Non-targeted screening methodology to characterise human internal chemical exposure: Application to halogenated compounds in human milk

Suspect and non-targeted screening approaches are a matter of increasing interest notably with regard to the Exposome contextual framework, but their application to human samples still remains limited at this date. The aim of the present study was to develop a non-targeted workflow from sample prepa...
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Autor*in:	Pourchet, Mariane [verfasserIn] Narduzzi, Luca [verfasserIn] Jean, Annabelle [verfasserIn] Guiffard, Ingrid [verfasserIn] Bichon, Emmanuelle [verfasserIn] Cariou, Ronan [verfasserIn] Guitton, Yann [verfasserIn] Hutinet, Sébastien [verfasserIn] Vlaanderen, Jelle [verfasserIn] Meijer, Jeroen [verfasserIn] Le Bizec, Bruno [verfasserIn] Antignac, Jean-Philippe [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	Non-targeted screening Human milk Human biomonitoring Internal chemical exposure HRMS HBM4EU

Übergeordnetes Werk:	Enthalten in: Talanta - Amsterdam [u.a.] : Elsevier Science, 1958, 225
Übergeordnetes Werk:	volume:225

DOI / URN:	10.1016/j.talanta.2020.121979

Katalog-ID:	ELV05305248X

Internformat


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245	1	0	\|a Non-targeted screening methodology to characterise human internal chemical exposure: Application to halogenated compounds in human milk
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520			\|a Suspect and non-targeted screening approaches are a matter of increasing interest notably with regard to the Exposome contextual framework, but their application to human samples still remains limited at this date. The aim of the present study was to develop a non-targeted workflow from sample preparation to data processing and method assessment to characterise the human internal chemical exposure at early life stage. The method was focused on human milk to investigate mother and newborn exposure to known organic contaminants and to extend the characterisation to unknown compounds. We specifically focused on halogenated biomarkers of exposure due to persistence and potential toxicological impact reasons. The newly developed approach was based on a simple and fast sample preparation followed by a comprehensive analysis by both liquid and gas phase chromatography coupled to high resolution mass spectrometry. Critical steps of the non-targeted workflow as the method assessment have been addressed with a reference mix of 30 chlorinated and brominated contaminants encompassing various substances groups and a statistical approach. Data processing until the identification of biomarkers of exposure was possible with homemade bioinformatics tools. On the other hand, the method was validated by the identification of historical chemicals as hexachlorobenzene and p,p’-DDE and emerging chemical as 4-hydroxychlorothalonil. This approach opens the door to further extensions and consolidations to offer new capabilities for exposomics and environmental health research.
650		4	\|a Non-targeted screening
650		4	\|a Human milk
650		4	\|a Human biomonitoring
650		4	\|a Internal chemical exposure
650		4	\|a HRMS
650		4	\|a HBM4EU
700	1		\|a Narduzzi, Luca \|e verfasserin \|0 (orcid)0000-0002-1921-651X \|4 aut
700	1		\|a Jean, Annabelle \|e verfasserin \|4 aut
700	1		\|a Guiffard, Ingrid \|e verfasserin \|4 aut
700	1		\|a Bichon, Emmanuelle \|e verfasserin \|4 aut
700	1		\|a Cariou, Ronan \|e verfasserin \|4 aut
700	1		\|a Guitton, Yann \|e verfasserin \|0 (orcid)0000-0002-4479-0636 \|4 aut
700	1		\|a Hutinet, Sébastien \|e verfasserin \|4 aut
700	1		\|a Vlaanderen, Jelle \|e verfasserin \|0 (orcid)0000-0002-9096-692X \|4 aut
700	1		\|a Meijer, Jeroen \|e verfasserin \|0 (orcid)0000-0002-4551-6823 \|4 aut
700	1		\|a Le Bizec, Bruno \|e verfasserin \|4 aut
700	1		\|a Antignac, Jean-Philippe \|e verfasserin \|0 (orcid)0000-0001-9512-9314 \|4 aut
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912			\|a GBV_ILN_602
912			\|a GBV_ILN_702
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
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912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
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912			\|a GBV_ILN_2034
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912			\|a GBV_ILN_2507
912			\|a GBV_ILN_2522
912			\|a GBV_ILN_4035
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4242
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4335
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4393
936	b	k	\|a 35.00 \|j Chemie: Allgemeines \|q VZ
951			\|a AR
952			\|d 225

Indexfelder

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publishDate	2020
allfields	10.1016/j.talanta.2020.121979 doi (DE-627)ELV05305248X (ELSEVIER)S0039-9140(20)31270-4 DE-627 ger DE-627 rda eng 540 VZ 35.00 bkl Pourchet, Mariane verfasserin aut Non-targeted screening methodology to characterise human internal chemical exposure: Application to halogenated compounds in human milk 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Suspect and non-targeted screening approaches are a matter of increasing interest notably with regard to the Exposome contextual framework, but their application to human samples still remains limited at this date. The aim of the present study was to develop a non-targeted workflow from sample preparation to data processing and method assessment to characterise the human internal chemical exposure at early life stage. The method was focused on human milk to investigate mother and newborn exposure to known organic contaminants and to extend the characterisation to unknown compounds. We specifically focused on halogenated biomarkers of exposure due to persistence and potential toxicological impact reasons. The newly developed approach was based on a simple and fast sample preparation followed by a comprehensive analysis by both liquid and gas phase chromatography coupled to high resolution mass spectrometry. Critical steps of the non-targeted workflow as the method assessment have been addressed with a reference mix of 30 chlorinated and brominated contaminants encompassing various substances groups and a statistical approach. Data processing until the identification of biomarkers of exposure was possible with homemade bioinformatics tools. On the other hand, the method was validated by the identification of historical chemicals as hexachlorobenzene and p,p’-DDE and emerging chemical as 4-hydroxychlorothalonil. This approach opens the door to further extensions and consolidations to offer new capabilities for exposomics and environmental health research. Non-targeted screening Human milk Human biomonitoring Internal chemical exposure HRMS HBM4EU Narduzzi, Luca verfasserin (orcid)0000-0002-1921-651X aut Jean, Annabelle verfasserin aut Guiffard, Ingrid verfasserin aut Bichon, Emmanuelle verfasserin aut Cariou, Ronan verfasserin aut Guitton, Yann verfasserin (orcid)0000-0002-4479-0636 aut Hutinet, Sébastien verfasserin aut Vlaanderen, Jelle verfasserin (orcid)0000-0002-9096-692X aut Meijer, Jeroen verfasserin (orcid)0000-0002-4551-6823 aut Le Bizec, Bruno verfasserin aut Antignac, Jean-Philippe verfasserin (orcid)0000-0001-9512-9314 aut Enthalten in Talanta Amsterdam [u.a.] : Elsevier Science, 1958 225 Online-Ressource (DE-627)306712571 (DE-600)1500969-5 (DE-576)251938158 1873-3573 nnns volume:225 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.00 Chemie: Allgemeines VZ AR 225
spelling	10.1016/j.talanta.2020.121979 doi (DE-627)ELV05305248X (ELSEVIER)S0039-9140(20)31270-4 DE-627 ger DE-627 rda eng 540 VZ 35.00 bkl Pourchet, Mariane verfasserin aut Non-targeted screening methodology to characterise human internal chemical exposure: Application to halogenated compounds in human milk 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Suspect and non-targeted screening approaches are a matter of increasing interest notably with regard to the Exposome contextual framework, but their application to human samples still remains limited at this date. The aim of the present study was to develop a non-targeted workflow from sample preparation to data processing and method assessment to characterise the human internal chemical exposure at early life stage. The method was focused on human milk to investigate mother and newborn exposure to known organic contaminants and to extend the characterisation to unknown compounds. We specifically focused on halogenated biomarkers of exposure due to persistence and potential toxicological impact reasons. The newly developed approach was based on a simple and fast sample preparation followed by a comprehensive analysis by both liquid and gas phase chromatography coupled to high resolution mass spectrometry. Critical steps of the non-targeted workflow as the method assessment have been addressed with a reference mix of 30 chlorinated and brominated contaminants encompassing various substances groups and a statistical approach. Data processing until the identification of biomarkers of exposure was possible with homemade bioinformatics tools. On the other hand, the method was validated by the identification of historical chemicals as hexachlorobenzene and p,p’-DDE and emerging chemical as 4-hydroxychlorothalonil. This approach opens the door to further extensions and consolidations to offer new capabilities for exposomics and environmental health research. Non-targeted screening Human milk Human biomonitoring Internal chemical exposure HRMS HBM4EU Narduzzi, Luca verfasserin (orcid)0000-0002-1921-651X aut Jean, Annabelle verfasserin aut Guiffard, Ingrid verfasserin aut Bichon, Emmanuelle verfasserin aut Cariou, Ronan verfasserin aut Guitton, Yann verfasserin (orcid)0000-0002-4479-0636 aut Hutinet, Sébastien verfasserin aut Vlaanderen, Jelle verfasserin (orcid)0000-0002-9096-692X aut Meijer, Jeroen verfasserin (orcid)0000-0002-4551-6823 aut Le Bizec, Bruno verfasserin aut Antignac, Jean-Philippe verfasserin (orcid)0000-0001-9512-9314 aut Enthalten in Talanta Amsterdam [u.a.] : Elsevier Science, 1958 225 Online-Ressource (DE-627)306712571 (DE-600)1500969-5 (DE-576)251938158 1873-3573 nnns volume:225 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.00 Chemie: Allgemeines VZ AR 225
allfields_unstemmed	10.1016/j.talanta.2020.121979 doi (DE-627)ELV05305248X (ELSEVIER)S0039-9140(20)31270-4 DE-627 ger DE-627 rda eng 540 VZ 35.00 bkl Pourchet, Mariane verfasserin aut Non-targeted screening methodology to characterise human internal chemical exposure: Application to halogenated compounds in human milk 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Suspect and non-targeted screening approaches are a matter of increasing interest notably with regard to the Exposome contextual framework, but their application to human samples still remains limited at this date. The aim of the present study was to develop a non-targeted workflow from sample preparation to data processing and method assessment to characterise the human internal chemical exposure at early life stage. The method was focused on human milk to investigate mother and newborn exposure to known organic contaminants and to extend the characterisation to unknown compounds. We specifically focused on halogenated biomarkers of exposure due to persistence and potential toxicological impact reasons. The newly developed approach was based on a simple and fast sample preparation followed by a comprehensive analysis by both liquid and gas phase chromatography coupled to high resolution mass spectrometry. Critical steps of the non-targeted workflow as the method assessment have been addressed with a reference mix of 30 chlorinated and brominated contaminants encompassing various substances groups and a statistical approach. Data processing until the identification of biomarkers of exposure was possible with homemade bioinformatics tools. On the other hand, the method was validated by the identification of historical chemicals as hexachlorobenzene and p,p’-DDE and emerging chemical as 4-hydroxychlorothalonil. This approach opens the door to further extensions and consolidations to offer new capabilities for exposomics and environmental health research. Non-targeted screening Human milk Human biomonitoring Internal chemical exposure HRMS HBM4EU Narduzzi, Luca verfasserin (orcid)0000-0002-1921-651X aut Jean, Annabelle verfasserin aut Guiffard, Ingrid verfasserin aut Bichon, Emmanuelle verfasserin aut Cariou, Ronan verfasserin aut Guitton, Yann verfasserin (orcid)0000-0002-4479-0636 aut Hutinet, Sébastien verfasserin aut Vlaanderen, Jelle verfasserin (orcid)0000-0002-9096-692X aut Meijer, Jeroen verfasserin (orcid)0000-0002-4551-6823 aut Le Bizec, Bruno verfasserin aut Antignac, Jean-Philippe verfasserin (orcid)0000-0001-9512-9314 aut Enthalten in Talanta Amsterdam [u.a.] : Elsevier Science, 1958 225 Online-Ressource (DE-627)306712571 (DE-600)1500969-5 (DE-576)251938158 1873-3573 nnns volume:225 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.00 Chemie: Allgemeines VZ AR 225
allfieldsGer	10.1016/j.talanta.2020.121979 doi (DE-627)ELV05305248X (ELSEVIER)S0039-9140(20)31270-4 DE-627 ger DE-627 rda eng 540 VZ 35.00 bkl Pourchet, Mariane verfasserin aut Non-targeted screening methodology to characterise human internal chemical exposure: Application to halogenated compounds in human milk 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Suspect and non-targeted screening approaches are a matter of increasing interest notably with regard to the Exposome contextual framework, but their application to human samples still remains limited at this date. The aim of the present study was to develop a non-targeted workflow from sample preparation to data processing and method assessment to characterise the human internal chemical exposure at early life stage. The method was focused on human milk to investigate mother and newborn exposure to known organic contaminants and to extend the characterisation to unknown compounds. We specifically focused on halogenated biomarkers of exposure due to persistence and potential toxicological impact reasons. The newly developed approach was based on a simple and fast sample preparation followed by a comprehensive analysis by both liquid and gas phase chromatography coupled to high resolution mass spectrometry. Critical steps of the non-targeted workflow as the method assessment have been addressed with a reference mix of 30 chlorinated and brominated contaminants encompassing various substances groups and a statistical approach. Data processing until the identification of biomarkers of exposure was possible with homemade bioinformatics tools. On the other hand, the method was validated by the identification of historical chemicals as hexachlorobenzene and p,p’-DDE and emerging chemical as 4-hydroxychlorothalonil. This approach opens the door to further extensions and consolidations to offer new capabilities for exposomics and environmental health research. Non-targeted screening Human milk Human biomonitoring Internal chemical exposure HRMS HBM4EU Narduzzi, Luca verfasserin (orcid)0000-0002-1921-651X aut Jean, Annabelle verfasserin aut Guiffard, Ingrid verfasserin aut Bichon, Emmanuelle verfasserin aut Cariou, Ronan verfasserin aut Guitton, Yann verfasserin (orcid)0000-0002-4479-0636 aut Hutinet, Sébastien verfasserin aut Vlaanderen, Jelle verfasserin (orcid)0000-0002-9096-692X aut Meijer, Jeroen verfasserin (orcid)0000-0002-4551-6823 aut Le Bizec, Bruno verfasserin aut Antignac, Jean-Philippe verfasserin (orcid)0000-0001-9512-9314 aut Enthalten in Talanta Amsterdam [u.a.] : Elsevier Science, 1958 225 Online-Ressource (DE-627)306712571 (DE-600)1500969-5 (DE-576)251938158 1873-3573 nnns volume:225 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.00 Chemie: Allgemeines VZ AR 225
allfieldsSound	10.1016/j.talanta.2020.121979 doi (DE-627)ELV05305248X (ELSEVIER)S0039-9140(20)31270-4 DE-627 ger DE-627 rda eng 540 VZ 35.00 bkl Pourchet, Mariane verfasserin aut Non-targeted screening methodology to characterise human internal chemical exposure: Application to halogenated compounds in human milk 2020 nicht spezifiziert zzz rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Suspect and non-targeted screening approaches are a matter of increasing interest notably with regard to the Exposome contextual framework, but their application to human samples still remains limited at this date. The aim of the present study was to develop a non-targeted workflow from sample preparation to data processing and method assessment to characterise the human internal chemical exposure at early life stage. The method was focused on human milk to investigate mother and newborn exposure to known organic contaminants and to extend the characterisation to unknown compounds. We specifically focused on halogenated biomarkers of exposure due to persistence and potential toxicological impact reasons. The newly developed approach was based on a simple and fast sample preparation followed by a comprehensive analysis by both liquid and gas phase chromatography coupled to high resolution mass spectrometry. Critical steps of the non-targeted workflow as the method assessment have been addressed with a reference mix of 30 chlorinated and brominated contaminants encompassing various substances groups and a statistical approach. Data processing until the identification of biomarkers of exposure was possible with homemade bioinformatics tools. On the other hand, the method was validated by the identification of historical chemicals as hexachlorobenzene and p,p’-DDE and emerging chemical as 4-hydroxychlorothalonil. This approach opens the door to further extensions and consolidations to offer new capabilities for exposomics and environmental health research. Non-targeted screening Human milk Human biomonitoring Internal chemical exposure HRMS HBM4EU Narduzzi, Luca verfasserin (orcid)0000-0002-1921-651X aut Jean, Annabelle verfasserin aut Guiffard, Ingrid verfasserin aut Bichon, Emmanuelle verfasserin aut Cariou, Ronan verfasserin aut Guitton, Yann verfasserin (orcid)0000-0002-4479-0636 aut Hutinet, Sébastien verfasserin aut Vlaanderen, Jelle verfasserin (orcid)0000-0002-9096-692X aut Meijer, Jeroen verfasserin (orcid)0000-0002-4551-6823 aut Le Bizec, Bruno verfasserin aut Antignac, Jean-Philippe verfasserin (orcid)0000-0001-9512-9314 aut Enthalten in Talanta Amsterdam [u.a.] : Elsevier Science, 1958 225 Online-Ressource (DE-627)306712571 (DE-600)1500969-5 (DE-576)251938158 1873-3573 nnns volume:225 GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 35.00 Chemie: Allgemeines VZ AR 225
language	English
source	Enthalten in Talanta 225 volume:225
sourceStr	Enthalten in Talanta 225 volume:225
format_phy_str_mv	Article
bklname	Chemie: Allgemeines
institution	findex.gbv.de
topic_facet	Non-targeted screening Human milk Human biomonitoring Internal chemical exposure HRMS HBM4EU
dewey-raw	540
isfreeaccess_bool	false
container_title	Talanta
authorswithroles_txt_mv	Pourchet, Mariane @@aut@@ Narduzzi, Luca @@aut@@ Jean, Annabelle @@aut@@ Guiffard, Ingrid @@aut@@ Bichon, Emmanuelle @@aut@@ Cariou, Ronan @@aut@@ Guitton, Yann @@aut@@ Hutinet, Sébastien @@aut@@ Vlaanderen, Jelle @@aut@@ Meijer, Jeroen @@aut@@ Le Bizec, Bruno @@aut@@ Antignac, Jean-Philippe @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	306712571
dewey-sort	3540
id	ELV05305248X
language_de	englisch
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author	Pourchet, Mariane
spellingShingle	Pourchet, Mariane ddc 540 bkl 35.00 misc Non-targeted screening misc Human milk misc Human biomonitoring misc Internal chemical exposure misc HRMS misc HBM4EU Non-targeted screening methodology to characterise human internal chemical exposure: Application to halogenated compounds in human milk
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title	Non-targeted screening methodology to characterise human internal chemical exposure: Application to halogenated compounds in human milk
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title_full	Non-targeted screening methodology to characterise human internal chemical exposure: Application to halogenated compounds in human milk
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author_browse	Pourchet, Mariane Narduzzi, Luca Jean, Annabelle Guiffard, Ingrid Bichon, Emmanuelle Cariou, Ronan Guitton, Yann Hutinet, Sébastien Vlaanderen, Jelle Meijer, Jeroen Le Bizec, Bruno Antignac, Jean-Philippe
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title_sort	non-targeted screening methodology to characterise human internal chemical exposure: application to halogenated compounds in human milk
title_auth	Non-targeted screening methodology to characterise human internal chemical exposure: Application to halogenated compounds in human milk
abstract	Suspect and non-targeted screening approaches are a matter of increasing interest notably with regard to the Exposome contextual framework, but their application to human samples still remains limited at this date. The aim of the present study was to develop a non-targeted workflow from sample preparation to data processing and method assessment to characterise the human internal chemical exposure at early life stage. The method was focused on human milk to investigate mother and newborn exposure to known organic contaminants and to extend the characterisation to unknown compounds. We specifically focused on halogenated biomarkers of exposure due to persistence and potential toxicological impact reasons. The newly developed approach was based on a simple and fast sample preparation followed by a comprehensive analysis by both liquid and gas phase chromatography coupled to high resolution mass spectrometry. Critical steps of the non-targeted workflow as the method assessment have been addressed with a reference mix of 30 chlorinated and brominated contaminants encompassing various substances groups and a statistical approach. Data processing until the identification of biomarkers of exposure was possible with homemade bioinformatics tools. On the other hand, the method was validated by the identification of historical chemicals as hexachlorobenzene and p,p’-DDE and emerging chemical as 4-hydroxychlorothalonil. This approach opens the door to further extensions and consolidations to offer new capabilities for exposomics and environmental health research.
abstractGer	Suspect and non-targeted screening approaches are a matter of increasing interest notably with regard to the Exposome contextual framework, but their application to human samples still remains limited at this date. The aim of the present study was to develop a non-targeted workflow from sample preparation to data processing and method assessment to characterise the human internal chemical exposure at early life stage. The method was focused on human milk to investigate mother and newborn exposure to known organic contaminants and to extend the characterisation to unknown compounds. We specifically focused on halogenated biomarkers of exposure due to persistence and potential toxicological impact reasons. The newly developed approach was based on a simple and fast sample preparation followed by a comprehensive analysis by both liquid and gas phase chromatography coupled to high resolution mass spectrometry. Critical steps of the non-targeted workflow as the method assessment have been addressed with a reference mix of 30 chlorinated and brominated contaminants encompassing various substances groups and a statistical approach. Data processing until the identification of biomarkers of exposure was possible with homemade bioinformatics tools. On the other hand, the method was validated by the identification of historical chemicals as hexachlorobenzene and p,p’-DDE and emerging chemical as 4-hydroxychlorothalonil. This approach opens the door to further extensions and consolidations to offer new capabilities for exposomics and environmental health research.
abstract_unstemmed	Suspect and non-targeted screening approaches are a matter of increasing interest notably with regard to the Exposome contextual framework, but their application to human samples still remains limited at this date. The aim of the present study was to develop a non-targeted workflow from sample preparation to data processing and method assessment to characterise the human internal chemical exposure at early life stage. The method was focused on human milk to investigate mother and newborn exposure to known organic contaminants and to extend the characterisation to unknown compounds. We specifically focused on halogenated biomarkers of exposure due to persistence and potential toxicological impact reasons. The newly developed approach was based on a simple and fast sample preparation followed by a comprehensive analysis by both liquid and gas phase chromatography coupled to high resolution mass spectrometry. Critical steps of the non-targeted workflow as the method assessment have been addressed with a reference mix of 30 chlorinated and brominated contaminants encompassing various substances groups and a statistical approach. Data processing until the identification of biomarkers of exposure was possible with homemade bioinformatics tools. On the other hand, the method was validated by the identification of historical chemicals as hexachlorobenzene and p,p’-DDE and emerging chemical as 4-hydroxychlorothalonil. This approach opens the door to further extensions and consolidations to offer new capabilities for exposomics and environmental health research.
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title_short	Non-targeted screening methodology to characterise human internal chemical exposure: Application to halogenated compounds in human milk
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author2	Narduzzi, Luca Jean, Annabelle Guiffard, Ingrid Bichon, Emmanuelle Cariou, Ronan Guitton, Yann Hutinet, Sébastien Vlaanderen, Jelle Meijer, Jeroen Le Bizec, Bruno Antignac, Jean-Philippe
author2Str	Narduzzi, Luca Jean, Annabelle Guiffard, Ingrid Bichon, Emmanuelle Cariou, Ronan Guitton, Yann Hutinet, Sébastien Vlaanderen, Jelle Meijer, Jeroen Le Bizec, Bruno Antignac, Jean-Philippe
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up_date	2024-07-06T17:52:39.951Z
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Data processing until the identification of biomarkers of exposure was possible with homemade bioinformatics tools. On the other hand, the method was validated by the identification of historical chemicals as hexachlorobenzene and p,p’-DDE and emerging chemical as 4-hydroxychlorothalonil. 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Non-targeted screening methodology to characterise human internal chemical exposure: Application to halogenated compounds in human milk

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