Diversity and Function of Glial Cell Types in Multiple Sclerosis
Glial subtype diversity is an emerging topic in neurobiology and immune-mediated neurological diseases such as multiple sclerosis (MS). We discuss recent conceptual and technological advances that allow a better understanding of the transcriptomic and functional heterogeneity of oligodendrocytes (OL...
Ausführliche Beschreibung
Gespeichert in:
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Schirmer, Lucas [verfasserIn] |
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2021transfer abstract |
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Enthalten in: The journey of a mental health professional with co-morbid mental health and alcohol use disorder from despair, to acceptance, to advocacy - Thomas, Brandon ELSEVIER, 2023, Amsterdam [u.a.] |
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volume:42 ; year:2021 ; number:3 ; pages:228-247 ; extent:20 |
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10.1016/j.it.2021.01.005 |
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| 520 | |a Glial subtype diversity is an emerging topic in neurobiology and immune-mediated neurological diseases such as multiple sclerosis (MS). We discuss recent conceptual and technological advances that allow a better understanding of the transcriptomic and functional heterogeneity of oligodendrocytes (OLs), astrocytes, and microglial cells under inflammatory–demyelinating conditions. Recent single cell transcriptomic studies suggest the occurrence of novel homeostatic and reactive glial subtypes and provide insight into the molecular events during disease progression. Multiplexed RNA in situ hybridization has enabled ‘mapping back’ dysregulated gene expression to glial subtypes within the MS lesion microenvironment. These findings suggest novel homeostatic and reactive glial-cell-type functions both in immune-related processes and neuroprotection relevant to understanding the pathology of MS. | ||
| 520 | |a Glial subtype diversity is an emerging topic in neurobiology and immune-mediated neurological diseases such as multiple sclerosis (MS). We discuss recent conceptual and technological advances that allow a better understanding of the transcriptomic and functional heterogeneity of oligodendrocytes (OLs), astrocytes, and microglial cells under inflammatory–demyelinating conditions. Recent single cell transcriptomic studies suggest the occurrence of novel homeostatic and reactive glial subtypes and provide insight into the molecular events during disease progression. Multiplexed RNA in situ hybridization has enabled ‘mapping back’ dysregulated gene expression to glial subtypes within the MS lesion microenvironment. These findings suggest novel homeostatic and reactive glial-cell-type functions both in immune-related processes and neuroprotection relevant to understanding the pathology of MS. | ||
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| 700 | 1 | |a Calabresi, Peter A. |4 oth | |
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10.1016/j.it.2021.01.005 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001309.pica (DE-627)ELV053217993 (ELSEVIER)S1471-4906(21)00005-3 DE-627 ger DE-627 rakwb eng Schirmer, Lucas verfasserin aut Diversity and Function of Glial Cell Types in Multiple Sclerosis 2021transfer abstract 20 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Glial subtype diversity is an emerging topic in neurobiology and immune-mediated neurological diseases such as multiple sclerosis (MS). We discuss recent conceptual and technological advances that allow a better understanding of the transcriptomic and functional heterogeneity of oligodendrocytes (OLs), astrocytes, and microglial cells under inflammatory–demyelinating conditions. Recent single cell transcriptomic studies suggest the occurrence of novel homeostatic and reactive glial subtypes and provide insight into the molecular events during disease progression. Multiplexed RNA in situ hybridization has enabled ‘mapping back’ dysregulated gene expression to glial subtypes within the MS lesion microenvironment. These findings suggest novel homeostatic and reactive glial-cell-type functions both in immune-related processes and neuroprotection relevant to understanding the pathology of MS. Glial subtype diversity is an emerging topic in neurobiology and immune-mediated neurological diseases such as multiple sclerosis (MS). We discuss recent conceptual and technological advances that allow a better understanding of the transcriptomic and functional heterogeneity of oligodendrocytes (OLs), astrocytes, and microglial cells under inflammatory–demyelinating conditions. Recent single cell transcriptomic studies suggest the occurrence of novel homeostatic and reactive glial subtypes and provide insight into the molecular events during disease progression. Multiplexed RNA in situ hybridization has enabled ‘mapping back’ dysregulated gene expression to glial subtypes within the MS lesion microenvironment. These findings suggest novel homeostatic and reactive glial-cell-type functions both in immune-related processes and neuroprotection relevant to understanding the pathology of MS. Schafer, Dorothy P. oth Bartels, Theresa oth Rowitch, David H. oth Calabresi, Peter A. oth Enthalten in Elsevier Science Thomas, Brandon ELSEVIER The journey of a mental health professional with co-morbid mental health and alcohol use disorder from despair, to acceptance, to advocacy 2023 Amsterdam [u.a.] (DE-627)ELV009586830 volume:42 year:2021 number:3 pages:228-247 extent:20 https://doi.org/10.1016/j.it.2021.01.005 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 42 2021 3 228-247 20 |
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10.1016/j.it.2021.01.005 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001309.pica (DE-627)ELV053217993 (ELSEVIER)S1471-4906(21)00005-3 DE-627 ger DE-627 rakwb eng Schirmer, Lucas verfasserin aut Diversity and Function of Glial Cell Types in Multiple Sclerosis 2021transfer abstract 20 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Glial subtype diversity is an emerging topic in neurobiology and immune-mediated neurological diseases such as multiple sclerosis (MS). We discuss recent conceptual and technological advances that allow a better understanding of the transcriptomic and functional heterogeneity of oligodendrocytes (OLs), astrocytes, and microglial cells under inflammatory–demyelinating conditions. Recent single cell transcriptomic studies suggest the occurrence of novel homeostatic and reactive glial subtypes and provide insight into the molecular events during disease progression. Multiplexed RNA in situ hybridization has enabled ‘mapping back’ dysregulated gene expression to glial subtypes within the MS lesion microenvironment. These findings suggest novel homeostatic and reactive glial-cell-type functions both in immune-related processes and neuroprotection relevant to understanding the pathology of MS. Glial subtype diversity is an emerging topic in neurobiology and immune-mediated neurological diseases such as multiple sclerosis (MS). We discuss recent conceptual and technological advances that allow a better understanding of the transcriptomic and functional heterogeneity of oligodendrocytes (OLs), astrocytes, and microglial cells under inflammatory–demyelinating conditions. Recent single cell transcriptomic studies suggest the occurrence of novel homeostatic and reactive glial subtypes and provide insight into the molecular events during disease progression. Multiplexed RNA in situ hybridization has enabled ‘mapping back’ dysregulated gene expression to glial subtypes within the MS lesion microenvironment. These findings suggest novel homeostatic and reactive glial-cell-type functions both in immune-related processes and neuroprotection relevant to understanding the pathology of MS. Schafer, Dorothy P. oth Bartels, Theresa oth Rowitch, David H. oth Calabresi, Peter A. oth Enthalten in Elsevier Science Thomas, Brandon ELSEVIER The journey of a mental health professional with co-morbid mental health and alcohol use disorder from despair, to acceptance, to advocacy 2023 Amsterdam [u.a.] (DE-627)ELV009586830 volume:42 year:2021 number:3 pages:228-247 extent:20 https://doi.org/10.1016/j.it.2021.01.005 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 42 2021 3 228-247 20 |
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10.1016/j.it.2021.01.005 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001309.pica (DE-627)ELV053217993 (ELSEVIER)S1471-4906(21)00005-3 DE-627 ger DE-627 rakwb eng Schirmer, Lucas verfasserin aut Diversity and Function of Glial Cell Types in Multiple Sclerosis 2021transfer abstract 20 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Glial subtype diversity is an emerging topic in neurobiology and immune-mediated neurological diseases such as multiple sclerosis (MS). We discuss recent conceptual and technological advances that allow a better understanding of the transcriptomic and functional heterogeneity of oligodendrocytes (OLs), astrocytes, and microglial cells under inflammatory–demyelinating conditions. Recent single cell transcriptomic studies suggest the occurrence of novel homeostatic and reactive glial subtypes and provide insight into the molecular events during disease progression. Multiplexed RNA in situ hybridization has enabled ‘mapping back’ dysregulated gene expression to glial subtypes within the MS lesion microenvironment. These findings suggest novel homeostatic and reactive glial-cell-type functions both in immune-related processes and neuroprotection relevant to understanding the pathology of MS. Glial subtype diversity is an emerging topic in neurobiology and immune-mediated neurological diseases such as multiple sclerosis (MS). We discuss recent conceptual and technological advances that allow a better understanding of the transcriptomic and functional heterogeneity of oligodendrocytes (OLs), astrocytes, and microglial cells under inflammatory–demyelinating conditions. Recent single cell transcriptomic studies suggest the occurrence of novel homeostatic and reactive glial subtypes and provide insight into the molecular events during disease progression. Multiplexed RNA in situ hybridization has enabled ‘mapping back’ dysregulated gene expression to glial subtypes within the MS lesion microenvironment. These findings suggest novel homeostatic and reactive glial-cell-type functions both in immune-related processes and neuroprotection relevant to understanding the pathology of MS. Schafer, Dorothy P. oth Bartels, Theresa oth Rowitch, David H. oth Calabresi, Peter A. oth Enthalten in Elsevier Science Thomas, Brandon ELSEVIER The journey of a mental health professional with co-morbid mental health and alcohol use disorder from despair, to acceptance, to advocacy 2023 Amsterdam [u.a.] (DE-627)ELV009586830 volume:42 year:2021 number:3 pages:228-247 extent:20 https://doi.org/10.1016/j.it.2021.01.005 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 42 2021 3 228-247 20 |
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10.1016/j.it.2021.01.005 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001309.pica (DE-627)ELV053217993 (ELSEVIER)S1471-4906(21)00005-3 DE-627 ger DE-627 rakwb eng Schirmer, Lucas verfasserin aut Diversity and Function of Glial Cell Types in Multiple Sclerosis 2021transfer abstract 20 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Glial subtype diversity is an emerging topic in neurobiology and immune-mediated neurological diseases such as multiple sclerosis (MS). We discuss recent conceptual and technological advances that allow a better understanding of the transcriptomic and functional heterogeneity of oligodendrocytes (OLs), astrocytes, and microglial cells under inflammatory–demyelinating conditions. Recent single cell transcriptomic studies suggest the occurrence of novel homeostatic and reactive glial subtypes and provide insight into the molecular events during disease progression. Multiplexed RNA in situ hybridization has enabled ‘mapping back’ dysregulated gene expression to glial subtypes within the MS lesion microenvironment. These findings suggest novel homeostatic and reactive glial-cell-type functions both in immune-related processes and neuroprotection relevant to understanding the pathology of MS. Glial subtype diversity is an emerging topic in neurobiology and immune-mediated neurological diseases such as multiple sclerosis (MS). We discuss recent conceptual and technological advances that allow a better understanding of the transcriptomic and functional heterogeneity of oligodendrocytes (OLs), astrocytes, and microglial cells under inflammatory–demyelinating conditions. Recent single cell transcriptomic studies suggest the occurrence of novel homeostatic and reactive glial subtypes and provide insight into the molecular events during disease progression. Multiplexed RNA in situ hybridization has enabled ‘mapping back’ dysregulated gene expression to glial subtypes within the MS lesion microenvironment. These findings suggest novel homeostatic and reactive glial-cell-type functions both in immune-related processes and neuroprotection relevant to understanding the pathology of MS. Schafer, Dorothy P. oth Bartels, Theresa oth Rowitch, David H. oth Calabresi, Peter A. oth Enthalten in Elsevier Science Thomas, Brandon ELSEVIER The journey of a mental health professional with co-morbid mental health and alcohol use disorder from despair, to acceptance, to advocacy 2023 Amsterdam [u.a.] (DE-627)ELV009586830 volume:42 year:2021 number:3 pages:228-247 extent:20 https://doi.org/10.1016/j.it.2021.01.005 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 42 2021 3 228-247 20 |
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Glial subtype diversity is an emerging topic in neurobiology and immune-mediated neurological diseases such as multiple sclerosis (MS). We discuss recent conceptual and technological advances that allow a better understanding of the transcriptomic and functional heterogeneity of oligodendrocytes (OLs), astrocytes, and microglial cells under inflammatory–demyelinating conditions. Recent single cell transcriptomic studies suggest the occurrence of novel homeostatic and reactive glial subtypes and provide insight into the molecular events during disease progression. Multiplexed RNA in situ hybridization has enabled ‘mapping back’ dysregulated gene expression to glial subtypes within the MS lesion microenvironment. These findings suggest novel homeostatic and reactive glial-cell-type functions both in immune-related processes and neuroprotection relevant to understanding the pathology of MS. |
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Glial subtype diversity is an emerging topic in neurobiology and immune-mediated neurological diseases such as multiple sclerosis (MS). We discuss recent conceptual and technological advances that allow a better understanding of the transcriptomic and functional heterogeneity of oligodendrocytes (OLs), astrocytes, and microglial cells under inflammatory–demyelinating conditions. Recent single cell transcriptomic studies suggest the occurrence of novel homeostatic and reactive glial subtypes and provide insight into the molecular events during disease progression. Multiplexed RNA in situ hybridization has enabled ‘mapping back’ dysregulated gene expression to glial subtypes within the MS lesion microenvironment. These findings suggest novel homeostatic and reactive glial-cell-type functions both in immune-related processes and neuroprotection relevant to understanding the pathology of MS. |
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Glial subtype diversity is an emerging topic in neurobiology and immune-mediated neurological diseases such as multiple sclerosis (MS). We discuss recent conceptual and technological advances that allow a better understanding of the transcriptomic and functional heterogeneity of oligodendrocytes (OLs), astrocytes, and microglial cells under inflammatory–demyelinating conditions. Recent single cell transcriptomic studies suggest the occurrence of novel homeostatic and reactive glial subtypes and provide insight into the molecular events during disease progression. Multiplexed RNA in situ hybridization has enabled ‘mapping back’ dysregulated gene expression to glial subtypes within the MS lesion microenvironment. These findings suggest novel homeostatic and reactive glial-cell-type functions both in immune-related processes and neuroprotection relevant to understanding the pathology of MS. |
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10.1016/j.it.2021.01.005 |
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2024-07-06T18:20:33.966Z |
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