfang: |
5 |
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Übergeordnetes Werk: |
Enthalten in: A study of Parylene coated Pd/Mg nanoblabes for reversible hydrogen storage - 2013transfer abstract, Amsterdam [u.a.] |
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Übergeordnetes Werk: |
volume:66 ; year:2020 ; pages:18-22 ; extent:5 |
Links: |
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DOI / URN: |
10.1016/j.clinimag.2020.04.026 |
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ELV051005786 |
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520 | |a Meningiomas are the most common non-malignant primary intracranial tumors, accounting for nearly 40% of all primary brain tumors, usually expressing high levels of somatostatin receptors (SSTR), particularly SSTR2. Because 68Ga-DOTATATE targets SSTR2, it is increasingly used clinically for meningioma evaluation. While previous apparent lack of SSTR expression in meningiomas has been reported in isolated cases, these prior studies utilized Indium-111 (111In) Octreotide, which is of lesser diagnostic accuracy compared to 68Ga-DOTATATE, as well as Technetium-99m (99mTc)-DTPA scintigraphy, which necessitates an intact blood-tumor-permeability barrier. This paper presents a histopathologic proven atypical meningioma, WHO Grade II, with low level avidity on 68Ga-DOTATATE PET/MRI, subsequently proven to be SSTR2-negative by immunohistochemistry, with a review and discussion of the current literature and imaging implications. | ||
520 | |a Meningiomas are the most common non-malignant primary intracranial tumors, accounting for nearly 40% of all primary brain tumors, usually expressing high levels of somatostatin receptors (SSTR), particularly SSTR2. Because 68Ga-DOTATATE targets SSTR2, it is increasingly used clinically for meningioma evaluation. While previous apparent lack of SSTR expression in meningiomas has been reported in isolated cases, these prior studies utilized Indium-111 (111In) Octreotide, which is of lesser diagnostic accuracy compared to 68Ga-DOTATATE, as well as Technetium-99m (99mTc)-DTPA scintigraphy, which necessitates an intact blood-tumor-permeability barrier. This paper presents a histopathologic proven atypical meningioma, WHO Grade II, with low level avidity on 68Ga-DOTATATE PET/MRI, subsequently proven to be SSTR2-negative by immunohistochemistry, with a review and discussion of the current literature and imaging implications. | ||
700 | 1 | |a Pisapia, David J. |4 oth | |
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700 | 1 | |a Ivanidze, Jana |4 oth | |
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10.1016/j.clinimag.2020.04.026 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001096.pica (DE-627)ELV051005786 (ELSEVIER)S0899-7071(20)30138-8 DE-627 ger DE-627 rakwb eng 660 VZ 620 VZ 610 VZ 44.94 bkl Roytman, Michelle verfasserin aut Somatostatin receptor-2 negative meningioma: pathologic correlation and imaging implications 2020transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Meningiomas are the most common non-malignant primary intracranial tumors, accounting for nearly 40% of all primary brain tumors, usually expressing high levels of somatostatin receptors (SSTR), particularly SSTR2. Because 68Ga-DOTATATE targets SSTR2, it is increasingly used clinically for meningioma evaluation. While previous apparent lack of SSTR expression in meningiomas has been reported in isolated cases, these prior studies utilized Indium-111 (111In) Octreotide, which is of lesser diagnostic accuracy compared to 68Ga-DOTATATE, as well as Technetium-99m (99mTc)-DTPA scintigraphy, which necessitates an intact blood-tumor-permeability barrier. This paper presents a histopathologic proven atypical meningioma, WHO Grade II, with low level avidity on 68Ga-DOTATATE PET/MRI, subsequently proven to be SSTR2-negative by immunohistochemistry, with a review and discussion of the current literature and imaging implications. Meningiomas are the most common non-malignant primary intracranial tumors, accounting for nearly 40% of all primary brain tumors, usually expressing high levels of somatostatin receptors (SSTR), particularly SSTR2. Because 68Ga-DOTATATE targets SSTR2, it is increasingly used clinically for meningioma evaluation. While previous apparent lack of SSTR expression in meningiomas has been reported in isolated cases, these prior studies utilized Indium-111 (111In) Octreotide, which is of lesser diagnostic accuracy compared to 68Ga-DOTATATE, as well as Technetium-99m (99mTc)-DTPA scintigraphy, which necessitates an intact blood-tumor-permeability barrier. This paper presents a histopathologic proven atypical meningioma, WHO Grade II, with low level avidity on 68Ga-DOTATATE PET/MRI, subsequently proven to be SSTR2-negative by immunohistochemistry, with a review and discussion of the current literature and imaging implications. Pisapia, David J. oth Liechty, Benjamin oth Lin, Eaton oth Skafida, Myrto oth Magge, Rajiv S. oth Osborne, Joseph R. oth Pannullo, Susan C. oth Knisely, Jonathan P.S. oth Ramakrishna, Rohan oth Ivanidze, Jana oth Enthalten in Elsevier Science A study of Parylene coated Pd/Mg nanoblabes for reversible hydrogen storage 2013transfer abstract Amsterdam [u.a.] (DE-627)ELV011562358 volume:66 year:2020 pages:18-22 extent:5 https://doi.org/10.1016/j.clinimag.2020.04.026 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_30 GBV_ILN_40 GBV_ILN_70 44.94 Hals-Nasen-Ohrenheilkunde VZ AR 66 2020 18-22 5 |
spelling |
10.1016/j.clinimag.2020.04.026 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001096.pica (DE-627)ELV051005786 (ELSEVIER)S0899-7071(20)30138-8 DE-627 ger DE-627 rakwb eng 660 VZ 620 VZ 610 VZ 44.94 bkl Roytman, Michelle verfasserin aut Somatostatin receptor-2 negative meningioma: pathologic correlation and imaging implications 2020transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Meningiomas are the most common non-malignant primary intracranial tumors, accounting for nearly 40% of all primary brain tumors, usually expressing high levels of somatostatin receptors (SSTR), particularly SSTR2. Because 68Ga-DOTATATE targets SSTR2, it is increasingly used clinically for meningioma evaluation. While previous apparent lack of SSTR expression in meningiomas has been reported in isolated cases, these prior studies utilized Indium-111 (111In) Octreotide, which is of lesser diagnostic accuracy compared to 68Ga-DOTATATE, as well as Technetium-99m (99mTc)-DTPA scintigraphy, which necessitates an intact blood-tumor-permeability barrier. This paper presents a histopathologic proven atypical meningioma, WHO Grade II, with low level avidity on 68Ga-DOTATATE PET/MRI, subsequently proven to be SSTR2-negative by immunohistochemistry, with a review and discussion of the current literature and imaging implications. Meningiomas are the most common non-malignant primary intracranial tumors, accounting for nearly 40% of all primary brain tumors, usually expressing high levels of somatostatin receptors (SSTR), particularly SSTR2. Because 68Ga-DOTATATE targets SSTR2, it is increasingly used clinically for meningioma evaluation. While previous apparent lack of SSTR expression in meningiomas has been reported in isolated cases, these prior studies utilized Indium-111 (111In) Octreotide, which is of lesser diagnostic accuracy compared to 68Ga-DOTATATE, as well as Technetium-99m (99mTc)-DTPA scintigraphy, which necessitates an intact blood-tumor-permeability barrier. This paper presents a histopathologic proven atypical meningioma, WHO Grade II, with low level avidity on 68Ga-DOTATATE PET/MRI, subsequently proven to be SSTR2-negative by immunohistochemistry, with a review and discussion of the current literature and imaging implications. Pisapia, David J. oth Liechty, Benjamin oth Lin, Eaton oth Skafida, Myrto oth Magge, Rajiv S. oth Osborne, Joseph R. oth Pannullo, Susan C. oth Knisely, Jonathan P.S. oth Ramakrishna, Rohan oth Ivanidze, Jana oth Enthalten in Elsevier Science A study of Parylene coated Pd/Mg nanoblabes for reversible hydrogen storage 2013transfer abstract Amsterdam [u.a.] (DE-627)ELV011562358 volume:66 year:2020 pages:18-22 extent:5 https://doi.org/10.1016/j.clinimag.2020.04.026 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_30 GBV_ILN_40 GBV_ILN_70 44.94 Hals-Nasen-Ohrenheilkunde VZ AR 66 2020 18-22 5 |
allfields_unstemmed |
10.1016/j.clinimag.2020.04.026 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001096.pica (DE-627)ELV051005786 (ELSEVIER)S0899-7071(20)30138-8 DE-627 ger DE-627 rakwb eng 660 VZ 620 VZ 610 VZ 44.94 bkl Roytman, Michelle verfasserin aut Somatostatin receptor-2 negative meningioma: pathologic correlation and imaging implications 2020transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Meningiomas are the most common non-malignant primary intracranial tumors, accounting for nearly 40% of all primary brain tumors, usually expressing high levels of somatostatin receptors (SSTR), particularly SSTR2. Because 68Ga-DOTATATE targets SSTR2, it is increasingly used clinically for meningioma evaluation. While previous apparent lack of SSTR expression in meningiomas has been reported in isolated cases, these prior studies utilized Indium-111 (111In) Octreotide, which is of lesser diagnostic accuracy compared to 68Ga-DOTATATE, as well as Technetium-99m (99mTc)-DTPA scintigraphy, which necessitates an intact blood-tumor-permeability barrier. This paper presents a histopathologic proven atypical meningioma, WHO Grade II, with low level avidity on 68Ga-DOTATATE PET/MRI, subsequently proven to be SSTR2-negative by immunohistochemistry, with a review and discussion of the current literature and imaging implications. Meningiomas are the most common non-malignant primary intracranial tumors, accounting for nearly 40% of all primary brain tumors, usually expressing high levels of somatostatin receptors (SSTR), particularly SSTR2. Because 68Ga-DOTATATE targets SSTR2, it is increasingly used clinically for meningioma evaluation. While previous apparent lack of SSTR expression in meningiomas has been reported in isolated cases, these prior studies utilized Indium-111 (111In) Octreotide, which is of lesser diagnostic accuracy compared to 68Ga-DOTATATE, as well as Technetium-99m (99mTc)-DTPA scintigraphy, which necessitates an intact blood-tumor-permeability barrier. This paper presents a histopathologic proven atypical meningioma, WHO Grade II, with low level avidity on 68Ga-DOTATATE PET/MRI, subsequently proven to be SSTR2-negative by immunohistochemistry, with a review and discussion of the current literature and imaging implications. Pisapia, David J. oth Liechty, Benjamin oth Lin, Eaton oth Skafida, Myrto oth Magge, Rajiv S. oth Osborne, Joseph R. oth Pannullo, Susan C. oth Knisely, Jonathan P.S. oth Ramakrishna, Rohan oth Ivanidze, Jana oth Enthalten in Elsevier Science A study of Parylene coated Pd/Mg nanoblabes for reversible hydrogen storage 2013transfer abstract Amsterdam [u.a.] (DE-627)ELV011562358 volume:66 year:2020 pages:18-22 extent:5 https://doi.org/10.1016/j.clinimag.2020.04.026 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_30 GBV_ILN_40 GBV_ILN_70 44.94 Hals-Nasen-Ohrenheilkunde VZ AR 66 2020 18-22 5 |
allfieldsGer |
10.1016/j.clinimag.2020.04.026 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001096.pica (DE-627)ELV051005786 (ELSEVIER)S0899-7071(20)30138-8 DE-627 ger DE-627 rakwb eng 660 VZ 620 VZ 610 VZ 44.94 bkl Roytman, Michelle verfasserin aut Somatostatin receptor-2 negative meningioma: pathologic correlation and imaging implications 2020transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Meningiomas are the most common non-malignant primary intracranial tumors, accounting for nearly 40% of all primary brain tumors, usually expressing high levels of somatostatin receptors (SSTR), particularly SSTR2. Because 68Ga-DOTATATE targets SSTR2, it is increasingly used clinically for meningioma evaluation. While previous apparent lack of SSTR expression in meningiomas has been reported in isolated cases, these prior studies utilized Indium-111 (111In) Octreotide, which is of lesser diagnostic accuracy compared to 68Ga-DOTATATE, as well as Technetium-99m (99mTc)-DTPA scintigraphy, which necessitates an intact blood-tumor-permeability barrier. This paper presents a histopathologic proven atypical meningioma, WHO Grade II, with low level avidity on 68Ga-DOTATATE PET/MRI, subsequently proven to be SSTR2-negative by immunohistochemistry, with a review and discussion of the current literature and imaging implications. Meningiomas are the most common non-malignant primary intracranial tumors, accounting for nearly 40% of all primary brain tumors, usually expressing high levels of somatostatin receptors (SSTR), particularly SSTR2. Because 68Ga-DOTATATE targets SSTR2, it is increasingly used clinically for meningioma evaluation. While previous apparent lack of SSTR expression in meningiomas has been reported in isolated cases, these prior studies utilized Indium-111 (111In) Octreotide, which is of lesser diagnostic accuracy compared to 68Ga-DOTATATE, as well as Technetium-99m (99mTc)-DTPA scintigraphy, which necessitates an intact blood-tumor-permeability barrier. This paper presents a histopathologic proven atypical meningioma, WHO Grade II, with low level avidity on 68Ga-DOTATATE PET/MRI, subsequently proven to be SSTR2-negative by immunohistochemistry, with a review and discussion of the current literature and imaging implications. Pisapia, David J. oth Liechty, Benjamin oth Lin, Eaton oth Skafida, Myrto oth Magge, Rajiv S. oth Osborne, Joseph R. oth Pannullo, Susan C. oth Knisely, Jonathan P.S. oth Ramakrishna, Rohan oth Ivanidze, Jana oth Enthalten in Elsevier Science A study of Parylene coated Pd/Mg nanoblabes for reversible hydrogen storage 2013transfer abstract Amsterdam [u.a.] (DE-627)ELV011562358 volume:66 year:2020 pages:18-22 extent:5 https://doi.org/10.1016/j.clinimag.2020.04.026 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_30 GBV_ILN_40 GBV_ILN_70 44.94 Hals-Nasen-Ohrenheilkunde VZ AR 66 2020 18-22 5 |
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10.1016/j.clinimag.2020.04.026 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001096.pica (DE-627)ELV051005786 (ELSEVIER)S0899-7071(20)30138-8 DE-627 ger DE-627 rakwb eng 660 VZ 620 VZ 610 VZ 44.94 bkl Roytman, Michelle verfasserin aut Somatostatin receptor-2 negative meningioma: pathologic correlation and imaging implications 2020transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Meningiomas are the most common non-malignant primary intracranial tumors, accounting for nearly 40% of all primary brain tumors, usually expressing high levels of somatostatin receptors (SSTR), particularly SSTR2. Because 68Ga-DOTATATE targets SSTR2, it is increasingly used clinically for meningioma evaluation. While previous apparent lack of SSTR expression in meningiomas has been reported in isolated cases, these prior studies utilized Indium-111 (111In) Octreotide, which is of lesser diagnostic accuracy compared to 68Ga-DOTATATE, as well as Technetium-99m (99mTc)-DTPA scintigraphy, which necessitates an intact blood-tumor-permeability barrier. This paper presents a histopathologic proven atypical meningioma, WHO Grade II, with low level avidity on 68Ga-DOTATATE PET/MRI, subsequently proven to be SSTR2-negative by immunohistochemistry, with a review and discussion of the current literature and imaging implications. Meningiomas are the most common non-malignant primary intracranial tumors, accounting for nearly 40% of all primary brain tumors, usually expressing high levels of somatostatin receptors (SSTR), particularly SSTR2. Because 68Ga-DOTATATE targets SSTR2, it is increasingly used clinically for meningioma evaluation. While previous apparent lack of SSTR expression in meningiomas has been reported in isolated cases, these prior studies utilized Indium-111 (111In) Octreotide, which is of lesser diagnostic accuracy compared to 68Ga-DOTATATE, as well as Technetium-99m (99mTc)-DTPA scintigraphy, which necessitates an intact blood-tumor-permeability barrier. This paper presents a histopathologic proven atypical meningioma, WHO Grade II, with low level avidity on 68Ga-DOTATATE PET/MRI, subsequently proven to be SSTR2-negative by immunohistochemistry, with a review and discussion of the current literature and imaging implications. Pisapia, David J. oth Liechty, Benjamin oth Lin, Eaton oth Skafida, Myrto oth Magge, Rajiv S. oth Osborne, Joseph R. oth Pannullo, Susan C. oth Knisely, Jonathan P.S. oth Ramakrishna, Rohan oth Ivanidze, Jana oth Enthalten in Elsevier Science A study of Parylene coated Pd/Mg nanoblabes for reversible hydrogen storage 2013transfer abstract Amsterdam [u.a.] (DE-627)ELV011562358 volume:66 year:2020 pages:18-22 extent:5 https://doi.org/10.1016/j.clinimag.2020.04.026 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_30 GBV_ILN_40 GBV_ILN_70 44.94 Hals-Nasen-Ohrenheilkunde VZ AR 66 2020 18-22 5 |
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somatostatin receptor-2 negative meningioma: pathologic correlation and imaging implications |
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Somatostatin receptor-2 negative meningioma: pathologic correlation and imaging implications |
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Meningiomas are the most common non-malignant primary intracranial tumors, accounting for nearly 40% of all primary brain tumors, usually expressing high levels of somatostatin receptors (SSTR), particularly SSTR2. Because 68Ga-DOTATATE targets SSTR2, it is increasingly used clinically for meningioma evaluation. While previous apparent lack of SSTR expression in meningiomas has been reported in isolated cases, these prior studies utilized Indium-111 (111In) Octreotide, which is of lesser diagnostic accuracy compared to 68Ga-DOTATATE, as well as Technetium-99m (99mTc)-DTPA scintigraphy, which necessitates an intact blood-tumor-permeability barrier. This paper presents a histopathologic proven atypical meningioma, WHO Grade II, with low level avidity on 68Ga-DOTATATE PET/MRI, subsequently proven to be SSTR2-negative by immunohistochemistry, with a review and discussion of the current literature and imaging implications. |
abstractGer |
Meningiomas are the most common non-malignant primary intracranial tumors, accounting for nearly 40% of all primary brain tumors, usually expressing high levels of somatostatin receptors (SSTR), particularly SSTR2. Because 68Ga-DOTATATE targets SSTR2, it is increasingly used clinically for meningioma evaluation. While previous apparent lack of SSTR expression in meningiomas has been reported in isolated cases, these prior studies utilized Indium-111 (111In) Octreotide, which is of lesser diagnostic accuracy compared to 68Ga-DOTATATE, as well as Technetium-99m (99mTc)-DTPA scintigraphy, which necessitates an intact blood-tumor-permeability barrier. This paper presents a histopathologic proven atypical meningioma, WHO Grade II, with low level avidity on 68Ga-DOTATATE PET/MRI, subsequently proven to be SSTR2-negative by immunohistochemistry, with a review and discussion of the current literature and imaging implications. |
abstract_unstemmed |
Meningiomas are the most common non-malignant primary intracranial tumors, accounting for nearly 40% of all primary brain tumors, usually expressing high levels of somatostatin receptors (SSTR), particularly SSTR2. Because 68Ga-DOTATATE targets SSTR2, it is increasingly used clinically for meningioma evaluation. While previous apparent lack of SSTR expression in meningiomas has been reported in isolated cases, these prior studies utilized Indium-111 (111In) Octreotide, which is of lesser diagnostic accuracy compared to 68Ga-DOTATATE, as well as Technetium-99m (99mTc)-DTPA scintigraphy, which necessitates an intact blood-tumor-permeability barrier. This paper presents a histopathologic proven atypical meningioma, WHO Grade II, with low level avidity on 68Ga-DOTATATE PET/MRI, subsequently proven to be SSTR2-negative by immunohistochemistry, with a review and discussion of the current literature and imaging implications. |
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Somatostatin receptor-2 negative meningioma: pathologic correlation and imaging implications |
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