Drug screening strategies using metal-based luminescent probes
Drug screening assays employing organic fluorophores are widely used for high-throughput screening of potential drugs. However, organic dyes generally possess short lifetimes and narrow Stokes shifts, and are susceptible to background signal interference. In recent years, metal-based luminescent pro...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Li, Guodong [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021transfer abstract |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: The effect of increasing Body Mass Index on sperm quality of subfertile men - Kozopas, N. ELSEVIER, 2019, TrAC, Amsterdam |
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| Übergeordnetes Werk: |
volume:139 ; year:2021 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1016/j.trac.2021.116270 |
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| 520 | |a Drug screening assays employing organic fluorophores are widely used for high-throughput screening of potential drugs. However, organic dyes generally possess short lifetimes and narrow Stokes shifts, and are susceptible to background signal interference. In recent years, metal-based luminescent probes, such as transition metal complexes (e.g. Ir(III), Ru(II)), lanthanide complexes (e.g. Eu(III) and Tb(III)), and metal-based nanomaterials or quantum dots, have found increasing use for biosensing and bioimaging owing to their distinct spectral and structural characteristics. In this review, we first introduce the photophysical properties of metal-based luminescent probes, and then describe representative examples of metal-based luminescent probes and their applications for drug screening, including competitive, oligonucleotide-based, reaction-based, and assembly-based drug screening strategies. We also present the combination of these metal-based probes with luminescence microscopy (e.g. TRES) or imaging techniques (e.g. PLIM), which could open new doors for translational biomedical and/or (pre)clinical studies of biomolecular regulators in more challenging biological systems. | ||
| 520 | |a Drug screening assays employing organic fluorophores are widely used for high-throughput screening of potential drugs. However, organic dyes generally possess short lifetimes and narrow Stokes shifts, and are susceptible to background signal interference. In recent years, metal-based luminescent probes, such as transition metal complexes (e.g. Ir(III), Ru(II)), lanthanide complexes (e.g. Eu(III) and Tb(III)), and metal-based nanomaterials or quantum dots, have found increasing use for biosensing and bioimaging owing to their distinct spectral and structural characteristics. In this review, we first introduce the photophysical properties of metal-based luminescent probes, and then describe representative examples of metal-based luminescent probes and their applications for drug screening, including competitive, oligonucleotide-based, reaction-based, and assembly-based drug screening strategies. We also present the combination of these metal-based probes with luminescence microscopy (e.g. TRES) or imaging techniques (e.g. PLIM), which could open new doors for translational biomedical and/or (pre)clinical studies of biomolecular regulators in more challenging biological systems. | ||
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10.1016/j.trac.2021.116270 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001578.pica (DE-627)ELV053894944 (ELSEVIER)S0165-9936(21)00093-5 DE-627 ger DE-627 rakwb eng 540 610 VZ 35.00 bkl 44.46 bkl Li, Guodong verfasserin aut Drug screening strategies using metal-based luminescent probes 2021transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Drug screening assays employing organic fluorophores are widely used for high-throughput screening of potential drugs. However, organic dyes generally possess short lifetimes and narrow Stokes shifts, and are susceptible to background signal interference. In recent years, metal-based luminescent probes, such as transition metal complexes (e.g. Ir(III), Ru(II)), lanthanide complexes (e.g. Eu(III) and Tb(III)), and metal-based nanomaterials or quantum dots, have found increasing use for biosensing and bioimaging owing to their distinct spectral and structural characteristics. In this review, we first introduce the photophysical properties of metal-based luminescent probes, and then describe representative examples of metal-based luminescent probes and their applications for drug screening, including competitive, oligonucleotide-based, reaction-based, and assembly-based drug screening strategies. We also present the combination of these metal-based probes with luminescence microscopy (e.g. TRES) or imaging techniques (e.g. PLIM), which could open new doors for translational biomedical and/or (pre)clinical studies of biomolecular regulators in more challenging biological systems. Drug screening assays employing organic fluorophores are widely used for high-throughput screening of potential drugs. However, organic dyes generally possess short lifetimes and narrow Stokes shifts, and are susceptible to background signal interference. In recent years, metal-based luminescent probes, such as transition metal complexes (e.g. Ir(III), Ru(II)), lanthanide complexes (e.g. Eu(III) and Tb(III)), and metal-based nanomaterials or quantum dots, have found increasing use for biosensing and bioimaging owing to their distinct spectral and structural characteristics. In this review, we first introduce the photophysical properties of metal-based luminescent probes, and then describe representative examples of metal-based luminescent probes and their applications for drug screening, including competitive, oligonucleotide-based, reaction-based, and assembly-based drug screening strategies. We also present the combination of these metal-based probes with luminescence microscopy (e.g. TRES) or imaging techniques (e.g. PLIM), which could open new doors for translational biomedical and/or (pre)clinical studies of biomolecular regulators in more challenging biological systems. Metal-based probes Elsevier Luminescence Elsevier Drug screening Elsevier Wu, Chun oth Ma, Dik-Lung oth Leung, Chung-Hang oth Enthalten in Elsevier Kozopas, N. ELSEVIER The effect of increasing Body Mass Index on sperm quality of subfertile men 2019 TrAC Amsterdam (DE-627)ELV002244268 volume:139 year:2021 pages:0 https://doi.org/10.1016/j.trac.2021.116270 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 35.00 Chemie: Allgemeines VZ 44.46 Klinische Pathologie VZ AR 139 2021 0 |
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10.1016/j.trac.2021.116270 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001578.pica (DE-627)ELV053894944 (ELSEVIER)S0165-9936(21)00093-5 DE-627 ger DE-627 rakwb eng 540 610 VZ 35.00 bkl 44.46 bkl Li, Guodong verfasserin aut Drug screening strategies using metal-based luminescent probes 2021transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Drug screening assays employing organic fluorophores are widely used for high-throughput screening of potential drugs. However, organic dyes generally possess short lifetimes and narrow Stokes shifts, and are susceptible to background signal interference. In recent years, metal-based luminescent probes, such as transition metal complexes (e.g. Ir(III), Ru(II)), lanthanide complexes (e.g. Eu(III) and Tb(III)), and metal-based nanomaterials or quantum dots, have found increasing use for biosensing and bioimaging owing to their distinct spectral and structural characteristics. In this review, we first introduce the photophysical properties of metal-based luminescent probes, and then describe representative examples of metal-based luminescent probes and their applications for drug screening, including competitive, oligonucleotide-based, reaction-based, and assembly-based drug screening strategies. We also present the combination of these metal-based probes with luminescence microscopy (e.g. TRES) or imaging techniques (e.g. PLIM), which could open new doors for translational biomedical and/or (pre)clinical studies of biomolecular regulators in more challenging biological systems. Drug screening assays employing organic fluorophores are widely used for high-throughput screening of potential drugs. However, organic dyes generally possess short lifetimes and narrow Stokes shifts, and are susceptible to background signal interference. In recent years, metal-based luminescent probes, such as transition metal complexes (e.g. Ir(III), Ru(II)), lanthanide complexes (e.g. Eu(III) and Tb(III)), and metal-based nanomaterials or quantum dots, have found increasing use for biosensing and bioimaging owing to their distinct spectral and structural characteristics. In this review, we first introduce the photophysical properties of metal-based luminescent probes, and then describe representative examples of metal-based luminescent probes and their applications for drug screening, including competitive, oligonucleotide-based, reaction-based, and assembly-based drug screening strategies. We also present the combination of these metal-based probes with luminescence microscopy (e.g. TRES) or imaging techniques (e.g. PLIM), which could open new doors for translational biomedical and/or (pre)clinical studies of biomolecular regulators in more challenging biological systems. Metal-based probes Elsevier Luminescence Elsevier Drug screening Elsevier Wu, Chun oth Ma, Dik-Lung oth Leung, Chung-Hang oth Enthalten in Elsevier Kozopas, N. ELSEVIER The effect of increasing Body Mass Index on sperm quality of subfertile men 2019 TrAC Amsterdam (DE-627)ELV002244268 volume:139 year:2021 pages:0 https://doi.org/10.1016/j.trac.2021.116270 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 35.00 Chemie: Allgemeines VZ 44.46 Klinische Pathologie VZ AR 139 2021 0 |
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10.1016/j.trac.2021.116270 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001578.pica (DE-627)ELV053894944 (ELSEVIER)S0165-9936(21)00093-5 DE-627 ger DE-627 rakwb eng 540 610 VZ 35.00 bkl 44.46 bkl Li, Guodong verfasserin aut Drug screening strategies using metal-based luminescent probes 2021transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Drug screening assays employing organic fluorophores are widely used for high-throughput screening of potential drugs. However, organic dyes generally possess short lifetimes and narrow Stokes shifts, and are susceptible to background signal interference. In recent years, metal-based luminescent probes, such as transition metal complexes (e.g. Ir(III), Ru(II)), lanthanide complexes (e.g. Eu(III) and Tb(III)), and metal-based nanomaterials or quantum dots, have found increasing use for biosensing and bioimaging owing to their distinct spectral and structural characteristics. In this review, we first introduce the photophysical properties of metal-based luminescent probes, and then describe representative examples of metal-based luminescent probes and their applications for drug screening, including competitive, oligonucleotide-based, reaction-based, and assembly-based drug screening strategies. We also present the combination of these metal-based probes with luminescence microscopy (e.g. TRES) or imaging techniques (e.g. PLIM), which could open new doors for translational biomedical and/or (pre)clinical studies of biomolecular regulators in more challenging biological systems. Drug screening assays employing organic fluorophores are widely used for high-throughput screening of potential drugs. However, organic dyes generally possess short lifetimes and narrow Stokes shifts, and are susceptible to background signal interference. In recent years, metal-based luminescent probes, such as transition metal complexes (e.g. Ir(III), Ru(II)), lanthanide complexes (e.g. Eu(III) and Tb(III)), and metal-based nanomaterials or quantum dots, have found increasing use for biosensing and bioimaging owing to their distinct spectral and structural characteristics. In this review, we first introduce the photophysical properties of metal-based luminescent probes, and then describe representative examples of metal-based luminescent probes and their applications for drug screening, including competitive, oligonucleotide-based, reaction-based, and assembly-based drug screening strategies. We also present the combination of these metal-based probes with luminescence microscopy (e.g. TRES) or imaging techniques (e.g. PLIM), which could open new doors for translational biomedical and/or (pre)clinical studies of biomolecular regulators in more challenging biological systems. Metal-based probes Elsevier Luminescence Elsevier Drug screening Elsevier Wu, Chun oth Ma, Dik-Lung oth Leung, Chung-Hang oth Enthalten in Elsevier Kozopas, N. ELSEVIER The effect of increasing Body Mass Index on sperm quality of subfertile men 2019 TrAC Amsterdam (DE-627)ELV002244268 volume:139 year:2021 pages:0 https://doi.org/10.1016/j.trac.2021.116270 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 35.00 Chemie: Allgemeines VZ 44.46 Klinische Pathologie VZ AR 139 2021 0 |
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10.1016/j.trac.2021.116270 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001578.pica (DE-627)ELV053894944 (ELSEVIER)S0165-9936(21)00093-5 DE-627 ger DE-627 rakwb eng 540 610 VZ 35.00 bkl 44.46 bkl Li, Guodong verfasserin aut Drug screening strategies using metal-based luminescent probes 2021transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Drug screening assays employing organic fluorophores are widely used for high-throughput screening of potential drugs. However, organic dyes generally possess short lifetimes and narrow Stokes shifts, and are susceptible to background signal interference. In recent years, metal-based luminescent probes, such as transition metal complexes (e.g. Ir(III), Ru(II)), lanthanide complexes (e.g. Eu(III) and Tb(III)), and metal-based nanomaterials or quantum dots, have found increasing use for biosensing and bioimaging owing to their distinct spectral and structural characteristics. In this review, we first introduce the photophysical properties of metal-based luminescent probes, and then describe representative examples of metal-based luminescent probes and their applications for drug screening, including competitive, oligonucleotide-based, reaction-based, and assembly-based drug screening strategies. We also present the combination of these metal-based probes with luminescence microscopy (e.g. TRES) or imaging techniques (e.g. PLIM), which could open new doors for translational biomedical and/or (pre)clinical studies of biomolecular regulators in more challenging biological systems. Drug screening assays employing organic fluorophores are widely used for high-throughput screening of potential drugs. However, organic dyes generally possess short lifetimes and narrow Stokes shifts, and are susceptible to background signal interference. In recent years, metal-based luminescent probes, such as transition metal complexes (e.g. Ir(III), Ru(II)), lanthanide complexes (e.g. Eu(III) and Tb(III)), and metal-based nanomaterials or quantum dots, have found increasing use for biosensing and bioimaging owing to their distinct spectral and structural characteristics. In this review, we first introduce the photophysical properties of metal-based luminescent probes, and then describe representative examples of metal-based luminescent probes and their applications for drug screening, including competitive, oligonucleotide-based, reaction-based, and assembly-based drug screening strategies. We also present the combination of these metal-based probes with luminescence microscopy (e.g. TRES) or imaging techniques (e.g. PLIM), which could open new doors for translational biomedical and/or (pre)clinical studies of biomolecular regulators in more challenging biological systems. Metal-based probes Elsevier Luminescence Elsevier Drug screening Elsevier Wu, Chun oth Ma, Dik-Lung oth Leung, Chung-Hang oth Enthalten in Elsevier Kozopas, N. ELSEVIER The effect of increasing Body Mass Index on sperm quality of subfertile men 2019 TrAC Amsterdam (DE-627)ELV002244268 volume:139 year:2021 pages:0 https://doi.org/10.1016/j.trac.2021.116270 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 35.00 Chemie: Allgemeines VZ 44.46 Klinische Pathologie VZ AR 139 2021 0 |
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10.1016/j.trac.2021.116270 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001578.pica (DE-627)ELV053894944 (ELSEVIER)S0165-9936(21)00093-5 DE-627 ger DE-627 rakwb eng 540 610 VZ 35.00 bkl 44.46 bkl Li, Guodong verfasserin aut Drug screening strategies using metal-based luminescent probes 2021transfer abstract nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Drug screening assays employing organic fluorophores are widely used for high-throughput screening of potential drugs. However, organic dyes generally possess short lifetimes and narrow Stokes shifts, and are susceptible to background signal interference. In recent years, metal-based luminescent probes, such as transition metal complexes (e.g. Ir(III), Ru(II)), lanthanide complexes (e.g. Eu(III) and Tb(III)), and metal-based nanomaterials or quantum dots, have found increasing use for biosensing and bioimaging owing to their distinct spectral and structural characteristics. In this review, we first introduce the photophysical properties of metal-based luminescent probes, and then describe representative examples of metal-based luminescent probes and their applications for drug screening, including competitive, oligonucleotide-based, reaction-based, and assembly-based drug screening strategies. We also present the combination of these metal-based probes with luminescence microscopy (e.g. TRES) or imaging techniques (e.g. PLIM), which could open new doors for translational biomedical and/or (pre)clinical studies of biomolecular regulators in more challenging biological systems. Drug screening assays employing organic fluorophores are widely used for high-throughput screening of potential drugs. However, organic dyes generally possess short lifetimes and narrow Stokes shifts, and are susceptible to background signal interference. In recent years, metal-based luminescent probes, such as transition metal complexes (e.g. Ir(III), Ru(II)), lanthanide complexes (e.g. Eu(III) and Tb(III)), and metal-based nanomaterials or quantum dots, have found increasing use for biosensing and bioimaging owing to their distinct spectral and structural characteristics. In this review, we first introduce the photophysical properties of metal-based luminescent probes, and then describe representative examples of metal-based luminescent probes and their applications for drug screening, including competitive, oligonucleotide-based, reaction-based, and assembly-based drug screening strategies. We also present the combination of these metal-based probes with luminescence microscopy (e.g. TRES) or imaging techniques (e.g. PLIM), which could open new doors for translational biomedical and/or (pre)clinical studies of biomolecular regulators in more challenging biological systems. Metal-based probes Elsevier Luminescence Elsevier Drug screening Elsevier Wu, Chun oth Ma, Dik-Lung oth Leung, Chung-Hang oth Enthalten in Elsevier Kozopas, N. ELSEVIER The effect of increasing Body Mass Index on sperm quality of subfertile men 2019 TrAC Amsterdam (DE-627)ELV002244268 volume:139 year:2021 pages:0 https://doi.org/10.1016/j.trac.2021.116270 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 35.00 Chemie: Allgemeines VZ 44.46 Klinische Pathologie VZ AR 139 2021 0 |
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Drug screening assays employing organic fluorophores are widely used for high-throughput screening of potential drugs. However, organic dyes generally possess short lifetimes and narrow Stokes shifts, and are susceptible to background signal interference. In recent years, metal-based luminescent probes, such as transition metal complexes (e.g. Ir(III), Ru(II)), lanthanide complexes (e.g. Eu(III) and Tb(III)), and metal-based nanomaterials or quantum dots, have found increasing use for biosensing and bioimaging owing to their distinct spectral and structural characteristics. In this review, we first introduce the photophysical properties of metal-based luminescent probes, and then describe representative examples of metal-based luminescent probes and their applications for drug screening, including competitive, oligonucleotide-based, reaction-based, and assembly-based drug screening strategies. We also present the combination of these metal-based probes with luminescence microscopy (e.g. TRES) or imaging techniques (e.g. PLIM), which could open new doors for translational biomedical and/or (pre)clinical studies of biomolecular regulators in more challenging biological systems. |
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Drug screening assays employing organic fluorophores are widely used for high-throughput screening of potential drugs. However, organic dyes generally possess short lifetimes and narrow Stokes shifts, and are susceptible to background signal interference. In recent years, metal-based luminescent probes, such as transition metal complexes (e.g. Ir(III), Ru(II)), lanthanide complexes (e.g. Eu(III) and Tb(III)), and metal-based nanomaterials or quantum dots, have found increasing use for biosensing and bioimaging owing to their distinct spectral and structural characteristics. In this review, we first introduce the photophysical properties of metal-based luminescent probes, and then describe representative examples of metal-based luminescent probes and their applications for drug screening, including competitive, oligonucleotide-based, reaction-based, and assembly-based drug screening strategies. We also present the combination of these metal-based probes with luminescence microscopy (e.g. TRES) or imaging techniques (e.g. PLIM), which could open new doors for translational biomedical and/or (pre)clinical studies of biomolecular regulators in more challenging biological systems. |
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Drug screening assays employing organic fluorophores are widely used for high-throughput screening of potential drugs. However, organic dyes generally possess short lifetimes and narrow Stokes shifts, and are susceptible to background signal interference. In recent years, metal-based luminescent probes, such as transition metal complexes (e.g. Ir(III), Ru(II)), lanthanide complexes (e.g. Eu(III) and Tb(III)), and metal-based nanomaterials or quantum dots, have found increasing use for biosensing and bioimaging owing to their distinct spectral and structural characteristics. In this review, we first introduce the photophysical properties of metal-based luminescent probes, and then describe representative examples of metal-based luminescent probes and their applications for drug screening, including competitive, oligonucleotide-based, reaction-based, and assembly-based drug screening strategies. We also present the combination of these metal-based probes with luminescence microscopy (e.g. TRES) or imaging techniques (e.g. PLIM), which could open new doors for translational biomedical and/or (pre)clinical studies of biomolecular regulators in more challenging biological systems. |
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