Syringic and cinnamic acids antiradical/antioxidant activities as R. ferruginea extract components and membrane physico-chemical influence
Syringic and cinnamic acids were previously identified as the major components on Rapanea ferruginea′s leaf extract. In this work, these phenolic acids were investigated and correlated in two aspects. The first one was referred to their role against DPPH and hydroxyl radicals, considering the concen...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Magalhães dos Santos, Desirée [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020transfer abstract |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Artificial neural network modelling of amido black dye sorption on iron composite nano material: Kinetics and thermodynamics studies - Ali, Imran ELSEVIER, 2017, New York, NY [u.a.] |
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| Übergeordnetes Werk: |
volume:1220 ; year:2020 ; day:15 ; month:11 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1016/j.molstruc.2020.128749 |
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ELV05134842X |
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| 245 | 1 | 0 | |a Syringic and cinnamic acids antiradical/antioxidant activities as R. ferruginea extract components and membrane physico-chemical influence |
| 264 | 1 | |c 2020transfer abstract | |
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| 520 | |a Syringic and cinnamic acids were previously identified as the major components on Rapanea ferruginea′s leaf extract. In this work, these phenolic acids were investigated and correlated in two aspects. The first one was referred to their role against DPPH and hydroxyl radicals, considering the concentration detected in R. ferruginea extract. The second one considered their effects on the physico-chemical properties of soy asolectin liposomes, such as hydration degree, trans-gauche isomerization, vibrational, rotational and translational motions, state-of-phase, size and surface charge. The half-maximum inhibitory concentration (IC50) related to syringic acid in DPPH assays was detected as 7.36 × 10−3 mM. At the cinnamic acid highest tested concentration (8.23 × 10−3 mM), the activity against DPPH was around 4.6%. Regarding hydroxyl radical-induced lipid peroxidation, the IC50 detected for syringic acid free in solution (free-form) was equivalent to 0.082 × 10−3 mM, a value 3.6 times lower than the detected for its liposome-loaded form. At the highest tested concentration (0.24 × 10−3 mM), the free-form cinnamic acid inhibited lipid peroxidation by 4 times the observed to its liposome-loaded form. Results showed that hydrogen donation is not the preferential mechanism in which the tested phenolic acids inhibit hydroxyl radical-induced lipid peroxidation. Syringic acid showed higher antioxidant potential than cinnamic acid, probably having a primordial role in the properties related to R. ferruginea. Liposomes’ physico-chemical data provided correlations between the phenolic acids’ antioxidant potential and their influence in the mobility of specific lipid groups. The findings of this work will contribute to the design and development of phenolic acids-based and plant extract-based pharmacological systems. | ||
| 520 | |a Syringic and cinnamic acids were previously identified as the major components on Rapanea ferruginea′s leaf extract. In this work, these phenolic acids were investigated and correlated in two aspects. The first one was referred to their role against DPPH and hydroxyl radicals, considering the concentration detected in R. ferruginea extract. The second one considered their effects on the physico-chemical properties of soy asolectin liposomes, such as hydration degree, trans-gauche isomerization, vibrational, rotational and translational motions, state-of-phase, size and surface charge. The half-maximum inhibitory concentration (IC50) related to syringic acid in DPPH assays was detected as 7.36 × 10−3 mM. At the cinnamic acid highest tested concentration (8.23 × 10−3 mM), the activity against DPPH was around 4.6%. Regarding hydroxyl radical-induced lipid peroxidation, the IC50 detected for syringic acid free in solution (free-form) was equivalent to 0.082 × 10−3 mM, a value 3.6 times lower than the detected for its liposome-loaded form. At the highest tested concentration (0.24 × 10−3 mM), the free-form cinnamic acid inhibited lipid peroxidation by 4 times the observed to its liposome-loaded form. Results showed that hydrogen donation is not the preferential mechanism in which the tested phenolic acids inhibit hydroxyl radical-induced lipid peroxidation. Syringic acid showed higher antioxidant potential than cinnamic acid, probably having a primordial role in the properties related to R. ferruginea. Liposomes’ physico-chemical data provided correlations between the phenolic acids’ antioxidant potential and their influence in the mobility of specific lipid groups. The findings of this work will contribute to the design and development of phenolic acids-based and plant extract-based pharmacological systems. | ||
| 650 | 7 | |a Syringic acid |2 Elsevier | |
| 650 | 7 | |a Cinnamic acid |2 Elsevier | |
| 650 | 7 | |a antiradical Activity |2 Elsevier | |
| 650 | 7 | |a R. ferruginea |2 Elsevier | |
| 650 | 7 | |a Liposomes |2 Elsevier | |
| 700 | 1 | |a Sanches, Mariele Paludetto |4 oth | |
| 700 | 1 | |a Poffo, Claudio Michel |4 oth | |
| 700 | 1 | |a Parize, Alexandre Luís |4 oth | |
| 700 | 1 | |a Sagrera Darelli, Gabriel Jorge |4 oth | |
| 700 | 1 | |a Rodrigues de Lima, Vânia |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |n Elsevier |a Ali, Imran ELSEVIER |t Artificial neural network modelling of amido black dye sorption on iron composite nano material: Kinetics and thermodynamics studies |d 2017 |g New York, NY [u.a.] |w (DE-627)ELV005044758 |
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10.1016/j.molstruc.2020.128749 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001963.pica (DE-627)ELV05134842X (ELSEVIER)S0022-2860(20)31074-7 DE-627 ger DE-627 rakwb eng 540 VZ 35.21 bkl Magalhães dos Santos, Desirée verfasserin aut Syringic and cinnamic acids antiradical/antioxidant activities as R. ferruginea extract components and membrane physico-chemical influence 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Syringic and cinnamic acids were previously identified as the major components on Rapanea ferruginea′s leaf extract. In this work, these phenolic acids were investigated and correlated in two aspects. The first one was referred to their role against DPPH and hydroxyl radicals, considering the concentration detected in R. ferruginea extract. The second one considered their effects on the physico-chemical properties of soy asolectin liposomes, such as hydration degree, trans-gauche isomerization, vibrational, rotational and translational motions, state-of-phase, size and surface charge. The half-maximum inhibitory concentration (IC50) related to syringic acid in DPPH assays was detected as 7.36 × 10−3 mM. At the cinnamic acid highest tested concentration (8.23 × 10−3 mM), the activity against DPPH was around 4.6%. Regarding hydroxyl radical-induced lipid peroxidation, the IC50 detected for syringic acid free in solution (free-form) was equivalent to 0.082 × 10−3 mM, a value 3.6 times lower than the detected for its liposome-loaded form. At the highest tested concentration (0.24 × 10−3 mM), the free-form cinnamic acid inhibited lipid peroxidation by 4 times the observed to its liposome-loaded form. Results showed that hydrogen donation is not the preferential mechanism in which the tested phenolic acids inhibit hydroxyl radical-induced lipid peroxidation. Syringic acid showed higher antioxidant potential than cinnamic acid, probably having a primordial role in the properties related to R. ferruginea. Liposomes’ physico-chemical data provided correlations between the phenolic acids’ antioxidant potential and their influence in the mobility of specific lipid groups. The findings of this work will contribute to the design and development of phenolic acids-based and plant extract-based pharmacological systems. Syringic and cinnamic acids were previously identified as the major components on Rapanea ferruginea′s leaf extract. In this work, these phenolic acids were investigated and correlated in two aspects. The first one was referred to their role against DPPH and hydroxyl radicals, considering the concentration detected in R. ferruginea extract. The second one considered their effects on the physico-chemical properties of soy asolectin liposomes, such as hydration degree, trans-gauche isomerization, vibrational, rotational and translational motions, state-of-phase, size and surface charge. The half-maximum inhibitory concentration (IC50) related to syringic acid in DPPH assays was detected as 7.36 × 10−3 mM. At the cinnamic acid highest tested concentration (8.23 × 10−3 mM), the activity against DPPH was around 4.6%. Regarding hydroxyl radical-induced lipid peroxidation, the IC50 detected for syringic acid free in solution (free-form) was equivalent to 0.082 × 10−3 mM, a value 3.6 times lower than the detected for its liposome-loaded form. At the highest tested concentration (0.24 × 10−3 mM), the free-form cinnamic acid inhibited lipid peroxidation by 4 times the observed to its liposome-loaded form. Results showed that hydrogen donation is not the preferential mechanism in which the tested phenolic acids inhibit hydroxyl radical-induced lipid peroxidation. Syringic acid showed higher antioxidant potential than cinnamic acid, probably having a primordial role in the properties related to R. ferruginea. Liposomes’ physico-chemical data provided correlations between the phenolic acids’ antioxidant potential and their influence in the mobility of specific lipid groups. The findings of this work will contribute to the design and development of phenolic acids-based and plant extract-based pharmacological systems. Syringic acid Elsevier Cinnamic acid Elsevier antiradical Activity Elsevier R. ferruginea Elsevier Liposomes Elsevier Sanches, Mariele Paludetto oth Poffo, Claudio Michel oth Parize, Alexandre Luís oth Sagrera Darelli, Gabriel Jorge oth Rodrigues de Lima, Vânia oth Enthalten in Elsevier Ali, Imran ELSEVIER Artificial neural network modelling of amido black dye sorption on iron composite nano material: Kinetics and thermodynamics studies 2017 New York, NY [u.a.] (DE-627)ELV005044758 volume:1220 year:2020 day:15 month:11 pages:0 https://doi.org/10.1016/j.molstruc.2020.128749 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 35.21 Lösungen Flüssigkeiten Physikalische Chemie VZ AR 1220 2020 15 1115 0 |
| spelling |
10.1016/j.molstruc.2020.128749 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001963.pica (DE-627)ELV05134842X (ELSEVIER)S0022-2860(20)31074-7 DE-627 ger DE-627 rakwb eng 540 VZ 35.21 bkl Magalhães dos Santos, Desirée verfasserin aut Syringic and cinnamic acids antiradical/antioxidant activities as R. ferruginea extract components and membrane physico-chemical influence 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Syringic and cinnamic acids were previously identified as the major components on Rapanea ferruginea′s leaf extract. In this work, these phenolic acids were investigated and correlated in two aspects. The first one was referred to their role against DPPH and hydroxyl radicals, considering the concentration detected in R. ferruginea extract. The second one considered their effects on the physico-chemical properties of soy asolectin liposomes, such as hydration degree, trans-gauche isomerization, vibrational, rotational and translational motions, state-of-phase, size and surface charge. The half-maximum inhibitory concentration (IC50) related to syringic acid in DPPH assays was detected as 7.36 × 10−3 mM. At the cinnamic acid highest tested concentration (8.23 × 10−3 mM), the activity against DPPH was around 4.6%. Regarding hydroxyl radical-induced lipid peroxidation, the IC50 detected for syringic acid free in solution (free-form) was equivalent to 0.082 × 10−3 mM, a value 3.6 times lower than the detected for its liposome-loaded form. At the highest tested concentration (0.24 × 10−3 mM), the free-form cinnamic acid inhibited lipid peroxidation by 4 times the observed to its liposome-loaded form. Results showed that hydrogen donation is not the preferential mechanism in which the tested phenolic acids inhibit hydroxyl radical-induced lipid peroxidation. Syringic acid showed higher antioxidant potential than cinnamic acid, probably having a primordial role in the properties related to R. ferruginea. Liposomes’ physico-chemical data provided correlations between the phenolic acids’ antioxidant potential and their influence in the mobility of specific lipid groups. The findings of this work will contribute to the design and development of phenolic acids-based and plant extract-based pharmacological systems. Syringic and cinnamic acids were previously identified as the major components on Rapanea ferruginea′s leaf extract. In this work, these phenolic acids were investigated and correlated in two aspects. The first one was referred to their role against DPPH and hydroxyl radicals, considering the concentration detected in R. ferruginea extract. The second one considered their effects on the physico-chemical properties of soy asolectin liposomes, such as hydration degree, trans-gauche isomerization, vibrational, rotational and translational motions, state-of-phase, size and surface charge. The half-maximum inhibitory concentration (IC50) related to syringic acid in DPPH assays was detected as 7.36 × 10−3 mM. At the cinnamic acid highest tested concentration (8.23 × 10−3 mM), the activity against DPPH was around 4.6%. Regarding hydroxyl radical-induced lipid peroxidation, the IC50 detected for syringic acid free in solution (free-form) was equivalent to 0.082 × 10−3 mM, a value 3.6 times lower than the detected for its liposome-loaded form. At the highest tested concentration (0.24 × 10−3 mM), the free-form cinnamic acid inhibited lipid peroxidation by 4 times the observed to its liposome-loaded form. Results showed that hydrogen donation is not the preferential mechanism in which the tested phenolic acids inhibit hydroxyl radical-induced lipid peroxidation. Syringic acid showed higher antioxidant potential than cinnamic acid, probably having a primordial role in the properties related to R. ferruginea. Liposomes’ physico-chemical data provided correlations between the phenolic acids’ antioxidant potential and their influence in the mobility of specific lipid groups. The findings of this work will contribute to the design and development of phenolic acids-based and plant extract-based pharmacological systems. Syringic acid Elsevier Cinnamic acid Elsevier antiradical Activity Elsevier R. ferruginea Elsevier Liposomes Elsevier Sanches, Mariele Paludetto oth Poffo, Claudio Michel oth Parize, Alexandre Luís oth Sagrera Darelli, Gabriel Jorge oth Rodrigues de Lima, Vânia oth Enthalten in Elsevier Ali, Imran ELSEVIER Artificial neural network modelling of amido black dye sorption on iron composite nano material: Kinetics and thermodynamics studies 2017 New York, NY [u.a.] (DE-627)ELV005044758 volume:1220 year:2020 day:15 month:11 pages:0 https://doi.org/10.1016/j.molstruc.2020.128749 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 35.21 Lösungen Flüssigkeiten Physikalische Chemie VZ AR 1220 2020 15 1115 0 |
| allfields_unstemmed |
10.1016/j.molstruc.2020.128749 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001963.pica (DE-627)ELV05134842X (ELSEVIER)S0022-2860(20)31074-7 DE-627 ger DE-627 rakwb eng 540 VZ 35.21 bkl Magalhães dos Santos, Desirée verfasserin aut Syringic and cinnamic acids antiradical/antioxidant activities as R. ferruginea extract components and membrane physico-chemical influence 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Syringic and cinnamic acids were previously identified as the major components on Rapanea ferruginea′s leaf extract. In this work, these phenolic acids were investigated and correlated in two aspects. The first one was referred to their role against DPPH and hydroxyl radicals, considering the concentration detected in R. ferruginea extract. The second one considered their effects on the physico-chemical properties of soy asolectin liposomes, such as hydration degree, trans-gauche isomerization, vibrational, rotational and translational motions, state-of-phase, size and surface charge. The half-maximum inhibitory concentration (IC50) related to syringic acid in DPPH assays was detected as 7.36 × 10−3 mM. At the cinnamic acid highest tested concentration (8.23 × 10−3 mM), the activity against DPPH was around 4.6%. Regarding hydroxyl radical-induced lipid peroxidation, the IC50 detected for syringic acid free in solution (free-form) was equivalent to 0.082 × 10−3 mM, a value 3.6 times lower than the detected for its liposome-loaded form. At the highest tested concentration (0.24 × 10−3 mM), the free-form cinnamic acid inhibited lipid peroxidation by 4 times the observed to its liposome-loaded form. Results showed that hydrogen donation is not the preferential mechanism in which the tested phenolic acids inhibit hydroxyl radical-induced lipid peroxidation. Syringic acid showed higher antioxidant potential than cinnamic acid, probably having a primordial role in the properties related to R. ferruginea. Liposomes’ physico-chemical data provided correlations between the phenolic acids’ antioxidant potential and their influence in the mobility of specific lipid groups. The findings of this work will contribute to the design and development of phenolic acids-based and plant extract-based pharmacological systems. Syringic and cinnamic acids were previously identified as the major components on Rapanea ferruginea′s leaf extract. In this work, these phenolic acids were investigated and correlated in two aspects. The first one was referred to their role against DPPH and hydroxyl radicals, considering the concentration detected in R. ferruginea extract. The second one considered their effects on the physico-chemical properties of soy asolectin liposomes, such as hydration degree, trans-gauche isomerization, vibrational, rotational and translational motions, state-of-phase, size and surface charge. The half-maximum inhibitory concentration (IC50) related to syringic acid in DPPH assays was detected as 7.36 × 10−3 mM. At the cinnamic acid highest tested concentration (8.23 × 10−3 mM), the activity against DPPH was around 4.6%. Regarding hydroxyl radical-induced lipid peroxidation, the IC50 detected for syringic acid free in solution (free-form) was equivalent to 0.082 × 10−3 mM, a value 3.6 times lower than the detected for its liposome-loaded form. At the highest tested concentration (0.24 × 10−3 mM), the free-form cinnamic acid inhibited lipid peroxidation by 4 times the observed to its liposome-loaded form. Results showed that hydrogen donation is not the preferential mechanism in which the tested phenolic acids inhibit hydroxyl radical-induced lipid peroxidation. Syringic acid showed higher antioxidant potential than cinnamic acid, probably having a primordial role in the properties related to R. ferruginea. Liposomes’ physico-chemical data provided correlations between the phenolic acids’ antioxidant potential and their influence in the mobility of specific lipid groups. The findings of this work will contribute to the design and development of phenolic acids-based and plant extract-based pharmacological systems. Syringic acid Elsevier Cinnamic acid Elsevier antiradical Activity Elsevier R. ferruginea Elsevier Liposomes Elsevier Sanches, Mariele Paludetto oth Poffo, Claudio Michel oth Parize, Alexandre Luís oth Sagrera Darelli, Gabriel Jorge oth Rodrigues de Lima, Vânia oth Enthalten in Elsevier Ali, Imran ELSEVIER Artificial neural network modelling of amido black dye sorption on iron composite nano material: Kinetics and thermodynamics studies 2017 New York, NY [u.a.] (DE-627)ELV005044758 volume:1220 year:2020 day:15 month:11 pages:0 https://doi.org/10.1016/j.molstruc.2020.128749 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 35.21 Lösungen Flüssigkeiten Physikalische Chemie VZ AR 1220 2020 15 1115 0 |
| allfieldsGer |
10.1016/j.molstruc.2020.128749 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001963.pica (DE-627)ELV05134842X (ELSEVIER)S0022-2860(20)31074-7 DE-627 ger DE-627 rakwb eng 540 VZ 35.21 bkl Magalhães dos Santos, Desirée verfasserin aut Syringic and cinnamic acids antiradical/antioxidant activities as R. ferruginea extract components and membrane physico-chemical influence 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Syringic and cinnamic acids were previously identified as the major components on Rapanea ferruginea′s leaf extract. In this work, these phenolic acids were investigated and correlated in two aspects. The first one was referred to their role against DPPH and hydroxyl radicals, considering the concentration detected in R. ferruginea extract. The second one considered their effects on the physico-chemical properties of soy asolectin liposomes, such as hydration degree, trans-gauche isomerization, vibrational, rotational and translational motions, state-of-phase, size and surface charge. The half-maximum inhibitory concentration (IC50) related to syringic acid in DPPH assays was detected as 7.36 × 10−3 mM. At the cinnamic acid highest tested concentration (8.23 × 10−3 mM), the activity against DPPH was around 4.6%. Regarding hydroxyl radical-induced lipid peroxidation, the IC50 detected for syringic acid free in solution (free-form) was equivalent to 0.082 × 10−3 mM, a value 3.6 times lower than the detected for its liposome-loaded form. At the highest tested concentration (0.24 × 10−3 mM), the free-form cinnamic acid inhibited lipid peroxidation by 4 times the observed to its liposome-loaded form. Results showed that hydrogen donation is not the preferential mechanism in which the tested phenolic acids inhibit hydroxyl radical-induced lipid peroxidation. Syringic acid showed higher antioxidant potential than cinnamic acid, probably having a primordial role in the properties related to R. ferruginea. Liposomes’ physico-chemical data provided correlations between the phenolic acids’ antioxidant potential and their influence in the mobility of specific lipid groups. The findings of this work will contribute to the design and development of phenolic acids-based and plant extract-based pharmacological systems. Syringic and cinnamic acids were previously identified as the major components on Rapanea ferruginea′s leaf extract. In this work, these phenolic acids were investigated and correlated in two aspects. The first one was referred to their role against DPPH and hydroxyl radicals, considering the concentration detected in R. ferruginea extract. The second one considered their effects on the physico-chemical properties of soy asolectin liposomes, such as hydration degree, trans-gauche isomerization, vibrational, rotational and translational motions, state-of-phase, size and surface charge. The half-maximum inhibitory concentration (IC50) related to syringic acid in DPPH assays was detected as 7.36 × 10−3 mM. At the cinnamic acid highest tested concentration (8.23 × 10−3 mM), the activity against DPPH was around 4.6%. Regarding hydroxyl radical-induced lipid peroxidation, the IC50 detected for syringic acid free in solution (free-form) was equivalent to 0.082 × 10−3 mM, a value 3.6 times lower than the detected for its liposome-loaded form. At the highest tested concentration (0.24 × 10−3 mM), the free-form cinnamic acid inhibited lipid peroxidation by 4 times the observed to its liposome-loaded form. Results showed that hydrogen donation is not the preferential mechanism in which the tested phenolic acids inhibit hydroxyl radical-induced lipid peroxidation. Syringic acid showed higher antioxidant potential than cinnamic acid, probably having a primordial role in the properties related to R. ferruginea. Liposomes’ physico-chemical data provided correlations between the phenolic acids’ antioxidant potential and their influence in the mobility of specific lipid groups. The findings of this work will contribute to the design and development of phenolic acids-based and plant extract-based pharmacological systems. Syringic acid Elsevier Cinnamic acid Elsevier antiradical Activity Elsevier R. ferruginea Elsevier Liposomes Elsevier Sanches, Mariele Paludetto oth Poffo, Claudio Michel oth Parize, Alexandre Luís oth Sagrera Darelli, Gabriel Jorge oth Rodrigues de Lima, Vânia oth Enthalten in Elsevier Ali, Imran ELSEVIER Artificial neural network modelling of amido black dye sorption on iron composite nano material: Kinetics and thermodynamics studies 2017 New York, NY [u.a.] (DE-627)ELV005044758 volume:1220 year:2020 day:15 month:11 pages:0 https://doi.org/10.1016/j.molstruc.2020.128749 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 35.21 Lösungen Flüssigkeiten Physikalische Chemie VZ AR 1220 2020 15 1115 0 |
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10.1016/j.molstruc.2020.128749 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001963.pica (DE-627)ELV05134842X (ELSEVIER)S0022-2860(20)31074-7 DE-627 ger DE-627 rakwb eng 540 VZ 35.21 bkl Magalhães dos Santos, Desirée verfasserin aut Syringic and cinnamic acids antiradical/antioxidant activities as R. ferruginea extract components and membrane physico-chemical influence 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Syringic and cinnamic acids were previously identified as the major components on Rapanea ferruginea′s leaf extract. In this work, these phenolic acids were investigated and correlated in two aspects. The first one was referred to their role against DPPH and hydroxyl radicals, considering the concentration detected in R. ferruginea extract. The second one considered their effects on the physico-chemical properties of soy asolectin liposomes, such as hydration degree, trans-gauche isomerization, vibrational, rotational and translational motions, state-of-phase, size and surface charge. The half-maximum inhibitory concentration (IC50) related to syringic acid in DPPH assays was detected as 7.36 × 10−3 mM. At the cinnamic acid highest tested concentration (8.23 × 10−3 mM), the activity against DPPH was around 4.6%. Regarding hydroxyl radical-induced lipid peroxidation, the IC50 detected for syringic acid free in solution (free-form) was equivalent to 0.082 × 10−3 mM, a value 3.6 times lower than the detected for its liposome-loaded form. At the highest tested concentration (0.24 × 10−3 mM), the free-form cinnamic acid inhibited lipid peroxidation by 4 times the observed to its liposome-loaded form. Results showed that hydrogen donation is not the preferential mechanism in which the tested phenolic acids inhibit hydroxyl radical-induced lipid peroxidation. Syringic acid showed higher antioxidant potential than cinnamic acid, probably having a primordial role in the properties related to R. ferruginea. Liposomes’ physico-chemical data provided correlations between the phenolic acids’ antioxidant potential and their influence in the mobility of specific lipid groups. The findings of this work will contribute to the design and development of phenolic acids-based and plant extract-based pharmacological systems. Syringic and cinnamic acids were previously identified as the major components on Rapanea ferruginea′s leaf extract. In this work, these phenolic acids were investigated and correlated in two aspects. The first one was referred to their role against DPPH and hydroxyl radicals, considering the concentration detected in R. ferruginea extract. The second one considered their effects on the physico-chemical properties of soy asolectin liposomes, such as hydration degree, trans-gauche isomerization, vibrational, rotational and translational motions, state-of-phase, size and surface charge. The half-maximum inhibitory concentration (IC50) related to syringic acid in DPPH assays was detected as 7.36 × 10−3 mM. At the cinnamic acid highest tested concentration (8.23 × 10−3 mM), the activity against DPPH was around 4.6%. Regarding hydroxyl radical-induced lipid peroxidation, the IC50 detected for syringic acid free in solution (free-form) was equivalent to 0.082 × 10−3 mM, a value 3.6 times lower than the detected for its liposome-loaded form. At the highest tested concentration (0.24 × 10−3 mM), the free-form cinnamic acid inhibited lipid peroxidation by 4 times the observed to its liposome-loaded form. Results showed that hydrogen donation is not the preferential mechanism in which the tested phenolic acids inhibit hydroxyl radical-induced lipid peroxidation. Syringic acid showed higher antioxidant potential than cinnamic acid, probably having a primordial role in the properties related to R. ferruginea. Liposomes’ physico-chemical data provided correlations between the phenolic acids’ antioxidant potential and their influence in the mobility of specific lipid groups. The findings of this work will contribute to the design and development of phenolic acids-based and plant extract-based pharmacological systems. Syringic acid Elsevier Cinnamic acid Elsevier antiradical Activity Elsevier R. ferruginea Elsevier Liposomes Elsevier Sanches, Mariele Paludetto oth Poffo, Claudio Michel oth Parize, Alexandre Luís oth Sagrera Darelli, Gabriel Jorge oth Rodrigues de Lima, Vânia oth Enthalten in Elsevier Ali, Imran ELSEVIER Artificial neural network modelling of amido black dye sorption on iron composite nano material: Kinetics and thermodynamics studies 2017 New York, NY [u.a.] (DE-627)ELV005044758 volume:1220 year:2020 day:15 month:11 pages:0 https://doi.org/10.1016/j.molstruc.2020.128749 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 35.21 Lösungen Flüssigkeiten Physikalische Chemie VZ AR 1220 2020 15 1115 0 |
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Syringic and cinnamic acids antiradical/antioxidant activities as R. ferruginea extract components and membrane physico-chemical influence |
| abstract |
Syringic and cinnamic acids were previously identified as the major components on Rapanea ferruginea′s leaf extract. In this work, these phenolic acids were investigated and correlated in two aspects. The first one was referred to their role against DPPH and hydroxyl radicals, considering the concentration detected in R. ferruginea extract. The second one considered their effects on the physico-chemical properties of soy asolectin liposomes, such as hydration degree, trans-gauche isomerization, vibrational, rotational and translational motions, state-of-phase, size and surface charge. The half-maximum inhibitory concentration (IC50) related to syringic acid in DPPH assays was detected as 7.36 × 10−3 mM. At the cinnamic acid highest tested concentration (8.23 × 10−3 mM), the activity against DPPH was around 4.6%. Regarding hydroxyl radical-induced lipid peroxidation, the IC50 detected for syringic acid free in solution (free-form) was equivalent to 0.082 × 10−3 mM, a value 3.6 times lower than the detected for its liposome-loaded form. At the highest tested concentration (0.24 × 10−3 mM), the free-form cinnamic acid inhibited lipid peroxidation by 4 times the observed to its liposome-loaded form. Results showed that hydrogen donation is not the preferential mechanism in which the tested phenolic acids inhibit hydroxyl radical-induced lipid peroxidation. Syringic acid showed higher antioxidant potential than cinnamic acid, probably having a primordial role in the properties related to R. ferruginea. Liposomes’ physico-chemical data provided correlations between the phenolic acids’ antioxidant potential and their influence in the mobility of specific lipid groups. The findings of this work will contribute to the design and development of phenolic acids-based and plant extract-based pharmacological systems. |
| abstractGer |
Syringic and cinnamic acids were previously identified as the major components on Rapanea ferruginea′s leaf extract. In this work, these phenolic acids were investigated and correlated in two aspects. The first one was referred to their role against DPPH and hydroxyl radicals, considering the concentration detected in R. ferruginea extract. The second one considered their effects on the physico-chemical properties of soy asolectin liposomes, such as hydration degree, trans-gauche isomerization, vibrational, rotational and translational motions, state-of-phase, size and surface charge. The half-maximum inhibitory concentration (IC50) related to syringic acid in DPPH assays was detected as 7.36 × 10−3 mM. At the cinnamic acid highest tested concentration (8.23 × 10−3 mM), the activity against DPPH was around 4.6%. Regarding hydroxyl radical-induced lipid peroxidation, the IC50 detected for syringic acid free in solution (free-form) was equivalent to 0.082 × 10−3 mM, a value 3.6 times lower than the detected for its liposome-loaded form. At the highest tested concentration (0.24 × 10−3 mM), the free-form cinnamic acid inhibited lipid peroxidation by 4 times the observed to its liposome-loaded form. Results showed that hydrogen donation is not the preferential mechanism in which the tested phenolic acids inhibit hydroxyl radical-induced lipid peroxidation. Syringic acid showed higher antioxidant potential than cinnamic acid, probably having a primordial role in the properties related to R. ferruginea. Liposomes’ physico-chemical data provided correlations between the phenolic acids’ antioxidant potential and their influence in the mobility of specific lipid groups. The findings of this work will contribute to the design and development of phenolic acids-based and plant extract-based pharmacological systems. |
| abstract_unstemmed |
Syringic and cinnamic acids were previously identified as the major components on Rapanea ferruginea′s leaf extract. In this work, these phenolic acids were investigated and correlated in two aspects. The first one was referred to their role against DPPH and hydroxyl radicals, considering the concentration detected in R. ferruginea extract. The second one considered their effects on the physico-chemical properties of soy asolectin liposomes, such as hydration degree, trans-gauche isomerization, vibrational, rotational and translational motions, state-of-phase, size and surface charge. The half-maximum inhibitory concentration (IC50) related to syringic acid in DPPH assays was detected as 7.36 × 10−3 mM. At the cinnamic acid highest tested concentration (8.23 × 10−3 mM), the activity against DPPH was around 4.6%. Regarding hydroxyl radical-induced lipid peroxidation, the IC50 detected for syringic acid free in solution (free-form) was equivalent to 0.082 × 10−3 mM, a value 3.6 times lower than the detected for its liposome-loaded form. At the highest tested concentration (0.24 × 10−3 mM), the free-form cinnamic acid inhibited lipid peroxidation by 4 times the observed to its liposome-loaded form. Results showed that hydrogen donation is not the preferential mechanism in which the tested phenolic acids inhibit hydroxyl radical-induced lipid peroxidation. Syringic acid showed higher antioxidant potential than cinnamic acid, probably having a primordial role in the properties related to R. ferruginea. Liposomes’ physico-chemical data provided correlations between the phenolic acids’ antioxidant potential and their influence in the mobility of specific lipid groups. The findings of this work will contribute to the design and development of phenolic acids-based and plant extract-based pharmacological systems. |
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Sanches, Mariele Paludetto Poffo, Claudio Michel Parize, Alexandre Luís Sagrera Darelli, Gabriel Jorge Rodrigues de Lima, Vânia |
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Sanches, Mariele Paludetto Poffo, Claudio Michel Parize, Alexandre Luís Sagrera Darelli, Gabriel Jorge Rodrigues de Lima, Vânia |
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10.1016/j.molstruc.2020.128749 |
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2024-07-06T20:01:20.449Z |
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