Association of serum microcystin levels with neurobehavior of school-age children in rural area of Southwest China: A cross-sectional study
To investigate whether microcystin-LR (MC-LR) influences children’s cognitive function and memory ability, we measured serum MC-LR and whole blood lead levels in 697 primary students, and collected their academic and neurobehavioral test scores. The median of serum MC-LR levels was 0.80 µg/L (the va...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Zeng, Hui [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021transfer abstract |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Erysipelas, the “Other” Cellulitis: A Practical Guide for Nurse Practitioners - Fetters, Lisa ELSEVIER, 2021, EES : official journal of the International Society of Ecotoxicology and Environmental safety, Amsterdam |
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| Übergeordnetes Werk: |
volume:212 ; year:2021 ; day:1 ; month:04 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1016/j.ecoenv.2021.111990 |
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| 245 | 1 | 0 | |a Association of serum microcystin levels with neurobehavior of school-age children in rural area of Southwest China: A cross-sectional study |
| 264 | 1 | |c 2021transfer abstract | |
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| 520 | |a To investigate whether microcystin-LR (MC-LR) influences children’s cognitive function and memory ability, we measured serum MC-LR and whole blood lead levels in 697 primary students, and collected their academic and neurobehavioral test scores. The median of serum MC-LR levels was 0.80 µg/L (the value below the limit of detection to 1.67 µg/L). The shapes of the associations of serum MC-LR levels (cut-point: 0.95 µg/L) with scores on academic achievements, digit symbol substitution test and long-term memory test were parabolic curves. Logistic regression analysis showed that MC-LR at concentrations of 0.80–0.95 µg/L was associated with the increased probability of higher achievements on academic achievements [odds ratio (OR) = 2.20, 95% confidence interval (CI): 1.28–3.79], and also with scores on digit symbol substitution test (OR = 1.73, 95% CI: 1.05–2.86), overall memory quotient (OR = 2.27, 95% CI: 1.21–4.26), long-term memory (OR = 1.85, 95% CI: 1.01–3.38) and short-term memory (OR = 2.13, 95% CI: 1.14–3.98) after adjustment for confounding factors. Antagonism of MC-LR and lead on long-term memory was observed (synergism index = 0.15, 95% CI: 0.03–0.74). In conclusion, serum MC-LR at concentrations of 0.80–0.95 µg/L was positively associated with higher scores on cognitive and neurobehavioral tests, and antagonism between MC-LR at concentrations of 0.80–1.67 µg/L and lead exposure was obviously observed on long-term memory in children. Concerning that MC-LR is a neurotoxin at high doses, our observation is interesting and need further investigation. | ||
| 520 | |a To investigate whether microcystin-LR (MC-LR) influences children’s cognitive function and memory ability, we measured serum MC-LR and whole blood lead levels in 697 primary students, and collected their academic and neurobehavioral test scores. The median of serum MC-LR levels was 0.80 µg/L (the value below the limit of detection to 1.67 µg/L). The shapes of the associations of serum MC-LR levels (cut-point: 0.95 µg/L) with scores on academic achievements, digit symbol substitution test and long-term memory test were parabolic curves. Logistic regression analysis showed that MC-LR at concentrations of 0.80–0.95 µg/L was associated with the increased probability of higher achievements on academic achievements [odds ratio (OR) = 2.20, 95% confidence interval (CI): 1.28–3.79], and also with scores on digit symbol substitution test (OR = 1.73, 95% CI: 1.05–2.86), overall memory quotient (OR = 2.27, 95% CI: 1.21–4.26), long-term memory (OR = 1.85, 95% CI: 1.01–3.38) and short-term memory (OR = 2.13, 95% CI: 1.14–3.98) after adjustment for confounding factors. Antagonism of MC-LR and lead on long-term memory was observed (synergism index = 0.15, 95% CI: 0.03–0.74). In conclusion, serum MC-LR at concentrations of 0.80–0.95 µg/L was positively associated with higher scores on cognitive and neurobehavioral tests, and antagonism between MC-LR at concentrations of 0.80–1.67 µg/L and lead exposure was obviously observed on long-term memory in children. Concerning that MC-LR is a neurotoxin at high doses, our observation is interesting and need further investigation. | ||
| 650 | 7 | |a Learning and memory ability |2 Elsevier | |
| 650 | 7 | |a MC-LR |2 Elsevier | |
| 650 | 7 | |a Children |2 Elsevier | |
| 650 | 7 | |a Cognitive function |2 Elsevier | |
| 700 | 1 | |a Tan, Yao |4 oth | |
| 700 | 1 | |a Wang, Lingqiao |4 oth | |
| 700 | 1 | |a Xiang, Menglong |4 oth | |
| 700 | 1 | |a Zhou, Ziyuan |4 oth | |
| 700 | 1 | |a Chen, Ji-an |4 oth | |
| 700 | 1 | |a Wang, Jia |4 oth | |
| 700 | 1 | |a Zhang, Renping |4 oth | |
| 700 | 1 | |a Tian, Yingqiao |4 oth | |
| 700 | 1 | |a Luo, Jiaohua |4 oth | |
| 700 | 1 | |a Huang, Yujing |4 oth | |
| 700 | 1 | |a Lv, Chen |4 oth | |
| 700 | 1 | |a Shu, Weiqun |4 oth | |
| 700 | 1 | |a Qiu, Zhiqun |4 oth | |
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10.1016/j.ecoenv.2021.111990 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001353.pica (DE-627)ELV053103955 (ELSEVIER)S0147-6513(21)00101-9 DE-627 ger DE-627 rakwb eng 610 VZ 44.63 bkl Zeng, Hui verfasserin aut Association of serum microcystin levels with neurobehavior of school-age children in rural area of Southwest China: A cross-sectional study 2021transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier To investigate whether microcystin-LR (MC-LR) influences children’s cognitive function and memory ability, we measured serum MC-LR and whole blood lead levels in 697 primary students, and collected their academic and neurobehavioral test scores. The median of serum MC-LR levels was 0.80 µg/L (the value below the limit of detection to 1.67 µg/L). The shapes of the associations of serum MC-LR levels (cut-point: 0.95 µg/L) with scores on academic achievements, digit symbol substitution test and long-term memory test were parabolic curves. Logistic regression analysis showed that MC-LR at concentrations of 0.80–0.95 µg/L was associated with the increased probability of higher achievements on academic achievements [odds ratio (OR) = 2.20, 95% confidence interval (CI): 1.28–3.79], and also with scores on digit symbol substitution test (OR = 1.73, 95% CI: 1.05–2.86), overall memory quotient (OR = 2.27, 95% CI: 1.21–4.26), long-term memory (OR = 1.85, 95% CI: 1.01–3.38) and short-term memory (OR = 2.13, 95% CI: 1.14–3.98) after adjustment for confounding factors. Antagonism of MC-LR and lead on long-term memory was observed (synergism index = 0.15, 95% CI: 0.03–0.74). In conclusion, serum MC-LR at concentrations of 0.80–0.95 µg/L was positively associated with higher scores on cognitive and neurobehavioral tests, and antagonism between MC-LR at concentrations of 0.80–1.67 µg/L and lead exposure was obviously observed on long-term memory in children. Concerning that MC-LR is a neurotoxin at high doses, our observation is interesting and need further investigation. To investigate whether microcystin-LR (MC-LR) influences children’s cognitive function and memory ability, we measured serum MC-LR and whole blood lead levels in 697 primary students, and collected their academic and neurobehavioral test scores. The median of serum MC-LR levels was 0.80 µg/L (the value below the limit of detection to 1.67 µg/L). The shapes of the associations of serum MC-LR levels (cut-point: 0.95 µg/L) with scores on academic achievements, digit symbol substitution test and long-term memory test were parabolic curves. Logistic regression analysis showed that MC-LR at concentrations of 0.80–0.95 µg/L was associated with the increased probability of higher achievements on academic achievements [odds ratio (OR) = 2.20, 95% confidence interval (CI): 1.28–3.79], and also with scores on digit symbol substitution test (OR = 1.73, 95% CI: 1.05–2.86), overall memory quotient (OR = 2.27, 95% CI: 1.21–4.26), long-term memory (OR = 1.85, 95% CI: 1.01–3.38) and short-term memory (OR = 2.13, 95% CI: 1.14–3.98) after adjustment for confounding factors. Antagonism of MC-LR and lead on long-term memory was observed (synergism index = 0.15, 95% CI: 0.03–0.74). In conclusion, serum MC-LR at concentrations of 0.80–0.95 µg/L was positively associated with higher scores on cognitive and neurobehavioral tests, and antagonism between MC-LR at concentrations of 0.80–1.67 µg/L and lead exposure was obviously observed on long-term memory in children. Concerning that MC-LR is a neurotoxin at high doses, our observation is interesting and need further investigation. Learning and memory ability Elsevier MC-LR Elsevier Children Elsevier Cognitive function Elsevier Tan, Yao oth Wang, Lingqiao oth Xiang, Menglong oth Zhou, Ziyuan oth Chen, Ji-an oth Wang, Jia oth Zhang, Renping oth Tian, Yingqiao oth Luo, Jiaohua oth Huang, Yujing oth Lv, Chen oth Shu, Weiqun oth Qiu, Zhiqun oth Enthalten in Elsevier Fetters, Lisa ELSEVIER Erysipelas, the “Other” Cellulitis: A Practical Guide for Nurse Practitioners 2021 EES : official journal of the International Society of Ecotoxicology and Environmental safety Amsterdam (DE-627)ELV006765629 volume:212 year:2021 day:1 month:04 pages:0 https://doi.org/10.1016/j.ecoenv.2021.111990 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 44.63 Krankenpflege VZ AR 212 2021 1 0401 0 |
| spelling |
10.1016/j.ecoenv.2021.111990 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001353.pica (DE-627)ELV053103955 (ELSEVIER)S0147-6513(21)00101-9 DE-627 ger DE-627 rakwb eng 610 VZ 44.63 bkl Zeng, Hui verfasserin aut Association of serum microcystin levels with neurobehavior of school-age children in rural area of Southwest China: A cross-sectional study 2021transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier To investigate whether microcystin-LR (MC-LR) influences children’s cognitive function and memory ability, we measured serum MC-LR and whole blood lead levels in 697 primary students, and collected their academic and neurobehavioral test scores. The median of serum MC-LR levels was 0.80 µg/L (the value below the limit of detection to 1.67 µg/L). The shapes of the associations of serum MC-LR levels (cut-point: 0.95 µg/L) with scores on academic achievements, digit symbol substitution test and long-term memory test were parabolic curves. Logistic regression analysis showed that MC-LR at concentrations of 0.80–0.95 µg/L was associated with the increased probability of higher achievements on academic achievements [odds ratio (OR) = 2.20, 95% confidence interval (CI): 1.28–3.79], and also with scores on digit symbol substitution test (OR = 1.73, 95% CI: 1.05–2.86), overall memory quotient (OR = 2.27, 95% CI: 1.21–4.26), long-term memory (OR = 1.85, 95% CI: 1.01–3.38) and short-term memory (OR = 2.13, 95% CI: 1.14–3.98) after adjustment for confounding factors. Antagonism of MC-LR and lead on long-term memory was observed (synergism index = 0.15, 95% CI: 0.03–0.74). In conclusion, serum MC-LR at concentrations of 0.80–0.95 µg/L was positively associated with higher scores on cognitive and neurobehavioral tests, and antagonism between MC-LR at concentrations of 0.80–1.67 µg/L and lead exposure was obviously observed on long-term memory in children. Concerning that MC-LR is a neurotoxin at high doses, our observation is interesting and need further investigation. To investigate whether microcystin-LR (MC-LR) influences children’s cognitive function and memory ability, we measured serum MC-LR and whole blood lead levels in 697 primary students, and collected their academic and neurobehavioral test scores. The median of serum MC-LR levels was 0.80 µg/L (the value below the limit of detection to 1.67 µg/L). The shapes of the associations of serum MC-LR levels (cut-point: 0.95 µg/L) with scores on academic achievements, digit symbol substitution test and long-term memory test were parabolic curves. Logistic regression analysis showed that MC-LR at concentrations of 0.80–0.95 µg/L was associated with the increased probability of higher achievements on academic achievements [odds ratio (OR) = 2.20, 95% confidence interval (CI): 1.28–3.79], and also with scores on digit symbol substitution test (OR = 1.73, 95% CI: 1.05–2.86), overall memory quotient (OR = 2.27, 95% CI: 1.21–4.26), long-term memory (OR = 1.85, 95% CI: 1.01–3.38) and short-term memory (OR = 2.13, 95% CI: 1.14–3.98) after adjustment for confounding factors. Antagonism of MC-LR and lead on long-term memory was observed (synergism index = 0.15, 95% CI: 0.03–0.74). In conclusion, serum MC-LR at concentrations of 0.80–0.95 µg/L was positively associated with higher scores on cognitive and neurobehavioral tests, and antagonism between MC-LR at concentrations of 0.80–1.67 µg/L and lead exposure was obviously observed on long-term memory in children. Concerning that MC-LR is a neurotoxin at high doses, our observation is interesting and need further investigation. Learning and memory ability Elsevier MC-LR Elsevier Children Elsevier Cognitive function Elsevier Tan, Yao oth Wang, Lingqiao oth Xiang, Menglong oth Zhou, Ziyuan oth Chen, Ji-an oth Wang, Jia oth Zhang, Renping oth Tian, Yingqiao oth Luo, Jiaohua oth Huang, Yujing oth Lv, Chen oth Shu, Weiqun oth Qiu, Zhiqun oth Enthalten in Elsevier Fetters, Lisa ELSEVIER Erysipelas, the “Other” Cellulitis: A Practical Guide for Nurse Practitioners 2021 EES : official journal of the International Society of Ecotoxicology and Environmental safety Amsterdam (DE-627)ELV006765629 volume:212 year:2021 day:1 month:04 pages:0 https://doi.org/10.1016/j.ecoenv.2021.111990 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 44.63 Krankenpflege VZ AR 212 2021 1 0401 0 |
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10.1016/j.ecoenv.2021.111990 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001353.pica (DE-627)ELV053103955 (ELSEVIER)S0147-6513(21)00101-9 DE-627 ger DE-627 rakwb eng 610 VZ 44.63 bkl Zeng, Hui verfasserin aut Association of serum microcystin levels with neurobehavior of school-age children in rural area of Southwest China: A cross-sectional study 2021transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier To investigate whether microcystin-LR (MC-LR) influences children’s cognitive function and memory ability, we measured serum MC-LR and whole blood lead levels in 697 primary students, and collected their academic and neurobehavioral test scores. The median of serum MC-LR levels was 0.80 µg/L (the value below the limit of detection to 1.67 µg/L). The shapes of the associations of serum MC-LR levels (cut-point: 0.95 µg/L) with scores on academic achievements, digit symbol substitution test and long-term memory test were parabolic curves. Logistic regression analysis showed that MC-LR at concentrations of 0.80–0.95 µg/L was associated with the increased probability of higher achievements on academic achievements [odds ratio (OR) = 2.20, 95% confidence interval (CI): 1.28–3.79], and also with scores on digit symbol substitution test (OR = 1.73, 95% CI: 1.05–2.86), overall memory quotient (OR = 2.27, 95% CI: 1.21–4.26), long-term memory (OR = 1.85, 95% CI: 1.01–3.38) and short-term memory (OR = 2.13, 95% CI: 1.14–3.98) after adjustment for confounding factors. Antagonism of MC-LR and lead on long-term memory was observed (synergism index = 0.15, 95% CI: 0.03–0.74). In conclusion, serum MC-LR at concentrations of 0.80–0.95 µg/L was positively associated with higher scores on cognitive and neurobehavioral tests, and antagonism between MC-LR at concentrations of 0.80–1.67 µg/L and lead exposure was obviously observed on long-term memory in children. Concerning that MC-LR is a neurotoxin at high doses, our observation is interesting and need further investigation. To investigate whether microcystin-LR (MC-LR) influences children’s cognitive function and memory ability, we measured serum MC-LR and whole blood lead levels in 697 primary students, and collected their academic and neurobehavioral test scores. The median of serum MC-LR levels was 0.80 µg/L (the value below the limit of detection to 1.67 µg/L). The shapes of the associations of serum MC-LR levels (cut-point: 0.95 µg/L) with scores on academic achievements, digit symbol substitution test and long-term memory test were parabolic curves. Logistic regression analysis showed that MC-LR at concentrations of 0.80–0.95 µg/L was associated with the increased probability of higher achievements on academic achievements [odds ratio (OR) = 2.20, 95% confidence interval (CI): 1.28–3.79], and also with scores on digit symbol substitution test (OR = 1.73, 95% CI: 1.05–2.86), overall memory quotient (OR = 2.27, 95% CI: 1.21–4.26), long-term memory (OR = 1.85, 95% CI: 1.01–3.38) and short-term memory (OR = 2.13, 95% CI: 1.14–3.98) after adjustment for confounding factors. Antagonism of MC-LR and lead on long-term memory was observed (synergism index = 0.15, 95% CI: 0.03–0.74). In conclusion, serum MC-LR at concentrations of 0.80–0.95 µg/L was positively associated with higher scores on cognitive and neurobehavioral tests, and antagonism between MC-LR at concentrations of 0.80–1.67 µg/L and lead exposure was obviously observed on long-term memory in children. Concerning that MC-LR is a neurotoxin at high doses, our observation is interesting and need further investigation. Learning and memory ability Elsevier MC-LR Elsevier Children Elsevier Cognitive function Elsevier Tan, Yao oth Wang, Lingqiao oth Xiang, Menglong oth Zhou, Ziyuan oth Chen, Ji-an oth Wang, Jia oth Zhang, Renping oth Tian, Yingqiao oth Luo, Jiaohua oth Huang, Yujing oth Lv, Chen oth Shu, Weiqun oth Qiu, Zhiqun oth Enthalten in Elsevier Fetters, Lisa ELSEVIER Erysipelas, the “Other” Cellulitis: A Practical Guide for Nurse Practitioners 2021 EES : official journal of the International Society of Ecotoxicology and Environmental safety Amsterdam (DE-627)ELV006765629 volume:212 year:2021 day:1 month:04 pages:0 https://doi.org/10.1016/j.ecoenv.2021.111990 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 44.63 Krankenpflege VZ AR 212 2021 1 0401 0 |
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10.1016/j.ecoenv.2021.111990 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001353.pica (DE-627)ELV053103955 (ELSEVIER)S0147-6513(21)00101-9 DE-627 ger DE-627 rakwb eng 610 VZ 44.63 bkl Zeng, Hui verfasserin aut Association of serum microcystin levels with neurobehavior of school-age children in rural area of Southwest China: A cross-sectional study 2021transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier To investigate whether microcystin-LR (MC-LR) influences children’s cognitive function and memory ability, we measured serum MC-LR and whole blood lead levels in 697 primary students, and collected their academic and neurobehavioral test scores. The median of serum MC-LR levels was 0.80 µg/L (the value below the limit of detection to 1.67 µg/L). The shapes of the associations of serum MC-LR levels (cut-point: 0.95 µg/L) with scores on academic achievements, digit symbol substitution test and long-term memory test were parabolic curves. Logistic regression analysis showed that MC-LR at concentrations of 0.80–0.95 µg/L was associated with the increased probability of higher achievements on academic achievements [odds ratio (OR) = 2.20, 95% confidence interval (CI): 1.28–3.79], and also with scores on digit symbol substitution test (OR = 1.73, 95% CI: 1.05–2.86), overall memory quotient (OR = 2.27, 95% CI: 1.21–4.26), long-term memory (OR = 1.85, 95% CI: 1.01–3.38) and short-term memory (OR = 2.13, 95% CI: 1.14–3.98) after adjustment for confounding factors. Antagonism of MC-LR and lead on long-term memory was observed (synergism index = 0.15, 95% CI: 0.03–0.74). In conclusion, serum MC-LR at concentrations of 0.80–0.95 µg/L was positively associated with higher scores on cognitive and neurobehavioral tests, and antagonism between MC-LR at concentrations of 0.80–1.67 µg/L and lead exposure was obviously observed on long-term memory in children. Concerning that MC-LR is a neurotoxin at high doses, our observation is interesting and need further investigation. To investigate whether microcystin-LR (MC-LR) influences children’s cognitive function and memory ability, we measured serum MC-LR and whole blood lead levels in 697 primary students, and collected their academic and neurobehavioral test scores. The median of serum MC-LR levels was 0.80 µg/L (the value below the limit of detection to 1.67 µg/L). The shapes of the associations of serum MC-LR levels (cut-point: 0.95 µg/L) with scores on academic achievements, digit symbol substitution test and long-term memory test were parabolic curves. Logistic regression analysis showed that MC-LR at concentrations of 0.80–0.95 µg/L was associated with the increased probability of higher achievements on academic achievements [odds ratio (OR) = 2.20, 95% confidence interval (CI): 1.28–3.79], and also with scores on digit symbol substitution test (OR = 1.73, 95% CI: 1.05–2.86), overall memory quotient (OR = 2.27, 95% CI: 1.21–4.26), long-term memory (OR = 1.85, 95% CI: 1.01–3.38) and short-term memory (OR = 2.13, 95% CI: 1.14–3.98) after adjustment for confounding factors. Antagonism of MC-LR and lead on long-term memory was observed (synergism index = 0.15, 95% CI: 0.03–0.74). In conclusion, serum MC-LR at concentrations of 0.80–0.95 µg/L was positively associated with higher scores on cognitive and neurobehavioral tests, and antagonism between MC-LR at concentrations of 0.80–1.67 µg/L and lead exposure was obviously observed on long-term memory in children. Concerning that MC-LR is a neurotoxin at high doses, our observation is interesting and need further investigation. Learning and memory ability Elsevier MC-LR Elsevier Children Elsevier Cognitive function Elsevier Tan, Yao oth Wang, Lingqiao oth Xiang, Menglong oth Zhou, Ziyuan oth Chen, Ji-an oth Wang, Jia oth Zhang, Renping oth Tian, Yingqiao oth Luo, Jiaohua oth Huang, Yujing oth Lv, Chen oth Shu, Weiqun oth Qiu, Zhiqun oth Enthalten in Elsevier Fetters, Lisa ELSEVIER Erysipelas, the “Other” Cellulitis: A Practical Guide for Nurse Practitioners 2021 EES : official journal of the International Society of Ecotoxicology and Environmental safety Amsterdam (DE-627)ELV006765629 volume:212 year:2021 day:1 month:04 pages:0 https://doi.org/10.1016/j.ecoenv.2021.111990 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 44.63 Krankenpflege VZ AR 212 2021 1 0401 0 |
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Association of serum microcystin levels with neurobehavior of school-age children in rural area of Southwest China: A cross-sectional study |
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To investigate whether microcystin-LR (MC-LR) influences children’s cognitive function and memory ability, we measured serum MC-LR and whole blood lead levels in 697 primary students, and collected their academic and neurobehavioral test scores. The median of serum MC-LR levels was 0.80 µg/L (the value below the limit of detection to 1.67 µg/L). The shapes of the associations of serum MC-LR levels (cut-point: 0.95 µg/L) with scores on academic achievements, digit symbol substitution test and long-term memory test were parabolic curves. Logistic regression analysis showed that MC-LR at concentrations of 0.80–0.95 µg/L was associated with the increased probability of higher achievements on academic achievements [odds ratio (OR) = 2.20, 95% confidence interval (CI): 1.28–3.79], and also with scores on digit symbol substitution test (OR = 1.73, 95% CI: 1.05–2.86), overall memory quotient (OR = 2.27, 95% CI: 1.21–4.26), long-term memory (OR = 1.85, 95% CI: 1.01–3.38) and short-term memory (OR = 2.13, 95% CI: 1.14–3.98) after adjustment for confounding factors. Antagonism of MC-LR and lead on long-term memory was observed (synergism index = 0.15, 95% CI: 0.03–0.74). In conclusion, serum MC-LR at concentrations of 0.80–0.95 µg/L was positively associated with higher scores on cognitive and neurobehavioral tests, and antagonism between MC-LR at concentrations of 0.80–1.67 µg/L and lead exposure was obviously observed on long-term memory in children. Concerning that MC-LR is a neurotoxin at high doses, our observation is interesting and need further investigation. |
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To investigate whether microcystin-LR (MC-LR) influences children’s cognitive function and memory ability, we measured serum MC-LR and whole blood lead levels in 697 primary students, and collected their academic and neurobehavioral test scores. The median of serum MC-LR levels was 0.80 µg/L (the value below the limit of detection to 1.67 µg/L). The shapes of the associations of serum MC-LR levels (cut-point: 0.95 µg/L) with scores on academic achievements, digit symbol substitution test and long-term memory test were parabolic curves. Logistic regression analysis showed that MC-LR at concentrations of 0.80–0.95 µg/L was associated with the increased probability of higher achievements on academic achievements [odds ratio (OR) = 2.20, 95% confidence interval (CI): 1.28–3.79], and also with scores on digit symbol substitution test (OR = 1.73, 95% CI: 1.05–2.86), overall memory quotient (OR = 2.27, 95% CI: 1.21–4.26), long-term memory (OR = 1.85, 95% CI: 1.01–3.38) and short-term memory (OR = 2.13, 95% CI: 1.14–3.98) after adjustment for confounding factors. Antagonism of MC-LR and lead on long-term memory was observed (synergism index = 0.15, 95% CI: 0.03–0.74). In conclusion, serum MC-LR at concentrations of 0.80–0.95 µg/L was positively associated with higher scores on cognitive and neurobehavioral tests, and antagonism between MC-LR at concentrations of 0.80–1.67 µg/L and lead exposure was obviously observed on long-term memory in children. Concerning that MC-LR is a neurotoxin at high doses, our observation is interesting and need further investigation. |
| abstract_unstemmed |
To investigate whether microcystin-LR (MC-LR) influences children’s cognitive function and memory ability, we measured serum MC-LR and whole blood lead levels in 697 primary students, and collected their academic and neurobehavioral test scores. The median of serum MC-LR levels was 0.80 µg/L (the value below the limit of detection to 1.67 µg/L). The shapes of the associations of serum MC-LR levels (cut-point: 0.95 µg/L) with scores on academic achievements, digit symbol substitution test and long-term memory test were parabolic curves. Logistic regression analysis showed that MC-LR at concentrations of 0.80–0.95 µg/L was associated with the increased probability of higher achievements on academic achievements [odds ratio (OR) = 2.20, 95% confidence interval (CI): 1.28–3.79], and also with scores on digit symbol substitution test (OR = 1.73, 95% CI: 1.05–2.86), overall memory quotient (OR = 2.27, 95% CI: 1.21–4.26), long-term memory (OR = 1.85, 95% CI: 1.01–3.38) and short-term memory (OR = 2.13, 95% CI: 1.14–3.98) after adjustment for confounding factors. Antagonism of MC-LR and lead on long-term memory was observed (synergism index = 0.15, 95% CI: 0.03–0.74). In conclusion, serum MC-LR at concentrations of 0.80–0.95 µg/L was positively associated with higher scores on cognitive and neurobehavioral tests, and antagonism between MC-LR at concentrations of 0.80–1.67 µg/L and lead exposure was obviously observed on long-term memory in children. Concerning that MC-LR is a neurotoxin at high doses, our observation is interesting and need further investigation. |
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| title_short |
Association of serum microcystin levels with neurobehavior of school-age children in rural area of Southwest China: A cross-sectional study |
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https://doi.org/10.1016/j.ecoenv.2021.111990 |
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Tan, Yao Wang, Lingqiao Xiang, Menglong Zhou, Ziyuan Chen, Ji-an Wang, Jia Zhang, Renping Tian, Yingqiao Luo, Jiaohua Huang, Yujing Lv, Chen Shu, Weiqun Qiu, Zhiqun |
| author2Str |
Tan, Yao Wang, Lingqiao Xiang, Menglong Zhou, Ziyuan Chen, Ji-an Wang, Jia Zhang, Renping Tian, Yingqiao Luo, Jiaohua Huang, Yujing Lv, Chen Shu, Weiqun Qiu, Zhiqun |
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| doi_str |
10.1016/j.ecoenv.2021.111990 |
| up_date |
2024-07-06T18:01:20.354Z |
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