Triterpenoids from the stems and leaves of Schisandra incarnata
Six undescribed triterpenoids, schincarins A‒F, categorized as the preschisanartane (schincarin A), 3,4-secocycloartane (schincarins B‒D), 3,4; 9,10-disecocycloartane (schincarin E), and 3,4-secolanostane (schincarin F) classes, along with twelve known analogues, were obtained from the stems and lea...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Zhou, Ming [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020transfer abstract |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: β-carotene isolated from the marine red alga, - Kavalappa, Yogendra Prasad ELSEVIER, 2018, the international journal of plant biochemistry and molecular biology : the official journal of the Phytochemical Society of Europe and the Phytochemical Society of North America, New York, NY [u.a.] |
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| Übergeordnetes Werk: |
volume:177 ; year:2020 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1016/j.phytochem.2020.112448 |
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ELV051025248 |
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| 520 | |a Six undescribed triterpenoids, schincarins A‒F, categorized as the preschisanartane (schincarin A), 3,4-secocycloartane (schincarins B‒D), 3,4; 9,10-disecocycloartane (schincarin E), and 3,4-secolanostane (schincarin F) classes, along with twelve known analogues, were obtained from the stems and leaves of Schisandra incarnata Stapf. Their structures were elucidated on the basis of extensive spectroscopic analyses. The absolute configuration of schincarin A was corroborated by analysis of the experimental ECD spectrum, and single-crystal X-ray diffraction with Mo Kα irradiation. Schincarin A represented the first example of preschisanartane-type triterpenoid with two oxa-bridged hemiketals. Among the selected compounds which were evaluated for immunosuppressive activities, schincarin C and kadsudilactone A showed potential inhibition against ConA-induced T-cell proliferation with IC50 values of 5.83 and 6.32 μM, and LPS-induced B cell proliferation with IC50 values of 10.21 and 11.49 μM, respectively. | ||
| 520 | |a Six undescribed triterpenoids, schincarins A‒F, categorized as the preschisanartane (schincarin A), 3,4-secocycloartane (schincarins B‒D), 3,4; 9,10-disecocycloartane (schincarin E), and 3,4-secolanostane (schincarin F) classes, along with twelve known analogues, were obtained from the stems and leaves of Schisandra incarnata Stapf. Their structures were elucidated on the basis of extensive spectroscopic analyses. The absolute configuration of schincarin A was corroborated by analysis of the experimental ECD spectrum, and single-crystal X-ray diffraction with Mo Kα irradiation. Schincarin A represented the first example of preschisanartane-type triterpenoid with two oxa-bridged hemiketals. Among the selected compounds which were evaluated for immunosuppressive activities, schincarin C and kadsudilactone A showed potential inhibition against ConA-induced T-cell proliferation with IC50 values of 5.83 and 6.32 μM, and LPS-induced B cell proliferation with IC50 values of 10.21 and 11.49 μM, respectively. | ||
| 650 | 7 | |a Immunosuppressive activity |2 Elsevier | |
| 650 | 7 | |a Triterpenoids |2 Elsevier | |
| 650 | 7 | |a Schisandra incarnata Stapf |2 Elsevier | |
| 650 | 7 | |a Schisandraceae |2 Elsevier | |
| 700 | 1 | |a Peng, Xiaogang |4 oth | |
| 700 | 1 | |a Zhou, Jia |4 oth | |
| 700 | 1 | |a Liu, Ye |4 oth | |
| 700 | 1 | |a Meng, Xianggao |4 oth | |
| 700 | 1 | |a Ruan, Hanli |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |n Elsevier Science |a Kavalappa, Yogendra Prasad ELSEVIER |t β-carotene isolated from the marine red alga, |d 2018 |d the international journal of plant biochemistry and molecular biology : the official journal of the Phytochemical Society of Europe and the Phytochemical Society of North America |g New York, NY [u.a.] |w (DE-627)ELV001360140 |
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10.1016/j.phytochem.2020.112448 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001098.pica (DE-627)ELV051025248 (ELSEVIER)S0031-9422(19)31130-6 DE-627 ger DE-627 rakwb eng 630 640 610 VZ Zhou, Ming verfasserin aut Triterpenoids from the stems and leaves of Schisandra incarnata 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Six undescribed triterpenoids, schincarins A‒F, categorized as the preschisanartane (schincarin A), 3,4-secocycloartane (schincarins B‒D), 3,4; 9,10-disecocycloartane (schincarin E), and 3,4-secolanostane (schincarin F) classes, along with twelve known analogues, were obtained from the stems and leaves of Schisandra incarnata Stapf. Their structures were elucidated on the basis of extensive spectroscopic analyses. The absolute configuration of schincarin A was corroborated by analysis of the experimental ECD spectrum, and single-crystal X-ray diffraction with Mo Kα irradiation. Schincarin A represented the first example of preschisanartane-type triterpenoid with two oxa-bridged hemiketals. Among the selected compounds which were evaluated for immunosuppressive activities, schincarin C and kadsudilactone A showed potential inhibition against ConA-induced T-cell proliferation with IC50 values of 5.83 and 6.32 μM, and LPS-induced B cell proliferation with IC50 values of 10.21 and 11.49 μM, respectively. Six undescribed triterpenoids, schincarins A‒F, categorized as the preschisanartane (schincarin A), 3,4-secocycloartane (schincarins B‒D), 3,4; 9,10-disecocycloartane (schincarin E), and 3,4-secolanostane (schincarin F) classes, along with twelve known analogues, were obtained from the stems and leaves of Schisandra incarnata Stapf. Their structures were elucidated on the basis of extensive spectroscopic analyses. The absolute configuration of schincarin A was corroborated by analysis of the experimental ECD spectrum, and single-crystal X-ray diffraction with Mo Kα irradiation. Schincarin A represented the first example of preschisanartane-type triterpenoid with two oxa-bridged hemiketals. Among the selected compounds which were evaluated for immunosuppressive activities, schincarin C and kadsudilactone A showed potential inhibition against ConA-induced T-cell proliferation with IC50 values of 5.83 and 6.32 μM, and LPS-induced B cell proliferation with IC50 values of 10.21 and 11.49 μM, respectively. Immunosuppressive activity Elsevier Triterpenoids Elsevier Schisandra incarnata Stapf Elsevier Schisandraceae Elsevier Peng, Xiaogang oth Zhou, Jia oth Liu, Ye oth Meng, Xianggao oth Ruan, Hanli oth Enthalten in Elsevier Science Kavalappa, Yogendra Prasad ELSEVIER β-carotene isolated from the marine red alga, 2018 the international journal of plant biochemistry and molecular biology : the official journal of the Phytochemical Society of Europe and the Phytochemical Society of North America New York, NY [u.a.] (DE-627)ELV001360140 volume:177 year:2020 pages:0 https://doi.org/10.1016/j.phytochem.2020.112448 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA AR 177 2020 0 |
| spelling |
10.1016/j.phytochem.2020.112448 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001098.pica (DE-627)ELV051025248 (ELSEVIER)S0031-9422(19)31130-6 DE-627 ger DE-627 rakwb eng 630 640 610 VZ Zhou, Ming verfasserin aut Triterpenoids from the stems and leaves of Schisandra incarnata 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Six undescribed triterpenoids, schincarins A‒F, categorized as the preschisanartane (schincarin A), 3,4-secocycloartane (schincarins B‒D), 3,4; 9,10-disecocycloartane (schincarin E), and 3,4-secolanostane (schincarin F) classes, along with twelve known analogues, were obtained from the stems and leaves of Schisandra incarnata Stapf. Their structures were elucidated on the basis of extensive spectroscopic analyses. The absolute configuration of schincarin A was corroborated by analysis of the experimental ECD spectrum, and single-crystal X-ray diffraction with Mo Kα irradiation. Schincarin A represented the first example of preschisanartane-type triterpenoid with two oxa-bridged hemiketals. Among the selected compounds which were evaluated for immunosuppressive activities, schincarin C and kadsudilactone A showed potential inhibition against ConA-induced T-cell proliferation with IC50 values of 5.83 and 6.32 μM, and LPS-induced B cell proliferation with IC50 values of 10.21 and 11.49 μM, respectively. Six undescribed triterpenoids, schincarins A‒F, categorized as the preschisanartane (schincarin A), 3,4-secocycloartane (schincarins B‒D), 3,4; 9,10-disecocycloartane (schincarin E), and 3,4-secolanostane (schincarin F) classes, along with twelve known analogues, were obtained from the stems and leaves of Schisandra incarnata Stapf. Their structures were elucidated on the basis of extensive spectroscopic analyses. The absolute configuration of schincarin A was corroborated by analysis of the experimental ECD spectrum, and single-crystal X-ray diffraction with Mo Kα irradiation. Schincarin A represented the first example of preschisanartane-type triterpenoid with two oxa-bridged hemiketals. Among the selected compounds which were evaluated for immunosuppressive activities, schincarin C and kadsudilactone A showed potential inhibition against ConA-induced T-cell proliferation with IC50 values of 5.83 and 6.32 μM, and LPS-induced B cell proliferation with IC50 values of 10.21 and 11.49 μM, respectively. Immunosuppressive activity Elsevier Triterpenoids Elsevier Schisandra incarnata Stapf Elsevier Schisandraceae Elsevier Peng, Xiaogang oth Zhou, Jia oth Liu, Ye oth Meng, Xianggao oth Ruan, Hanli oth Enthalten in Elsevier Science Kavalappa, Yogendra Prasad ELSEVIER β-carotene isolated from the marine red alga, 2018 the international journal of plant biochemistry and molecular biology : the official journal of the Phytochemical Society of Europe and the Phytochemical Society of North America New York, NY [u.a.] (DE-627)ELV001360140 volume:177 year:2020 pages:0 https://doi.org/10.1016/j.phytochem.2020.112448 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA AR 177 2020 0 |
| allfields_unstemmed |
10.1016/j.phytochem.2020.112448 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001098.pica (DE-627)ELV051025248 (ELSEVIER)S0031-9422(19)31130-6 DE-627 ger DE-627 rakwb eng 630 640 610 VZ Zhou, Ming verfasserin aut Triterpenoids from the stems and leaves of Schisandra incarnata 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Six undescribed triterpenoids, schincarins A‒F, categorized as the preschisanartane (schincarin A), 3,4-secocycloartane (schincarins B‒D), 3,4; 9,10-disecocycloartane (schincarin E), and 3,4-secolanostane (schincarin F) classes, along with twelve known analogues, were obtained from the stems and leaves of Schisandra incarnata Stapf. Their structures were elucidated on the basis of extensive spectroscopic analyses. The absolute configuration of schincarin A was corroborated by analysis of the experimental ECD spectrum, and single-crystal X-ray diffraction with Mo Kα irradiation. Schincarin A represented the first example of preschisanartane-type triterpenoid with two oxa-bridged hemiketals. Among the selected compounds which were evaluated for immunosuppressive activities, schincarin C and kadsudilactone A showed potential inhibition against ConA-induced T-cell proliferation with IC50 values of 5.83 and 6.32 μM, and LPS-induced B cell proliferation with IC50 values of 10.21 and 11.49 μM, respectively. Six undescribed triterpenoids, schincarins A‒F, categorized as the preschisanartane (schincarin A), 3,4-secocycloartane (schincarins B‒D), 3,4; 9,10-disecocycloartane (schincarin E), and 3,4-secolanostane (schincarin F) classes, along with twelve known analogues, were obtained from the stems and leaves of Schisandra incarnata Stapf. Their structures were elucidated on the basis of extensive spectroscopic analyses. The absolute configuration of schincarin A was corroborated by analysis of the experimental ECD spectrum, and single-crystal X-ray diffraction with Mo Kα irradiation. Schincarin A represented the first example of preschisanartane-type triterpenoid with two oxa-bridged hemiketals. Among the selected compounds which were evaluated for immunosuppressive activities, schincarin C and kadsudilactone A showed potential inhibition against ConA-induced T-cell proliferation with IC50 values of 5.83 and 6.32 μM, and LPS-induced B cell proliferation with IC50 values of 10.21 and 11.49 μM, respectively. Immunosuppressive activity Elsevier Triterpenoids Elsevier Schisandra incarnata Stapf Elsevier Schisandraceae Elsevier Peng, Xiaogang oth Zhou, Jia oth Liu, Ye oth Meng, Xianggao oth Ruan, Hanli oth Enthalten in Elsevier Science Kavalappa, Yogendra Prasad ELSEVIER β-carotene isolated from the marine red alga, 2018 the international journal of plant biochemistry and molecular biology : the official journal of the Phytochemical Society of Europe and the Phytochemical Society of North America New York, NY [u.a.] (DE-627)ELV001360140 volume:177 year:2020 pages:0 https://doi.org/10.1016/j.phytochem.2020.112448 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA AR 177 2020 0 |
| allfieldsGer |
10.1016/j.phytochem.2020.112448 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001098.pica (DE-627)ELV051025248 (ELSEVIER)S0031-9422(19)31130-6 DE-627 ger DE-627 rakwb eng 630 640 610 VZ Zhou, Ming verfasserin aut Triterpenoids from the stems and leaves of Schisandra incarnata 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Six undescribed triterpenoids, schincarins A‒F, categorized as the preschisanartane (schincarin A), 3,4-secocycloartane (schincarins B‒D), 3,4; 9,10-disecocycloartane (schincarin E), and 3,4-secolanostane (schincarin F) classes, along with twelve known analogues, were obtained from the stems and leaves of Schisandra incarnata Stapf. Their structures were elucidated on the basis of extensive spectroscopic analyses. The absolute configuration of schincarin A was corroborated by analysis of the experimental ECD spectrum, and single-crystal X-ray diffraction with Mo Kα irradiation. Schincarin A represented the first example of preschisanartane-type triterpenoid with two oxa-bridged hemiketals. Among the selected compounds which were evaluated for immunosuppressive activities, schincarin C and kadsudilactone A showed potential inhibition against ConA-induced T-cell proliferation with IC50 values of 5.83 and 6.32 μM, and LPS-induced B cell proliferation with IC50 values of 10.21 and 11.49 μM, respectively. Six undescribed triterpenoids, schincarins A‒F, categorized as the preschisanartane (schincarin A), 3,4-secocycloartane (schincarins B‒D), 3,4; 9,10-disecocycloartane (schincarin E), and 3,4-secolanostane (schincarin F) classes, along with twelve known analogues, were obtained from the stems and leaves of Schisandra incarnata Stapf. Their structures were elucidated on the basis of extensive spectroscopic analyses. The absolute configuration of schincarin A was corroborated by analysis of the experimental ECD spectrum, and single-crystal X-ray diffraction with Mo Kα irradiation. Schincarin A represented the first example of preschisanartane-type triterpenoid with two oxa-bridged hemiketals. Among the selected compounds which were evaluated for immunosuppressive activities, schincarin C and kadsudilactone A showed potential inhibition against ConA-induced T-cell proliferation with IC50 values of 5.83 and 6.32 μM, and LPS-induced B cell proliferation with IC50 values of 10.21 and 11.49 μM, respectively. Immunosuppressive activity Elsevier Triterpenoids Elsevier Schisandra incarnata Stapf Elsevier Schisandraceae Elsevier Peng, Xiaogang oth Zhou, Jia oth Liu, Ye oth Meng, Xianggao oth Ruan, Hanli oth Enthalten in Elsevier Science Kavalappa, Yogendra Prasad ELSEVIER β-carotene isolated from the marine red alga, 2018 the international journal of plant biochemistry and molecular biology : the official journal of the Phytochemical Society of Europe and the Phytochemical Society of North America New York, NY [u.a.] (DE-627)ELV001360140 volume:177 year:2020 pages:0 https://doi.org/10.1016/j.phytochem.2020.112448 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA AR 177 2020 0 |
| allfieldsSound |
10.1016/j.phytochem.2020.112448 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001098.pica (DE-627)ELV051025248 (ELSEVIER)S0031-9422(19)31130-6 DE-627 ger DE-627 rakwb eng 630 640 610 VZ Zhou, Ming verfasserin aut Triterpenoids from the stems and leaves of Schisandra incarnata 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Six undescribed triterpenoids, schincarins A‒F, categorized as the preschisanartane (schincarin A), 3,4-secocycloartane (schincarins B‒D), 3,4; 9,10-disecocycloartane (schincarin E), and 3,4-secolanostane (schincarin F) classes, along with twelve known analogues, were obtained from the stems and leaves of Schisandra incarnata Stapf. Their structures were elucidated on the basis of extensive spectroscopic analyses. The absolute configuration of schincarin A was corroborated by analysis of the experimental ECD spectrum, and single-crystal X-ray diffraction with Mo Kα irradiation. Schincarin A represented the first example of preschisanartane-type triterpenoid with two oxa-bridged hemiketals. Among the selected compounds which were evaluated for immunosuppressive activities, schincarin C and kadsudilactone A showed potential inhibition against ConA-induced T-cell proliferation with IC50 values of 5.83 and 6.32 μM, and LPS-induced B cell proliferation with IC50 values of 10.21 and 11.49 μM, respectively. Six undescribed triterpenoids, schincarins A‒F, categorized as the preschisanartane (schincarin A), 3,4-secocycloartane (schincarins B‒D), 3,4; 9,10-disecocycloartane (schincarin E), and 3,4-secolanostane (schincarin F) classes, along with twelve known analogues, were obtained from the stems and leaves of Schisandra incarnata Stapf. Their structures were elucidated on the basis of extensive spectroscopic analyses. The absolute configuration of schincarin A was corroborated by analysis of the experimental ECD spectrum, and single-crystal X-ray diffraction with Mo Kα irradiation. Schincarin A represented the first example of preschisanartane-type triterpenoid with two oxa-bridged hemiketals. Among the selected compounds which were evaluated for immunosuppressive activities, schincarin C and kadsudilactone A showed potential inhibition against ConA-induced T-cell proliferation with IC50 values of 5.83 and 6.32 μM, and LPS-induced B cell proliferation with IC50 values of 10.21 and 11.49 μM, respectively. Immunosuppressive activity Elsevier Triterpenoids Elsevier Schisandra incarnata Stapf Elsevier Schisandraceae Elsevier Peng, Xiaogang oth Zhou, Jia oth Liu, Ye oth Meng, Xianggao oth Ruan, Hanli oth Enthalten in Elsevier Science Kavalappa, Yogendra Prasad ELSEVIER β-carotene isolated from the marine red alga, 2018 the international journal of plant biochemistry and molecular biology : the official journal of the Phytochemical Society of Europe and the Phytochemical Society of North America New York, NY [u.a.] (DE-627)ELV001360140 volume:177 year:2020 pages:0 https://doi.org/10.1016/j.phytochem.2020.112448 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA AR 177 2020 0 |
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Enthalten in β-carotene isolated from the marine red alga, New York, NY [u.a.] volume:177 year:2020 pages:0 |
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Enthalten in β-carotene isolated from the marine red alga, New York, NY [u.a.] volume:177 year:2020 pages:0 |
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β-carotene isolated from the marine red alga, |
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Zhou, Ming @@aut@@ Peng, Xiaogang @@oth@@ Zhou, Jia @@oth@@ Liu, Ye @@oth@@ Meng, Xianggao @@oth@@ Ruan, Hanli @@oth@@ |
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Their structures were elucidated on the basis of extensive spectroscopic analyses. The absolute configuration of schincarin A was corroborated by analysis of the experimental ECD spectrum, and single-crystal X-ray diffraction with Mo Kα irradiation. Schincarin A represented the first example of preschisanartane-type triterpenoid with two oxa-bridged hemiketals. Among the selected compounds which were evaluated for immunosuppressive activities, schincarin C and kadsudilactone A showed potential inhibition against ConA-induced T-cell proliferation with IC50 values of 5.83 and 6.32 μM, and LPS-induced B cell proliferation with IC50 values of 10.21 and 11.49 μM, respectively.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Six undescribed triterpenoids, schincarins A‒F, categorized as the preschisanartane (schincarin A), 3,4-secocycloartane (schincarins B‒D), 3,4; 9,10-disecocycloartane (schincarin E), and 3,4-secolanostane (schincarin F) classes, along with twelve known analogues, were obtained from the stems and leaves of Schisandra incarnata Stapf. Their structures were elucidated on the basis of extensive spectroscopic analyses. The absolute configuration of schincarin A was corroborated by analysis of the experimental ECD spectrum, and single-crystal X-ray diffraction with Mo Kα irradiation. 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Triterpenoids from the stems and leaves of Schisandra incarnata |
| abstract |
Six undescribed triterpenoids, schincarins A‒F, categorized as the preschisanartane (schincarin A), 3,4-secocycloartane (schincarins B‒D), 3,4; 9,10-disecocycloartane (schincarin E), and 3,4-secolanostane (schincarin F) classes, along with twelve known analogues, were obtained from the stems and leaves of Schisandra incarnata Stapf. Their structures were elucidated on the basis of extensive spectroscopic analyses. The absolute configuration of schincarin A was corroborated by analysis of the experimental ECD spectrum, and single-crystal X-ray diffraction with Mo Kα irradiation. Schincarin A represented the first example of preschisanartane-type triterpenoid with two oxa-bridged hemiketals. Among the selected compounds which were evaluated for immunosuppressive activities, schincarin C and kadsudilactone A showed potential inhibition against ConA-induced T-cell proliferation with IC50 values of 5.83 and 6.32 μM, and LPS-induced B cell proliferation with IC50 values of 10.21 and 11.49 μM, respectively. |
| abstractGer |
Six undescribed triterpenoids, schincarins A‒F, categorized as the preschisanartane (schincarin A), 3,4-secocycloartane (schincarins B‒D), 3,4; 9,10-disecocycloartane (schincarin E), and 3,4-secolanostane (schincarin F) classes, along with twelve known analogues, were obtained from the stems and leaves of Schisandra incarnata Stapf. Their structures were elucidated on the basis of extensive spectroscopic analyses. The absolute configuration of schincarin A was corroborated by analysis of the experimental ECD spectrum, and single-crystal X-ray diffraction with Mo Kα irradiation. Schincarin A represented the first example of preschisanartane-type triterpenoid with two oxa-bridged hemiketals. Among the selected compounds which were evaluated for immunosuppressive activities, schincarin C and kadsudilactone A showed potential inhibition against ConA-induced T-cell proliferation with IC50 values of 5.83 and 6.32 μM, and LPS-induced B cell proliferation with IC50 values of 10.21 and 11.49 μM, respectively. |
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Six undescribed triterpenoids, schincarins A‒F, categorized as the preschisanartane (schincarin A), 3,4-secocycloartane (schincarins B‒D), 3,4; 9,10-disecocycloartane (schincarin E), and 3,4-secolanostane (schincarin F) classes, along with twelve known analogues, were obtained from the stems and leaves of Schisandra incarnata Stapf. Their structures were elucidated on the basis of extensive spectroscopic analyses. The absolute configuration of schincarin A was corroborated by analysis of the experimental ECD spectrum, and single-crystal X-ray diffraction with Mo Kα irradiation. Schincarin A represented the first example of preschisanartane-type triterpenoid with two oxa-bridged hemiketals. Among the selected compounds which were evaluated for immunosuppressive activities, schincarin C and kadsudilactone A showed potential inhibition against ConA-induced T-cell proliferation with IC50 values of 5.83 and 6.32 μM, and LPS-induced B cell proliferation with IC50 values of 10.21 and 11.49 μM, respectively. |
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