Influence of calcium phosphates incorporation into poly(lactic-co-glycolic acid) electrospun membranes for guided bone regeneration
In cases of bone critical size defects, a guided bone regeneration (GBR) membrane is used to promote space for bone reconstruction. Calcium phosphates have been widely added to these GBR membranes to increment bioactivity and osteoconduction; however, there is a lack of understanding of their effect...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
dos Santos, Vivian Inês [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020transfer abstract |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Patient and Graft Survival After Pre-emptive Versus Non-pre-emptive Kidney Transplantation: A Single-Center Experience From Turkey - 2013, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:179 ; year:2020 ; pages:0 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.polymdegradstab.2020.109253 |
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ELV051119188 |
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| 245 | 1 | 0 | |a Influence of calcium phosphates incorporation into poly(lactic-co-glycolic acid) electrospun membranes for guided bone regeneration |
| 264 | 1 | |c 2020transfer abstract | |
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| 520 | |a In cases of bone critical size defects, a guided bone regeneration (GBR) membrane is used to promote space for bone reconstruction. Calcium phosphates have been widely added to these GBR membranes to increment bioactivity and osteoconduction; however, there is a lack of understanding of their effects on the membranes' properties, other than the biological ones. Therefore, this study developed electrospun membranes of PLGA with additions of HAp (hydroxyapatite):β-TCP (β-tricalcium phosphate) in the proportions of 60:40, 70:30 and 85:15 to evaluate the additions' influence. Results have shown, as expected, that the incorporation of calcium phosphates improved osteoblastic size, spreading and migration into the highly porous membranes. Fibre diameters and crystallinity degrees were influenced differently by each phosphate proportion and their characteristics. The group with the lowest HAp:β-TCP ratio (60:40) had a significant difference in the degradation rate faster (aiding in the optimization of the degradation profile) and was the best in terms of osteoblastic behaviour. Additionally, an unprecedented degradation study has shown that the degradation process increased fibre diameters unexpectedly, a behaviour that was detailed and explained. Taken together, results have shown that the calcium phosphates incorporation, if used pointedly, can tune the membranes’ properties and the reconstruction of the anatomical bone. | ||
| 520 | |a In cases of bone critical size defects, a guided bone regeneration (GBR) membrane is used to promote space for bone reconstruction. Calcium phosphates have been widely added to these GBR membranes to increment bioactivity and osteoconduction; however, there is a lack of understanding of their effects on the membranes' properties, other than the biological ones. Therefore, this study developed electrospun membranes of PLGA with additions of HAp (hydroxyapatite):β-TCP (β-tricalcium phosphate) in the proportions of 60:40, 70:30 and 85:15 to evaluate the additions' influence. Results have shown, as expected, that the incorporation of calcium phosphates improved osteoblastic size, spreading and migration into the highly porous membranes. Fibre diameters and crystallinity degrees were influenced differently by each phosphate proportion and their characteristics. The group with the lowest HAp:β-TCP ratio (60:40) had a significant difference in the degradation rate faster (aiding in the optimization of the degradation profile) and was the best in terms of osteoblastic behaviour. Additionally, an unprecedented degradation study has shown that the degradation process increased fibre diameters unexpectedly, a behaviour that was detailed and explained. Taken together, results have shown that the calcium phosphates incorporation, if used pointedly, can tune the membranes’ properties and the reconstruction of the anatomical bone. | ||
| 650 | 7 | |a Degradation |2 Elsevier | |
| 650 | 7 | |a PLGA |2 Elsevier | |
| 650 | 7 | |a Electrospinning |2 Elsevier | |
| 650 | 7 | |a Membrane |2 Elsevier | |
| 650 | 7 | |a Calcium phosphate |2 Elsevier | |
| 650 | 7 | |a Guided bone regeneration |2 Elsevier | |
| 700 | 1 | |a Merlini, Claudia |4 oth | |
| 700 | 1 | |a Aragones, Águedo |4 oth | |
| 700 | 1 | |a Cesca, Karina |4 oth | |
| 700 | 1 | |a Fredel, Márcio Celso |4 oth | |
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10.1016/j.polymdegradstab.2020.109253 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001109.pica (DE-627)ELV051119188 (ELSEVIER)S0141-3910(20)30185-3 DE-627 ger DE-627 rakwb eng 610 VZ 550 VZ 38.86 bkl 43.50 bkl 58.51 bkl dos Santos, Vivian Inês verfasserin aut Influence of calcium phosphates incorporation into poly(lactic-co-glycolic acid) electrospun membranes for guided bone regeneration 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In cases of bone critical size defects, a guided bone regeneration (GBR) membrane is used to promote space for bone reconstruction. Calcium phosphates have been widely added to these GBR membranes to increment bioactivity and osteoconduction; however, there is a lack of understanding of their effects on the membranes' properties, other than the biological ones. Therefore, this study developed electrospun membranes of PLGA with additions of HAp (hydroxyapatite):β-TCP (β-tricalcium phosphate) in the proportions of 60:40, 70:30 and 85:15 to evaluate the additions' influence. Results have shown, as expected, that the incorporation of calcium phosphates improved osteoblastic size, spreading and migration into the highly porous membranes. Fibre diameters and crystallinity degrees were influenced differently by each phosphate proportion and their characteristics. The group with the lowest HAp:β-TCP ratio (60:40) had a significant difference in the degradation rate faster (aiding in the optimization of the degradation profile) and was the best in terms of osteoblastic behaviour. Additionally, an unprecedented degradation study has shown that the degradation process increased fibre diameters unexpectedly, a behaviour that was detailed and explained. Taken together, results have shown that the calcium phosphates incorporation, if used pointedly, can tune the membranes’ properties and the reconstruction of the anatomical bone. In cases of bone critical size defects, a guided bone regeneration (GBR) membrane is used to promote space for bone reconstruction. Calcium phosphates have been widely added to these GBR membranes to increment bioactivity and osteoconduction; however, there is a lack of understanding of their effects on the membranes' properties, other than the biological ones. Therefore, this study developed electrospun membranes of PLGA with additions of HAp (hydroxyapatite):β-TCP (β-tricalcium phosphate) in the proportions of 60:40, 70:30 and 85:15 to evaluate the additions' influence. Results have shown, as expected, that the incorporation of calcium phosphates improved osteoblastic size, spreading and migration into the highly porous membranes. Fibre diameters and crystallinity degrees were influenced differently by each phosphate proportion and their characteristics. The group with the lowest HAp:β-TCP ratio (60:40) had a significant difference in the degradation rate faster (aiding in the optimization of the degradation profile) and was the best in terms of osteoblastic behaviour. Additionally, an unprecedented degradation study has shown that the degradation process increased fibre diameters unexpectedly, a behaviour that was detailed and explained. Taken together, results have shown that the calcium phosphates incorporation, if used pointedly, can tune the membranes’ properties and the reconstruction of the anatomical bone. Degradation Elsevier PLGA Elsevier Electrospinning Elsevier Membrane Elsevier Calcium phosphate Elsevier Guided bone regeneration Elsevier Merlini, Claudia oth Aragones, Águedo oth Cesca, Karina oth Fredel, Márcio Celso oth Enthalten in Elsevier Science Patient and Graft Survival After Pre-emptive Versus Non-pre-emptive Kidney Transplantation: A Single-Center Experience From Turkey 2013 Amsterdam [u.a.] (DE-627)ELV016597362 volume:179 year:2020 pages:0 https://doi.org/10.1016/j.polymdegradstab.2020.109253 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO 38.86 Grundwasser VZ 43.50 Umweltbelastungen VZ 58.51 Abwassertechnik Wasseraufbereitung VZ AR 179 2020 0 |
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10.1016/j.polymdegradstab.2020.109253 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001109.pica (DE-627)ELV051119188 (ELSEVIER)S0141-3910(20)30185-3 DE-627 ger DE-627 rakwb eng 610 VZ 550 VZ 38.86 bkl 43.50 bkl 58.51 bkl dos Santos, Vivian Inês verfasserin aut Influence of calcium phosphates incorporation into poly(lactic-co-glycolic acid) electrospun membranes for guided bone regeneration 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In cases of bone critical size defects, a guided bone regeneration (GBR) membrane is used to promote space for bone reconstruction. Calcium phosphates have been widely added to these GBR membranes to increment bioactivity and osteoconduction; however, there is a lack of understanding of their effects on the membranes' properties, other than the biological ones. Therefore, this study developed electrospun membranes of PLGA with additions of HAp (hydroxyapatite):β-TCP (β-tricalcium phosphate) in the proportions of 60:40, 70:30 and 85:15 to evaluate the additions' influence. Results have shown, as expected, that the incorporation of calcium phosphates improved osteoblastic size, spreading and migration into the highly porous membranes. Fibre diameters and crystallinity degrees were influenced differently by each phosphate proportion and their characteristics. The group with the lowest HAp:β-TCP ratio (60:40) had a significant difference in the degradation rate faster (aiding in the optimization of the degradation profile) and was the best in terms of osteoblastic behaviour. Additionally, an unprecedented degradation study has shown that the degradation process increased fibre diameters unexpectedly, a behaviour that was detailed and explained. Taken together, results have shown that the calcium phosphates incorporation, if used pointedly, can tune the membranes’ properties and the reconstruction of the anatomical bone. In cases of bone critical size defects, a guided bone regeneration (GBR) membrane is used to promote space for bone reconstruction. Calcium phosphates have been widely added to these GBR membranes to increment bioactivity and osteoconduction; however, there is a lack of understanding of their effects on the membranes' properties, other than the biological ones. Therefore, this study developed electrospun membranes of PLGA with additions of HAp (hydroxyapatite):β-TCP (β-tricalcium phosphate) in the proportions of 60:40, 70:30 and 85:15 to evaluate the additions' influence. Results have shown, as expected, that the incorporation of calcium phosphates improved osteoblastic size, spreading and migration into the highly porous membranes. Fibre diameters and crystallinity degrees were influenced differently by each phosphate proportion and their characteristics. The group with the lowest HAp:β-TCP ratio (60:40) had a significant difference in the degradation rate faster (aiding in the optimization of the degradation profile) and was the best in terms of osteoblastic behaviour. Additionally, an unprecedented degradation study has shown that the degradation process increased fibre diameters unexpectedly, a behaviour that was detailed and explained. Taken together, results have shown that the calcium phosphates incorporation, if used pointedly, can tune the membranes’ properties and the reconstruction of the anatomical bone. Degradation Elsevier PLGA Elsevier Electrospinning Elsevier Membrane Elsevier Calcium phosphate Elsevier Guided bone regeneration Elsevier Merlini, Claudia oth Aragones, Águedo oth Cesca, Karina oth Fredel, Márcio Celso oth Enthalten in Elsevier Science Patient and Graft Survival After Pre-emptive Versus Non-pre-emptive Kidney Transplantation: A Single-Center Experience From Turkey 2013 Amsterdam [u.a.] (DE-627)ELV016597362 volume:179 year:2020 pages:0 https://doi.org/10.1016/j.polymdegradstab.2020.109253 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO 38.86 Grundwasser VZ 43.50 Umweltbelastungen VZ 58.51 Abwassertechnik Wasseraufbereitung VZ AR 179 2020 0 |
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10.1016/j.polymdegradstab.2020.109253 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001109.pica (DE-627)ELV051119188 (ELSEVIER)S0141-3910(20)30185-3 DE-627 ger DE-627 rakwb eng 610 VZ 550 VZ 38.86 bkl 43.50 bkl 58.51 bkl dos Santos, Vivian Inês verfasserin aut Influence of calcium phosphates incorporation into poly(lactic-co-glycolic acid) electrospun membranes for guided bone regeneration 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In cases of bone critical size defects, a guided bone regeneration (GBR) membrane is used to promote space for bone reconstruction. Calcium phosphates have been widely added to these GBR membranes to increment bioactivity and osteoconduction; however, there is a lack of understanding of their effects on the membranes' properties, other than the biological ones. Therefore, this study developed electrospun membranes of PLGA with additions of HAp (hydroxyapatite):β-TCP (β-tricalcium phosphate) in the proportions of 60:40, 70:30 and 85:15 to evaluate the additions' influence. Results have shown, as expected, that the incorporation of calcium phosphates improved osteoblastic size, spreading and migration into the highly porous membranes. Fibre diameters and crystallinity degrees were influenced differently by each phosphate proportion and their characteristics. The group with the lowest HAp:β-TCP ratio (60:40) had a significant difference in the degradation rate faster (aiding in the optimization of the degradation profile) and was the best in terms of osteoblastic behaviour. Additionally, an unprecedented degradation study has shown that the degradation process increased fibre diameters unexpectedly, a behaviour that was detailed and explained. Taken together, results have shown that the calcium phosphates incorporation, if used pointedly, can tune the membranes’ properties and the reconstruction of the anatomical bone. In cases of bone critical size defects, a guided bone regeneration (GBR) membrane is used to promote space for bone reconstruction. Calcium phosphates have been widely added to these GBR membranes to increment bioactivity and osteoconduction; however, there is a lack of understanding of their effects on the membranes' properties, other than the biological ones. Therefore, this study developed electrospun membranes of PLGA with additions of HAp (hydroxyapatite):β-TCP (β-tricalcium phosphate) in the proportions of 60:40, 70:30 and 85:15 to evaluate the additions' influence. Results have shown, as expected, that the incorporation of calcium phosphates improved osteoblastic size, spreading and migration into the highly porous membranes. Fibre diameters and crystallinity degrees were influenced differently by each phosphate proportion and their characteristics. The group with the lowest HAp:β-TCP ratio (60:40) had a significant difference in the degradation rate faster (aiding in the optimization of the degradation profile) and was the best in terms of osteoblastic behaviour. Additionally, an unprecedented degradation study has shown that the degradation process increased fibre diameters unexpectedly, a behaviour that was detailed and explained. Taken together, results have shown that the calcium phosphates incorporation, if used pointedly, can tune the membranes’ properties and the reconstruction of the anatomical bone. Degradation Elsevier PLGA Elsevier Electrospinning Elsevier Membrane Elsevier Calcium phosphate Elsevier Guided bone regeneration Elsevier Merlini, Claudia oth Aragones, Águedo oth Cesca, Karina oth Fredel, Márcio Celso oth Enthalten in Elsevier Science Patient and Graft Survival After Pre-emptive Versus Non-pre-emptive Kidney Transplantation: A Single-Center Experience From Turkey 2013 Amsterdam [u.a.] (DE-627)ELV016597362 volume:179 year:2020 pages:0 https://doi.org/10.1016/j.polymdegradstab.2020.109253 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO 38.86 Grundwasser VZ 43.50 Umweltbelastungen VZ 58.51 Abwassertechnik Wasseraufbereitung VZ AR 179 2020 0 |
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10.1016/j.polymdegradstab.2020.109253 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001109.pica (DE-627)ELV051119188 (ELSEVIER)S0141-3910(20)30185-3 DE-627 ger DE-627 rakwb eng 610 VZ 550 VZ 38.86 bkl 43.50 bkl 58.51 bkl dos Santos, Vivian Inês verfasserin aut Influence of calcium phosphates incorporation into poly(lactic-co-glycolic acid) electrospun membranes for guided bone regeneration 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In cases of bone critical size defects, a guided bone regeneration (GBR) membrane is used to promote space for bone reconstruction. Calcium phosphates have been widely added to these GBR membranes to increment bioactivity and osteoconduction; however, there is a lack of understanding of their effects on the membranes' properties, other than the biological ones. Therefore, this study developed electrospun membranes of PLGA with additions of HAp (hydroxyapatite):β-TCP (β-tricalcium phosphate) in the proportions of 60:40, 70:30 and 85:15 to evaluate the additions' influence. Results have shown, as expected, that the incorporation of calcium phosphates improved osteoblastic size, spreading and migration into the highly porous membranes. Fibre diameters and crystallinity degrees were influenced differently by each phosphate proportion and their characteristics. The group with the lowest HAp:β-TCP ratio (60:40) had a significant difference in the degradation rate faster (aiding in the optimization of the degradation profile) and was the best in terms of osteoblastic behaviour. Additionally, an unprecedented degradation study has shown that the degradation process increased fibre diameters unexpectedly, a behaviour that was detailed and explained. Taken together, results have shown that the calcium phosphates incorporation, if used pointedly, can tune the membranes’ properties and the reconstruction of the anatomical bone. In cases of bone critical size defects, a guided bone regeneration (GBR) membrane is used to promote space for bone reconstruction. Calcium phosphates have been widely added to these GBR membranes to increment bioactivity and osteoconduction; however, there is a lack of understanding of their effects on the membranes' properties, other than the biological ones. Therefore, this study developed electrospun membranes of PLGA with additions of HAp (hydroxyapatite):β-TCP (β-tricalcium phosphate) in the proportions of 60:40, 70:30 and 85:15 to evaluate the additions' influence. Results have shown, as expected, that the incorporation of calcium phosphates improved osteoblastic size, spreading and migration into the highly porous membranes. Fibre diameters and crystallinity degrees were influenced differently by each phosphate proportion and their characteristics. The group with the lowest HAp:β-TCP ratio (60:40) had a significant difference in the degradation rate faster (aiding in the optimization of the degradation profile) and was the best in terms of osteoblastic behaviour. Additionally, an unprecedented degradation study has shown that the degradation process increased fibre diameters unexpectedly, a behaviour that was detailed and explained. Taken together, results have shown that the calcium phosphates incorporation, if used pointedly, can tune the membranes’ properties and the reconstruction of the anatomical bone. Degradation Elsevier PLGA Elsevier Electrospinning Elsevier Membrane Elsevier Calcium phosphate Elsevier Guided bone regeneration Elsevier Merlini, Claudia oth Aragones, Águedo oth Cesca, Karina oth Fredel, Márcio Celso oth Enthalten in Elsevier Science Patient and Graft Survival After Pre-emptive Versus Non-pre-emptive Kidney Transplantation: A Single-Center Experience From Turkey 2013 Amsterdam [u.a.] (DE-627)ELV016597362 volume:179 year:2020 pages:0 https://doi.org/10.1016/j.polymdegradstab.2020.109253 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO 38.86 Grundwasser VZ 43.50 Umweltbelastungen VZ 58.51 Abwassertechnik Wasseraufbereitung VZ AR 179 2020 0 |
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10.1016/j.polymdegradstab.2020.109253 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001109.pica (DE-627)ELV051119188 (ELSEVIER)S0141-3910(20)30185-3 DE-627 ger DE-627 rakwb eng 610 VZ 550 VZ 38.86 bkl 43.50 bkl 58.51 bkl dos Santos, Vivian Inês verfasserin aut Influence of calcium phosphates incorporation into poly(lactic-co-glycolic acid) electrospun membranes for guided bone regeneration 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In cases of bone critical size defects, a guided bone regeneration (GBR) membrane is used to promote space for bone reconstruction. Calcium phosphates have been widely added to these GBR membranes to increment bioactivity and osteoconduction; however, there is a lack of understanding of their effects on the membranes' properties, other than the biological ones. Therefore, this study developed electrospun membranes of PLGA with additions of HAp (hydroxyapatite):β-TCP (β-tricalcium phosphate) in the proportions of 60:40, 70:30 and 85:15 to evaluate the additions' influence. Results have shown, as expected, that the incorporation of calcium phosphates improved osteoblastic size, spreading and migration into the highly porous membranes. Fibre diameters and crystallinity degrees were influenced differently by each phosphate proportion and their characteristics. The group with the lowest HAp:β-TCP ratio (60:40) had a significant difference in the degradation rate faster (aiding in the optimization of the degradation profile) and was the best in terms of osteoblastic behaviour. Additionally, an unprecedented degradation study has shown that the degradation process increased fibre diameters unexpectedly, a behaviour that was detailed and explained. Taken together, results have shown that the calcium phosphates incorporation, if used pointedly, can tune the membranes’ properties and the reconstruction of the anatomical bone. In cases of bone critical size defects, a guided bone regeneration (GBR) membrane is used to promote space for bone reconstruction. Calcium phosphates have been widely added to these GBR membranes to increment bioactivity and osteoconduction; however, there is a lack of understanding of their effects on the membranes' properties, other than the biological ones. Therefore, this study developed electrospun membranes of PLGA with additions of HAp (hydroxyapatite):β-TCP (β-tricalcium phosphate) in the proportions of 60:40, 70:30 and 85:15 to evaluate the additions' influence. Results have shown, as expected, that the incorporation of calcium phosphates improved osteoblastic size, spreading and migration into the highly porous membranes. Fibre diameters and crystallinity degrees were influenced differently by each phosphate proportion and their characteristics. The group with the lowest HAp:β-TCP ratio (60:40) had a significant difference in the degradation rate faster (aiding in the optimization of the degradation profile) and was the best in terms of osteoblastic behaviour. Additionally, an unprecedented degradation study has shown that the degradation process increased fibre diameters unexpectedly, a behaviour that was detailed and explained. Taken together, results have shown that the calcium phosphates incorporation, if used pointedly, can tune the membranes’ properties and the reconstruction of the anatomical bone. Degradation Elsevier PLGA Elsevier Electrospinning Elsevier Membrane Elsevier Calcium phosphate Elsevier Guided bone regeneration Elsevier Merlini, Claudia oth Aragones, Águedo oth Cesca, Karina oth Fredel, Márcio Celso oth Enthalten in Elsevier Science Patient and Graft Survival After Pre-emptive Versus Non-pre-emptive Kidney Transplantation: A Single-Center Experience From Turkey 2013 Amsterdam [u.a.] (DE-627)ELV016597362 volume:179 year:2020 pages:0 https://doi.org/10.1016/j.polymdegradstab.2020.109253 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO 38.86 Grundwasser VZ 43.50 Umweltbelastungen VZ 58.51 Abwassertechnik Wasseraufbereitung VZ AR 179 2020 0 |
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Enthalten in Patient and Graft Survival After Pre-emptive Versus Non-pre-emptive Kidney Transplantation: A Single-Center Experience From Turkey Amsterdam [u.a.] volume:179 year:2020 pages:0 |
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Patient and Graft Survival After Pre-emptive Versus Non-pre-emptive Kidney Transplantation: A Single-Center Experience From Turkey |
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Patient and Graft Survival After Pre-emptive Versus Non-pre-emptive Kidney Transplantation: A Single-Center Experience From Turkey |
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influence of calcium phosphates incorporation into poly(lactic-co-glycolic acid) electrospun membranes for guided bone regeneration |
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Influence of calcium phosphates incorporation into poly(lactic-co-glycolic acid) electrospun membranes for guided bone regeneration |
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In cases of bone critical size defects, a guided bone regeneration (GBR) membrane is used to promote space for bone reconstruction. Calcium phosphates have been widely added to these GBR membranes to increment bioactivity and osteoconduction; however, there is a lack of understanding of their effects on the membranes' properties, other than the biological ones. Therefore, this study developed electrospun membranes of PLGA with additions of HAp (hydroxyapatite):β-TCP (β-tricalcium phosphate) in the proportions of 60:40, 70:30 and 85:15 to evaluate the additions' influence. Results have shown, as expected, that the incorporation of calcium phosphates improved osteoblastic size, spreading and migration into the highly porous membranes. Fibre diameters and crystallinity degrees were influenced differently by each phosphate proportion and their characteristics. The group with the lowest HAp:β-TCP ratio (60:40) had a significant difference in the degradation rate faster (aiding in the optimization of the degradation profile) and was the best in terms of osteoblastic behaviour. Additionally, an unprecedented degradation study has shown that the degradation process increased fibre diameters unexpectedly, a behaviour that was detailed and explained. Taken together, results have shown that the calcium phosphates incorporation, if used pointedly, can tune the membranes’ properties and the reconstruction of the anatomical bone. |
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In cases of bone critical size defects, a guided bone regeneration (GBR) membrane is used to promote space for bone reconstruction. Calcium phosphates have been widely added to these GBR membranes to increment bioactivity and osteoconduction; however, there is a lack of understanding of their effects on the membranes' properties, other than the biological ones. Therefore, this study developed electrospun membranes of PLGA with additions of HAp (hydroxyapatite):β-TCP (β-tricalcium phosphate) in the proportions of 60:40, 70:30 and 85:15 to evaluate the additions' influence. Results have shown, as expected, that the incorporation of calcium phosphates improved osteoblastic size, spreading and migration into the highly porous membranes. Fibre diameters and crystallinity degrees were influenced differently by each phosphate proportion and their characteristics. The group with the lowest HAp:β-TCP ratio (60:40) had a significant difference in the degradation rate faster (aiding in the optimization of the degradation profile) and was the best in terms of osteoblastic behaviour. Additionally, an unprecedented degradation study has shown that the degradation process increased fibre diameters unexpectedly, a behaviour that was detailed and explained. Taken together, results have shown that the calcium phosphates incorporation, if used pointedly, can tune the membranes’ properties and the reconstruction of the anatomical bone. |
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In cases of bone critical size defects, a guided bone regeneration (GBR) membrane is used to promote space for bone reconstruction. Calcium phosphates have been widely added to these GBR membranes to increment bioactivity and osteoconduction; however, there is a lack of understanding of their effects on the membranes' properties, other than the biological ones. Therefore, this study developed electrospun membranes of PLGA with additions of HAp (hydroxyapatite):β-TCP (β-tricalcium phosphate) in the proportions of 60:40, 70:30 and 85:15 to evaluate the additions' influence. Results have shown, as expected, that the incorporation of calcium phosphates improved osteoblastic size, spreading and migration into the highly porous membranes. Fibre diameters and crystallinity degrees were influenced differently by each phosphate proportion and their characteristics. The group with the lowest HAp:β-TCP ratio (60:40) had a significant difference in the degradation rate faster (aiding in the optimization of the degradation profile) and was the best in terms of osteoblastic behaviour. Additionally, an unprecedented degradation study has shown that the degradation process increased fibre diameters unexpectedly, a behaviour that was detailed and explained. Taken together, results have shown that the calcium phosphates incorporation, if used pointedly, can tune the membranes’ properties and the reconstruction of the anatomical bone. |
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