Fluorescence turn-off magnetic COF composite as a novel nanocarrier for drug loading and targeted delivery
Covalent organic frameworks (COFs) have unique chemical bonds and special molecular structure and possess great potential for biology applications. However, their utilization in drug delivery has been greatly limited on account of harsh synthesis conditions, poor solubility and single function. Here...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Zhao, Kai [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021transfer abstract |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Impact of North Atlantic-East Asian teleconnections on extremely high January PM - Kim, Jeong-Hun ELSEVIER, 2021, the official journal of the International Zeolite Association, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:311 ; year:2021 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1016/j.micromeso.2020.110713 |
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ELV052391043 |
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| 245 | 1 | 0 | |a Fluorescence turn-off magnetic COF composite as a novel nanocarrier for drug loading and targeted delivery |
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| 520 | |a Covalent organic frameworks (COFs) have unique chemical bonds and special molecular structure and possess great potential for biology applications. However, their utilization in drug delivery has been greatly limited on account of harsh synthesis conditions, poor solubility and single function. Herein, a novel concept of multifunctional COFs-based core-shell nanocomposite with good dispersity in various media was demonstrated and integrated it as a highly efficient targeted drug delivery system with excellent photothermal and magnetic performance. To achieve this, a facile sonication associated method to synthesize the nanocomposite at room temperature without any special equipment was developed, and then was modified by folic acid pre-linked bovine serum albumin, which further allowed long-time stability in media and special targeting toward cancer cells. Interestingly, the nanocomposite well quenched the fluorescence of doxorubicin, and this endowed us for the first time to visually detect drug loading by “turn-off” fluorescence. What's more, the effective combination of photothermal therapy and chemotherapy then achieved much better therapeutic effect than single therapy. Our work integrated magnetic COFs as a novel and effective drug carrier with good surface modification, excellent photothermal performance and high drug loading capacity, and reported the first experimental example of Fe3O4COF in the application of cancer chemo-photothermal therapy. | ||
| 520 | |a Covalent organic frameworks (COFs) have unique chemical bonds and special molecular structure and possess great potential for biology applications. However, their utilization in drug delivery has been greatly limited on account of harsh synthesis conditions, poor solubility and single function. Herein, a novel concept of multifunctional COFs-based core-shell nanocomposite with good dispersity in various media was demonstrated and integrated it as a highly efficient targeted drug delivery system with excellent photothermal and magnetic performance. To achieve this, a facile sonication associated method to synthesize the nanocomposite at room temperature without any special equipment was developed, and then was modified by folic acid pre-linked bovine serum albumin, which further allowed long-time stability in media and special targeting toward cancer cells. Interestingly, the nanocomposite well quenched the fluorescence of doxorubicin, and this endowed us for the first time to visually detect drug loading by “turn-off” fluorescence. What's more, the effective combination of photothermal therapy and chemotherapy then achieved much better therapeutic effect than single therapy. Our work integrated magnetic COFs as a novel and effective drug carrier with good surface modification, excellent photothermal performance and high drug loading capacity, and reported the first experimental example of Fe3O4COF in the application of cancer chemo-photothermal therapy. | ||
| 650 | 7 | |a Surface modification |2 Elsevier | |
| 650 | 7 | |a COFs |2 Elsevier | |
| 650 | 7 | |a Fluorescence |2 Elsevier | |
| 650 | 7 | |a Core-shell structure |2 Elsevier | |
| 650 | 7 | |a Drug delivery |2 Elsevier | |
| 700 | 1 | |a Gong, Peiwei |4 oth | |
| 700 | 1 | |a Huang, Jie |4 oth | |
| 700 | 1 | |a Huang, Yan |4 oth | |
| 700 | 1 | |a Wang, Dandan |4 oth | |
| 700 | 1 | |a Peng, Jingyi |4 oth | |
| 700 | 1 | |a Shen, Duyi |4 oth | |
| 700 | 1 | |a Zheng, Xiaofeng |4 oth | |
| 700 | 1 | |a You, Jinmao |4 oth | |
| 700 | 1 | |a Liu, Zhe |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |n Elsevier |a Kim, Jeong-Hun ELSEVIER |t Impact of North Atlantic-East Asian teleconnections on extremely high January PM |d 2021 |d the official journal of the International Zeolite Association |g Amsterdam [u.a.] |w (DE-627)ELV006778283 |
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10.1016/j.micromeso.2020.110713 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001229.pica (DE-627)ELV052391043 (ELSEVIER)S1387-1811(20)30713-7 DE-627 ger DE-627 rakwb eng 333.7 570 690 VZ BIODIV DE-30 fid 48.00 bkl Zhao, Kai verfasserin aut Fluorescence turn-off magnetic COF composite as a novel nanocarrier for drug loading and targeted delivery 2021transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Covalent organic frameworks (COFs) have unique chemical bonds and special molecular structure and possess great potential for biology applications. However, their utilization in drug delivery has been greatly limited on account of harsh synthesis conditions, poor solubility and single function. Herein, a novel concept of multifunctional COFs-based core-shell nanocomposite with good dispersity in various media was demonstrated and integrated it as a highly efficient targeted drug delivery system with excellent photothermal and magnetic performance. To achieve this, a facile sonication associated method to synthesize the nanocomposite at room temperature without any special equipment was developed, and then was modified by folic acid pre-linked bovine serum albumin, which further allowed long-time stability in media and special targeting toward cancer cells. Interestingly, the nanocomposite well quenched the fluorescence of doxorubicin, and this endowed us for the first time to visually detect drug loading by “turn-off” fluorescence. What's more, the effective combination of photothermal therapy and chemotherapy then achieved much better therapeutic effect than single therapy. Our work integrated magnetic COFs as a novel and effective drug carrier with good surface modification, excellent photothermal performance and high drug loading capacity, and reported the first experimental example of Fe3O4COF in the application of cancer chemo-photothermal therapy. Covalent organic frameworks (COFs) have unique chemical bonds and special molecular structure and possess great potential for biology applications. However, their utilization in drug delivery has been greatly limited on account of harsh synthesis conditions, poor solubility and single function. Herein, a novel concept of multifunctional COFs-based core-shell nanocomposite with good dispersity in various media was demonstrated and integrated it as a highly efficient targeted drug delivery system with excellent photothermal and magnetic performance. To achieve this, a facile sonication associated method to synthesize the nanocomposite at room temperature without any special equipment was developed, and then was modified by folic acid pre-linked bovine serum albumin, which further allowed long-time stability in media and special targeting toward cancer cells. Interestingly, the nanocomposite well quenched the fluorescence of doxorubicin, and this endowed us for the first time to visually detect drug loading by “turn-off” fluorescence. What's more, the effective combination of photothermal therapy and chemotherapy then achieved much better therapeutic effect than single therapy. Our work integrated magnetic COFs as a novel and effective drug carrier with good surface modification, excellent photothermal performance and high drug loading capacity, and reported the first experimental example of Fe3O4COF in the application of cancer chemo-photothermal therapy. Surface modification Elsevier COFs Elsevier Fluorescence Elsevier Core-shell structure Elsevier Drug delivery Elsevier Gong, Peiwei oth Huang, Jie oth Huang, Yan oth Wang, Dandan oth Peng, Jingyi oth Shen, Duyi oth Zheng, Xiaofeng oth You, Jinmao oth Liu, Zhe oth Enthalten in Elsevier Kim, Jeong-Hun ELSEVIER Impact of North Atlantic-East Asian teleconnections on extremely high January PM 2021 the official journal of the International Zeolite Association Amsterdam [u.a.] (DE-627)ELV006778283 volume:311 year:2021 pages:0 https://doi.org/10.1016/j.micromeso.2020.110713 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA SSG-OPC-FOR 48.00 Land- und Forstwirtschaft: Allgemeines VZ AR 311 2021 0 |
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10.1016/j.micromeso.2020.110713 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001229.pica (DE-627)ELV052391043 (ELSEVIER)S1387-1811(20)30713-7 DE-627 ger DE-627 rakwb eng 333.7 570 690 VZ BIODIV DE-30 fid 48.00 bkl Zhao, Kai verfasserin aut Fluorescence turn-off magnetic COF composite as a novel nanocarrier for drug loading and targeted delivery 2021transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Covalent organic frameworks (COFs) have unique chemical bonds and special molecular structure and possess great potential for biology applications. However, their utilization in drug delivery has been greatly limited on account of harsh synthesis conditions, poor solubility and single function. Herein, a novel concept of multifunctional COFs-based core-shell nanocomposite with good dispersity in various media was demonstrated and integrated it as a highly efficient targeted drug delivery system with excellent photothermal and magnetic performance. To achieve this, a facile sonication associated method to synthesize the nanocomposite at room temperature without any special equipment was developed, and then was modified by folic acid pre-linked bovine serum albumin, which further allowed long-time stability in media and special targeting toward cancer cells. Interestingly, the nanocomposite well quenched the fluorescence of doxorubicin, and this endowed us for the first time to visually detect drug loading by “turn-off” fluorescence. What's more, the effective combination of photothermal therapy and chemotherapy then achieved much better therapeutic effect than single therapy. Our work integrated magnetic COFs as a novel and effective drug carrier with good surface modification, excellent photothermal performance and high drug loading capacity, and reported the first experimental example of Fe3O4COF in the application of cancer chemo-photothermal therapy. Covalent organic frameworks (COFs) have unique chemical bonds and special molecular structure and possess great potential for biology applications. However, their utilization in drug delivery has been greatly limited on account of harsh synthesis conditions, poor solubility and single function. Herein, a novel concept of multifunctional COFs-based core-shell nanocomposite with good dispersity in various media was demonstrated and integrated it as a highly efficient targeted drug delivery system with excellent photothermal and magnetic performance. To achieve this, a facile sonication associated method to synthesize the nanocomposite at room temperature without any special equipment was developed, and then was modified by folic acid pre-linked bovine serum albumin, which further allowed long-time stability in media and special targeting toward cancer cells. Interestingly, the nanocomposite well quenched the fluorescence of doxorubicin, and this endowed us for the first time to visually detect drug loading by “turn-off” fluorescence. What's more, the effective combination of photothermal therapy and chemotherapy then achieved much better therapeutic effect than single therapy. Our work integrated magnetic COFs as a novel and effective drug carrier with good surface modification, excellent photothermal performance and high drug loading capacity, and reported the first experimental example of Fe3O4COF in the application of cancer chemo-photothermal therapy. Surface modification Elsevier COFs Elsevier Fluorescence Elsevier Core-shell structure Elsevier Drug delivery Elsevier Gong, Peiwei oth Huang, Jie oth Huang, Yan oth Wang, Dandan oth Peng, Jingyi oth Shen, Duyi oth Zheng, Xiaofeng oth You, Jinmao oth Liu, Zhe oth Enthalten in Elsevier Kim, Jeong-Hun ELSEVIER Impact of North Atlantic-East Asian teleconnections on extremely high January PM 2021 the official journal of the International Zeolite Association Amsterdam [u.a.] (DE-627)ELV006778283 volume:311 year:2021 pages:0 https://doi.org/10.1016/j.micromeso.2020.110713 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA SSG-OPC-FOR 48.00 Land- und Forstwirtschaft: Allgemeines VZ AR 311 2021 0 |
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10.1016/j.micromeso.2020.110713 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001229.pica (DE-627)ELV052391043 (ELSEVIER)S1387-1811(20)30713-7 DE-627 ger DE-627 rakwb eng 333.7 570 690 VZ BIODIV DE-30 fid 48.00 bkl Zhao, Kai verfasserin aut Fluorescence turn-off magnetic COF composite as a novel nanocarrier for drug loading and targeted delivery 2021transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Covalent organic frameworks (COFs) have unique chemical bonds and special molecular structure and possess great potential for biology applications. However, their utilization in drug delivery has been greatly limited on account of harsh synthesis conditions, poor solubility and single function. Herein, a novel concept of multifunctional COFs-based core-shell nanocomposite with good dispersity in various media was demonstrated and integrated it as a highly efficient targeted drug delivery system with excellent photothermal and magnetic performance. To achieve this, a facile sonication associated method to synthesize the nanocomposite at room temperature without any special equipment was developed, and then was modified by folic acid pre-linked bovine serum albumin, which further allowed long-time stability in media and special targeting toward cancer cells. Interestingly, the nanocomposite well quenched the fluorescence of doxorubicin, and this endowed us for the first time to visually detect drug loading by “turn-off” fluorescence. What's more, the effective combination of photothermal therapy and chemotherapy then achieved much better therapeutic effect than single therapy. Our work integrated magnetic COFs as a novel and effective drug carrier with good surface modification, excellent photothermal performance and high drug loading capacity, and reported the first experimental example of Fe3O4COF in the application of cancer chemo-photothermal therapy. Covalent organic frameworks (COFs) have unique chemical bonds and special molecular structure and possess great potential for biology applications. However, their utilization in drug delivery has been greatly limited on account of harsh synthesis conditions, poor solubility and single function. Herein, a novel concept of multifunctional COFs-based core-shell nanocomposite with good dispersity in various media was demonstrated and integrated it as a highly efficient targeted drug delivery system with excellent photothermal and magnetic performance. To achieve this, a facile sonication associated method to synthesize the nanocomposite at room temperature without any special equipment was developed, and then was modified by folic acid pre-linked bovine serum albumin, which further allowed long-time stability in media and special targeting toward cancer cells. Interestingly, the nanocomposite well quenched the fluorescence of doxorubicin, and this endowed us for the first time to visually detect drug loading by “turn-off” fluorescence. What's more, the effective combination of photothermal therapy and chemotherapy then achieved much better therapeutic effect than single therapy. Our work integrated magnetic COFs as a novel and effective drug carrier with good surface modification, excellent photothermal performance and high drug loading capacity, and reported the first experimental example of Fe3O4COF in the application of cancer chemo-photothermal therapy. Surface modification Elsevier COFs Elsevier Fluorescence Elsevier Core-shell structure Elsevier Drug delivery Elsevier Gong, Peiwei oth Huang, Jie oth Huang, Yan oth Wang, Dandan oth Peng, Jingyi oth Shen, Duyi oth Zheng, Xiaofeng oth You, Jinmao oth Liu, Zhe oth Enthalten in Elsevier Kim, Jeong-Hun ELSEVIER Impact of North Atlantic-East Asian teleconnections on extremely high January PM 2021 the official journal of the International Zeolite Association Amsterdam [u.a.] (DE-627)ELV006778283 volume:311 year:2021 pages:0 https://doi.org/10.1016/j.micromeso.2020.110713 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA SSG-OPC-FOR 48.00 Land- und Forstwirtschaft: Allgemeines VZ AR 311 2021 0 |
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10.1016/j.micromeso.2020.110713 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001229.pica (DE-627)ELV052391043 (ELSEVIER)S1387-1811(20)30713-7 DE-627 ger DE-627 rakwb eng 333.7 570 690 VZ BIODIV DE-30 fid 48.00 bkl Zhao, Kai verfasserin aut Fluorescence turn-off magnetic COF composite as a novel nanocarrier for drug loading and targeted delivery 2021transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Covalent organic frameworks (COFs) have unique chemical bonds and special molecular structure and possess great potential for biology applications. However, their utilization in drug delivery has been greatly limited on account of harsh synthesis conditions, poor solubility and single function. Herein, a novel concept of multifunctional COFs-based core-shell nanocomposite with good dispersity in various media was demonstrated and integrated it as a highly efficient targeted drug delivery system with excellent photothermal and magnetic performance. To achieve this, a facile sonication associated method to synthesize the nanocomposite at room temperature without any special equipment was developed, and then was modified by folic acid pre-linked bovine serum albumin, which further allowed long-time stability in media and special targeting toward cancer cells. Interestingly, the nanocomposite well quenched the fluorescence of doxorubicin, and this endowed us for the first time to visually detect drug loading by “turn-off” fluorescence. What's more, the effective combination of photothermal therapy and chemotherapy then achieved much better therapeutic effect than single therapy. Our work integrated magnetic COFs as a novel and effective drug carrier with good surface modification, excellent photothermal performance and high drug loading capacity, and reported the first experimental example of Fe3O4COF in the application of cancer chemo-photothermal therapy. Covalent organic frameworks (COFs) have unique chemical bonds and special molecular structure and possess great potential for biology applications. However, their utilization in drug delivery has been greatly limited on account of harsh synthesis conditions, poor solubility and single function. Herein, a novel concept of multifunctional COFs-based core-shell nanocomposite with good dispersity in various media was demonstrated and integrated it as a highly efficient targeted drug delivery system with excellent photothermal and magnetic performance. To achieve this, a facile sonication associated method to synthesize the nanocomposite at room temperature without any special equipment was developed, and then was modified by folic acid pre-linked bovine serum albumin, which further allowed long-time stability in media and special targeting toward cancer cells. Interestingly, the nanocomposite well quenched the fluorescence of doxorubicin, and this endowed us for the first time to visually detect drug loading by “turn-off” fluorescence. What's more, the effective combination of photothermal therapy and chemotherapy then achieved much better therapeutic effect than single therapy. Our work integrated magnetic COFs as a novel and effective drug carrier with good surface modification, excellent photothermal performance and high drug loading capacity, and reported the first experimental example of Fe3O4COF in the application of cancer chemo-photothermal therapy. Surface modification Elsevier COFs Elsevier Fluorescence Elsevier Core-shell structure Elsevier Drug delivery Elsevier Gong, Peiwei oth Huang, Jie oth Huang, Yan oth Wang, Dandan oth Peng, Jingyi oth Shen, Duyi oth Zheng, Xiaofeng oth You, Jinmao oth Liu, Zhe oth Enthalten in Elsevier Kim, Jeong-Hun ELSEVIER Impact of North Atlantic-East Asian teleconnections on extremely high January PM 2021 the official journal of the International Zeolite Association Amsterdam [u.a.] (DE-627)ELV006778283 volume:311 year:2021 pages:0 https://doi.org/10.1016/j.micromeso.2020.110713 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA SSG-OPC-FOR 48.00 Land- und Forstwirtschaft: Allgemeines VZ AR 311 2021 0 |
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10.1016/j.micromeso.2020.110713 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001229.pica (DE-627)ELV052391043 (ELSEVIER)S1387-1811(20)30713-7 DE-627 ger DE-627 rakwb eng 333.7 570 690 VZ BIODIV DE-30 fid 48.00 bkl Zhao, Kai verfasserin aut Fluorescence turn-off magnetic COF composite as a novel nanocarrier for drug loading and targeted delivery 2021transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Covalent organic frameworks (COFs) have unique chemical bonds and special molecular structure and possess great potential for biology applications. However, their utilization in drug delivery has been greatly limited on account of harsh synthesis conditions, poor solubility and single function. Herein, a novel concept of multifunctional COFs-based core-shell nanocomposite with good dispersity in various media was demonstrated and integrated it as a highly efficient targeted drug delivery system with excellent photothermal and magnetic performance. To achieve this, a facile sonication associated method to synthesize the nanocomposite at room temperature without any special equipment was developed, and then was modified by folic acid pre-linked bovine serum albumin, which further allowed long-time stability in media and special targeting toward cancer cells. Interestingly, the nanocomposite well quenched the fluorescence of doxorubicin, and this endowed us for the first time to visually detect drug loading by “turn-off” fluorescence. What's more, the effective combination of photothermal therapy and chemotherapy then achieved much better therapeutic effect than single therapy. Our work integrated magnetic COFs as a novel and effective drug carrier with good surface modification, excellent photothermal performance and high drug loading capacity, and reported the first experimental example of Fe3O4COF in the application of cancer chemo-photothermal therapy. Covalent organic frameworks (COFs) have unique chemical bonds and special molecular structure and possess great potential for biology applications. However, their utilization in drug delivery has been greatly limited on account of harsh synthesis conditions, poor solubility and single function. Herein, a novel concept of multifunctional COFs-based core-shell nanocomposite with good dispersity in various media was demonstrated and integrated it as a highly efficient targeted drug delivery system with excellent photothermal and magnetic performance. To achieve this, a facile sonication associated method to synthesize the nanocomposite at room temperature without any special equipment was developed, and then was modified by folic acid pre-linked bovine serum albumin, which further allowed long-time stability in media and special targeting toward cancer cells. Interestingly, the nanocomposite well quenched the fluorescence of doxorubicin, and this endowed us for the first time to visually detect drug loading by “turn-off” fluorescence. What's more, the effective combination of photothermal therapy and chemotherapy then achieved much better therapeutic effect than single therapy. Our work integrated magnetic COFs as a novel and effective drug carrier with good surface modification, excellent photothermal performance and high drug loading capacity, and reported the first experimental example of Fe3O4COF in the application of cancer chemo-photothermal therapy. Surface modification Elsevier COFs Elsevier Fluorescence Elsevier Core-shell structure Elsevier Drug delivery Elsevier Gong, Peiwei oth Huang, Jie oth Huang, Yan oth Wang, Dandan oth Peng, Jingyi oth Shen, Duyi oth Zheng, Xiaofeng oth You, Jinmao oth Liu, Zhe oth Enthalten in Elsevier Kim, Jeong-Hun ELSEVIER Impact of North Atlantic-East Asian teleconnections on extremely high January PM 2021 the official journal of the International Zeolite Association Amsterdam [u.a.] (DE-627)ELV006778283 volume:311 year:2021 pages:0 https://doi.org/10.1016/j.micromeso.2020.110713 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA SSG-OPC-FOR 48.00 Land- und Forstwirtschaft: Allgemeines VZ AR 311 2021 0 |
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Fluorescence turn-off magnetic COF composite as a novel nanocarrier for drug loading and targeted delivery |
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Covalent organic frameworks (COFs) have unique chemical bonds and special molecular structure and possess great potential for biology applications. However, their utilization in drug delivery has been greatly limited on account of harsh synthesis conditions, poor solubility and single function. Herein, a novel concept of multifunctional COFs-based core-shell nanocomposite with good dispersity in various media was demonstrated and integrated it as a highly efficient targeted drug delivery system with excellent photothermal and magnetic performance. To achieve this, a facile sonication associated method to synthesize the nanocomposite at room temperature without any special equipment was developed, and then was modified by folic acid pre-linked bovine serum albumin, which further allowed long-time stability in media and special targeting toward cancer cells. Interestingly, the nanocomposite well quenched the fluorescence of doxorubicin, and this endowed us for the first time to visually detect drug loading by “turn-off” fluorescence. What's more, the effective combination of photothermal therapy and chemotherapy then achieved much better therapeutic effect than single therapy. Our work integrated magnetic COFs as a novel and effective drug carrier with good surface modification, excellent photothermal performance and high drug loading capacity, and reported the first experimental example of Fe3O4COF in the application of cancer chemo-photothermal therapy. |
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Covalent organic frameworks (COFs) have unique chemical bonds and special molecular structure and possess great potential for biology applications. However, their utilization in drug delivery has been greatly limited on account of harsh synthesis conditions, poor solubility and single function. Herein, a novel concept of multifunctional COFs-based core-shell nanocomposite with good dispersity in various media was demonstrated and integrated it as a highly efficient targeted drug delivery system with excellent photothermal and magnetic performance. To achieve this, a facile sonication associated method to synthesize the nanocomposite at room temperature without any special equipment was developed, and then was modified by folic acid pre-linked bovine serum albumin, which further allowed long-time stability in media and special targeting toward cancer cells. Interestingly, the nanocomposite well quenched the fluorescence of doxorubicin, and this endowed us for the first time to visually detect drug loading by “turn-off” fluorescence. What's more, the effective combination of photothermal therapy and chemotherapy then achieved much better therapeutic effect than single therapy. Our work integrated magnetic COFs as a novel and effective drug carrier with good surface modification, excellent photothermal performance and high drug loading capacity, and reported the first experimental example of Fe3O4COF in the application of cancer chemo-photothermal therapy. |
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Covalent organic frameworks (COFs) have unique chemical bonds and special molecular structure and possess great potential for biology applications. However, their utilization in drug delivery has been greatly limited on account of harsh synthesis conditions, poor solubility and single function. Herein, a novel concept of multifunctional COFs-based core-shell nanocomposite with good dispersity in various media was demonstrated and integrated it as a highly efficient targeted drug delivery system with excellent photothermal and magnetic performance. To achieve this, a facile sonication associated method to synthesize the nanocomposite at room temperature without any special equipment was developed, and then was modified by folic acid pre-linked bovine serum albumin, which further allowed long-time stability in media and special targeting toward cancer cells. Interestingly, the nanocomposite well quenched the fluorescence of doxorubicin, and this endowed us for the first time to visually detect drug loading by “turn-off” fluorescence. What's more, the effective combination of photothermal therapy and chemotherapy then achieved much better therapeutic effect than single therapy. Our work integrated magnetic COFs as a novel and effective drug carrier with good surface modification, excellent photothermal performance and high drug loading capacity, and reported the first experimental example of Fe3O4COF in the application of cancer chemo-photothermal therapy. |
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