LncRNA-Meg3 promotes Nlrp3-mediated microglial inflammation by targeting miR-7a-5p
• LPS promoted microglia activation and inflammation, upregulated Meg3, and reduced miR-7a-5p. • Meg3 was a direct target of miR-7a-5p that negatively regulates miR-7a-5p expression. • Meg3/miR-7a-5p induced microglial inflammation by regulating Nlrp3 expression.
Gespeichert in:
| Autor*in: |
Meng, Jiao [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2021 |
|---|
| Schlagwörter: |
|---|
| Übergeordnetes Werk: |
Enthalten in: International immunopharmacology - Laupland, Kevin B. ELSEVIER, 2022, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:90 ; year:2021 ; pages:0 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.intimp.2020.107141 |
|---|
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ELV052719138 |
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LncRNA-Meg3 promotes Nlrp3-mediated microglial inflammation by targeting miR-7a-5p |
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• LPS promoted microglia activation and inflammation, upregulated Meg3, and reduced miR-7a-5p. • Meg3 was a direct target of miR-7a-5p that negatively regulates miR-7a-5p expression. • Meg3/miR-7a-5p induced microglial inflammation by regulating Nlrp3 expression. |
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• LPS promoted microglia activation and inflammation, upregulated Meg3, and reduced miR-7a-5p. • Meg3 was a direct target of miR-7a-5p that negatively regulates miR-7a-5p expression. • Meg3/miR-7a-5p induced microglial inflammation by regulating Nlrp3 expression. |
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• LPS promoted microglia activation and inflammation, upregulated Meg3, and reduced miR-7a-5p. • Meg3 was a direct target of miR-7a-5p that negatively regulates miR-7a-5p expression. • Meg3/miR-7a-5p induced microglial inflammation by regulating Nlrp3 expression. |
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