From gut to glutes: The critical role of niche signals in the maintenance and renewal of adult stem cells
Stem cell behavior is tightly regulated by spatiotemporal signaling from the niche, which is a four-dimensional microenvironment that can instruct stem cells to remain quiescent, self-renew, proliferate, or differentiate. In this review, we discuss recent advances in understanding the signaling cues...
Ausführliche Beschreibung
Autor*in: |
Trentesaux, Coralie [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2020transfer abstract |
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Schlagwörter: |
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Umfang: |
14 |
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Übergeordnetes Werk: |
Enthalten in: EVEROLIMUS–ELUTING VERSUS SIROLIMUS–ELUTING CORONARY STENTS IN PATIENTS WITH AND WITHOUT DIABETES MELLITUS - Kang, Si–Hyuck ELSEVIER, 2013, review articles, recommended reading, bibliography of the world literature, Amsterdam [u.a.] |
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Übergeordnetes Werk: |
volume:63 ; year:2020 ; pages:88-101 ; extent:14 |
Links: |
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DOI / URN: |
10.1016/j.ceb.2020.01.004 |
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Katalog-ID: |
ELV051487640 |
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520 | |a Stem cell behavior is tightly regulated by spatiotemporal signaling from the niche, which is a four-dimensional microenvironment that can instruct stem cells to remain quiescent, self-renew, proliferate, or differentiate. In this review, we discuss recent advances in understanding the signaling cues provided by the stem cell niche in two contrasting adult tissues, the rapidly cycling intestinal epithelium and the slowly renewing skeletal muscle. Drawing comparisons between these two systems, we discuss the effects of niche-derived growth factors and signaling molecules, metabolic cues, the extracellular matrix and biomechanical cues, and immune signals on stem cells. We also discuss the influence of the niche in defining stem cell identity and function in both normal and pathophysiologic states. | ||
520 | |a Stem cell behavior is tightly regulated by spatiotemporal signaling from the niche, which is a four-dimensional microenvironment that can instruct stem cells to remain quiescent, self-renew, proliferate, or differentiate. In this review, we discuss recent advances in understanding the signaling cues provided by the stem cell niche in two contrasting adult tissues, the rapidly cycling intestinal epithelium and the slowly renewing skeletal muscle. Drawing comparisons between these two systems, we discuss the effects of niche-derived growth factors and signaling molecules, metabolic cues, the extracellular matrix and biomechanical cues, and immune signals on stem cells. We also discuss the influence of the niche in defining stem cell identity and function in both normal and pathophysiologic states. | ||
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10.1016/j.ceb.2020.01.004 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001142.pica (DE-627)ELV051487640 (ELSEVIER)S0955-0674(20)30005-3 DE-627 ger DE-627 rakwb eng 610 VZ 600 690 VZ 51.00 bkl 51.32 bkl Trentesaux, Coralie verfasserin aut From gut to glutes: The critical role of niche signals in the maintenance and renewal of adult stem cells 2020transfer abstract 14 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Stem cell behavior is tightly regulated by spatiotemporal signaling from the niche, which is a four-dimensional microenvironment that can instruct stem cells to remain quiescent, self-renew, proliferate, or differentiate. In this review, we discuss recent advances in understanding the signaling cues provided by the stem cell niche in two contrasting adult tissues, the rapidly cycling intestinal epithelium and the slowly renewing skeletal muscle. Drawing comparisons between these two systems, we discuss the effects of niche-derived growth factors and signaling molecules, metabolic cues, the extracellular matrix and biomechanical cues, and immune signals on stem cells. We also discuss the influence of the niche in defining stem cell identity and function in both normal and pathophysiologic states. Stem cell behavior is tightly regulated by spatiotemporal signaling from the niche, which is a four-dimensional microenvironment that can instruct stem cells to remain quiescent, self-renew, proliferate, or differentiate. In this review, we discuss recent advances in understanding the signaling cues provided by the stem cell niche in two contrasting adult tissues, the rapidly cycling intestinal epithelium and the slowly renewing skeletal muscle. Drawing comparisons between these two systems, we discuss the effects of niche-derived growth factors and signaling molecules, metabolic cues, the extracellular matrix and biomechanical cues, and immune signals on stem cells. We also discuss the influence of the niche in defining stem cell identity and function in both normal and pathophysiologic states. Stem cell niche Elsevier Intestinal stem cells Elsevier Stem cells Elsevier Muscle stem cells Satellite cells Elsevier Cell signaling Elsevier Striedinger, Katharine oth Pomerantz, Jason H. oth Klein, Ophir D. oth Enthalten in Elsevier Kang, Si–Hyuck ELSEVIER EVEROLIMUS–ELUTING VERSUS SIROLIMUS–ELUTING CORONARY STENTS IN PATIENTS WITH AND WITHOUT DIABETES MELLITUS 2013 review articles, recommended reading, bibliography of the world literature Amsterdam [u.a.] (DE-627)ELV011624515 volume:63 year:2020 pages:88-101 extent:14 https://doi.org/10.1016/j.ceb.2020.01.004 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_39 GBV_ILN_62 GBV_ILN_69 GBV_ILN_121 GBV_ILN_813 GBV_ILN_2043 51.00 Werkstoffkunde: Allgemeines VZ 51.32 Werkstoffmechanik VZ AR 63 2020 88-101 14 |
spelling |
10.1016/j.ceb.2020.01.004 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001142.pica (DE-627)ELV051487640 (ELSEVIER)S0955-0674(20)30005-3 DE-627 ger DE-627 rakwb eng 610 VZ 600 690 VZ 51.00 bkl 51.32 bkl Trentesaux, Coralie verfasserin aut From gut to glutes: The critical role of niche signals in the maintenance and renewal of adult stem cells 2020transfer abstract 14 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Stem cell behavior is tightly regulated by spatiotemporal signaling from the niche, which is a four-dimensional microenvironment that can instruct stem cells to remain quiescent, self-renew, proliferate, or differentiate. In this review, we discuss recent advances in understanding the signaling cues provided by the stem cell niche in two contrasting adult tissues, the rapidly cycling intestinal epithelium and the slowly renewing skeletal muscle. Drawing comparisons between these two systems, we discuss the effects of niche-derived growth factors and signaling molecules, metabolic cues, the extracellular matrix and biomechanical cues, and immune signals on stem cells. We also discuss the influence of the niche in defining stem cell identity and function in both normal and pathophysiologic states. Stem cell behavior is tightly regulated by spatiotemporal signaling from the niche, which is a four-dimensional microenvironment that can instruct stem cells to remain quiescent, self-renew, proliferate, or differentiate. In this review, we discuss recent advances in understanding the signaling cues provided by the stem cell niche in two contrasting adult tissues, the rapidly cycling intestinal epithelium and the slowly renewing skeletal muscle. Drawing comparisons between these two systems, we discuss the effects of niche-derived growth factors and signaling molecules, metabolic cues, the extracellular matrix and biomechanical cues, and immune signals on stem cells. We also discuss the influence of the niche in defining stem cell identity and function in both normal and pathophysiologic states. Stem cell niche Elsevier Intestinal stem cells Elsevier Stem cells Elsevier Muscle stem cells Satellite cells Elsevier Cell signaling Elsevier Striedinger, Katharine oth Pomerantz, Jason H. oth Klein, Ophir D. oth Enthalten in Elsevier Kang, Si–Hyuck ELSEVIER EVEROLIMUS–ELUTING VERSUS SIROLIMUS–ELUTING CORONARY STENTS IN PATIENTS WITH AND WITHOUT DIABETES MELLITUS 2013 review articles, recommended reading, bibliography of the world literature Amsterdam [u.a.] (DE-627)ELV011624515 volume:63 year:2020 pages:88-101 extent:14 https://doi.org/10.1016/j.ceb.2020.01.004 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_39 GBV_ILN_62 GBV_ILN_69 GBV_ILN_121 GBV_ILN_813 GBV_ILN_2043 51.00 Werkstoffkunde: Allgemeines VZ 51.32 Werkstoffmechanik VZ AR 63 2020 88-101 14 |
allfields_unstemmed |
10.1016/j.ceb.2020.01.004 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001142.pica (DE-627)ELV051487640 (ELSEVIER)S0955-0674(20)30005-3 DE-627 ger DE-627 rakwb eng 610 VZ 600 690 VZ 51.00 bkl 51.32 bkl Trentesaux, Coralie verfasserin aut From gut to glutes: The critical role of niche signals in the maintenance and renewal of adult stem cells 2020transfer abstract 14 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Stem cell behavior is tightly regulated by spatiotemporal signaling from the niche, which is a four-dimensional microenvironment that can instruct stem cells to remain quiescent, self-renew, proliferate, or differentiate. In this review, we discuss recent advances in understanding the signaling cues provided by the stem cell niche in two contrasting adult tissues, the rapidly cycling intestinal epithelium and the slowly renewing skeletal muscle. Drawing comparisons between these two systems, we discuss the effects of niche-derived growth factors and signaling molecules, metabolic cues, the extracellular matrix and biomechanical cues, and immune signals on stem cells. We also discuss the influence of the niche in defining stem cell identity and function in both normal and pathophysiologic states. Stem cell behavior is tightly regulated by spatiotemporal signaling from the niche, which is a four-dimensional microenvironment that can instruct stem cells to remain quiescent, self-renew, proliferate, or differentiate. In this review, we discuss recent advances in understanding the signaling cues provided by the stem cell niche in two contrasting adult tissues, the rapidly cycling intestinal epithelium and the slowly renewing skeletal muscle. Drawing comparisons between these two systems, we discuss the effects of niche-derived growth factors and signaling molecules, metabolic cues, the extracellular matrix and biomechanical cues, and immune signals on stem cells. We also discuss the influence of the niche in defining stem cell identity and function in both normal and pathophysiologic states. Stem cell niche Elsevier Intestinal stem cells Elsevier Stem cells Elsevier Muscle stem cells Satellite cells Elsevier Cell signaling Elsevier Striedinger, Katharine oth Pomerantz, Jason H. oth Klein, Ophir D. oth Enthalten in Elsevier Kang, Si–Hyuck ELSEVIER EVEROLIMUS–ELUTING VERSUS SIROLIMUS–ELUTING CORONARY STENTS IN PATIENTS WITH AND WITHOUT DIABETES MELLITUS 2013 review articles, recommended reading, bibliography of the world literature Amsterdam [u.a.] (DE-627)ELV011624515 volume:63 year:2020 pages:88-101 extent:14 https://doi.org/10.1016/j.ceb.2020.01.004 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_39 GBV_ILN_62 GBV_ILN_69 GBV_ILN_121 GBV_ILN_813 GBV_ILN_2043 51.00 Werkstoffkunde: Allgemeines VZ 51.32 Werkstoffmechanik VZ AR 63 2020 88-101 14 |
allfieldsGer |
10.1016/j.ceb.2020.01.004 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001142.pica (DE-627)ELV051487640 (ELSEVIER)S0955-0674(20)30005-3 DE-627 ger DE-627 rakwb eng 610 VZ 600 690 VZ 51.00 bkl 51.32 bkl Trentesaux, Coralie verfasserin aut From gut to glutes: The critical role of niche signals in the maintenance and renewal of adult stem cells 2020transfer abstract 14 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Stem cell behavior is tightly regulated by spatiotemporal signaling from the niche, which is a four-dimensional microenvironment that can instruct stem cells to remain quiescent, self-renew, proliferate, or differentiate. In this review, we discuss recent advances in understanding the signaling cues provided by the stem cell niche in two contrasting adult tissues, the rapidly cycling intestinal epithelium and the slowly renewing skeletal muscle. Drawing comparisons between these two systems, we discuss the effects of niche-derived growth factors and signaling molecules, metabolic cues, the extracellular matrix and biomechanical cues, and immune signals on stem cells. We also discuss the influence of the niche in defining stem cell identity and function in both normal and pathophysiologic states. Stem cell behavior is tightly regulated by spatiotemporal signaling from the niche, which is a four-dimensional microenvironment that can instruct stem cells to remain quiescent, self-renew, proliferate, or differentiate. In this review, we discuss recent advances in understanding the signaling cues provided by the stem cell niche in two contrasting adult tissues, the rapidly cycling intestinal epithelium and the slowly renewing skeletal muscle. Drawing comparisons between these two systems, we discuss the effects of niche-derived growth factors and signaling molecules, metabolic cues, the extracellular matrix and biomechanical cues, and immune signals on stem cells. We also discuss the influence of the niche in defining stem cell identity and function in both normal and pathophysiologic states. Stem cell niche Elsevier Intestinal stem cells Elsevier Stem cells Elsevier Muscle stem cells Satellite cells Elsevier Cell signaling Elsevier Striedinger, Katharine oth Pomerantz, Jason H. oth Klein, Ophir D. oth Enthalten in Elsevier Kang, Si–Hyuck ELSEVIER EVEROLIMUS–ELUTING VERSUS SIROLIMUS–ELUTING CORONARY STENTS IN PATIENTS WITH AND WITHOUT DIABETES MELLITUS 2013 review articles, recommended reading, bibliography of the world literature Amsterdam [u.a.] (DE-627)ELV011624515 volume:63 year:2020 pages:88-101 extent:14 https://doi.org/10.1016/j.ceb.2020.01.004 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_39 GBV_ILN_62 GBV_ILN_69 GBV_ILN_121 GBV_ILN_813 GBV_ILN_2043 51.00 Werkstoffkunde: Allgemeines VZ 51.32 Werkstoffmechanik VZ AR 63 2020 88-101 14 |
allfieldsSound |
10.1016/j.ceb.2020.01.004 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001142.pica (DE-627)ELV051487640 (ELSEVIER)S0955-0674(20)30005-3 DE-627 ger DE-627 rakwb eng 610 VZ 600 690 VZ 51.00 bkl 51.32 bkl Trentesaux, Coralie verfasserin aut From gut to glutes: The critical role of niche signals in the maintenance and renewal of adult stem cells 2020transfer abstract 14 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Stem cell behavior is tightly regulated by spatiotemporal signaling from the niche, which is a four-dimensional microenvironment that can instruct stem cells to remain quiescent, self-renew, proliferate, or differentiate. In this review, we discuss recent advances in understanding the signaling cues provided by the stem cell niche in two contrasting adult tissues, the rapidly cycling intestinal epithelium and the slowly renewing skeletal muscle. Drawing comparisons between these two systems, we discuss the effects of niche-derived growth factors and signaling molecules, metabolic cues, the extracellular matrix and biomechanical cues, and immune signals on stem cells. We also discuss the influence of the niche in defining stem cell identity and function in both normal and pathophysiologic states. Stem cell behavior is tightly regulated by spatiotemporal signaling from the niche, which is a four-dimensional microenvironment that can instruct stem cells to remain quiescent, self-renew, proliferate, or differentiate. In this review, we discuss recent advances in understanding the signaling cues provided by the stem cell niche in two contrasting adult tissues, the rapidly cycling intestinal epithelium and the slowly renewing skeletal muscle. Drawing comparisons between these two systems, we discuss the effects of niche-derived growth factors and signaling molecules, metabolic cues, the extracellular matrix and biomechanical cues, and immune signals on stem cells. We also discuss the influence of the niche in defining stem cell identity and function in both normal and pathophysiologic states. Stem cell niche Elsevier Intestinal stem cells Elsevier Stem cells Elsevier Muscle stem cells Satellite cells Elsevier Cell signaling Elsevier Striedinger, Katharine oth Pomerantz, Jason H. oth Klein, Ophir D. oth Enthalten in Elsevier Kang, Si–Hyuck ELSEVIER EVEROLIMUS–ELUTING VERSUS SIROLIMUS–ELUTING CORONARY STENTS IN PATIENTS WITH AND WITHOUT DIABETES MELLITUS 2013 review articles, recommended reading, bibliography of the world literature Amsterdam [u.a.] (DE-627)ELV011624515 volume:63 year:2020 pages:88-101 extent:14 https://doi.org/10.1016/j.ceb.2020.01.004 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_39 GBV_ILN_62 GBV_ILN_69 GBV_ILN_121 GBV_ILN_813 GBV_ILN_2043 51.00 Werkstoffkunde: Allgemeines VZ 51.32 Werkstoffmechanik VZ AR 63 2020 88-101 14 |
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Enthalten in EVEROLIMUS–ELUTING VERSUS SIROLIMUS–ELUTING CORONARY STENTS IN PATIENTS WITH AND WITHOUT DIABETES MELLITUS Amsterdam [u.a.] volume:63 year:2020 pages:88-101 extent:14 |
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Enthalten in EVEROLIMUS–ELUTING VERSUS SIROLIMUS–ELUTING CORONARY STENTS IN PATIENTS WITH AND WITHOUT DIABETES MELLITUS Amsterdam [u.a.] volume:63 year:2020 pages:88-101 extent:14 |
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From gut to glutes: The critical role of niche signals in the maintenance and renewal of adult stem cells |
abstract |
Stem cell behavior is tightly regulated by spatiotemporal signaling from the niche, which is a four-dimensional microenvironment that can instruct stem cells to remain quiescent, self-renew, proliferate, or differentiate. In this review, we discuss recent advances in understanding the signaling cues provided by the stem cell niche in two contrasting adult tissues, the rapidly cycling intestinal epithelium and the slowly renewing skeletal muscle. Drawing comparisons between these two systems, we discuss the effects of niche-derived growth factors and signaling molecules, metabolic cues, the extracellular matrix and biomechanical cues, and immune signals on stem cells. We also discuss the influence of the niche in defining stem cell identity and function in both normal and pathophysiologic states. |
abstractGer |
Stem cell behavior is tightly regulated by spatiotemporal signaling from the niche, which is a four-dimensional microenvironment that can instruct stem cells to remain quiescent, self-renew, proliferate, or differentiate. In this review, we discuss recent advances in understanding the signaling cues provided by the stem cell niche in two contrasting adult tissues, the rapidly cycling intestinal epithelium and the slowly renewing skeletal muscle. Drawing comparisons between these two systems, we discuss the effects of niche-derived growth factors and signaling molecules, metabolic cues, the extracellular matrix and biomechanical cues, and immune signals on stem cells. We also discuss the influence of the niche in defining stem cell identity and function in both normal and pathophysiologic states. |
abstract_unstemmed |
Stem cell behavior is tightly regulated by spatiotemporal signaling from the niche, which is a four-dimensional microenvironment that can instruct stem cells to remain quiescent, self-renew, proliferate, or differentiate. In this review, we discuss recent advances in understanding the signaling cues provided by the stem cell niche in two contrasting adult tissues, the rapidly cycling intestinal epithelium and the slowly renewing skeletal muscle. Drawing comparisons between these two systems, we discuss the effects of niche-derived growth factors and signaling molecules, metabolic cues, the extracellular matrix and biomechanical cues, and immune signals on stem cells. We also discuss the influence of the niche in defining stem cell identity and function in both normal and pathophysiologic states. |
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From gut to glutes: The critical role of niche signals in the maintenance and renewal of adult stem cells |
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