Splicing to Keep Cycling: The Importance of Pre-mRNA Splicing during the Cell Cycle
Pre-mRNA splicing is a fundamental process in mammalian gene expression, and alternative splicing plays an extensive role in generating protein diversity. Because the majority of genes undergo pre-mRNA splicing, most cellular processes depend on proper spliceosome function. We focus on the cell cycl...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Petasny, Mayra [verfasserIn] |
|---|
| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021transfer abstract |
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| Umfang: |
13 |
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| Übergeordnetes Werk: |
Enthalten in: Degrading chlorinated aliphatics by reductive dechlorination of groundwater samples from the Santa Susana Field Laboratory - Dutta, Nalok ELSEVIER, 2022, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:37 ; year:2021 ; number:3 ; pages:266-278 ; extent:13 |
| Links: |
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| DOI / URN: |
10.1016/j.tig.2020.08.013 |
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ELV053118758 |
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| 520 | |a Pre-mRNA splicing is a fundamental process in mammalian gene expression, and alternative splicing plays an extensive role in generating protein diversity. Because the majority of genes undergo pre-mRNA splicing, most cellular processes depend on proper spliceosome function. We focus on the cell cycle and describe its dependence on pre-mRNA splicing and accurate alternative splicing. We outline the key cell-cycle factors and their known alternative splicing isoforms. We discuss different levels of pre-mRNA splicing regulation such as post-translational modifications and changes in the expression of splicing factors. We describe the effect of chromatin dynamics on pre-mRNA splicing during the cell cycle. In addition, we focus on spliceosome component SF3B1, which is mutated in many types of cancer, and describe the link between SF3B1 and its inhibitors and the cell cycle. | ||
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10.1016/j.tig.2020.08.013 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001314.pica (DE-627)ELV053118758 (ELSEVIER)S0168-9525(20)30213-4 DE-627 ger DE-627 rakwb eng 333.7 VZ 43.00 bkl Petasny, Mayra verfasserin aut Splicing to Keep Cycling: The Importance of Pre-mRNA Splicing during the Cell Cycle 2021transfer abstract 13 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Pre-mRNA splicing is a fundamental process in mammalian gene expression, and alternative splicing plays an extensive role in generating protein diversity. Because the majority of genes undergo pre-mRNA splicing, most cellular processes depend on proper spliceosome function. We focus on the cell cycle and describe its dependence on pre-mRNA splicing and accurate alternative splicing. We outline the key cell-cycle factors and their known alternative splicing isoforms. We discuss different levels of pre-mRNA splicing regulation such as post-translational modifications and changes in the expression of splicing factors. We describe the effect of chromatin dynamics on pre-mRNA splicing during the cell cycle. In addition, we focus on spliceosome component SF3B1, which is mutated in many types of cancer, and describe the link between SF3B1 and its inhibitors and the cell cycle. Pre-mRNA splicing is a fundamental process in mammalian gene expression, and alternative splicing plays an extensive role in generating protein diversity. Because the majority of genes undergo pre-mRNA splicing, most cellular processes depend on proper spliceosome function. We focus on the cell cycle and describe its dependence on pre-mRNA splicing and accurate alternative splicing. We outline the key cell-cycle factors and their known alternative splicing isoforms. We discuss different levels of pre-mRNA splicing regulation such as post-translational modifications and changes in the expression of splicing factors. We describe the effect of chromatin dynamics on pre-mRNA splicing during the cell cycle. In addition, we focus on spliceosome component SF3B1, which is mutated in many types of cancer, and describe the link between SF3B1 and its inhibitors and the cell cycle. Bentata, Mercedes oth Pawellek, Andrea oth Baker, Mai oth Kay, Gillian oth Salton, Maayan oth Enthalten in Elsevier Science Dutta, Nalok ELSEVIER Degrading chlorinated aliphatics by reductive dechlorination of groundwater samples from the Santa Susana Field Laboratory 2022 Amsterdam [u.a.] (DE-627)ELV00781545X volume:37 year:2021 number:3 pages:266-278 extent:13 https://doi.org/10.1016/j.tig.2020.08.013 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-GGO 43.00 Umweltforschung Umweltschutz: Allgemeines VZ AR 37 2021 3 266-278 13 |
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10.1016/j.tig.2020.08.013 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001314.pica (DE-627)ELV053118758 (ELSEVIER)S0168-9525(20)30213-4 DE-627 ger DE-627 rakwb eng 333.7 VZ 43.00 bkl Petasny, Mayra verfasserin aut Splicing to Keep Cycling: The Importance of Pre-mRNA Splicing during the Cell Cycle 2021transfer abstract 13 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Pre-mRNA splicing is a fundamental process in mammalian gene expression, and alternative splicing plays an extensive role in generating protein diversity. Because the majority of genes undergo pre-mRNA splicing, most cellular processes depend on proper spliceosome function. We focus on the cell cycle and describe its dependence on pre-mRNA splicing and accurate alternative splicing. We outline the key cell-cycle factors and their known alternative splicing isoforms. We discuss different levels of pre-mRNA splicing regulation such as post-translational modifications and changes in the expression of splicing factors. We describe the effect of chromatin dynamics on pre-mRNA splicing during the cell cycle. In addition, we focus on spliceosome component SF3B1, which is mutated in many types of cancer, and describe the link between SF3B1 and its inhibitors and the cell cycle. Pre-mRNA splicing is a fundamental process in mammalian gene expression, and alternative splicing plays an extensive role in generating protein diversity. Because the majority of genes undergo pre-mRNA splicing, most cellular processes depend on proper spliceosome function. We focus on the cell cycle and describe its dependence on pre-mRNA splicing and accurate alternative splicing. We outline the key cell-cycle factors and their known alternative splicing isoforms. We discuss different levels of pre-mRNA splicing regulation such as post-translational modifications and changes in the expression of splicing factors. We describe the effect of chromatin dynamics on pre-mRNA splicing during the cell cycle. In addition, we focus on spliceosome component SF3B1, which is mutated in many types of cancer, and describe the link between SF3B1 and its inhibitors and the cell cycle. Bentata, Mercedes oth Pawellek, Andrea oth Baker, Mai oth Kay, Gillian oth Salton, Maayan oth Enthalten in Elsevier Science Dutta, Nalok ELSEVIER Degrading chlorinated aliphatics by reductive dechlorination of groundwater samples from the Santa Susana Field Laboratory 2022 Amsterdam [u.a.] (DE-627)ELV00781545X volume:37 year:2021 number:3 pages:266-278 extent:13 https://doi.org/10.1016/j.tig.2020.08.013 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-GGO 43.00 Umweltforschung Umweltschutz: Allgemeines VZ AR 37 2021 3 266-278 13 |
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10.1016/j.tig.2020.08.013 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001314.pica (DE-627)ELV053118758 (ELSEVIER)S0168-9525(20)30213-4 DE-627 ger DE-627 rakwb eng 333.7 VZ 43.00 bkl Petasny, Mayra verfasserin aut Splicing to Keep Cycling: The Importance of Pre-mRNA Splicing during the Cell Cycle 2021transfer abstract 13 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Pre-mRNA splicing is a fundamental process in mammalian gene expression, and alternative splicing plays an extensive role in generating protein diversity. Because the majority of genes undergo pre-mRNA splicing, most cellular processes depend on proper spliceosome function. We focus on the cell cycle and describe its dependence on pre-mRNA splicing and accurate alternative splicing. We outline the key cell-cycle factors and their known alternative splicing isoforms. We discuss different levels of pre-mRNA splicing regulation such as post-translational modifications and changes in the expression of splicing factors. We describe the effect of chromatin dynamics on pre-mRNA splicing during the cell cycle. In addition, we focus on spliceosome component SF3B1, which is mutated in many types of cancer, and describe the link between SF3B1 and its inhibitors and the cell cycle. Pre-mRNA splicing is a fundamental process in mammalian gene expression, and alternative splicing plays an extensive role in generating protein diversity. Because the majority of genes undergo pre-mRNA splicing, most cellular processes depend on proper spliceosome function. We focus on the cell cycle and describe its dependence on pre-mRNA splicing and accurate alternative splicing. We outline the key cell-cycle factors and their known alternative splicing isoforms. We discuss different levels of pre-mRNA splicing regulation such as post-translational modifications and changes in the expression of splicing factors. We describe the effect of chromatin dynamics on pre-mRNA splicing during the cell cycle. In addition, we focus on spliceosome component SF3B1, which is mutated in many types of cancer, and describe the link between SF3B1 and its inhibitors and the cell cycle. Bentata, Mercedes oth Pawellek, Andrea oth Baker, Mai oth Kay, Gillian oth Salton, Maayan oth Enthalten in Elsevier Science Dutta, Nalok ELSEVIER Degrading chlorinated aliphatics by reductive dechlorination of groundwater samples from the Santa Susana Field Laboratory 2022 Amsterdam [u.a.] (DE-627)ELV00781545X volume:37 year:2021 number:3 pages:266-278 extent:13 https://doi.org/10.1016/j.tig.2020.08.013 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-GGO 43.00 Umweltforschung Umweltschutz: Allgemeines VZ AR 37 2021 3 266-278 13 |
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10.1016/j.tig.2020.08.013 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001314.pica (DE-627)ELV053118758 (ELSEVIER)S0168-9525(20)30213-4 DE-627 ger DE-627 rakwb eng 333.7 VZ 43.00 bkl Petasny, Mayra verfasserin aut Splicing to Keep Cycling: The Importance of Pre-mRNA Splicing during the Cell Cycle 2021transfer abstract 13 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Pre-mRNA splicing is a fundamental process in mammalian gene expression, and alternative splicing plays an extensive role in generating protein diversity. Because the majority of genes undergo pre-mRNA splicing, most cellular processes depend on proper spliceosome function. We focus on the cell cycle and describe its dependence on pre-mRNA splicing and accurate alternative splicing. We outline the key cell-cycle factors and their known alternative splicing isoforms. We discuss different levels of pre-mRNA splicing regulation such as post-translational modifications and changes in the expression of splicing factors. We describe the effect of chromatin dynamics on pre-mRNA splicing during the cell cycle. In addition, we focus on spliceosome component SF3B1, which is mutated in many types of cancer, and describe the link between SF3B1 and its inhibitors and the cell cycle. Pre-mRNA splicing is a fundamental process in mammalian gene expression, and alternative splicing plays an extensive role in generating protein diversity. Because the majority of genes undergo pre-mRNA splicing, most cellular processes depend on proper spliceosome function. We focus on the cell cycle and describe its dependence on pre-mRNA splicing and accurate alternative splicing. We outline the key cell-cycle factors and their known alternative splicing isoforms. We discuss different levels of pre-mRNA splicing regulation such as post-translational modifications and changes in the expression of splicing factors. We describe the effect of chromatin dynamics on pre-mRNA splicing during the cell cycle. In addition, we focus on spliceosome component SF3B1, which is mutated in many types of cancer, and describe the link between SF3B1 and its inhibitors and the cell cycle. Bentata, Mercedes oth Pawellek, Andrea oth Baker, Mai oth Kay, Gillian oth Salton, Maayan oth Enthalten in Elsevier Science Dutta, Nalok ELSEVIER Degrading chlorinated aliphatics by reductive dechlorination of groundwater samples from the Santa Susana Field Laboratory 2022 Amsterdam [u.a.] (DE-627)ELV00781545X volume:37 year:2021 number:3 pages:266-278 extent:13 https://doi.org/10.1016/j.tig.2020.08.013 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-GGO 43.00 Umweltforschung Umweltschutz: Allgemeines VZ AR 37 2021 3 266-278 13 |
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Degrading chlorinated aliphatics by reductive dechlorination of groundwater samples from the Santa Susana Field Laboratory |
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Degrading chlorinated aliphatics by reductive dechlorination of groundwater samples from the Santa Susana Field Laboratory |
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Splicing to Keep Cycling: The Importance of Pre-mRNA Splicing during the Cell Cycle |
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Splicing to Keep Cycling: The Importance of Pre-mRNA Splicing during the Cell Cycle |
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Petasny, Mayra |
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Degrading chlorinated aliphatics by reductive dechlorination of groundwater samples from the Santa Susana Field Laboratory |
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Degrading chlorinated aliphatics by reductive dechlorination of groundwater samples from the Santa Susana Field Laboratory |
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10.1016/j.tig.2020.08.013 |
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splicing to keep cycling: the importance of pre-mrna splicing during the cell cycle |
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Splicing to Keep Cycling: The Importance of Pre-mRNA Splicing during the Cell Cycle |
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Pre-mRNA splicing is a fundamental process in mammalian gene expression, and alternative splicing plays an extensive role in generating protein diversity. Because the majority of genes undergo pre-mRNA splicing, most cellular processes depend on proper spliceosome function. We focus on the cell cycle and describe its dependence on pre-mRNA splicing and accurate alternative splicing. We outline the key cell-cycle factors and their known alternative splicing isoforms. We discuss different levels of pre-mRNA splicing regulation such as post-translational modifications and changes in the expression of splicing factors. We describe the effect of chromatin dynamics on pre-mRNA splicing during the cell cycle. In addition, we focus on spliceosome component SF3B1, which is mutated in many types of cancer, and describe the link between SF3B1 and its inhibitors and the cell cycle. |
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Pre-mRNA splicing is a fundamental process in mammalian gene expression, and alternative splicing plays an extensive role in generating protein diversity. Because the majority of genes undergo pre-mRNA splicing, most cellular processes depend on proper spliceosome function. We focus on the cell cycle and describe its dependence on pre-mRNA splicing and accurate alternative splicing. We outline the key cell-cycle factors and their known alternative splicing isoforms. We discuss different levels of pre-mRNA splicing regulation such as post-translational modifications and changes in the expression of splicing factors. We describe the effect of chromatin dynamics on pre-mRNA splicing during the cell cycle. In addition, we focus on spliceosome component SF3B1, which is mutated in many types of cancer, and describe the link between SF3B1 and its inhibitors and the cell cycle. |
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Pre-mRNA splicing is a fundamental process in mammalian gene expression, and alternative splicing plays an extensive role in generating protein diversity. Because the majority of genes undergo pre-mRNA splicing, most cellular processes depend on proper spliceosome function. We focus on the cell cycle and describe its dependence on pre-mRNA splicing and accurate alternative splicing. We outline the key cell-cycle factors and their known alternative splicing isoforms. We discuss different levels of pre-mRNA splicing regulation such as post-translational modifications and changes in the expression of splicing factors. We describe the effect of chromatin dynamics on pre-mRNA splicing during the cell cycle. In addition, we focus on spliceosome component SF3B1, which is mutated in many types of cancer, and describe the link between SF3B1 and its inhibitors and the cell cycle. |
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Splicing to Keep Cycling: The Importance of Pre-mRNA Splicing during the Cell Cycle |
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Bentata, Mercedes Pawellek, Andrea Baker, Mai Kay, Gillian Salton, Maayan |
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