Selenium enrichment improves anti-proliferative effect of oolong tea extract on human hepatoma HuH-7 cells
Selenium (Se)-enriched tea is attracting increasing interests due to its significantly improved health benefits. This study was to investigate the anti-proliferative effects of Se-enriched oolong tea against human hepatoma HuH-7 cells. Compared with regular oolong tea extract (TE, 0.04 μg selenium/g...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Wang, Qi [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021transfer abstract |
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| Übergeordnetes Werk: |
Enthalten in: Numerical simulations on static Vertical Axis Wind Turbine blade icing - Manatbayev, Rustem ELSEVIER, 2021, New York, NY [u.a.] |
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| Übergeordnetes Werk: |
volume:147 ; year:2021 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1016/j.fct.2020.111873 |
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| 520 | |a Selenium (Se)-enriched tea is attracting increasing interests due to its significantly improved health benefits. This study was to investigate the anti-proliferative effects of Se-enriched oolong tea against human hepatoma HuH-7 cells. Compared with regular oolong tea extract (TE, 0.04 μg selenium/g), Se-enriched oolong tea extract (Se-TE, 0.51 μg selenium/g) exhibited more prominent anti-proliferative effect against HuH-7 cells with an IC50 of 203.1 μg/mL, mainly due to the synergistic effects of organic selenium and tea polyphenols. Our results found that Se-TE increased intracellular ROS production, arrested the cell cycle at G2/M phase, and thus induced cell apoptosis. In addition, western blotting assay revealed the increased expressions of the p53, Bax, caspase 3, and a reduction of Bcl-2 and CDK2, resulting in Se-TE-induced apoptosis. The improved anti-proliferative effect makes Se-enriched oolong tea extract a promising health-promoting ingredient in food industry. | ||
| 520 | |a Selenium (Se)-enriched tea is attracting increasing interests due to its significantly improved health benefits. This study was to investigate the anti-proliferative effects of Se-enriched oolong tea against human hepatoma HuH-7 cells. Compared with regular oolong tea extract (TE, 0.04 μg selenium/g), Se-enriched oolong tea extract (Se-TE, 0.51 μg selenium/g) exhibited more prominent anti-proliferative effect against HuH-7 cells with an IC50 of 203.1 μg/mL, mainly due to the synergistic effects of organic selenium and tea polyphenols. Our results found that Se-TE increased intracellular ROS production, arrested the cell cycle at G2/M phase, and thus induced cell apoptosis. In addition, western blotting assay revealed the increased expressions of the p53, Bax, caspase 3, and a reduction of Bcl-2 and CDK2, resulting in Se-TE-induced apoptosis. The improved anti-proliferative effect makes Se-enriched oolong tea extract a promising health-promoting ingredient in food industry. | ||
| 650 | 7 | |a Oolong tea |2 Elsevier | |
| 650 | 7 | |a Human hepatoma cell |2 Elsevier | |
| 650 | 7 | |a Anti-proliferative effect |2 Elsevier | |
| 650 | 7 | |a Selenium |2 Elsevier | |
| 650 | 7 | |a Apoptosis |2 Elsevier | |
| 700 | 1 | |a Guan, Xuefang |4 oth | |
| 700 | 1 | |a Lai, Chengchun |4 oth | |
| 700 | 1 | |a Gao, Huiying |4 oth | |
| 700 | 1 | |a Zheng, Yafeng |4 oth | |
| 700 | 1 | |a Huang, Juqing |4 oth | |
| 700 | 1 | |a Lin, Bin |4 oth | |
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10.1016/j.fct.2020.111873 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001374.pica (DE-627)ELV052612163 (ELSEVIER)S0278-6915(20)30763-8 DE-627 ger DE-627 rakwb eng 530 620 VZ 52.56 bkl Wang, Qi verfasserin aut Selenium enrichment improves anti-proliferative effect of oolong tea extract on human hepatoma HuH-7 cells 2021transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Selenium (Se)-enriched tea is attracting increasing interests due to its significantly improved health benefits. This study was to investigate the anti-proliferative effects of Se-enriched oolong tea against human hepatoma HuH-7 cells. Compared with regular oolong tea extract (TE, 0.04 μg selenium/g), Se-enriched oolong tea extract (Se-TE, 0.51 μg selenium/g) exhibited more prominent anti-proliferative effect against HuH-7 cells with an IC50 of 203.1 μg/mL, mainly due to the synergistic effects of organic selenium and tea polyphenols. Our results found that Se-TE increased intracellular ROS production, arrested the cell cycle at G2/M phase, and thus induced cell apoptosis. In addition, western blotting assay revealed the increased expressions of the p53, Bax, caspase 3, and a reduction of Bcl-2 and CDK2, resulting in Se-TE-induced apoptosis. The improved anti-proliferative effect makes Se-enriched oolong tea extract a promising health-promoting ingredient in food industry. Selenium (Se)-enriched tea is attracting increasing interests due to its significantly improved health benefits. This study was to investigate the anti-proliferative effects of Se-enriched oolong tea against human hepatoma HuH-7 cells. Compared with regular oolong tea extract (TE, 0.04 μg selenium/g), Se-enriched oolong tea extract (Se-TE, 0.51 μg selenium/g) exhibited more prominent anti-proliferative effect against HuH-7 cells with an IC50 of 203.1 μg/mL, mainly due to the synergistic effects of organic selenium and tea polyphenols. Our results found that Se-TE increased intracellular ROS production, arrested the cell cycle at G2/M phase, and thus induced cell apoptosis. In addition, western blotting assay revealed the increased expressions of the p53, Bax, caspase 3, and a reduction of Bcl-2 and CDK2, resulting in Se-TE-induced apoptosis. The improved anti-proliferative effect makes Se-enriched oolong tea extract a promising health-promoting ingredient in food industry. Oolong tea Elsevier Human hepatoma cell Elsevier Anti-proliferative effect Elsevier Selenium Elsevier Apoptosis Elsevier Guan, Xuefang oth Lai, Chengchun oth Gao, Huiying oth Zheng, Yafeng oth Huang, Juqing oth Lin, Bin oth Enthalten in Elsevier Manatbayev, Rustem ELSEVIER Numerical simulations on static Vertical Axis Wind Turbine blade icing 2021 New York, NY [u.a.] (DE-627)ELV005709407 volume:147 year:2021 pages:0 https://doi.org/10.1016/j.fct.2020.111873 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 52.56 Regenerative Energieformen alternative Energieformen VZ AR 147 2021 0 |
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10.1016/j.fct.2020.111873 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001374.pica (DE-627)ELV052612163 (ELSEVIER)S0278-6915(20)30763-8 DE-627 ger DE-627 rakwb eng 530 620 VZ 52.56 bkl Wang, Qi verfasserin aut Selenium enrichment improves anti-proliferative effect of oolong tea extract on human hepatoma HuH-7 cells 2021transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Selenium (Se)-enriched tea is attracting increasing interests due to its significantly improved health benefits. This study was to investigate the anti-proliferative effects of Se-enriched oolong tea against human hepatoma HuH-7 cells. Compared with regular oolong tea extract (TE, 0.04 μg selenium/g), Se-enriched oolong tea extract (Se-TE, 0.51 μg selenium/g) exhibited more prominent anti-proliferative effect against HuH-7 cells with an IC50 of 203.1 μg/mL, mainly due to the synergistic effects of organic selenium and tea polyphenols. Our results found that Se-TE increased intracellular ROS production, arrested the cell cycle at G2/M phase, and thus induced cell apoptosis. In addition, western blotting assay revealed the increased expressions of the p53, Bax, caspase 3, and a reduction of Bcl-2 and CDK2, resulting in Se-TE-induced apoptosis. The improved anti-proliferative effect makes Se-enriched oolong tea extract a promising health-promoting ingredient in food industry. Selenium (Se)-enriched tea is attracting increasing interests due to its significantly improved health benefits. This study was to investigate the anti-proliferative effects of Se-enriched oolong tea against human hepatoma HuH-7 cells. Compared with regular oolong tea extract (TE, 0.04 μg selenium/g), Se-enriched oolong tea extract (Se-TE, 0.51 μg selenium/g) exhibited more prominent anti-proliferative effect against HuH-7 cells with an IC50 of 203.1 μg/mL, mainly due to the synergistic effects of organic selenium and tea polyphenols. Our results found that Se-TE increased intracellular ROS production, arrested the cell cycle at G2/M phase, and thus induced cell apoptosis. In addition, western blotting assay revealed the increased expressions of the p53, Bax, caspase 3, and a reduction of Bcl-2 and CDK2, resulting in Se-TE-induced apoptosis. The improved anti-proliferative effect makes Se-enriched oolong tea extract a promising health-promoting ingredient in food industry. Oolong tea Elsevier Human hepatoma cell Elsevier Anti-proliferative effect Elsevier Selenium Elsevier Apoptosis Elsevier Guan, Xuefang oth Lai, Chengchun oth Gao, Huiying oth Zheng, Yafeng oth Huang, Juqing oth Lin, Bin oth Enthalten in Elsevier Manatbayev, Rustem ELSEVIER Numerical simulations on static Vertical Axis Wind Turbine blade icing 2021 New York, NY [u.a.] (DE-627)ELV005709407 volume:147 year:2021 pages:0 https://doi.org/10.1016/j.fct.2020.111873 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 52.56 Regenerative Energieformen alternative Energieformen VZ AR 147 2021 0 |
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10.1016/j.fct.2020.111873 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001374.pica (DE-627)ELV052612163 (ELSEVIER)S0278-6915(20)30763-8 DE-627 ger DE-627 rakwb eng 530 620 VZ 52.56 bkl Wang, Qi verfasserin aut Selenium enrichment improves anti-proliferative effect of oolong tea extract on human hepatoma HuH-7 cells 2021transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Selenium (Se)-enriched tea is attracting increasing interests due to its significantly improved health benefits. This study was to investigate the anti-proliferative effects of Se-enriched oolong tea against human hepatoma HuH-7 cells. Compared with regular oolong tea extract (TE, 0.04 μg selenium/g), Se-enriched oolong tea extract (Se-TE, 0.51 μg selenium/g) exhibited more prominent anti-proliferative effect against HuH-7 cells with an IC50 of 203.1 μg/mL, mainly due to the synergistic effects of organic selenium and tea polyphenols. Our results found that Se-TE increased intracellular ROS production, arrested the cell cycle at G2/M phase, and thus induced cell apoptosis. In addition, western blotting assay revealed the increased expressions of the p53, Bax, caspase 3, and a reduction of Bcl-2 and CDK2, resulting in Se-TE-induced apoptosis. The improved anti-proliferative effect makes Se-enriched oolong tea extract a promising health-promoting ingredient in food industry. Selenium (Se)-enriched tea is attracting increasing interests due to its significantly improved health benefits. This study was to investigate the anti-proliferative effects of Se-enriched oolong tea against human hepatoma HuH-7 cells. Compared with regular oolong tea extract (TE, 0.04 μg selenium/g), Se-enriched oolong tea extract (Se-TE, 0.51 μg selenium/g) exhibited more prominent anti-proliferative effect against HuH-7 cells with an IC50 of 203.1 μg/mL, mainly due to the synergistic effects of organic selenium and tea polyphenols. Our results found that Se-TE increased intracellular ROS production, arrested the cell cycle at G2/M phase, and thus induced cell apoptosis. In addition, western blotting assay revealed the increased expressions of the p53, Bax, caspase 3, and a reduction of Bcl-2 and CDK2, resulting in Se-TE-induced apoptosis. The improved anti-proliferative effect makes Se-enriched oolong tea extract a promising health-promoting ingredient in food industry. Oolong tea Elsevier Human hepatoma cell Elsevier Anti-proliferative effect Elsevier Selenium Elsevier Apoptosis Elsevier Guan, Xuefang oth Lai, Chengchun oth Gao, Huiying oth Zheng, Yafeng oth Huang, Juqing oth Lin, Bin oth Enthalten in Elsevier Manatbayev, Rustem ELSEVIER Numerical simulations on static Vertical Axis Wind Turbine blade icing 2021 New York, NY [u.a.] (DE-627)ELV005709407 volume:147 year:2021 pages:0 https://doi.org/10.1016/j.fct.2020.111873 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 52.56 Regenerative Energieformen alternative Energieformen VZ AR 147 2021 0 |
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10.1016/j.fct.2020.111873 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001374.pica (DE-627)ELV052612163 (ELSEVIER)S0278-6915(20)30763-8 DE-627 ger DE-627 rakwb eng 530 620 VZ 52.56 bkl Wang, Qi verfasserin aut Selenium enrichment improves anti-proliferative effect of oolong tea extract on human hepatoma HuH-7 cells 2021transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Selenium (Se)-enriched tea is attracting increasing interests due to its significantly improved health benefits. This study was to investigate the anti-proliferative effects of Se-enriched oolong tea against human hepatoma HuH-7 cells. Compared with regular oolong tea extract (TE, 0.04 μg selenium/g), Se-enriched oolong tea extract (Se-TE, 0.51 μg selenium/g) exhibited more prominent anti-proliferative effect against HuH-7 cells with an IC50 of 203.1 μg/mL, mainly due to the synergistic effects of organic selenium and tea polyphenols. Our results found that Se-TE increased intracellular ROS production, arrested the cell cycle at G2/M phase, and thus induced cell apoptosis. In addition, western blotting assay revealed the increased expressions of the p53, Bax, caspase 3, and a reduction of Bcl-2 and CDK2, resulting in Se-TE-induced apoptosis. The improved anti-proliferative effect makes Se-enriched oolong tea extract a promising health-promoting ingredient in food industry. Selenium (Se)-enriched tea is attracting increasing interests due to its significantly improved health benefits. This study was to investigate the anti-proliferative effects of Se-enriched oolong tea against human hepatoma HuH-7 cells. Compared with regular oolong tea extract (TE, 0.04 μg selenium/g), Se-enriched oolong tea extract (Se-TE, 0.51 μg selenium/g) exhibited more prominent anti-proliferative effect against HuH-7 cells with an IC50 of 203.1 μg/mL, mainly due to the synergistic effects of organic selenium and tea polyphenols. Our results found that Se-TE increased intracellular ROS production, arrested the cell cycle at G2/M phase, and thus induced cell apoptosis. In addition, western blotting assay revealed the increased expressions of the p53, Bax, caspase 3, and a reduction of Bcl-2 and CDK2, resulting in Se-TE-induced apoptosis. The improved anti-proliferative effect makes Se-enriched oolong tea extract a promising health-promoting ingredient in food industry. Oolong tea Elsevier Human hepatoma cell Elsevier Anti-proliferative effect Elsevier Selenium Elsevier Apoptosis Elsevier Guan, Xuefang oth Lai, Chengchun oth Gao, Huiying oth Zheng, Yafeng oth Huang, Juqing oth Lin, Bin oth Enthalten in Elsevier Manatbayev, Rustem ELSEVIER Numerical simulations on static Vertical Axis Wind Turbine blade icing 2021 New York, NY [u.a.] (DE-627)ELV005709407 volume:147 year:2021 pages:0 https://doi.org/10.1016/j.fct.2020.111873 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 52.56 Regenerative Energieformen alternative Energieformen VZ AR 147 2021 0 |
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10.1016/j.fct.2020.111873 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001374.pica (DE-627)ELV052612163 (ELSEVIER)S0278-6915(20)30763-8 DE-627 ger DE-627 rakwb eng 530 620 VZ 52.56 bkl Wang, Qi verfasserin aut Selenium enrichment improves anti-proliferative effect of oolong tea extract on human hepatoma HuH-7 cells 2021transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Selenium (Se)-enriched tea is attracting increasing interests due to its significantly improved health benefits. This study was to investigate the anti-proliferative effects of Se-enriched oolong tea against human hepatoma HuH-7 cells. Compared with regular oolong tea extract (TE, 0.04 μg selenium/g), Se-enriched oolong tea extract (Se-TE, 0.51 μg selenium/g) exhibited more prominent anti-proliferative effect against HuH-7 cells with an IC50 of 203.1 μg/mL, mainly due to the synergistic effects of organic selenium and tea polyphenols. Our results found that Se-TE increased intracellular ROS production, arrested the cell cycle at G2/M phase, and thus induced cell apoptosis. In addition, western blotting assay revealed the increased expressions of the p53, Bax, caspase 3, and a reduction of Bcl-2 and CDK2, resulting in Se-TE-induced apoptosis. The improved anti-proliferative effect makes Se-enriched oolong tea extract a promising health-promoting ingredient in food industry. Selenium (Se)-enriched tea is attracting increasing interests due to its significantly improved health benefits. This study was to investigate the anti-proliferative effects of Se-enriched oolong tea against human hepatoma HuH-7 cells. Compared with regular oolong tea extract (TE, 0.04 μg selenium/g), Se-enriched oolong tea extract (Se-TE, 0.51 μg selenium/g) exhibited more prominent anti-proliferative effect against HuH-7 cells with an IC50 of 203.1 μg/mL, mainly due to the synergistic effects of organic selenium and tea polyphenols. Our results found that Se-TE increased intracellular ROS production, arrested the cell cycle at G2/M phase, and thus induced cell apoptosis. In addition, western blotting assay revealed the increased expressions of the p53, Bax, caspase 3, and a reduction of Bcl-2 and CDK2, resulting in Se-TE-induced apoptosis. The improved anti-proliferative effect makes Se-enriched oolong tea extract a promising health-promoting ingredient in food industry. Oolong tea Elsevier Human hepatoma cell Elsevier Anti-proliferative effect Elsevier Selenium Elsevier Apoptosis Elsevier Guan, Xuefang oth Lai, Chengchun oth Gao, Huiying oth Zheng, Yafeng oth Huang, Juqing oth Lin, Bin oth Enthalten in Elsevier Manatbayev, Rustem ELSEVIER Numerical simulations on static Vertical Axis Wind Turbine blade icing 2021 New York, NY [u.a.] (DE-627)ELV005709407 volume:147 year:2021 pages:0 https://doi.org/10.1016/j.fct.2020.111873 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 52.56 Regenerative Energieformen alternative Energieformen VZ AR 147 2021 0 |
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This study was to investigate the anti-proliferative effects of Se-enriched oolong tea against human hepatoma HuH-7 cells. Compared with regular oolong tea extract (TE, 0.04 μg selenium/g), Se-enriched oolong tea extract (Se-TE, 0.51 μg selenium/g) exhibited more prominent anti-proliferative effect against HuH-7 cells with an IC50 of 203.1 μg/mL, mainly due to the synergistic effects of organic selenium and tea polyphenols. Our results found that Se-TE increased intracellular ROS production, arrested the cell cycle at G2/M phase, and thus induced cell apoptosis. In addition, western blotting assay revealed the increased expressions of the p53, Bax, caspase 3, and a reduction of Bcl-2 and CDK2, resulting in Se-TE-induced apoptosis. 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In addition, western blotting assay revealed the increased expressions of the p53, Bax, caspase 3, and a reduction of Bcl-2 and CDK2, resulting in Se-TE-induced apoptosis. 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Selenium enrichment improves anti-proliferative effect of oolong tea extract on human hepatoma HuH-7 cells |
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Selenium (Se)-enriched tea is attracting increasing interests due to its significantly improved health benefits. This study was to investigate the anti-proliferative effects of Se-enriched oolong tea against human hepatoma HuH-7 cells. Compared with regular oolong tea extract (TE, 0.04 μg selenium/g), Se-enriched oolong tea extract (Se-TE, 0.51 μg selenium/g) exhibited more prominent anti-proliferative effect against HuH-7 cells with an IC50 of 203.1 μg/mL, mainly due to the synergistic effects of organic selenium and tea polyphenols. Our results found that Se-TE increased intracellular ROS production, arrested the cell cycle at G2/M phase, and thus induced cell apoptosis. In addition, western blotting assay revealed the increased expressions of the p53, Bax, caspase 3, and a reduction of Bcl-2 and CDK2, resulting in Se-TE-induced apoptosis. The improved anti-proliferative effect makes Se-enriched oolong tea extract a promising health-promoting ingredient in food industry. |
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Selenium (Se)-enriched tea is attracting increasing interests due to its significantly improved health benefits. This study was to investigate the anti-proliferative effects of Se-enriched oolong tea against human hepatoma HuH-7 cells. Compared with regular oolong tea extract (TE, 0.04 μg selenium/g), Se-enriched oolong tea extract (Se-TE, 0.51 μg selenium/g) exhibited more prominent anti-proliferative effect against HuH-7 cells with an IC50 of 203.1 μg/mL, mainly due to the synergistic effects of organic selenium and tea polyphenols. Our results found that Se-TE increased intracellular ROS production, arrested the cell cycle at G2/M phase, and thus induced cell apoptosis. In addition, western blotting assay revealed the increased expressions of the p53, Bax, caspase 3, and a reduction of Bcl-2 and CDK2, resulting in Se-TE-induced apoptosis. The improved anti-proliferative effect makes Se-enriched oolong tea extract a promising health-promoting ingredient in food industry. |
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Selenium (Se)-enriched tea is attracting increasing interests due to its significantly improved health benefits. This study was to investigate the anti-proliferative effects of Se-enriched oolong tea against human hepatoma HuH-7 cells. Compared with regular oolong tea extract (TE, 0.04 μg selenium/g), Se-enriched oolong tea extract (Se-TE, 0.51 μg selenium/g) exhibited more prominent anti-proliferative effect against HuH-7 cells with an IC50 of 203.1 μg/mL, mainly due to the synergistic effects of organic selenium and tea polyphenols. Our results found that Se-TE increased intracellular ROS production, arrested the cell cycle at G2/M phase, and thus induced cell apoptosis. In addition, western blotting assay revealed the increased expressions of the p53, Bax, caspase 3, and a reduction of Bcl-2 and CDK2, resulting in Se-TE-induced apoptosis. The improved anti-proliferative effect makes Se-enriched oolong tea extract a promising health-promoting ingredient in food industry. |
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