The development of 11C-carbonylation chemistry: A systematic view
The prospects for using carbon-11 labelled compounds in molecular imaging has improved with the development of diverse synthesis methods, including 11C-carbonylations and refined techniques to handle [11C]carbon monoxide at a nanomole scale. Facilitating biological research and molecular imaging was...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Eriksson, Jonas [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021transfer abstract |
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| Umfang: |
23 |
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| Übergeordnetes Werk: |
Enthalten in: Inflammatory Expression Profiles in Bladder Exstrophy Smooth Muscle: Normalization Over Time - Michaud, Jason E. ELSEVIER, 2023, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:92 ; year:2021 ; pages:115-137 ; extent:23 |
| Links: |
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| DOI / URN: |
10.1016/j.nucmedbio.2020.02.005 |
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| 245 | 1 | 4 | |a The development of 11C-carbonylation chemistry: A systematic view |
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| 520 | |a The prospects for using carbon-11 labelled compounds in molecular imaging has improved with the development of diverse synthesis methods, including 11C-carbonylations and refined techniques to handle [11C]carbon monoxide at a nanomole scale. Facilitating biological research and molecular imaging was the driving force when [11C]carbon monoxide was used in the first in vivo application with carbon-11 in human (1945) and when [11C]carbon monoxide was used for the first time as a chemical reagent in the synthesis of [11C]phosgene (1978). This review examines a rich plethora of labelled compounds synthesized from [11C]carbon monoxide, their chemistry and use in molecular imaging. While the strong development of the 11C-carbonylation chemistry has expanded the carbon-11 domain considerably, it could be argued that the number of 11C-carbonyl compounds entering biological investigations should be higher. The reason for this may partly be the lack of commercially available synthesis instruments designed for 11C-carbonylations. But as this review shows, novel and greatly simplified methods to handle [11C]carbon monoxide have been developed. The next important challenge is to make full use of these technologies and synthesis methods in PET research. When there is a PET-tracer that meets a more general need, the incentive to implement 11C-carbonylation protocols will increase. | ||
| 520 | |a The prospects for using carbon-11 labelled compounds in molecular imaging has improved with the development of diverse synthesis methods, including 11C-carbonylations and refined techniques to handle [11C]carbon monoxide at a nanomole scale. Facilitating biological research and molecular imaging was the driving force when [11C]carbon monoxide was used in the first in vivo application with carbon-11 in human (1945) and when [11C]carbon monoxide was used for the first time as a chemical reagent in the synthesis of [11C]phosgene (1978). This review examines a rich plethora of labelled compounds synthesized from [11C]carbon monoxide, their chemistry and use in molecular imaging. While the strong development of the 11C-carbonylation chemistry has expanded the carbon-11 domain considerably, it could be argued that the number of 11C-carbonyl compounds entering biological investigations should be higher. The reason for this may partly be the lack of commercially available synthesis instruments designed for 11C-carbonylations. But as this review shows, novel and greatly simplified methods to handle [11C]carbon monoxide have been developed. The next important challenge is to make full use of these technologies and synthesis methods in PET research. When there is a PET-tracer that meets a more general need, the incentive to implement 11C-carbonylation protocols will increase. | ||
| 700 | 1 | |a Antoni, Gunnar |4 oth | |
| 700 | 1 | |a Långström, Bengt |4 oth | |
| 700 | 1 | |a Itsenko, Oleksiy |4 oth | |
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10.1016/j.nucmedbio.2020.02.005 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001288.pica (DE-627)ELV053001605 (ELSEVIER)S0969-8051(20)30038-X DE-627 ger DE-627 rakwb eng 610 VZ 44.88 bkl Eriksson, Jonas verfasserin aut The development of 11C-carbonylation chemistry: A systematic view 2021transfer abstract 23 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The prospects for using carbon-11 labelled compounds in molecular imaging has improved with the development of diverse synthesis methods, including 11C-carbonylations and refined techniques to handle [11C]carbon monoxide at a nanomole scale. Facilitating biological research and molecular imaging was the driving force when [11C]carbon monoxide was used in the first in vivo application with carbon-11 in human (1945) and when [11C]carbon monoxide was used for the first time as a chemical reagent in the synthesis of [11C]phosgene (1978). This review examines a rich plethora of labelled compounds synthesized from [11C]carbon monoxide, their chemistry and use in molecular imaging. While the strong development of the 11C-carbonylation chemistry has expanded the carbon-11 domain considerably, it could be argued that the number of 11C-carbonyl compounds entering biological investigations should be higher. The reason for this may partly be the lack of commercially available synthesis instruments designed for 11C-carbonylations. But as this review shows, novel and greatly simplified methods to handle [11C]carbon monoxide have been developed. The next important challenge is to make full use of these technologies and synthesis methods in PET research. When there is a PET-tracer that meets a more general need, the incentive to implement 11C-carbonylation protocols will increase. The prospects for using carbon-11 labelled compounds in molecular imaging has improved with the development of diverse synthesis methods, including 11C-carbonylations and refined techniques to handle [11C]carbon monoxide at a nanomole scale. Facilitating biological research and molecular imaging was the driving force when [11C]carbon monoxide was used in the first in vivo application with carbon-11 in human (1945) and when [11C]carbon monoxide was used for the first time as a chemical reagent in the synthesis of [11C]phosgene (1978). This review examines a rich plethora of labelled compounds synthesized from [11C]carbon monoxide, their chemistry and use in molecular imaging. While the strong development of the 11C-carbonylation chemistry has expanded the carbon-11 domain considerably, it could be argued that the number of 11C-carbonyl compounds entering biological investigations should be higher. The reason for this may partly be the lack of commercially available synthesis instruments designed for 11C-carbonylations. But as this review shows, novel and greatly simplified methods to handle [11C]carbon monoxide have been developed. The next important challenge is to make full use of these technologies and synthesis methods in PET research. When there is a PET-tracer that meets a more general need, the incentive to implement 11C-carbonylation protocols will increase. Antoni, Gunnar oth Långström, Bengt oth Itsenko, Oleksiy oth Enthalten in Elsevier Science Michaud, Jason E. ELSEVIER Inflammatory Expression Profiles in Bladder Exstrophy Smooth Muscle: Normalization Over Time 2023 Amsterdam [u.a.] (DE-627)ELV010596976 volume:92 year:2021 pages:115-137 extent:23 https://doi.org/10.1016/j.nucmedbio.2020.02.005 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.88 Urologie Nephrologie VZ AR 92 2021 115-137 23 |
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10.1016/j.nucmedbio.2020.02.005 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001288.pica (DE-627)ELV053001605 (ELSEVIER)S0969-8051(20)30038-X DE-627 ger DE-627 rakwb eng 610 VZ 44.88 bkl Eriksson, Jonas verfasserin aut The development of 11C-carbonylation chemistry: A systematic view 2021transfer abstract 23 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The prospects for using carbon-11 labelled compounds in molecular imaging has improved with the development of diverse synthesis methods, including 11C-carbonylations and refined techniques to handle [11C]carbon monoxide at a nanomole scale. Facilitating biological research and molecular imaging was the driving force when [11C]carbon monoxide was used in the first in vivo application with carbon-11 in human (1945) and when [11C]carbon monoxide was used for the first time as a chemical reagent in the synthesis of [11C]phosgene (1978). This review examines a rich plethora of labelled compounds synthesized from [11C]carbon monoxide, their chemistry and use in molecular imaging. While the strong development of the 11C-carbonylation chemistry has expanded the carbon-11 domain considerably, it could be argued that the number of 11C-carbonyl compounds entering biological investigations should be higher. The reason for this may partly be the lack of commercially available synthesis instruments designed for 11C-carbonylations. But as this review shows, novel and greatly simplified methods to handle [11C]carbon monoxide have been developed. The next important challenge is to make full use of these technologies and synthesis methods in PET research. When there is a PET-tracer that meets a more general need, the incentive to implement 11C-carbonylation protocols will increase. The prospects for using carbon-11 labelled compounds in molecular imaging has improved with the development of diverse synthesis methods, including 11C-carbonylations and refined techniques to handle [11C]carbon monoxide at a nanomole scale. Facilitating biological research and molecular imaging was the driving force when [11C]carbon monoxide was used in the first in vivo application with carbon-11 in human (1945) and when [11C]carbon monoxide was used for the first time as a chemical reagent in the synthesis of [11C]phosgene (1978). This review examines a rich plethora of labelled compounds synthesized from [11C]carbon monoxide, their chemistry and use in molecular imaging. While the strong development of the 11C-carbonylation chemistry has expanded the carbon-11 domain considerably, it could be argued that the number of 11C-carbonyl compounds entering biological investigations should be higher. The reason for this may partly be the lack of commercially available synthesis instruments designed for 11C-carbonylations. But as this review shows, novel and greatly simplified methods to handle [11C]carbon monoxide have been developed. The next important challenge is to make full use of these technologies and synthesis methods in PET research. When there is a PET-tracer that meets a more general need, the incentive to implement 11C-carbonylation protocols will increase. Antoni, Gunnar oth Långström, Bengt oth Itsenko, Oleksiy oth Enthalten in Elsevier Science Michaud, Jason E. ELSEVIER Inflammatory Expression Profiles in Bladder Exstrophy Smooth Muscle: Normalization Over Time 2023 Amsterdam [u.a.] (DE-627)ELV010596976 volume:92 year:2021 pages:115-137 extent:23 https://doi.org/10.1016/j.nucmedbio.2020.02.005 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.88 Urologie Nephrologie VZ AR 92 2021 115-137 23 |
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10.1016/j.nucmedbio.2020.02.005 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001288.pica (DE-627)ELV053001605 (ELSEVIER)S0969-8051(20)30038-X DE-627 ger DE-627 rakwb eng 610 VZ 44.88 bkl Eriksson, Jonas verfasserin aut The development of 11C-carbonylation chemistry: A systematic view 2021transfer abstract 23 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The prospects for using carbon-11 labelled compounds in molecular imaging has improved with the development of diverse synthesis methods, including 11C-carbonylations and refined techniques to handle [11C]carbon monoxide at a nanomole scale. Facilitating biological research and molecular imaging was the driving force when [11C]carbon monoxide was used in the first in vivo application with carbon-11 in human (1945) and when [11C]carbon monoxide was used for the first time as a chemical reagent in the synthesis of [11C]phosgene (1978). This review examines a rich plethora of labelled compounds synthesized from [11C]carbon monoxide, their chemistry and use in molecular imaging. While the strong development of the 11C-carbonylation chemistry has expanded the carbon-11 domain considerably, it could be argued that the number of 11C-carbonyl compounds entering biological investigations should be higher. The reason for this may partly be the lack of commercially available synthesis instruments designed for 11C-carbonylations. But as this review shows, novel and greatly simplified methods to handle [11C]carbon monoxide have been developed. The next important challenge is to make full use of these technologies and synthesis methods in PET research. When there is a PET-tracer that meets a more general need, the incentive to implement 11C-carbonylation protocols will increase. The prospects for using carbon-11 labelled compounds in molecular imaging has improved with the development of diverse synthesis methods, including 11C-carbonylations and refined techniques to handle [11C]carbon monoxide at a nanomole scale. Facilitating biological research and molecular imaging was the driving force when [11C]carbon monoxide was used in the first in vivo application with carbon-11 in human (1945) and when [11C]carbon monoxide was used for the first time as a chemical reagent in the synthesis of [11C]phosgene (1978). This review examines a rich plethora of labelled compounds synthesized from [11C]carbon monoxide, their chemistry and use in molecular imaging. While the strong development of the 11C-carbonylation chemistry has expanded the carbon-11 domain considerably, it could be argued that the number of 11C-carbonyl compounds entering biological investigations should be higher. The reason for this may partly be the lack of commercially available synthesis instruments designed for 11C-carbonylations. But as this review shows, novel and greatly simplified methods to handle [11C]carbon monoxide have been developed. The next important challenge is to make full use of these technologies and synthesis methods in PET research. When there is a PET-tracer that meets a more general need, the incentive to implement 11C-carbonylation protocols will increase. Antoni, Gunnar oth Långström, Bengt oth Itsenko, Oleksiy oth Enthalten in Elsevier Science Michaud, Jason E. ELSEVIER Inflammatory Expression Profiles in Bladder Exstrophy Smooth Muscle: Normalization Over Time 2023 Amsterdam [u.a.] (DE-627)ELV010596976 volume:92 year:2021 pages:115-137 extent:23 https://doi.org/10.1016/j.nucmedbio.2020.02.005 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.88 Urologie Nephrologie VZ AR 92 2021 115-137 23 |
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10.1016/j.nucmedbio.2020.02.005 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001288.pica (DE-627)ELV053001605 (ELSEVIER)S0969-8051(20)30038-X DE-627 ger DE-627 rakwb eng 610 VZ 44.88 bkl Eriksson, Jonas verfasserin aut The development of 11C-carbonylation chemistry: A systematic view 2021transfer abstract 23 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The prospects for using carbon-11 labelled compounds in molecular imaging has improved with the development of diverse synthesis methods, including 11C-carbonylations and refined techniques to handle [11C]carbon monoxide at a nanomole scale. Facilitating biological research and molecular imaging was the driving force when [11C]carbon monoxide was used in the first in vivo application with carbon-11 in human (1945) and when [11C]carbon monoxide was used for the first time as a chemical reagent in the synthesis of [11C]phosgene (1978). This review examines a rich plethora of labelled compounds synthesized from [11C]carbon monoxide, their chemistry and use in molecular imaging. While the strong development of the 11C-carbonylation chemistry has expanded the carbon-11 domain considerably, it could be argued that the number of 11C-carbonyl compounds entering biological investigations should be higher. The reason for this may partly be the lack of commercially available synthesis instruments designed for 11C-carbonylations. But as this review shows, novel and greatly simplified methods to handle [11C]carbon monoxide have been developed. The next important challenge is to make full use of these technologies and synthesis methods in PET research. When there is a PET-tracer that meets a more general need, the incentive to implement 11C-carbonylation protocols will increase. The prospects for using carbon-11 labelled compounds in molecular imaging has improved with the development of diverse synthesis methods, including 11C-carbonylations and refined techniques to handle [11C]carbon monoxide at a nanomole scale. Facilitating biological research and molecular imaging was the driving force when [11C]carbon monoxide was used in the first in vivo application with carbon-11 in human (1945) and when [11C]carbon monoxide was used for the first time as a chemical reagent in the synthesis of [11C]phosgene (1978). This review examines a rich plethora of labelled compounds synthesized from [11C]carbon monoxide, their chemistry and use in molecular imaging. While the strong development of the 11C-carbonylation chemistry has expanded the carbon-11 domain considerably, it could be argued that the number of 11C-carbonyl compounds entering biological investigations should be higher. The reason for this may partly be the lack of commercially available synthesis instruments designed for 11C-carbonylations. But as this review shows, novel and greatly simplified methods to handle [11C]carbon monoxide have been developed. The next important challenge is to make full use of these technologies and synthesis methods in PET research. When there is a PET-tracer that meets a more general need, the incentive to implement 11C-carbonylation protocols will increase. Antoni, Gunnar oth Långström, Bengt oth Itsenko, Oleksiy oth Enthalten in Elsevier Science Michaud, Jason E. ELSEVIER Inflammatory Expression Profiles in Bladder Exstrophy Smooth Muscle: Normalization Over Time 2023 Amsterdam [u.a.] (DE-627)ELV010596976 volume:92 year:2021 pages:115-137 extent:23 https://doi.org/10.1016/j.nucmedbio.2020.02.005 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.88 Urologie Nephrologie VZ AR 92 2021 115-137 23 |
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10.1016/j.nucmedbio.2020.02.005 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001288.pica (DE-627)ELV053001605 (ELSEVIER)S0969-8051(20)30038-X DE-627 ger DE-627 rakwb eng 610 VZ 44.88 bkl Eriksson, Jonas verfasserin aut The development of 11C-carbonylation chemistry: A systematic view 2021transfer abstract 23 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The prospects for using carbon-11 labelled compounds in molecular imaging has improved with the development of diverse synthesis methods, including 11C-carbonylations and refined techniques to handle [11C]carbon monoxide at a nanomole scale. Facilitating biological research and molecular imaging was the driving force when [11C]carbon monoxide was used in the first in vivo application with carbon-11 in human (1945) and when [11C]carbon monoxide was used for the first time as a chemical reagent in the synthesis of [11C]phosgene (1978). This review examines a rich plethora of labelled compounds synthesized from [11C]carbon monoxide, their chemistry and use in molecular imaging. While the strong development of the 11C-carbonylation chemistry has expanded the carbon-11 domain considerably, it could be argued that the number of 11C-carbonyl compounds entering biological investigations should be higher. The reason for this may partly be the lack of commercially available synthesis instruments designed for 11C-carbonylations. But as this review shows, novel and greatly simplified methods to handle [11C]carbon monoxide have been developed. The next important challenge is to make full use of these technologies and synthesis methods in PET research. When there is a PET-tracer that meets a more general need, the incentive to implement 11C-carbonylation protocols will increase. The prospects for using carbon-11 labelled compounds in molecular imaging has improved with the development of diverse synthesis methods, including 11C-carbonylations and refined techniques to handle [11C]carbon monoxide at a nanomole scale. Facilitating biological research and molecular imaging was the driving force when [11C]carbon monoxide was used in the first in vivo application with carbon-11 in human (1945) and when [11C]carbon monoxide was used for the first time as a chemical reagent in the synthesis of [11C]phosgene (1978). This review examines a rich plethora of labelled compounds synthesized from [11C]carbon monoxide, their chemistry and use in molecular imaging. While the strong development of the 11C-carbonylation chemistry has expanded the carbon-11 domain considerably, it could be argued that the number of 11C-carbonyl compounds entering biological investigations should be higher. The reason for this may partly be the lack of commercially available synthesis instruments designed for 11C-carbonylations. But as this review shows, novel and greatly simplified methods to handle [11C]carbon monoxide have been developed. The next important challenge is to make full use of these technologies and synthesis methods in PET research. When there is a PET-tracer that meets a more general need, the incentive to implement 11C-carbonylation protocols will increase. Antoni, Gunnar oth Långström, Bengt oth Itsenko, Oleksiy oth Enthalten in Elsevier Science Michaud, Jason E. ELSEVIER Inflammatory Expression Profiles in Bladder Exstrophy Smooth Muscle: Normalization Over Time 2023 Amsterdam [u.a.] (DE-627)ELV010596976 volume:92 year:2021 pages:115-137 extent:23 https://doi.org/10.1016/j.nucmedbio.2020.02.005 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.88 Urologie Nephrologie VZ AR 92 2021 115-137 23 |
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The prospects for using carbon-11 labelled compounds in molecular imaging has improved with the development of diverse synthesis methods, including 11C-carbonylations and refined techniques to handle [11C]carbon monoxide at a nanomole scale. Facilitating biological research and molecular imaging was the driving force when [11C]carbon monoxide was used in the first in vivo application with carbon-11 in human (1945) and when [11C]carbon monoxide was used for the first time as a chemical reagent in the synthesis of [11C]phosgene (1978). This review examines a rich plethora of labelled compounds synthesized from [11C]carbon monoxide, their chemistry and use in molecular imaging. While the strong development of the 11C-carbonylation chemistry has expanded the carbon-11 domain considerably, it could be argued that the number of 11C-carbonyl compounds entering biological investigations should be higher. The reason for this may partly be the lack of commercially available synthesis instruments designed for 11C-carbonylations. But as this review shows, novel and greatly simplified methods to handle [11C]carbon monoxide have been developed. The next important challenge is to make full use of these technologies and synthesis methods in PET research. When there is a PET-tracer that meets a more general need, the incentive to implement 11C-carbonylation protocols will increase. |
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The prospects for using carbon-11 labelled compounds in molecular imaging has improved with the development of diverse synthesis methods, including 11C-carbonylations and refined techniques to handle [11C]carbon monoxide at a nanomole scale. Facilitating biological research and molecular imaging was the driving force when [11C]carbon monoxide was used in the first in vivo application with carbon-11 in human (1945) and when [11C]carbon monoxide was used for the first time as a chemical reagent in the synthesis of [11C]phosgene (1978). This review examines a rich plethora of labelled compounds synthesized from [11C]carbon monoxide, their chemistry and use in molecular imaging. While the strong development of the 11C-carbonylation chemistry has expanded the carbon-11 domain considerably, it could be argued that the number of 11C-carbonyl compounds entering biological investigations should be higher. The reason for this may partly be the lack of commercially available synthesis instruments designed for 11C-carbonylations. But as this review shows, novel and greatly simplified methods to handle [11C]carbon monoxide have been developed. The next important challenge is to make full use of these technologies and synthesis methods in PET research. When there is a PET-tracer that meets a more general need, the incentive to implement 11C-carbonylation protocols will increase. |
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The prospects for using carbon-11 labelled compounds in molecular imaging has improved with the development of diverse synthesis methods, including 11C-carbonylations and refined techniques to handle [11C]carbon monoxide at a nanomole scale. Facilitating biological research and molecular imaging was the driving force when [11C]carbon monoxide was used in the first in vivo application with carbon-11 in human (1945) and when [11C]carbon monoxide was used for the first time as a chemical reagent in the synthesis of [11C]phosgene (1978). This review examines a rich plethora of labelled compounds synthesized from [11C]carbon monoxide, their chemistry and use in molecular imaging. While the strong development of the 11C-carbonylation chemistry has expanded the carbon-11 domain considerably, it could be argued that the number of 11C-carbonyl compounds entering biological investigations should be higher. The reason for this may partly be the lack of commercially available synthesis instruments designed for 11C-carbonylations. But as this review shows, novel and greatly simplified methods to handle [11C]carbon monoxide have been developed. The next important challenge is to make full use of these technologies and synthesis methods in PET research. When there is a PET-tracer that meets a more general need, the incentive to implement 11C-carbonylation protocols will increase. |
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