The role of osmoregulated periplasmic glucans in the biofilm antibiotic resistance of Yersinia enterocolitica
The formation of biofilms by bacteria is of great significance because it involves many physiological changes that serve to protect the cells from various stresses. One of the best-known biofilm-specific properties of bacteria is that bacteria that grow in biofilms are generally more resistant to an...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Meng, Jiao [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020transfer abstract |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Cardio-protective impact of gabapentin against doxorubicin-induced myocardial toxicity in rats; emphasis on modulation of inflammatory-apoptotic signaling - Samra, Yara A. ELSEVIER, 2020, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:147 ; year:2020 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1016/j.micpath.2020.104284 |
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| 245 | 1 | 4 | |a The role of osmoregulated periplasmic glucans in the biofilm antibiotic resistance of Yersinia enterocolitica |
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| 520 | |a The formation of biofilms by bacteria is of great significance because it involves many physiological changes that serve to protect the cells from various stresses. One of the best-known biofilm-specific properties of bacteria is that bacteria that grow in biofilms are generally more resistant to antibiotics than their planktonic counterparts. In a previous study, osmoregulated periplasmic glucans (OPGs), catalyzed by the opgGH operon, were identified and found to function in Rcs signalling in Yersinia enterocolitica. In this study, the possible contribution of OPGs to antimicrobial resistance of Y. enterocolitica biofilms were investigated, and the results showed that OPGs, especially when overexpressed, conferred a high level of biofilm resistance to two different classes of antibiotics onto Y. enterocolitica. Subsequent analysis revealed that OPGs regulated the biofilm architecture in Y. enterocolitica by promoting the bacteria to form large cell aggregates. Moreover, the opgGH genes in biofilms showed higher expression than in planktonic cultures. OPGs were required to induce the expression of genes related to flagella, extracellular polysaccharide, and c-di-GMP biosynthesis in Y. enterocolitica biofilms and this effect was more significant when OPGs were overproduced. The current investigation showed an extension in the biological role of OPGs in Y. enterocolitica and provided a strong theoretical basis to further study this resistance mechanism at the molecular level to identify new drug targets or disinfectants for the treatment of infections caused by Y. enterocolitica within biofilms. | ||
| 520 | |a The formation of biofilms by bacteria is of great significance because it involves many physiological changes that serve to protect the cells from various stresses. One of the best-known biofilm-specific properties of bacteria is that bacteria that grow in biofilms are generally more resistant to antibiotics than their planktonic counterparts. In a previous study, osmoregulated periplasmic glucans (OPGs), catalyzed by the opgGH operon, were identified and found to function in Rcs signalling in Yersinia enterocolitica. In this study, the possible contribution of OPGs to antimicrobial resistance of Y. enterocolitica biofilms were investigated, and the results showed that OPGs, especially when overexpressed, conferred a high level of biofilm resistance to two different classes of antibiotics onto Y. enterocolitica. Subsequent analysis revealed that OPGs regulated the biofilm architecture in Y. enterocolitica by promoting the bacteria to form large cell aggregates. Moreover, the opgGH genes in biofilms showed higher expression than in planktonic cultures. OPGs were required to induce the expression of genes related to flagella, extracellular polysaccharide, and c-di-GMP biosynthesis in Y. enterocolitica biofilms and this effect was more significant when OPGs were overproduced. The current investigation showed an extension in the biological role of OPGs in Y. enterocolitica and provided a strong theoretical basis to further study this resistance mechanism at the molecular level to identify new drug targets or disinfectants for the treatment of infections caused by Y. enterocolitica within biofilms. | ||
| 650 | 7 | |a Osmoregulated periplasmic glucans |2 Elsevier | |
| 650 | 7 | |a Yersinia enterocolitica |2 Elsevier | |
| 650 | 7 | |a Biofilm antibiotic resistance |2 Elsevier | |
| 700 | 1 | |a Xu, Jingguo |4 oth | |
| 700 | 1 | |a Chen, Jingyu |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |n Elsevier |a Samra, Yara A. ELSEVIER |t Cardio-protective impact of gabapentin against doxorubicin-induced myocardial toxicity in rats; emphasis on modulation of inflammatory-apoptotic signaling |d 2020 |g Amsterdam [u.a.] |w (DE-627)ELV00536194X |
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10.1016/j.micpath.2020.104284 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001236.pica (DE-627)ELV051505916 (ELSEVIER)S0882-4010(20)30650-1 DE-627 ger DE-627 rakwb eng 610 VZ PHARM DE-84 fid 44.38 bkl Meng, Jiao verfasserin aut The role of osmoregulated periplasmic glucans in the biofilm antibiotic resistance of Yersinia enterocolitica 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The formation of biofilms by bacteria is of great significance because it involves many physiological changes that serve to protect the cells from various stresses. One of the best-known biofilm-specific properties of bacteria is that bacteria that grow in biofilms are generally more resistant to antibiotics than their planktonic counterparts. In a previous study, osmoregulated periplasmic glucans (OPGs), catalyzed by the opgGH operon, were identified and found to function in Rcs signalling in Yersinia enterocolitica. In this study, the possible contribution of OPGs to antimicrobial resistance of Y. enterocolitica biofilms were investigated, and the results showed that OPGs, especially when overexpressed, conferred a high level of biofilm resistance to two different classes of antibiotics onto Y. enterocolitica. Subsequent analysis revealed that OPGs regulated the biofilm architecture in Y. enterocolitica by promoting the bacteria to form large cell aggregates. Moreover, the opgGH genes in biofilms showed higher expression than in planktonic cultures. OPGs were required to induce the expression of genes related to flagella, extracellular polysaccharide, and c-di-GMP biosynthesis in Y. enterocolitica biofilms and this effect was more significant when OPGs were overproduced. The current investigation showed an extension in the biological role of OPGs in Y. enterocolitica and provided a strong theoretical basis to further study this resistance mechanism at the molecular level to identify new drug targets or disinfectants for the treatment of infections caused by Y. enterocolitica within biofilms. The formation of biofilms by bacteria is of great significance because it involves many physiological changes that serve to protect the cells from various stresses. One of the best-known biofilm-specific properties of bacteria is that bacteria that grow in biofilms are generally more resistant to antibiotics than their planktonic counterparts. In a previous study, osmoregulated periplasmic glucans (OPGs), catalyzed by the opgGH operon, were identified and found to function in Rcs signalling in Yersinia enterocolitica. In this study, the possible contribution of OPGs to antimicrobial resistance of Y. enterocolitica biofilms were investigated, and the results showed that OPGs, especially when overexpressed, conferred a high level of biofilm resistance to two different classes of antibiotics onto Y. enterocolitica. Subsequent analysis revealed that OPGs regulated the biofilm architecture in Y. enterocolitica by promoting the bacteria to form large cell aggregates. Moreover, the opgGH genes in biofilms showed higher expression than in planktonic cultures. OPGs were required to induce the expression of genes related to flagella, extracellular polysaccharide, and c-di-GMP biosynthesis in Y. enterocolitica biofilms and this effect was more significant when OPGs were overproduced. The current investigation showed an extension in the biological role of OPGs in Y. enterocolitica and provided a strong theoretical basis to further study this resistance mechanism at the molecular level to identify new drug targets or disinfectants for the treatment of infections caused by Y. enterocolitica within biofilms. Osmoregulated periplasmic glucans Elsevier Yersinia enterocolitica Elsevier Biofilm antibiotic resistance Elsevier Xu, Jingguo oth Chen, Jingyu oth Enthalten in Elsevier Samra, Yara A. ELSEVIER Cardio-protective impact of gabapentin against doxorubicin-induced myocardial toxicity in rats; emphasis on modulation of inflammatory-apoptotic signaling 2020 Amsterdam [u.a.] (DE-627)ELV00536194X volume:147 year:2020 pages:0 https://doi.org/10.1016/j.micpath.2020.104284 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-PHARM SSG-OLC-PHA SSG-OPC-PHA 44.38 Pharmakologie VZ AR 147 2020 0 |
| spelling |
10.1016/j.micpath.2020.104284 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001236.pica (DE-627)ELV051505916 (ELSEVIER)S0882-4010(20)30650-1 DE-627 ger DE-627 rakwb eng 610 VZ PHARM DE-84 fid 44.38 bkl Meng, Jiao verfasserin aut The role of osmoregulated periplasmic glucans in the biofilm antibiotic resistance of Yersinia enterocolitica 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The formation of biofilms by bacteria is of great significance because it involves many physiological changes that serve to protect the cells from various stresses. One of the best-known biofilm-specific properties of bacteria is that bacteria that grow in biofilms are generally more resistant to antibiotics than their planktonic counterparts. In a previous study, osmoregulated periplasmic glucans (OPGs), catalyzed by the opgGH operon, were identified and found to function in Rcs signalling in Yersinia enterocolitica. In this study, the possible contribution of OPGs to antimicrobial resistance of Y. enterocolitica biofilms were investigated, and the results showed that OPGs, especially when overexpressed, conferred a high level of biofilm resistance to two different classes of antibiotics onto Y. enterocolitica. Subsequent analysis revealed that OPGs regulated the biofilm architecture in Y. enterocolitica by promoting the bacteria to form large cell aggregates. Moreover, the opgGH genes in biofilms showed higher expression than in planktonic cultures. OPGs were required to induce the expression of genes related to flagella, extracellular polysaccharide, and c-di-GMP biosynthesis in Y. enterocolitica biofilms and this effect was more significant when OPGs were overproduced. The current investigation showed an extension in the biological role of OPGs in Y. enterocolitica and provided a strong theoretical basis to further study this resistance mechanism at the molecular level to identify new drug targets or disinfectants for the treatment of infections caused by Y. enterocolitica within biofilms. The formation of biofilms by bacteria is of great significance because it involves many physiological changes that serve to protect the cells from various stresses. One of the best-known biofilm-specific properties of bacteria is that bacteria that grow in biofilms are generally more resistant to antibiotics than their planktonic counterparts. In a previous study, osmoregulated periplasmic glucans (OPGs), catalyzed by the opgGH operon, were identified and found to function in Rcs signalling in Yersinia enterocolitica. In this study, the possible contribution of OPGs to antimicrobial resistance of Y. enterocolitica biofilms were investigated, and the results showed that OPGs, especially when overexpressed, conferred a high level of biofilm resistance to two different classes of antibiotics onto Y. enterocolitica. Subsequent analysis revealed that OPGs regulated the biofilm architecture in Y. enterocolitica by promoting the bacteria to form large cell aggregates. Moreover, the opgGH genes in biofilms showed higher expression than in planktonic cultures. OPGs were required to induce the expression of genes related to flagella, extracellular polysaccharide, and c-di-GMP biosynthesis in Y. enterocolitica biofilms and this effect was more significant when OPGs were overproduced. The current investigation showed an extension in the biological role of OPGs in Y. enterocolitica and provided a strong theoretical basis to further study this resistance mechanism at the molecular level to identify new drug targets or disinfectants for the treatment of infections caused by Y. enterocolitica within biofilms. Osmoregulated periplasmic glucans Elsevier Yersinia enterocolitica Elsevier Biofilm antibiotic resistance Elsevier Xu, Jingguo oth Chen, Jingyu oth Enthalten in Elsevier Samra, Yara A. ELSEVIER Cardio-protective impact of gabapentin against doxorubicin-induced myocardial toxicity in rats; emphasis on modulation of inflammatory-apoptotic signaling 2020 Amsterdam [u.a.] (DE-627)ELV00536194X volume:147 year:2020 pages:0 https://doi.org/10.1016/j.micpath.2020.104284 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-PHARM SSG-OLC-PHA SSG-OPC-PHA 44.38 Pharmakologie VZ AR 147 2020 0 |
| allfields_unstemmed |
10.1016/j.micpath.2020.104284 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001236.pica (DE-627)ELV051505916 (ELSEVIER)S0882-4010(20)30650-1 DE-627 ger DE-627 rakwb eng 610 VZ PHARM DE-84 fid 44.38 bkl Meng, Jiao verfasserin aut The role of osmoregulated periplasmic glucans in the biofilm antibiotic resistance of Yersinia enterocolitica 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The formation of biofilms by bacteria is of great significance because it involves many physiological changes that serve to protect the cells from various stresses. One of the best-known biofilm-specific properties of bacteria is that bacteria that grow in biofilms are generally more resistant to antibiotics than their planktonic counterparts. In a previous study, osmoregulated periplasmic glucans (OPGs), catalyzed by the opgGH operon, were identified and found to function in Rcs signalling in Yersinia enterocolitica. In this study, the possible contribution of OPGs to antimicrobial resistance of Y. enterocolitica biofilms were investigated, and the results showed that OPGs, especially when overexpressed, conferred a high level of biofilm resistance to two different classes of antibiotics onto Y. enterocolitica. Subsequent analysis revealed that OPGs regulated the biofilm architecture in Y. enterocolitica by promoting the bacteria to form large cell aggregates. Moreover, the opgGH genes in biofilms showed higher expression than in planktonic cultures. OPGs were required to induce the expression of genes related to flagella, extracellular polysaccharide, and c-di-GMP biosynthesis in Y. enterocolitica biofilms and this effect was more significant when OPGs were overproduced. The current investigation showed an extension in the biological role of OPGs in Y. enterocolitica and provided a strong theoretical basis to further study this resistance mechanism at the molecular level to identify new drug targets or disinfectants for the treatment of infections caused by Y. enterocolitica within biofilms. The formation of biofilms by bacteria is of great significance because it involves many physiological changes that serve to protect the cells from various stresses. One of the best-known biofilm-specific properties of bacteria is that bacteria that grow in biofilms are generally more resistant to antibiotics than their planktonic counterparts. In a previous study, osmoregulated periplasmic glucans (OPGs), catalyzed by the opgGH operon, were identified and found to function in Rcs signalling in Yersinia enterocolitica. In this study, the possible contribution of OPGs to antimicrobial resistance of Y. enterocolitica biofilms were investigated, and the results showed that OPGs, especially when overexpressed, conferred a high level of biofilm resistance to two different classes of antibiotics onto Y. enterocolitica. Subsequent analysis revealed that OPGs regulated the biofilm architecture in Y. enterocolitica by promoting the bacteria to form large cell aggregates. Moreover, the opgGH genes in biofilms showed higher expression than in planktonic cultures. OPGs were required to induce the expression of genes related to flagella, extracellular polysaccharide, and c-di-GMP biosynthesis in Y. enterocolitica biofilms and this effect was more significant when OPGs were overproduced. The current investigation showed an extension in the biological role of OPGs in Y. enterocolitica and provided a strong theoretical basis to further study this resistance mechanism at the molecular level to identify new drug targets or disinfectants for the treatment of infections caused by Y. enterocolitica within biofilms. Osmoregulated periplasmic glucans Elsevier Yersinia enterocolitica Elsevier Biofilm antibiotic resistance Elsevier Xu, Jingguo oth Chen, Jingyu oth Enthalten in Elsevier Samra, Yara A. ELSEVIER Cardio-protective impact of gabapentin against doxorubicin-induced myocardial toxicity in rats; emphasis on modulation of inflammatory-apoptotic signaling 2020 Amsterdam [u.a.] (DE-627)ELV00536194X volume:147 year:2020 pages:0 https://doi.org/10.1016/j.micpath.2020.104284 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-PHARM SSG-OLC-PHA SSG-OPC-PHA 44.38 Pharmakologie VZ AR 147 2020 0 |
| allfieldsGer |
10.1016/j.micpath.2020.104284 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001236.pica (DE-627)ELV051505916 (ELSEVIER)S0882-4010(20)30650-1 DE-627 ger DE-627 rakwb eng 610 VZ PHARM DE-84 fid 44.38 bkl Meng, Jiao verfasserin aut The role of osmoregulated periplasmic glucans in the biofilm antibiotic resistance of Yersinia enterocolitica 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The formation of biofilms by bacteria is of great significance because it involves many physiological changes that serve to protect the cells from various stresses. One of the best-known biofilm-specific properties of bacteria is that bacteria that grow in biofilms are generally more resistant to antibiotics than their planktonic counterparts. In a previous study, osmoregulated periplasmic glucans (OPGs), catalyzed by the opgGH operon, were identified and found to function in Rcs signalling in Yersinia enterocolitica. In this study, the possible contribution of OPGs to antimicrobial resistance of Y. enterocolitica biofilms were investigated, and the results showed that OPGs, especially when overexpressed, conferred a high level of biofilm resistance to two different classes of antibiotics onto Y. enterocolitica. Subsequent analysis revealed that OPGs regulated the biofilm architecture in Y. enterocolitica by promoting the bacteria to form large cell aggregates. Moreover, the opgGH genes in biofilms showed higher expression than in planktonic cultures. OPGs were required to induce the expression of genes related to flagella, extracellular polysaccharide, and c-di-GMP biosynthesis in Y. enterocolitica biofilms and this effect was more significant when OPGs were overproduced. The current investigation showed an extension in the biological role of OPGs in Y. enterocolitica and provided a strong theoretical basis to further study this resistance mechanism at the molecular level to identify new drug targets or disinfectants for the treatment of infections caused by Y. enterocolitica within biofilms. The formation of biofilms by bacteria is of great significance because it involves many physiological changes that serve to protect the cells from various stresses. One of the best-known biofilm-specific properties of bacteria is that bacteria that grow in biofilms are generally more resistant to antibiotics than their planktonic counterparts. In a previous study, osmoregulated periplasmic glucans (OPGs), catalyzed by the opgGH operon, were identified and found to function in Rcs signalling in Yersinia enterocolitica. In this study, the possible contribution of OPGs to antimicrobial resistance of Y. enterocolitica biofilms were investigated, and the results showed that OPGs, especially when overexpressed, conferred a high level of biofilm resistance to two different classes of antibiotics onto Y. enterocolitica. Subsequent analysis revealed that OPGs regulated the biofilm architecture in Y. enterocolitica by promoting the bacteria to form large cell aggregates. Moreover, the opgGH genes in biofilms showed higher expression than in planktonic cultures. OPGs were required to induce the expression of genes related to flagella, extracellular polysaccharide, and c-di-GMP biosynthesis in Y. enterocolitica biofilms and this effect was more significant when OPGs were overproduced. The current investigation showed an extension in the biological role of OPGs in Y. enterocolitica and provided a strong theoretical basis to further study this resistance mechanism at the molecular level to identify new drug targets or disinfectants for the treatment of infections caused by Y. enterocolitica within biofilms. Osmoregulated periplasmic glucans Elsevier Yersinia enterocolitica Elsevier Biofilm antibiotic resistance Elsevier Xu, Jingguo oth Chen, Jingyu oth Enthalten in Elsevier Samra, Yara A. ELSEVIER Cardio-protective impact of gabapentin against doxorubicin-induced myocardial toxicity in rats; emphasis on modulation of inflammatory-apoptotic signaling 2020 Amsterdam [u.a.] (DE-627)ELV00536194X volume:147 year:2020 pages:0 https://doi.org/10.1016/j.micpath.2020.104284 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-PHARM SSG-OLC-PHA SSG-OPC-PHA 44.38 Pharmakologie VZ AR 147 2020 0 |
| allfieldsSound |
10.1016/j.micpath.2020.104284 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001236.pica (DE-627)ELV051505916 (ELSEVIER)S0882-4010(20)30650-1 DE-627 ger DE-627 rakwb eng 610 VZ PHARM DE-84 fid 44.38 bkl Meng, Jiao verfasserin aut The role of osmoregulated periplasmic glucans in the biofilm antibiotic resistance of Yersinia enterocolitica 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The formation of biofilms by bacteria is of great significance because it involves many physiological changes that serve to protect the cells from various stresses. One of the best-known biofilm-specific properties of bacteria is that bacteria that grow in biofilms are generally more resistant to antibiotics than their planktonic counterparts. In a previous study, osmoregulated periplasmic glucans (OPGs), catalyzed by the opgGH operon, were identified and found to function in Rcs signalling in Yersinia enterocolitica. In this study, the possible contribution of OPGs to antimicrobial resistance of Y. enterocolitica biofilms were investigated, and the results showed that OPGs, especially when overexpressed, conferred a high level of biofilm resistance to two different classes of antibiotics onto Y. enterocolitica. Subsequent analysis revealed that OPGs regulated the biofilm architecture in Y. enterocolitica by promoting the bacteria to form large cell aggregates. Moreover, the opgGH genes in biofilms showed higher expression than in planktonic cultures. OPGs were required to induce the expression of genes related to flagella, extracellular polysaccharide, and c-di-GMP biosynthesis in Y. enterocolitica biofilms and this effect was more significant when OPGs were overproduced. The current investigation showed an extension in the biological role of OPGs in Y. enterocolitica and provided a strong theoretical basis to further study this resistance mechanism at the molecular level to identify new drug targets or disinfectants for the treatment of infections caused by Y. enterocolitica within biofilms. The formation of biofilms by bacteria is of great significance because it involves many physiological changes that serve to protect the cells from various stresses. One of the best-known biofilm-specific properties of bacteria is that bacteria that grow in biofilms are generally more resistant to antibiotics than their planktonic counterparts. In a previous study, osmoregulated periplasmic glucans (OPGs), catalyzed by the opgGH operon, were identified and found to function in Rcs signalling in Yersinia enterocolitica. In this study, the possible contribution of OPGs to antimicrobial resistance of Y. enterocolitica biofilms were investigated, and the results showed that OPGs, especially when overexpressed, conferred a high level of biofilm resistance to two different classes of antibiotics onto Y. enterocolitica. Subsequent analysis revealed that OPGs regulated the biofilm architecture in Y. enterocolitica by promoting the bacteria to form large cell aggregates. Moreover, the opgGH genes in biofilms showed higher expression than in planktonic cultures. OPGs were required to induce the expression of genes related to flagella, extracellular polysaccharide, and c-di-GMP biosynthesis in Y. enterocolitica biofilms and this effect was more significant when OPGs were overproduced. The current investigation showed an extension in the biological role of OPGs in Y. enterocolitica and provided a strong theoretical basis to further study this resistance mechanism at the molecular level to identify new drug targets or disinfectants for the treatment of infections caused by Y. enterocolitica within biofilms. Osmoregulated periplasmic glucans Elsevier Yersinia enterocolitica Elsevier Biofilm antibiotic resistance Elsevier Xu, Jingguo oth Chen, Jingyu oth Enthalten in Elsevier Samra, Yara A. ELSEVIER Cardio-protective impact of gabapentin against doxorubicin-induced myocardial toxicity in rats; emphasis on modulation of inflammatory-apoptotic signaling 2020 Amsterdam [u.a.] (DE-627)ELV00536194X volume:147 year:2020 pages:0 https://doi.org/10.1016/j.micpath.2020.104284 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-PHARM SSG-OLC-PHA SSG-OPC-PHA 44.38 Pharmakologie VZ AR 147 2020 0 |
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Enthalten in Cardio-protective impact of gabapentin against doxorubicin-induced myocardial toxicity in rats; emphasis on modulation of inflammatory-apoptotic signaling Amsterdam [u.a.] volume:147 year:2020 pages:0 |
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The role of osmoregulated periplasmic glucans in the biofilm antibiotic resistance of Yersinia enterocolitica |
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The formation of biofilms by bacteria is of great significance because it involves many physiological changes that serve to protect the cells from various stresses. One of the best-known biofilm-specific properties of bacteria is that bacteria that grow in biofilms are generally more resistant to antibiotics than their planktonic counterparts. In a previous study, osmoregulated periplasmic glucans (OPGs), catalyzed by the opgGH operon, were identified and found to function in Rcs signalling in Yersinia enterocolitica. In this study, the possible contribution of OPGs to antimicrobial resistance of Y. enterocolitica biofilms were investigated, and the results showed that OPGs, especially when overexpressed, conferred a high level of biofilm resistance to two different classes of antibiotics onto Y. enterocolitica. Subsequent analysis revealed that OPGs regulated the biofilm architecture in Y. enterocolitica by promoting the bacteria to form large cell aggregates. Moreover, the opgGH genes in biofilms showed higher expression than in planktonic cultures. OPGs were required to induce the expression of genes related to flagella, extracellular polysaccharide, and c-di-GMP biosynthesis in Y. enterocolitica biofilms and this effect was more significant when OPGs were overproduced. The current investigation showed an extension in the biological role of OPGs in Y. enterocolitica and provided a strong theoretical basis to further study this resistance mechanism at the molecular level to identify new drug targets or disinfectants for the treatment of infections caused by Y. enterocolitica within biofilms. |
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The formation of biofilms by bacteria is of great significance because it involves many physiological changes that serve to protect the cells from various stresses. One of the best-known biofilm-specific properties of bacteria is that bacteria that grow in biofilms are generally more resistant to antibiotics than their planktonic counterparts. In a previous study, osmoregulated periplasmic glucans (OPGs), catalyzed by the opgGH operon, were identified and found to function in Rcs signalling in Yersinia enterocolitica. In this study, the possible contribution of OPGs to antimicrobial resistance of Y. enterocolitica biofilms were investigated, and the results showed that OPGs, especially when overexpressed, conferred a high level of biofilm resistance to two different classes of antibiotics onto Y. enterocolitica. Subsequent analysis revealed that OPGs regulated the biofilm architecture in Y. enterocolitica by promoting the bacteria to form large cell aggregates. Moreover, the opgGH genes in biofilms showed higher expression than in planktonic cultures. OPGs were required to induce the expression of genes related to flagella, extracellular polysaccharide, and c-di-GMP biosynthesis in Y. enterocolitica biofilms and this effect was more significant when OPGs were overproduced. The current investigation showed an extension in the biological role of OPGs in Y. enterocolitica and provided a strong theoretical basis to further study this resistance mechanism at the molecular level to identify new drug targets or disinfectants for the treatment of infections caused by Y. enterocolitica within biofilms. |
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