Metabolomics: An emerging potential approach to decipher critical illnesses
Critical illnesses contribute to the maximum morbidity and mortality of hospitalized patients. Acute respiratory distress syndrome (ARDS) and sepsis/septic shock are the two most common acute illnesses associated with intensive care unit (ICU) admission. Once triggered, both have an identical underl...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Siddiqui, Mohd Adnan [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020transfer abstract |
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| Übergeordnetes Werk: |
Enthalten in: “We can and should do better” - an interview with the 2020 Nobel prize laureates who revolutionized hepatology - Baumert, Thomas F. ELSEVIER, 2021, an international journal devoted to the physics and chemistry of biological phenomena, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:267 ; year:2020 ; pages:0 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.bpc.2020.106462 |
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| 520 | |a Critical illnesses contribute to the maximum morbidity and mortality of hospitalized patients. Acute respiratory distress syndrome (ARDS) and sepsis/septic shock are the two most common acute illnesses associated with intensive care unit (ICU) admission. Once triggered, both have an identical underlying mechanism, portrayed by inflammation and endothelial dysfunction. The diagnosis of ARDS is based on clinical findings, laboratory tests, and radiological imaging. Blood cultures remain the gold standard for the diagnosis of sepsis, with the limitation of time delay and low positive yield. A combination of biomarkers has been proposed to diagnose and prognosticate these acute disorders with strengths and limitations, but still, the gold standard has been elusive to clinicians. In this review article, we illustrate the potential of metabolomics to unravel biomarkers that can be clinically utilized as a rapid prognostic and diagnostic tool associated with specific patient populations (ARDS and sepsis/septic shock) based on the available scientific data. | ||
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10.1016/j.bpc.2020.106462 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001209.pica (DE-627)ELV052113191 (ELSEVIER)S0301-4622(20)30170-8 DE-627 ger DE-627 rakwb eng 610 VZ 44.87 bkl Siddiqui, Mohd Adnan verfasserin aut Metabolomics: An emerging potential approach to decipher critical illnesses 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Critical illnesses contribute to the maximum morbidity and mortality of hospitalized patients. Acute respiratory distress syndrome (ARDS) and sepsis/septic shock are the two most common acute illnesses associated with intensive care unit (ICU) admission. Once triggered, both have an identical underlying mechanism, portrayed by inflammation and endothelial dysfunction. The diagnosis of ARDS is based on clinical findings, laboratory tests, and radiological imaging. Blood cultures remain the gold standard for the diagnosis of sepsis, with the limitation of time delay and low positive yield. A combination of biomarkers has been proposed to diagnose and prognosticate these acute disorders with strengths and limitations, but still, the gold standard has been elusive to clinicians. In this review article, we illustrate the potential of metabolomics to unravel biomarkers that can be clinically utilized as a rapid prognostic and diagnostic tool associated with specific patient populations (ARDS and sepsis/septic shock) based on the available scientific data. Critical illnesses contribute to the maximum morbidity and mortality of hospitalized patients. Acute respiratory distress syndrome (ARDS) and sepsis/septic shock are the two most common acute illnesses associated with intensive care unit (ICU) admission. Once triggered, both have an identical underlying mechanism, portrayed by inflammation and endothelial dysfunction. The diagnosis of ARDS is based on clinical findings, laboratory tests, and radiological imaging. Blood cultures remain the gold standard for the diagnosis of sepsis, with the limitation of time delay and low positive yield. A combination of biomarkers has been proposed to diagnose and prognosticate these acute disorders with strengths and limitations, but still, the gold standard has been elusive to clinicians. In this review article, we illustrate the potential of metabolomics to unravel biomarkers that can be clinically utilized as a rapid prognostic and diagnostic tool associated with specific patient populations (ARDS and sepsis/septic shock) based on the available scientific data. Pandey, Swarnima oth Azim, Afzal oth Sinha, Neeraj oth Siddiqui, Mohammed Haris oth Enthalten in Elsevier Science Baumert, Thomas F. ELSEVIER “We can and should do better” - an interview with the 2020 Nobel prize laureates who revolutionized hepatology 2021 an international journal devoted to the physics and chemistry of biological phenomena Amsterdam [u.a.] (DE-627)ELV006315437 volume:267 year:2020 pages:0 https://doi.org/10.1016/j.bpc.2020.106462 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.87 Gastroenterologie VZ AR 267 2020 0 |
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10.1016/j.bpc.2020.106462 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001209.pica (DE-627)ELV052113191 (ELSEVIER)S0301-4622(20)30170-8 DE-627 ger DE-627 rakwb eng 610 VZ 44.87 bkl Siddiqui, Mohd Adnan verfasserin aut Metabolomics: An emerging potential approach to decipher critical illnesses 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Critical illnesses contribute to the maximum morbidity and mortality of hospitalized patients. Acute respiratory distress syndrome (ARDS) and sepsis/septic shock are the two most common acute illnesses associated with intensive care unit (ICU) admission. Once triggered, both have an identical underlying mechanism, portrayed by inflammation and endothelial dysfunction. The diagnosis of ARDS is based on clinical findings, laboratory tests, and radiological imaging. Blood cultures remain the gold standard for the diagnosis of sepsis, with the limitation of time delay and low positive yield. A combination of biomarkers has been proposed to diagnose and prognosticate these acute disorders with strengths and limitations, but still, the gold standard has been elusive to clinicians. In this review article, we illustrate the potential of metabolomics to unravel biomarkers that can be clinically utilized as a rapid prognostic and diagnostic tool associated with specific patient populations (ARDS and sepsis/septic shock) based on the available scientific data. Critical illnesses contribute to the maximum morbidity and mortality of hospitalized patients. Acute respiratory distress syndrome (ARDS) and sepsis/septic shock are the two most common acute illnesses associated with intensive care unit (ICU) admission. Once triggered, both have an identical underlying mechanism, portrayed by inflammation and endothelial dysfunction. The diagnosis of ARDS is based on clinical findings, laboratory tests, and radiological imaging. Blood cultures remain the gold standard for the diagnosis of sepsis, with the limitation of time delay and low positive yield. A combination of biomarkers has been proposed to diagnose and prognosticate these acute disorders with strengths and limitations, but still, the gold standard has been elusive to clinicians. In this review article, we illustrate the potential of metabolomics to unravel biomarkers that can be clinically utilized as a rapid prognostic and diagnostic tool associated with specific patient populations (ARDS and sepsis/septic shock) based on the available scientific data. Pandey, Swarnima oth Azim, Afzal oth Sinha, Neeraj oth Siddiqui, Mohammed Haris oth Enthalten in Elsevier Science Baumert, Thomas F. ELSEVIER “We can and should do better” - an interview with the 2020 Nobel prize laureates who revolutionized hepatology 2021 an international journal devoted to the physics and chemistry of biological phenomena Amsterdam [u.a.] (DE-627)ELV006315437 volume:267 year:2020 pages:0 https://doi.org/10.1016/j.bpc.2020.106462 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.87 Gastroenterologie VZ AR 267 2020 0 |
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10.1016/j.bpc.2020.106462 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001209.pica (DE-627)ELV052113191 (ELSEVIER)S0301-4622(20)30170-8 DE-627 ger DE-627 rakwb eng 610 VZ 44.87 bkl Siddiqui, Mohd Adnan verfasserin aut Metabolomics: An emerging potential approach to decipher critical illnesses 2020transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Critical illnesses contribute to the maximum morbidity and mortality of hospitalized patients. Acute respiratory distress syndrome (ARDS) and sepsis/septic shock are the two most common acute illnesses associated with intensive care unit (ICU) admission. Once triggered, both have an identical underlying mechanism, portrayed by inflammation and endothelial dysfunction. The diagnosis of ARDS is based on clinical findings, laboratory tests, and radiological imaging. Blood cultures remain the gold standard for the diagnosis of sepsis, with the limitation of time delay and low positive yield. A combination of biomarkers has been proposed to diagnose and prognosticate these acute disorders with strengths and limitations, but still, the gold standard has been elusive to clinicians. In this review article, we illustrate the potential of metabolomics to unravel biomarkers that can be clinically utilized as a rapid prognostic and diagnostic tool associated with specific patient populations (ARDS and sepsis/septic shock) based on the available scientific data. Critical illnesses contribute to the maximum morbidity and mortality of hospitalized patients. Acute respiratory distress syndrome (ARDS) and sepsis/septic shock are the two most common acute illnesses associated with intensive care unit (ICU) admission. Once triggered, both have an identical underlying mechanism, portrayed by inflammation and endothelial dysfunction. The diagnosis of ARDS is based on clinical findings, laboratory tests, and radiological imaging. Blood cultures remain the gold standard for the diagnosis of sepsis, with the limitation of time delay and low positive yield. A combination of biomarkers has been proposed to diagnose and prognosticate these acute disorders with strengths and limitations, but still, the gold standard has been elusive to clinicians. In this review article, we illustrate the potential of metabolomics to unravel biomarkers that can be clinically utilized as a rapid prognostic and diagnostic tool associated with specific patient populations (ARDS and sepsis/septic shock) based on the available scientific data. Pandey, Swarnima oth Azim, Afzal oth Sinha, Neeraj oth Siddiqui, Mohammed Haris oth Enthalten in Elsevier Science Baumert, Thomas F. ELSEVIER “We can and should do better” - an interview with the 2020 Nobel prize laureates who revolutionized hepatology 2021 an international journal devoted to the physics and chemistry of biological phenomena Amsterdam [u.a.] (DE-627)ELV006315437 volume:267 year:2020 pages:0 https://doi.org/10.1016/j.bpc.2020.106462 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.87 Gastroenterologie VZ AR 267 2020 0 |
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Siddiqui, Mohd Adnan |
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“We can and should do better” - an interview with the 2020 Nobel prize laureates who revolutionized hepatology |
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“We can and should do better” - an interview with the 2020 Nobel prize laureates who revolutionized hepatology |
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10.1016/j.bpc.2020.106462 |
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metabolomics: an emerging potential approach to decipher critical illnesses |
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Metabolomics: An emerging potential approach to decipher critical illnesses |
| abstract |
Critical illnesses contribute to the maximum morbidity and mortality of hospitalized patients. Acute respiratory distress syndrome (ARDS) and sepsis/septic shock are the two most common acute illnesses associated with intensive care unit (ICU) admission. Once triggered, both have an identical underlying mechanism, portrayed by inflammation and endothelial dysfunction. The diagnosis of ARDS is based on clinical findings, laboratory tests, and radiological imaging. Blood cultures remain the gold standard for the diagnosis of sepsis, with the limitation of time delay and low positive yield. A combination of biomarkers has been proposed to diagnose and prognosticate these acute disorders with strengths and limitations, but still, the gold standard has been elusive to clinicians. In this review article, we illustrate the potential of metabolomics to unravel biomarkers that can be clinically utilized as a rapid prognostic and diagnostic tool associated with specific patient populations (ARDS and sepsis/septic shock) based on the available scientific data. |
| abstractGer |
Critical illnesses contribute to the maximum morbidity and mortality of hospitalized patients. Acute respiratory distress syndrome (ARDS) and sepsis/septic shock are the two most common acute illnesses associated with intensive care unit (ICU) admission. Once triggered, both have an identical underlying mechanism, portrayed by inflammation and endothelial dysfunction. The diagnosis of ARDS is based on clinical findings, laboratory tests, and radiological imaging. Blood cultures remain the gold standard for the diagnosis of sepsis, with the limitation of time delay and low positive yield. A combination of biomarkers has been proposed to diagnose and prognosticate these acute disorders with strengths and limitations, but still, the gold standard has been elusive to clinicians. In this review article, we illustrate the potential of metabolomics to unravel biomarkers that can be clinically utilized as a rapid prognostic and diagnostic tool associated with specific patient populations (ARDS and sepsis/septic shock) based on the available scientific data. |
| abstract_unstemmed |
Critical illnesses contribute to the maximum morbidity and mortality of hospitalized patients. Acute respiratory distress syndrome (ARDS) and sepsis/septic shock are the two most common acute illnesses associated with intensive care unit (ICU) admission. Once triggered, both have an identical underlying mechanism, portrayed by inflammation and endothelial dysfunction. The diagnosis of ARDS is based on clinical findings, laboratory tests, and radiological imaging. Blood cultures remain the gold standard for the diagnosis of sepsis, with the limitation of time delay and low positive yield. A combination of biomarkers has been proposed to diagnose and prognosticate these acute disorders with strengths and limitations, but still, the gold standard has been elusive to clinicians. In this review article, we illustrate the potential of metabolomics to unravel biomarkers that can be clinically utilized as a rapid prognostic and diagnostic tool associated with specific patient populations (ARDS and sepsis/septic shock) based on the available scientific data. |
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Metabolomics: An emerging potential approach to decipher critical illnesses |
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Pandey, Swarnima Azim, Afzal Sinha, Neeraj Siddiqui, Mohammed Haris |
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