Simplified phenotyping of CYP2D6 for tamoxifen treatment using the N-desmethyl-tamoxifen/ endoxifen ratio
CYP2D6 protein activity can be inferred from the ratio of N-desmethyl-tamoxifen (NDMT) to endoxifen (E). CYP2D6 polymorphisms are common and can affect CYP2D6 protein activity and E level. Some retrospective studies indicate that E < 16 nM may relate to worse outcome.
Gespeichert in:
| Autor*in: |
Lee, Clara Inkyung [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Schlagwörter: |
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| Umfang: |
6 |
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| Übergeordnetes Werk: |
Enthalten in: The clinical outcomes of endovenous microwave and laser ablation for varicose veins: A prospective study - Yang, Lin ELSEVIER, 2020, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:54 ; year:2020 ; pages:229-234 ; extent:6 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.breast.2020.10.008 |
|---|
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| 650 | 7 | |a Phenotype |2 Elsevier | |
| 650 | 7 | |a Endoxifen |2 Elsevier | |
| 650 | 7 | |a CYP2D6 |2 Elsevier | |
| 650 | 7 | |a Tamoxifen |2 Elsevier | |
| 650 | 7 | |a Metabolism |2 Elsevier | |
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10.1016/j.breast.2020.10.008 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001241.pica (DE-627)ELV052517365 (ELSEVIER)S0960-9776(20)30199-5 DE-627 ger DE-627 rakwb eng 610 VZ 44.65 bkl Lee, Clara Inkyung verfasserin aut Simplified phenotyping of CYP2D6 for tamoxifen treatment using the N-desmethyl-tamoxifen/ endoxifen ratio 2020 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier CYP2D6 protein activity can be inferred from the ratio of N-desmethyl-tamoxifen (NDMT) to endoxifen (E). CYP2D6 polymorphisms are common and can affect CYP2D6 protein activity and E level. Some retrospective studies indicate that E < 16 nM may relate to worse outcome. Phenotype Elsevier Endoxifen Elsevier CYP2D6 Elsevier Tamoxifen Elsevier Metabolism Elsevier Low, Siew Kee oth Maldonado, Ricardo oth Fox, Peter oth Balakrishnar, Bavanthi oth Coulter, Sally oth de Bruijn, Peter oth Koolen, Stijn L.W. oth Gao, Bo oth Lynch, Jodi oth Zdenkowski, Nicholas oth Hui, Rina oth Liddle, Christopher oth Mathijssen, Ron H.J. oth Wilcken, Nicholas oth Wong, Mark oth Gurney, Howard oth Enthalten in Elsevier Yang, Lin ELSEVIER The clinical outcomes of endovenous microwave and laser ablation for varicose veins: A prospective study 2020 Amsterdam [u.a.] (DE-627)ELV004843835 volume:54 year:2020 pages:229-234 extent:6 https://doi.org/10.1016/j.breast.2020.10.008 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.65 Chirurgie VZ AR 54 2020 229-234 6 |
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Lee, Clara Inkyung |
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Lee, Clara Inkyung |
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10.1016/j.breast.2020.10.008 |
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| title_sort |
simplified phenotyping of cyp2d6 for tamoxifen treatment using the n-desmethyl-tamoxifen/ endoxifen ratio |
| title_auth |
Simplified phenotyping of CYP2D6 for tamoxifen treatment using the N-desmethyl-tamoxifen/ endoxifen ratio |
| abstract |
CYP2D6 protein activity can be inferred from the ratio of N-desmethyl-tamoxifen (NDMT) to endoxifen (E). CYP2D6 polymorphisms are common and can affect CYP2D6 protein activity and E level. Some retrospective studies indicate that E < 16 nM may relate to worse outcome. |
| abstractGer |
CYP2D6 protein activity can be inferred from the ratio of N-desmethyl-tamoxifen (NDMT) to endoxifen (E). CYP2D6 polymorphisms are common and can affect CYP2D6 protein activity and E level. Some retrospective studies indicate that E < 16 nM may relate to worse outcome. |
| abstract_unstemmed |
CYP2D6 protein activity can be inferred from the ratio of N-desmethyl-tamoxifen (NDMT) to endoxifen (E). CYP2D6 polymorphisms are common and can affect CYP2D6 protein activity and E level. Some retrospective studies indicate that E < 16 nM may relate to worse outcome. |
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GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA |
| title_short |
Simplified phenotyping of CYP2D6 for tamoxifen treatment using the N-desmethyl-tamoxifen/ endoxifen ratio |
| url |
https://doi.org/10.1016/j.breast.2020.10.008 |
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Low, Siew Kee Maldonado, Ricardo Fox, Peter Balakrishnar, Bavanthi Coulter, Sally de Bruijn, Peter Koolen, Stijn L.W. Gao, Bo Lynch, Jodi Zdenkowski, Nicholas Hui, Rina Liddle, Christopher Mathijssen, Ron H.J. Wilcken, Nicholas Wong, Mark Gurney, Howard |
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Low, Siew Kee Maldonado, Ricardo Fox, Peter Balakrishnar, Bavanthi Coulter, Sally de Bruijn, Peter Koolen, Stijn L.W. Gao, Bo Lynch, Jodi Zdenkowski, Nicholas Hui, Rina Liddle, Christopher Mathijssen, Ron H.J. Wilcken, Nicholas Wong, Mark Gurney, Howard |
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10.1016/j.breast.2020.10.008 |
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2024-07-06T23:14:46.465Z |
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